{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:01:15Z","timestamp":1792144875405,"version":"4.4.0"},"reference-count":116,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.neuroscience.2016.10.041","type":"journal-article","created":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T06:17:17Z","timestamp":1477289837000},"page":"101-116","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Down-regulation of serotonin and dopamine transporter genes in individual rats expressing a gambling-prone profile: A possible role for epigenetic mechanisms"],"prefix":"10.1016","volume":"340","author":[{"given":"Francesca","family":"Zoratto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esterina","family":"Pascale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Pucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Falconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"Dell\u2019Osso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Maccarrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Laviola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"D\u2019Addario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Adriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2016.10.041_b0005","unstructured":"A.P.A. APA (2000) Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR; 4th edition, text revision). Washington, DC, USA."},{"key":"10.1016\/j.neuroscience.2016.10.041_b0010","unstructured":"A.P.A. APA (2013) Diagnostic and statistical manual of mental disorders (DSM-5; 5th edition). Arlington, VA, USA."},{"key":"10.1016\/j.neuroscience.2016.10.041_b0015","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2165\/00129785-200505030-00002","article-title":"Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope","volume":"5","author":"Abdolmaleky","year":"2005","journal-title":"Am J Pharmacogenomics"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0020","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2202-7-52","article-title":"Delay aversion but preference for large and rare rewards in two choice tasks: implications for the measurement of self-control parameters","volume":"7","author":"Adriani","year":"2006","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0025","first-page":"385","article-title":"Animal models and mechanisms of impulsivity in adolescence","volume":"vol. 9","author":"Adriani","year":"2009"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0030","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1038\/sj.npp.1300962","article-title":"Methylphenidate administration to adolescent rats determines plastic changes on reward-related behavior and striatal gene expression","volume":"31","author":"Adriani","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0035","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neuroscience.2008.11.042","article-title":"Increased impulsive behavior and risk proneness following lentivirus-mediated dopamine transporter over-expression in rats\u2019 nucleus accumbens","volume":"159","author":"Adriani","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0040","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1017\/S1461145709991210","article-title":"Social withdrawal and gambling-like profile after lentiviral manipulation of DAT expression in the rat accumbens","volume":"13","author":"Adriani","year":"2010","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0045","series-title":"Psychology of gambling: new research","first-page":"73","article-title":"Home-cage testing of choice behaviour: proneness to risk in a gambling task","author":"Adriani","year":"2012"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0050","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bbr.2014.12.003","article-title":"Does reward unpredictability reflect risk?","volume":"280","author":"Anselme","year":"2014","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0055","article-title":"Complex factors and behaviors in the gambling population of Italy","author":"Bastiani","year":"2012","journal-title":"J Gambl Stud"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0060","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/01.NMD.0000050942.86352.47","article-title":"Quality of life and family history in pathological gambling","volume":"191","author":"Black","year":"2003","journal-title":"J Nerv Ment Dis"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0065","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.psychres.2005.12.005","article-title":"A family study of pathological gambling","volume":"141","author":"Black","year":"2006","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0070","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1176\/ajp.153.1.119","article-title":"Pathological gambling and platelet MAO activity: a psychobiological study","volume":"153","author":"Blanco","year":"1996","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0075","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.neunet.2006.03.001","article-title":"Neuropsychological correlates of decision-making in ambiguous and risky situations","volume":"19","author":"Brand","year":"2006","journal-title":"Neural Netw"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0080","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/sj.mp.4001908","article-title":"Serotonin transporter gene variation impacts innate fear processing: acoustic startle response and emotional startle","volume":"11","author":"Brocke","year":"2006","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0085","doi-asserted-by":"crossref","first-page":"204","DOI":"10.2174\/22115560113029990008","article-title":"Update on the pharmacological treatment of pathological gambling","volume":"2","author":"Bullock","year":"2013","journal-title":"Curr