{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:31:34Z","timestamp":1771306294164,"version":"3.50.1"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministry of Health & Welfare, Republic of Korea","award":["B120029"],"award-info":[{"award-number":["B120029"]}]},{"name":"Ministry of Trade, Industry & Energy, Republic of Korea","award":["10051960"],"award-info":[{"award-number":["10051960"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.neuroscience.2016.10.029","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T09:33:41Z","timestamp":1476869621000},"page":"166-175","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Protective effects of a herbal extract combination of Bupleurum falcatum , Paeonia suffruticosa , and Angelica dahurica against MPTP-induced neurotoxicity via regulation of nuclear receptor-related 1 protein"],"prefix":"10.1016","volume":"340","author":[{"given":"Yeomoon","family":"Sim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunhyuk","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeyoon","family":"Eo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Huh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pil Sung","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8353-2034","authenticated-orcid":false,"given":"Seon-Pyo","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngmi Kim","family":"Pak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung Sook","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2016.10.029_b0005","doi-asserted-by":"crossref","DOI":"10.1186\/1423-0127-21-27","article-title":"The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed","volume":"21","author":"Alavian","year":"2014","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0010","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jep.2010.12.016","article-title":"The neuroprotective effect of modified Yeoldahanso-tang via autophagy enhancement in models of Parkinson\u2019s disease","volume":"134","author":"Bae","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0015","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jep.2010.12.030","article-title":"Polygalae radix inhibits toxin-induced neuronal death in the Parkinson\u2019s disease models","volume":"134","author":"Choi","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0020","doi-asserted-by":"crossref","first-page":"11035","DOI":"10.1073\/pnas.1831768100","article-title":"Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons","volume":"100","author":"Cyr","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0025","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","article-title":"Parkinson\u2019s disease: mechanisms and models","volume":"39","author":"Dauer","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0030","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1096\/fj.00-0817rev","article-title":"The vesicular neurotransmitter transporters: current perspectives and future prospects","volume":"14","author":"Eiden","year":"2000","journal-title":"FASEB J"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0035","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2015.00020","article-title":"Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model for Parkinson\u2019s disease","volume":"7","author":"Esteves","year":"2015","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0040","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1159\/000204229","article-title":"Nurr1 expression and its modulation in microglia","volume":"16","author":"Fan","year":"2009","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0045","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S1474-4422(08)70214-X","article-title":"Non-dopaminergic treatments in development for Parkinson\u2019s disease","volume":"7","author":"Fox","year":"2008","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0050","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1111\/j.1471-4159.2009.06069.x","article-title":"A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer\u2019s amyloid beta proteins in vitro and in vivo","volume":"109","author":"Fujiwara","year":"2009","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0055","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neulet.2011.10.037","article-title":"Regulatory effects of costunolide on dopamine metabolism-associated genes inhibit dopamine-induced apoptosis in human dopaminergic SH-SY5Y cells","volume":"507","author":"Ham","year":"2012","journal-title":"Neurosci Lett"},{"issue":"Suppl","key":"10.1016\/j.neuroscience.2016.10.029_b0060","doi-asserted-by":"crossref","first-page":"299S","DOI":"10.1016\/0197-0186(92)90256-Q","article-title":"The MPTP-treated mouse as a model of Parkinsonism: how good is it?","volume":"20","author":"Heikkila","year":"1992","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0065","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jep.2010.11.017","article-title":"Dangguijakyak-san, a medicinal herbal formula, protects dopaminergic neurons from 6-hydroxydopamine-induced neurotoxicity","volume":"133","author":"Hwang","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0070","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1046\/j.1440-1819.2000.00756.x","article-title":"Effectiveness of the Kampo kami-shoyo-san (TJ-24) for tremor of antipsychotic-induced parkinsonism","volume":"54","author":"Ishikawa","year":"2000","journal-title":"Psychiatry Clin Neurosci"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0075","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.pneurobio.2005.09.001","article-title":"The role of Nurr1 in the development of dopaminergic neurons and Parkinson\u2019s disease","volume":"77","author":"Jankovic","year":"2005","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0080","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.fct.2010.05.002","article-title":"Cassiae semen, a seed of Cassia obtusifolia, has neuroprotective effects in Parkinson\u2019s disease models","volume":"48","author":"Ju","year":"2010","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0085","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.tiv.2009.12.026","article-title":"Protective effects of standardized Thuja orientalis leaves against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells","volume":"24","author":"Ju","year":"2010","journal-title":"Toxicol In Vitro"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0090","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.pnpbp.2009.11.019","article-title":"Successful treatment with Yokukansan for behavioral and psychological symptoms of Parkinsonian dementia","volume":"34","author":"Kawanabe","year":"2010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0095","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jep.2013.04.038","article-title":"Cyperi Rhizoma inhibits the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced reduction in nigrostriatal dopaminergenic neurons in estrogen-deprived