{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:14:00Z","timestamp":1790327640083,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01-MH093362"],"award-info":[{"award-number":["R01-MH093362"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["2I01BX001075"],"award-info":[{"award-number":["2I01BX001075"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.neuroscience.2017.01.003","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T05:47:41Z","timestamp":1484113661000},"page":"423-433","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Differential behavioral sensitivity to carbon dioxide (CO2) inhalation in rats"],"prefix":"10.1016","volume":"346","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9142-7565","authenticated-orcid":false,"given":"Andrew","family":"Winter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Ahlbrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devanshi","family":"Naik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Sah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2017.01.003_b0005","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.psychres.2011.11.005","article-title":"Exploration of a possible association between the tryptophan hydroxylase 2 (TPH2) gene and panic symptoms induced by carbon dioxide in healthy individuals","volume":"197","author":"Abe","year":"2012","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0015","series-title":"The rat nervous system","first-page":"183","article-title":"The locus coeruleus A5 and A7 noradrenergic cell groups","author":"Aston-Jones","year":"1995"},{"issue":"pt 3","key":"10.1016\/j.neuroscience.2017.01.003_b0020","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.neubiorev.2014.04.005","article-title":"Early-life risk factors for panic and separation anxiety disorder: Insights and outstanding questions arising from human and animal studies of CO2 sensitivity","volume":"46","author":"Battaglia","year":"2014","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0025","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.jpsychires.2006.12.002","article-title":"A genetic study of the acute anxious response to carbon dioxide stimulation in man","volume":"41","author":"Battaglia","year":"2007","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0030","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1001\/archgenpsychiatry.2008.513","article-title":"A genetically informed study of the association between childhood separation anxiety, sensitivity to CO2, panic disorder, and the effect of childhood parental loss","volume":"66","author":"Battaglia","year":"2009","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0035","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1176\/ajp.155.9.1184","article-title":"CO2-induced panic attacks: a twin study","volume":"155","author":"Bellodi","year":"1998","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0040","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s00424-007-0338-8","article-title":"Locus coeruleus noradrenergic neurons and CO2 drive to breathing","volume":"455","author":"Biancardi","year":"2008","journal-title":"Pfl\u00fcgers Arch Eur J Physiol"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0045","first-page":"1","article-title":"Dysfunctional inhibitory mechanisms in locus coeruleus neurons of the wistar kyoto rat","author":"Bruzos-Cid\u00f3n","year":"2015","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0050","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bbr.2013.05.016","article-title":"Significant divergences between the temporal structure of the behavior in Wistar and in the spontaneously more anxious DA\/Han strain of rats tested in elevated plus maze","volume":"250","author":"Casarrubea","year":"2013","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0055","doi-asserted-by":"crossref","first-page":"25131","DOI":"10.1038\/srep25131","article-title":"Histone modifications in a mouse model of early adversities and panic disorder: role for asic1 and neurodevelopmental genes","volume":"6","author":"Cittaro","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0060","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/00006842-195111000-00001","article-title":"Life situations, emotions, and neurocirculatory asthenia (anxiety neurosis, neurasthenia, effort syndrome)","volume":"13","author":"Cohen","year":"1951","journal-title":"Psychosom Med"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0065","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1038\/npp.2008.31","article-title":"Carbon dioxide induced emotion and respiratory symptoms in healthy volunteers","volume":"33","author":"Colasanti","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0070","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1001\/archpsyc.1997.01830190069007","article-title":"Clinical improvement with fluoxetine therapy and noradrenergic function in patients with panic disorder","volume":"54","author":"Coplan","year":"1997","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0075","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S0006-3223(00)01089-1","article-title":"Aberrant respiratory sensitivity to CO2 as a trait of familial panic disorder","volume":"49","author":"Coryell","year":"2001","journal-title":"Biol Psychiatry"},{"issue":"4","key":"10.1016\/j.neuroscience.2017.01.003_b0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018637","article-title":"Unstable maternal environment, separation anxiety, and heightened CO2 sensitivity induced by gene-by-environment interplay","volume":"6","author":"D'Amato","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0090","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.resp.2010.12.004","article-title":"Hypercapnic ventilatory response of anesthetized female rats subjected to neonatal maternal separation: Insight into the origins of panic attacks?","volume":"175","author":"Dumont","year":"2010","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.neuroscience.2017.01.003_b9000","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1177\/0269881108093844","article-title":"The effects of opiod receptor blockade on experimental panic provocation with CO2","volume":"23","author":"Esquivel","year":"2009","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0095","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1177\/0269881109104847","article-title":"Acids in the brain: a factor in panic?","volume":"24","author":"Esquivel","year":"2010","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0100","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00213-010-2089-z","article-title":"Functional topography of midbrain and pontine serotonergic systems: implications for synaptic regulation of serotonergic circuits","volume":"213","author":"Hale","year":"2011","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0105","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s10571-012-9827-1","article-title":"Stress-related serotonergic systems: implications for symptomatology of anxiety and affective disorders","volume":"32","author":"Hale","year":"2012","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0110","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.1113\/jphysiol.2011.214759","article-title":"Redefining the components of central CO2 chemosensitivity\u2013towards a better understanding of mechanism","volume":"589","author":"Huckstepp","year":"2011","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0115","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1177\/0269881107082900","article-title":"Disruption of GABAergic tone in the dorsomedial hypothalamus attenuates responses in a subset of serotonergic neurons in the dorsal raphe nucleus following lactate-induced