Psychopharmacol"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0090","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1471-2202-6-37","article-title":"Effects of lesions of the nucleus accumbens core on choice between small certain rewards and large uncertain rewards in rats","volume":"6","author":"Cardinal","year":"2005","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0095","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1600-0447.1994.tb01619.x","article-title":"Low platelet monoamine oxidase activity in pathological gambling","volume":"90","author":"Carrasco","year":"1994","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0100","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0105","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s00213-005-0104-6","article-title":"Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity","volume":"182","author":"Clark","year":"2005","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0110","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1001\/archpsyc.1996.01830060075010","article-title":"Impulsive aggression in personality disorder correlates with tritiated paroxetine binding in the platelet","volume":"53","author":"Coccaro","year":"1996","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0115","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.biopsych.2013.08.026","article-title":"A selective role for dopamine D(4) receptors in modulating reward expectancy in a rodent slot machine task","volume":"75","author":"Cocker","year":"2013","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0120","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1196\/annals.1299.124","article-title":"Dopaminergic modulation of apoptosis in human peripheral blood mononuclear cells: possible relevance for Parkinson\u2019s disease","volume":"1010","author":"Colombo","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0125","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1034\/j.1399-0004.2001.600204.x","article-title":"The additive effect of neurotransmitter genes in pathological gambling","volume":"60","author":"Comings","year":"2001","journal-title":"Clin Genet"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0130","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/npp.2010.121","article-title":"Serotonin and dopamine: unifying affective, activational, and decision functions","volume":"36","author":"Cools","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0135","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1182\/blood-2006-01-028423","article-title":"Human CD4+CD25+ regulatory T cells selectively express tyrosine hydroxylase and contain endogenous catecholamines subserving an autocrine\/paracrine inhibitory functional loop","volume":"109","author":"Cosentino","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0140","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1126\/science.284.5420.1670","article-title":"Genetics of mouse behavior: interactions with laboratory environment","volume":"284","author":"Crabbe","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0145","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.biopsych.2005.04.037","article-title":"Cue-induced brain activity in pathological gamblers","volume":"58","author":"Crockford","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0150","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.bbr.2009.04.003","article-title":"Effects of lesions of the nucleus accumbens core on inter-temporal choice: further observations with an adjusting-delay procedure","volume":"202","author":"da Costa Araujo","year":"2009","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0155","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bbr.2008.05.015","article-title":"Decision-making impairment is related to serotonin transporter promoter polymorphism in a sample of patients with obsessive-compulsive disorder","volume":"195","author":"da Rocha","year":"2008","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0160","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1006\/bbrc.1998.8891","article-title":"Differential expression of human histone deacetylase mRNAs in response to immune cell apoptosis induction by trichostatin A and butyrate","volume":"247","author":"Dangond","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0165","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.bbr.2015.07.025","article-title":"Role of serotonin transporter function in rat orbitofrontal cortex in impulsive choice","volume":"293","author":"Darna","year":"2015","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0170","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1089\/gte.1997.1.151","article-title":"Methylation analysis of the fragile X syndrome by PCR","volume":"1","author":"Das","year":"1997","journal-title":"Genet Test"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0175","doi-asserted-by":"crossref","first-page":"R43","DOI":"10.1186\/gb-2012-13-6-r43","article-title":"Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood","volume":"13","author":"Davies","year":"2012","journal-title":"Genome Biol"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0180","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1042\/bj20021321","article-title":"Histone deacetylases (HDACs): characterization of the classical HDAC family","volume":"370","author":"de Ruijter","year":"2003","journal-title":"Biochem J"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0185","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2011.00109","article-title":"Rodent versions of the iowa gambling task: opportunities and challenges for the understanding of decision-making","volume":"5","author":"de Visser","year":"2011","journal-title":"Front Neurosci"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0190","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1745-0179-1-21","article-title":"Comorbidity