{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:27:36Z","timestamp":1790735256760,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL 72006"],"award-info":[{"award-number":["HL 72006"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.neuroscience.2016.09.038","type":"journal-article","created":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T09:54:39Z","timestamp":1475229279000},"page":"47-53","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Direct projections from hypothalamic orexin neurons to brainstem cardiac vagal neurons"],"prefix":"10.1016","volume":"339","author":[{"given":"Olga","family":"Dergacheva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vsevolod Y.","family":"Polotsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mendelowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2016.09.038_b0005","doi-asserted-by":"crossref","first-page":"R1801","DOI":"10.1152\/ajpregu.2001.281.6.R1801","article-title":"Orexins\/hypocretins excite rat sympathetic preganglionic neurons in vivo and in vitro","volume":"281","author":"Antunes","year":"2001","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0010","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1523\/JNEUROSCI.5269-14.2015","article-title":"Optogenetic evidence for inhibitory signaling from orexin to MCH neurons via local microcircuits","volume":"35","author":"Apergis-Schoute","year":"2015","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0015","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/sleep\/34.2.213","article-title":"Sleep related changes in blood pressure in hypocretin-deficient narcoleptic mice","volume":"34","author":"Bastianini","year":"2011","journal-title":"Sleep"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0020","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1152\/japplphysiol.00277.2004","article-title":"Respiratory sinus arrhythmia in freely moving and anesthetized rats 1985","volume":"97","author":"Bouairi","year":"2004","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0025","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1113\/jphysiol.1965.sp007547","article-title":"Effects on heart rate of electrical stimulation of medullary vagal structures in the cat","volume":"176","author":"Calaresu","year":"1965","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0030","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3389\/fnins.2013.00257","article-title":"Orexin, orexin receptor antagonists and central cardiovascular control","volume":"7","author":"Carrive","year":"2013","journal-title":"Front Neurosci"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0035","doi-asserted-by":"crossref","first-page":"R692","DOI":"10.1152\/ajpregu.2000.278.3.R692","article-title":"Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rats","volume":"278","author":"Chen","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0040","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/(SICI)1096-9861(19990726)410:2<320::AID-CNE12>3.0.CO;2-5","article-title":"Projections of the dorsal motor nucleus of the vagus to cardiac ganglia of rat atria: an anterograde tracing study","volume":"410","author":"Cheng","year":"1999","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0045","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0165-1838(82)90086-8","article-title":"Medullary origin of vagal preganglionic axons to the heart of the cat","volume":"5","author":"Ciriello","year":"1982","journal-title":"J Auton Nerv Syst"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0050","doi-asserted-by":"crossref","first-page":"R1611","DOI":"10.1152\/ajpregu.00719.2002","article-title":"Cardiac effects of hypocretin-1 in nucleus ambiguus","volume":"284","author":"Ciriello","year":"2003","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0055","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.brainres.2003.08.008","article-title":"Cardioacceleratory responses to hypocretin-1 injections into rostral ventromedial medulla","volume":"991","author":"Ciriello","year":"2003","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0060","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1073\/pnas.96.2.748","article-title":"Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems","volume":"96","author":"Date","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0065","doi-asserted-by":"crossref","first-page":"H1369","DOI":"10.1152\/ajpheart.00877.2002","article-title":"Cardiovascular effects of hypocretin-1 in nucleus of the solitary tract","volume":"284","author":"de Oliveira","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0070","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1523\/JNEUROSCI.4269-12.2013","article-title":"Glutamatergic neurotransmission between the C1 neurons and the parasympathetic preganglionic neurons of the dorsal motor nucleus of the vagus","volume":"33","author":"DePuy","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0075","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1152\/jn.00302.2014","article-title":"Chronic intermittent hypoxia alters neurotransmission from lateral paragigantocellular nucleus to parasympathetic cardiac neurons in the brain stem","volume":"113","author":"Dergacheva","year":"2015","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0080","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1152\/jn.01054.2012","article-title":"Developmental changes in GABAergic neurotransmission to presympathetic and cardiac parasympathetic neurons in the brainstem","volume":"110","author":"Dergacheva","year":"2013","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0085","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1161\/HYPERTENSIONAHA.114.03603","article-title":"Chronic intermittent hypoxia and hypercapnia inhibit the hypothalamic paraventricular nucleus neurotransmission to parasympathetic cardiac neurons in the brain stem","volume":"64","author":"Dergacheva","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0090","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1124\/jpet.105.086421","article-title":"Hypocretin-1 (orexin-A) facilitates inhibitory and diminishes excitatory synaptic pathways to cardiac vagal neurons in the nucleus ambiguus","volume":"314","author":"Dergacheva","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0095","first-page":"02016","article-title":"Hypoxia and hypercapnia inhibit hypothalamic orexin neurons in rats","volume":"00196","author":"Dergacheva","year":"2016","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0100","doi-asserted-by":"crossref","first-page":"519","DOI":"10.5665\/sleep.1738","article-title":"Abnormal sleep-cardiovascular system interaction in narcolepsy with cataplexy: effects of hypocretin deficiency in humans","volume":"35","author":"Grimaldi","year":"2012","journal-title":"Sleep"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0105","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.neuroscience.2010.06.003","article-title":"Immunohistochemical evidence for synaptic release of glutamate from orexin terminals in the locus coeruleus","volume":"169","author":"Henny","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0110","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1124\/jpet.110.167791","article-title":"Orexins depolarize rostral ventrolateral medulla neurons and increase arterial pressure and heart rate in rats mainly via orexin 2 