mice","volume":"148","author":"Kim","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0100","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/j.1742-7843.2010.00612.x","article-title":"Protective effects of Chunghyuldan against ROS-mediated neuronal cell death in models of Parkinson\u2019s disease","volume":"107","author":"Kim","year":"2010","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0105","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1017\/S0007114510000218","article-title":"Mulberry fruit protects dopaminergic neurons in toxin-induced Parkinson\u2019s disease models","volume":"104","author":"Kim","year":"2010","journal-title":"Br J Nutr"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0110","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1248\/bpb.b13-00268","article-title":"Repeated heat exposure impairs nigrostriatal dopaminergic neurons in mice","volume":"36","author":"Kim","year":"2013","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0115","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.fct.2013.12.037","article-title":"Effects of the root bark of Paeonia suffruticosa on mitochondria-mediated neuroprotection in an MPTP-induced model of Parkinson\u2019s disease","volume":"65","author":"Kim","year":"2014","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0120","doi-asserted-by":"crossref","first-page":"275","DOI":"10.4062\/biomolther.2014.068","article-title":"Neuroprotective effect of chebulagic acid via autophagy induction in SH-SY5Y cells","volume":"22","author":"Kim","year":"2014","journal-title":"Biomol Ther (Seoul)"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0125","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.pnpbp.2009.11.015","article-title":"Antidepressant-like effect of the methanolic extract from Bupleurum falcatum in the tail suspension test","volume":"34","author":"Kwon","year":"2010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0130","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1523\/JNEUROSCI.3206-12.2013","article-title":"Aging-induced Nrf2-ARE pathway disruption in the subventricular zone drives neurogenic impairment in parkinsonian mice via PI3K-Wnt\/beta-catenin dysregulation","volume":"33","author":"L\u2019Episcopo","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0135","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jns.2008.06.007","article-title":"Decreased NURR1 gene expression in patients with Parkinson\u2019s disease","volume":"273","author":"Le","year":"2008","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0140","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1248\/bpb.32.1392","article-title":"Effect of Bupleurum falcatum on the stress-induced impairment of spatial working memory in rats","volume":"32","author":"Lee","year":"2009","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0145","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1089\/jmf.2009.1252","article-title":"Protective effect of Cyperi rhizoma against 6-hydroxydopamine-induced neuronal damage","volume":"13","author":"Lee","year":"2010","journal-title":"J Med Food"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0150","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/00001756-200401190-00020","article-title":"Differential role of ERK in cAMP-induced Nurr1 expression in N2A and C6 cells","volume":"15","author":"Lee","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0155","doi-asserted-by":"crossref","first-page":"155S","DOI":"10.1592\/phco.27.12part2.155S","article-title":"Overview of Parkinson\u2019s disease","volume":"27","author":"Lew","year":"2007","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0160","doi-asserted-by":"crossref","first-page":"7888","DOI":"10.1523\/JNEUROSCI.20-21-07888.2000","article-title":"Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice: gender and brain region differences","volume":"20","author":"Li","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0165","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/00008877-200609000-00006","article-title":"Traditional Chinese medicine for Parkinson\u2019s disease: a review of Chinese literature","volume":"17","author":"Li","year":"2006","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0170","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.fitote.2012.12.009","article-title":"Recent advances in herbal medicines treating Parkinson\u2019s disease","volume":"84","author":"Li","year":"2013","journal-title":"Fitoterapia"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0175","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/j.1468-1331.2011.03644.x","article-title":"Decreased NURR1 and PITX3 gene expression in Chinese patients with Parkinson\u2019s disease","volume":"19","author":"Liu","year":"2012","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0180","first-page":"1791","article-title":"Association of Nurr1 gene mutations with Parkinson\u2019s disease in the Han population living in the Hubei province of China","volume":"7","author":"Lou","year":"2012","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0185","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.biocel.2011.09.007","article-title":"DJ-1 upregulates tyrosine hydroxylase gene expression by activating its transcriptional factor Nurr1 via the ERK1\/2 pathway","volume":"44","author":"Lu","year":"2012","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0190","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17020151","article-title":"Microglia-mediated neuroinflammation and neurotrophic factor-induced protection in the MPTP mouse model of Parkinson\u2019s disease \u2013 Lessons from transgenic mice","volume":"17","author":"Machado","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0195","first-page":"133","article-title":"Saikosaponin a protects TBI rats after controlled cortical impact and the underlying mechanism","volume":"8","author":"Mao","year":"2016","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0200","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/1531-8257(200001)15:1<3::AID-MDS1003>3.0.CO;2-E","article-title":"Pathophysiology of motor response complications in Parkinson\u2019s disease: hypotheses on the why, where, and what","volume":"15","author":"Metman","year":"2000","journal-title":"Mov Disord"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0205","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/exnr.1998.7008","article-title":"Immunochemical analysis of vesicular monoamine transporter (VMAT2) protein in Parkinson\u2019s disease","volume":"156","author":"Miller","year":"1999","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0210","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s12640-009-9037-x","article-title":"Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson\u2019s disease by blocking microglial activation","volume":"15","author":"Moon","year":"2009","journal-title":"Neurotox Res"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0215","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/jnr.22734","article-title":"Inhibition of