issues in the pharmacological treatment of Pathological Gambling: a critical review","volume":"1","author":"Dell\u2019Osso","year":"2005","journal-title":"Clin Pract Epidemiol Ment Health"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0195","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1176\/appi.ajp.162.5.915","article-title":"Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652","volume":"162","author":"Frankle","year":"2005","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0200","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.neubiorev.2009.10.010","article-title":"Histone modifications, DNA methylation, and schizophrenia","volume":"34","author":"Gavin","year":"2010","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0205","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jneuroim.2014.11.008","article-title":"Detection of auto-antibodies to DAT in the serum: interactions with DAT genotype and psycho-stimulant therapy for ADHD","volume":"278","author":"Giana","year":"2015","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0210","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1111\/add.12899","article-title":"Global statistics on addictive behaviours: 2014 status report","volume":"110","author":"Gowing","year":"2015","journal-title":"Addiction"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0215","first-page":"129","article-title":"Pharmacological treatment of adolescent pathological gambling","volume":"22","author":"Grant","year":"2010","journal-title":"Int J Adolesc Med Health"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0220","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.pharmthera.2005.01.007","article-title":"The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (+\/-) in schizophrenia","volume":"111","author":"Grayson","year":"2006","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0225","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3922\/j.psns.2010.2.009","article-title":"Learning processes and the neural analysis of conditioning","volume":"3","author":"Guerra","year":"2010","journal-title":"Psychol Neurosci"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0230","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.neuropharm.2010.07.008","article-title":"Serotonin transporter gene-linked polymorphic region (5-HTTLPR) influences decision making under ambiguity and risk in a large Chinese sample","volume":"59","author":"He","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0235","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.pnpbp.2015.05.013","article-title":"Alterations in DNA-methylation of the dopamine-receptor 2 gene are associated with abstinence and health care utilization in individuals with a lifetime history of pathologic gambling","volume":"63","author":"Hillemacher","year":"2015","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0240","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0197-0186(05)80003-8","article-title":"Serotonin transporters in adult rat brain astrocytes revealed by [3H]5-HT uptake into glial plasmalemmal vesicles","volume":"33","author":"Hirst","year":"1998","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0245","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/S0140-6736(10)62185-X","article-title":"Gambling disorders","volume":"378","author":"Hodgins","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0250","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0193-953X(05)70185-4","article-title":"Pathological gambling","volume":"23","author":"Hollander","year":"2000","journal-title":"Psychiatr Clin North Am"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0255","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0006-3223(00)00241-9","article-title":"A randomized double-blind fluvoxamine\/placebo crossover trial in pathologic gambling","volume":"47","author":"Hollander","year":"2000","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0260","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10899-004-1932-8","article-title":"Pharmacological treatments of pathological gambling","volume":"21","author":"Hollander","year":"2005","journal-title":"J Gambl Stud"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0265","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.beproc.2012.03.003","article-title":"Estimating the subjective value of future rewards: comparison of adjusting-amount and adjusting-delay procedures","volume":"90","author":"Holt","year":"2012","journal-title":"Behav Processes"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0270","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.neubiorev.2011.06.001","article-title":"Serotonin and decision making processes","volume":"36","author":"Homberg","year":"2012","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0275","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.neuropharm.2008.04.016","article-title":"Serotonin transporter dosage modulates long-term decision-making in rat and human","volume":"55","author":"Homberg","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0280","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1111\/j.1471-4159.2006.04430.x","article-title":"Dopaminergic neurons intrinsic to the striatum","volume":"101","author":"Huot","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0285","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1023\/A:1021271029163","article-title":"Genetics of pathological gambling","volume":"19","author":"Ibanez","year":"2003","journal-title":"J Gambl Stud"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0290","doi-asserted-by":"crossref","first-page":"6999","DOI":"10.1523\/JNEUROSCI.5996-09.2010","article-title":"Electrophysiological and morphological characteristics and synaptic connectivity of tyrosine hydroxylase-expressing