receptors","volume":"334","author":"Huang","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0115","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1469-7793.2001.00511.x","article-title":"Mechanisms of orexin-induced depolarizations in rat dorsal motor nucleus of vagus neurones in vitro","volume":"537","author":"Hwang","year":"2001","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0120","doi-asserted-by":"crossref","first-page":"R1011","DOI":"10.1152\/ajpregu.00263.2012","article-title":"Blockade of orexin receptors with Almorexant reduces cardiorespiratory responses evoked from the hypothalamus but not baro- or chemoreceptor reflex responses","volume":"303","author":"Iigaya","year":"2012","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0125","doi-asserted-by":"crossref","first-page":"R581","DOI":"10.1152\/ajpregu.00671.2002","article-title":"Attenuated defense response and low basal blood pressure in orexin knockout mice","volume":"285","author":"Kayaba","year":"2003","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0130","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.neuroscience.2011.11.073","article-title":"Orexin microinjection in the medullary raphe increases heart rate and arterial pressure but does not reduce tail skin blood flow in the awake rat","volume":"202","author":"Luong","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0135","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0167-0115(01)00351-2","article-title":"Pressor response to microinjection of orexin\/hypocretin into rostral ventrolateral medulla of awake rats","volume":"104","author":"Machado","year":"2002","journal-title":"Regul Pept"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0140","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/cvr\/cvs212","article-title":"Cardioprotection evoked by remote ischaemic preconditioning is critically dependent on the activity of vagal pre-ganglionic neurones","volume":"95","author":"Mastitskaya","year":"2012","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0145","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1161\/01.HYP.37.6.1382","article-title":"Central orexin-A augments sympathoadrenal outflow in conscious rabbits","volume":"37","author":"Matsumura","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0150","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/cne.901860106","article-title":"Localization of vagal cardioinhibitory preganglionic neurons with rat brain stem","volume":"186","author":"Nosaka","year":"1979","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0155","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nn1891","article-title":"Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections","volume":"10","author":"Petreanu","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0160","doi-asserted-by":"crossref","first-page":"9996","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998","article-title":"Neurons containing hypocretin (orexin) project to multiple neuronal systems","volume":"18","author":"Peyron","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0165","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jneumeth.2012.07.022","article-title":"Optogenetic approaches to characterize the long-range synaptic pathways from the hypothalamus to brain stem autonomic nuclei","volume":"210","author":"Pinol","year":"2012","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0170","doi-asserted-by":"crossref","first-page":"e112138","DOI":"10.1371\/journal.pone.0112138","article-title":"Visualization of oxytocin release that mediates paired pulse facilitation in hypothalamic pathways to brainstem autonomic neurons","volume":"9","author":"Pinol","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0175","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0006-8993(99)01457-2","article-title":"Cardiovascular regulatory actions of the hypocretins in brain","volume":"831","author":"Samson","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0180","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1113\/expphysiol.2009.051219","article-title":"Channelrhodopsin as a tool to investigate synaptic transmission and plasticity","volume":"96","author":"Schoenenberger","year":"2011","journal-title":"Exp Physiol"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0185","doi-asserted-by":"crossref","first-page":"12437","DOI":"10.1523\/JNEUROSCI.0706-12.2012","article-title":"Optogenetic probing of fast glutamatergic transmission from hypocretin\/orexin to histamine neurons in situ","volume":"32","author":"Schone","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0190","first-page":"R1780","article-title":"Sympathetic and cardiovascular actions of orexins in conscious rats","volume":"277","author":"Shirasaka","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0195","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/jsr.12081","article-title":"Sleep and cardiovascular phenotype in middle-aged hypocretin-deficient narcoleptic mice","volume":"23","author":"Silvani","year":"2014","journal-title":"J Sleep Res"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0200","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0006-8993(02)03048-2","article-title":"Microinjection of orexin into the rat nucleus tractus solitarius causes increases in blood pressure","volume":"950","author":"Smith","year":"2002","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0205","doi-asserted-by":"crossref","first-page":"91","DOI":"10.5665\/sleep.2308","article-title":"Attenuated heart rate response is associated with hypocretin deficiency in patients with narcolepsy","volume":"36","author":"Sorensen","year":"2013","journal-title":"Sleep"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0210","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000145422","article-title":"An orthograde labelling study of axons of the dorsal motor nucleus of the vagus to rat cardiac ganglia as demonstrated by autoradiography","volume":"110","author":"Sullivan","year":"1981","journal-title":"Acta Anat"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0215","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0306-4522(03)00238-0","article-title":"Colocalization of orexin a and glutamate immunoreactivity in axon terminals in the tuberomammillary nucleus in rats","volume":"119","author":"Torrealba","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0220","doi-asserted-by":"crossref","first-page":"6182","DOI":"10.1523\/JNEUROSCI.5093-13.2014","article-title":"Optogenetic stimulation of locus ceruleus neurons augments inhibitory transmission to parasympathetic cardiac vagal neurons via activation of brainstem alpha1 and beta1 receptors","volume":"34","author":"Wang","year":"2014","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2016.09.038_b0225","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neulet.2005.05.032","article-title":"Respiratory and cardiovascular actions of orexin-A in mice","volume":"385","author":"Zhang","year":"2005","journal-title":"Neurosci Lett"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452216304857?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452216304857?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T00:51:39Z","timestamp":1568422299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452216304857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":45,"alternative-id":["S0306452216304857"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2016.09.038","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}