inflammation and oxidative stress by Angelica dahurica radix extract decreases apoptotic cell death and improves functional recovery after spinal cord injury","volume":"90","author":"Moon","year":"2012","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0220","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0378-8741(02)00285-4","article-title":"Inhibitory effects of the root cortex of Paeonia suffruticosa on interleukin-8 and macrophage chemoattractant protein-1 secretions in U937 cells","volume":"84","author":"Oh","year":"2003","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0225","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.pbb.2013.01.017","article-title":"Ropinirole protects against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity in mice via anti-apoptotic mechanism","volume":"104","author":"Park","year":"2013","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0230","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/ptr.903","article-title":"Effect of saikosaponin-A, a triterpenoid glycoside, isolated from Bupleurum falcatum on experimental allergic asthma","volume":"16","author":"Park","year":"2002","journal-title":"Phytother Res"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0235","series-title":"The mouse brain in stereotaxic coordinates","author":"Paxinos","year":"2001"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0240","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1248\/bpb.28.661","article-title":"Inhibition of production of reactive oxygen species and gene expression profile by treatment of ethanol extract of Moutan Cortex Radicis in oxidative stressed PC12 cells","volume":"28","author":"Rho","year":"2005","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0245","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1590\/S1677-55382012000400013","article-title":"Structural alterations of foreskin caused by chronic smoking may explain high levels of urethral reconstruction failure using foreskin flaps","volume":"38","author":"Rosado","year":"2012","journal-title":"Int Braz J Urol"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0250","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1073\/pnas.95.7.4013","article-title":"Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons","volume":"95","author":"Saucedo-Cardenas","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12017-007-8016-8","article-title":"Neurodegenerative diseases: neurotoxins as sufficient etiologic agents?","volume":"10","author":"Shaw","year":"2008","journal-title":"Neuromolecular Med"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0260","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jep.2009.08.023","article-title":"Effects of the hook of Uncaria rhynchophylla on neurotoxicity in the 6-hydroxydopamine model of Parkinson\u2019s disease","volume":"126","author":"Shim","year":"2009","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.febslet.2004.03.063","article-title":"Alpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson\u2019s disease","volume":"565","author":"Sidhu","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0270","first-page":"22","article-title":"A Nurr1 agonist causes neuroprotection in a Parkinson\u2019s disease lesion model primed with the Toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C)","volume":"10","author":"Smith","year":"2015","journal-title":"Plos One"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0275","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1046\/j.1460-9568.2003.02885.x","article-title":"Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons","volume":"18","author":"Smits","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0280","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.2042-7158.1991.tb03461.x","article-title":"Effects of a polysaccharide fraction from the roots of Bupleurum falcatum L. on experimental gastric ulcer models in rats and mice","volume":"43","author":"Sun","year":"1991","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0285","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1111\/j.1471-4159.2008.05310.x","article-title":"MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation\u2013relevance in a mouse model of Parkinson\u2019s disease","volume":"105","author":"Thomas","year":"2008","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0290","doi-asserted-by":"crossref","first-page":"6467","DOI":"10.1523\/JNEUROSCI.1676-05.2005","article-title":"Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections","volume":"25","author":"Thompson","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0295","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.fitote.2013.07.007","article-title":"The protective activity of imperatorin in cultured neural cells exposed to hypoxia re-oxygenation injury via anti-apoptosis","volume":"90","author":"Wang","year":"2013","journal-title":"Fitoterapia"},{"key":"10.1016\/j.neuroscience.2016.10.029_b9000","doi-asserted-by":"crossref","first-page":"5876","DOI":"10.1007\/s12035-015-9477-7","article-title":"Contra-directional coupling of Nur77 and Nurr1 in Neurodegeneration: A novel mechanism for Memantine-induced anti-inflammation and anti-mitochondrial impairment","volume":"53","author":"Wei","year":"2016","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0300","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1078\/0944-7113-00060","article-title":"Synergy and other interactions in phytomedicines","volume":"8","author":"Williamson","year":"2001","journal-title":"Phytomedicine"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0305","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0169-328X(96)00074-5","article-title":"Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system","volume":"41","author":"Zetterstrom","year":"1996","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0310","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.neulet.2007.06.041","article-title":"Nurr1 is phosphorylated by ERK2 in vitro and its phosphorylation upregulates tyrosine hydroxylase expression in SH-SY5Y cells","volume":"423","author":"Zhang","year":"2007","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2016.10.029_b0315","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.brainresbull.2014.09.008","article-title":"Paeonol pretreatment attenuates cerebral ischemic injury via upregulating expression of pAkt, Nrf2, HO-1 and ameliorating BBB permeability in mice","volume":"109","author":"Zhao","year":"2014","journal-title":"Brain Res Bull"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452216305693?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452216305693?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T16:00:57Z","timestamp":1568476857000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452216305693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":64,"alternative-id":["S0306452216305693"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2016.10.029","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}