neurons in adult mouse striatum","volume":"30","author":"Ibanez-Sandoval","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0295","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neulet.2006.02.044","article-title":"Gene expression and association analysis of LIM (PDLIM5) in major depression","volume":"400","author":"Iga","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0300","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrg2045","article-title":"Environmental epigenomics and disease susceptibility","volume":"8","author":"Jirtle","year":"2007","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0305","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.neuropharm.2011.11.002","article-title":"Compromised decision-making and increased gambling proneness following dietary serotonin depletion in rats","volume":"62","author":"Koot","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0310","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0014-2999(01)00906-2","article-title":"Regulation of serotonin transporter gene expression in human glial cells by growth factors","volume":"417","author":"Kubota","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0315","doi-asserted-by":"crossref","DOI":"10.1038\/sj.embor.7401008","article-title":"Linking emotion to the social brain. The role of the serotonin transporter in human social behaviour","volume":"8","author":"Lesch","year":"2007","journal-title":"EMBO Rep"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0320","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1111\/j.1471-4159.1993.tb03522.x","article-title":"Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter","volume":"60","author":"Lesch","year":"1993","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0325","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1126\/science.274.5292.1527","article-title":"Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region","volume":"274","author":"Lesch","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0330","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0306-4603(87)90019-0","article-title":"Pathological gambling among high school students","volume":"12","author":"Lesieur","year":"1987","journal-title":"Addict Behav"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0335","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0340","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1111\/j.1360-0443.2009.02671.x","article-title":"Genetic aspects of pathological gambling: a complex disorder with shared genetic vulnerabilities","volume":"104","author":"Lobo","year":"2009","journal-title":"Addiction"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0345","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.biopsycho.2010.04.008","article-title":"Association of functional variants in the dopamine D2-like receptors with risk for gambling behaviour in healthy Caucasian subjects","volume":"85","author":"Lobo","year":"2010","journal-title":"Biol Psychol"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0350","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1093\/clinchem\/47.5.844","article-title":"Quantification of HER2\/neu gene amplification by competitive pcr using fluorescent melting curve analysis","volume":"47","author":"Lyon","year":"2001","journal-title":"Clin Chem"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0355","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1017\/S0033291798007946","article-title":"Alteration of the platelet serotonin transporter in romantic love","volume":"29","author":"Marazziti","year":"1999","journal-title":"Psychol Med"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0360","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000068869","article-title":"Jealousy and subthreshold psychopathology: a serotonergic link","volume":"47","author":"Marazziti","year":"2003","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0365","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000129665","article-title":"Decreased density of the platelet serotonin transporter in pathological gamblers","volume":"57","author":"Marazziti","year":"2008","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0370","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s002130000385","article-title":"Effect of central 5-hydroxytryptamine depletion on inter-temporal choice: a quantitative analysis","volume":"149","author":"Mobini","year":"2000","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0375","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1002\/hup.470060503","article-title":"Serotonin and gambling dependence","volume":"6","author":"Moreno","year":"1991","journal-title":"Hum Psychopharmacol - Clin Exp"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0380","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jad.2007.02.001","article-title":"Major depressive disorder, serotonin transporter, and personality traits: Why patients use suboptimal decision-making strategies?","volume":"103","author":"Must","year":"2007","journal-title":"J Affect Disord"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2013.04.004","article-title":"Epigenetic mechanisms of drug addiction","volume":"76","author":"Nestler","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0390","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jpsychires.2005.06.003","article-title":"CSF monoamine patterns in pathological gamblers and healthy controls","volume":"40","author":"Nordin","year":"2006","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0395","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fimmu.2014.00117","article-title":"The dopaminergic system in autoimmune diseases","volume":"5","author":"Pacheco","year":"2014","journal-title":"Front Immunol"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0400","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fnbeh.2014.00033","article-title":"Nonhuman gamblers: lessons from rodents, primates, and robots","volume":"8","author":"Paglieri","year":"2014","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0405","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.4088\/JCP.v63n1114","article-title":"Nefazodone treatment of pathological gambling: a prospective open-label controlled trial","volume":"63","author":"Pallanti","year":"2002","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0410","doi-asserted-by":"crossref","first-page":"559","DOI":"10.4088\/JCP.v63n0704","article-title":"Lithium and valproate treatment of pathological gambling: a randomized single-blind study","volume":"63","author":"Pallanti","year":"2002","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0415","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1017\/S1092852900015145","article-title":"Serotonin dysfunction in pathological gamblers: increased prolactin response to oral m-CPP versus placebo","volume":"11","author":"Pallanti","year":"2006","journal-title":"CNS Spectr"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0420","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1177\/0269881109106907","article-title":"Serotonin function in pathological gambling: blunted growth hormone response to Sumatriptan","volume":"24","author":"Pallanti","year":"2010","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0425","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.tins.2009.05.001","article-title":"Tripartite synapses: astrocytes process and control synaptic information","volume":"32","author":"Perea","year":"2009","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0430","first-page":"397","article-title":"Genetic contribution to pathological gambling: possible association between a functional DNA polymorphism at the serotonin transporter gene (5-HTT) and affected men","volume":"9","author":"Perez de Castro","year":"1999","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0435","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.2174\/13894501113149990203","article-title":"Astrocyte-neuron interaction at tripartite synapses","volume":"14","author":"Perez-Alvarez","year":"2013","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0440","doi-asserted-by":"crossref","first-page":"564","DOI":"10.4088\/JCP.v66n0504","article-title":"Comorbidity of DSM-IV pathological gambling and other psychiatric disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions","volume":"66","author":"Petry","year":"2005","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0445","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1176\/appi.ajp.160.11.1990","article-title":"An FMRI Stroop task study of ventromedial prefrontal cortical function in pathological gamblers","volume":"160","author":"Potenza","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0450","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1001\/archpsyc.60.8.828","article-title":"Gambling urges in pathological gambling: a functional magnetic resonance imaging study","volume":"60","author":"Potenza","year":"2003","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0455","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S1074-7427(03)00077-7","article-title":"Acetylcholine actions in the dorsomedial striatum support the flexible shifting of response patterns","volume":"80","author":"Ragozzino","year":"2003","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0460","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nn1378","article-title":"Pathological gambling is linked to reduced activation of the mesolimbic reward system","volume":"8","author":"Reuter","year":"2005","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0465","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bandc.2004.09.016","article-title":"Neurocognitive mechanisms of cognitive control: the role of prefrontal cortex in action selection, response inhibition, performance monitoring, and reward-based learning","volume":"56","author":"Ridderinkhof","year":"2004","journal-title":"Brain Cogn"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0470","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/npp.2010.165","article-title":"The roles of dopamine and serotonin in decision making: evidence from pharmacological experiments in humans","volume":"36","author":"Rogers","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0475","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.pscychresns.2006.06.001","article-title":"Regional brain serotonin and dopamine transporter binding capacity in suicide attempters relate to impulsiveness and mental energy","volume":"148","author":"Ryding","year":"2006","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0480","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1016\/j.neuropsychologia.2005.10.012","article-title":"Temporal and probabilistic discounting of rewards in children and adolescents: effects of age and ADHD symptoms","volume":"44","author":"Scheres","year":"2006","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0485","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.psychres.2005.09.020","article-title":"Pooling pharmacogenetic studies on the serotonin transporter: a mega-analysis","volume":"145","author":"Serretti","year":"2006","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0490","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1901\/jeab.2009.92-1","article-title":"Probability discounting of gains and losses: implications for risk attitudes and impulsivity","volume":"92","author":"Shead","year":"2009","journal-title":"J Exp Anal Behav"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0495","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1038\/npp.2009.48","article-title":"Balancing risk and reward: a rat model of risky decision making","volume":"34","author":"Simon","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0500","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11920-003-0003-7","article-title":"Diagnosis and treatment of pathologic gambling","volume":"5","author":"Sood","year":"2003","journal-title":"Curr Psychiatry Rep"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0505","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1001\/archpsyc.1977.01770170019001","article-title":"The human platelet. A diagnostic and research tool for the study of biogenic amines in psychiatric and neurologic disorders","volume":"34","author":"Stahl","year":"1977","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0510","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.neuropharm.2009.09.010","article-title":"Gender moderates the association between 5-HTTLPR and decision-making under ambiguity but not under risk","volume":"58","author":"Stoltenberg","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0515","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12033-009-9216-2","article-title":"DNA methylation: an introduction to the biology and the disease-associated changes of a promising biomarker","volume":"44","author":"Tost","year":"2010","journal-title":"Mol Biotechnol"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0520","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.neulet.2006.06.004","article-title":"Brain and platelet serotonin transporter in humans-correlation between [123I]-ADAM SPECT and serotonergic measurements in platelets","volume":"406","author":"Uebelhack","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0525","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/B978-0-12-411512-5.00004-X","article-title":"Brain neurons partly expressing dopaminergic phenotype: location, development, functional significance, and regulation","volume":"68","author":"Ugrumov","year":"2013","journal-title":"Adv Pharmacol"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0530","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3758\/BF03192801","article-title":"Toward a rodent model of the Iowa gambling task","volume":"38","author":"van den Bos","year":"2006","journal-title":"Behav Res Methods"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0535","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.neuropharm.2008.10.002","article-title":"The effect of COMT Val(158) Met genotype on decision-making and preliminary findings on its interaction with the 5-HTTLPR in healthy females","volume":"56","author":"van den Bos","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0540","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/neu.10173","article-title":"Different data from different labs: lessons from studies of gene-environment interaction","volume":"54","author":"Wahlsten","year":"2003","journal-title":"J Neurobiol"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0545","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/j.1601-183X.2008.00406.x","article-title":"Rats bred for high alcohol drinking are more sensitive to delayed and probabilistic outcomes","volume":"7","author":"Wilhelm","year":"2008","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0550","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/npp.2010.230","article-title":"Dopamine modulates reward expectancy during performance of a slot machine task in rats: evidence for a \u2019near-miss\u2019 effect","volume":"36","author":"Winstanley","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0555","doi-asserted-by":"crossref","first-page":"6584","DOI":"10.1523\/JNEUROSCI.0195-15.2015","article-title":"Are striatal tyrosine hydroxylase interneurons dopaminergic?","volume":"35","author":"Xenias","year":"2015","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0560","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neuroscience.2015.11.033","article-title":"Individual differences in impulsive action and dopamine transporter function in rat orbitofrontal cortex","volume":"313","author":"Yates","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0565","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1038\/npp.2009.62","article-title":"Serotonergic and dopaminergic modulation of gambling behavior as assessed using a novel rat gambling task","volume":"34","author":"Zeeb","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0570","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/syn.21570","article-title":"Choice with delayed or uncertain reinforcers in rats: influence of timeout duration and session length","volume":"66","author":"Zoratto","year":"2012","journal-title":"Synapse"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0575","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.neuropharm.2012.11.024","article-title":"Gambling proneness in rats during the transition from adolescence to young adulthood: a home-cage method","volume":"67","author":"Zoratto","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2016.10.041_b0580","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.neulet.2016.02.026","article-title":"The subjective value of probabilistic outcomes: Impact of reward magnitude on choice with uncertain rewards in rats","volume":"617","author":"Zoratto","year":"2016","journal-title":"Neurosci Lett"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452216305814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452216305814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T01:54:36Z","timestamp":1657504476000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452216305814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":116,"alternative-id":["S0306452216305814"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2016.10.041","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}