panic","volume":"22","author":"Johnson","year":"2008","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0120","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1177\/0269881109353464","article-title":"Induction of c-Fos in \u201cpanic\/defence\u201d-related brain circuits following brief hypercarbic gas exposure","volume":"25","author":"Johnson","year":"2011","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0125","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1196\/annals.1296.006","article-title":"A functional subset of serotonergic neurons in the rat ventrolateral periaqueductal gray implicated in the inhibition of sympathoexcitation and panic","volume":"1018","author":"Johnson","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0130","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1038\/npp.2012.38","article-title":"Activation of the orexin 1 receptor is a critical component of CO2-mediated anxiety and hypertension but not bradycardia","volume":"37","author":"Johnson","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0135","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.neubiorev.2014.07.027","article-title":"Etiology, triggers and neurochemical circuits associated with unexpected, expected, and laboratory-induced panic attacks","volume":"46","author":"Johnson","year":"2014","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0140","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrn.2015.8","article-title":"Neurobiology of rodent self-grooming and its value for translational neuroscience","volume":"17","author":"Kalueff","year":"2016","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0145","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbr.2014.10.039","article-title":"Strain and sex differences in brain and behaviour of adult rats: Learning and memory, anxiety and volumetric estimates","volume":"288","author":"Keeley","year":"2015","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0150","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.biopsycho.2013.06.004","article-title":"Carbon dioxide inhalation as a human experimental model of panic: The relationship between emotions and cardiovascular physiology","volume":"94","author":"Leibold","year":"2013","journal-title":"Biol Psychol"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0155","doi-asserted-by":"crossref","first-page":"e885","DOI":"10.1038\/tp.2016.162","article-title":"CO2 exposure as translational cross-species experimental model for panic","volume":"6","author":"Leibold","year":"2016","journal-title":"Trans Psychiatry"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0160","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1515\/REVNEURO.2006.17.1-2.111","article-title":"Rearing on hind legs, environmental novelty, and the hippocampal formation","volume":"17","author":"Lever","year":"2006","journal-title":"Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0165","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1196\/annals.1410.004","article-title":"Serotonergic systems, anxiety, and affective disorder: focus on the dorsomedial part of the dorsal raphe nucleus","volume":"1148","author":"Lowry","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0170","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.resp.2010.04.024","article-title":"The locus coeruleus and central chemosensitivity","volume":"173","author":"Gargaglioni","year":"2010","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0175","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neuroscience.2013.01.070","article-title":"Development\u00d7environment interactions control tph2 mRNA expression","volume":"237","author":"Lukkes","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0180","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/sj.mp.4002137","article-title":"Elevated brain lactate responses to neural activation in panic disorder: A dynamic 1H-MRS study","volume":"14","author":"Maddock","year":"2009","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0185","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1177\/0145445503256316","article-title":"The conditioning of dyspneic suffocation fear. Effects of carbon dioxide concentration on behavioral freezing and analgesia","volume":"27","author":"Mongeluzi","year":"2003","journal-title":"Behav Modif"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0190","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-1-61779-458-2_7","article-title":"Modeling depression in animal models","volume":"829","author":"Overstreet","year":"2012","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0195","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1176\/ajp.150.8.1149","article-title":"Carbon dioxide hypersensitivity, hyperventilation, and panic disorder","volume":"150","author":"Papp","year":"1993","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0205","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/0031-9384(93)90291-M","article-title":"Passive-avoidance behavior in Wistar-Kyoto (WKY), Wistar, and Fischer-344 rats","volume":"54","author":"Pare","year":"1993","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0210","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.neuroimage.2008.09.007","article-title":"Determination of the human brainstem respiratory control network and its cortical connections in vivo using functional and structural imaging","volume":"44","author":"Pattinson","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0215","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1176\/ajp.153.8.1060","article-title":"Family history of panic disorder and hypersensitivity to CO2 in patients with panic disorder","volume":"153","author":"Perna","year":"1996","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0220","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/00004714-200206000-00011","article-title":"Antipanic drug modulation of 35% CO2 hyperreactivity and short-term treatment outcome","volume":"22","author":"Perna","year":"2002","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0887-6185(02)00181-0","article-title":"Carbon dioxide in the study of panic disorder: issues of definition, methodology, and outcome","volume":"17","author":"Rassovsky","year":"2003","journal-title":"J Anxiety Disord"},{"key":"10.1016\/j.neuroscience.2017.01.003_b9015","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/da.22038","article-title":"Evidence for distinct genetic effects associated with response to 35% CO2","volume":"30","author":"Roberson-Nay","year":"2013","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0230","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.biopsycho.2015.04.006","article-title":"Validation of candidate anxiety disorder genes using a carbon dioxide challenge task","volume":"109","author":"Savage","year":"2015","journal-title":"Biol Psychol"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0235","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neuroscience.2011.10.032","article-title":"Evidence of a suffocation alarm system within the periaqueductal gray matter of the rat","volume":"200","author":"Schimitel","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0240","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/nn1130","article-title":"Midbrain serotonergic neurons are central pH chemoreceptors","volume":"6","author":"Severson","year":"2003","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0245","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/ajmg.b.31144","article-title":"Gene-environment interactions in panic disorder and CO\u2082 sensitivity: Effects of events occurring early in life","volume":"156B","author":"Spatola","year":"2011","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0255","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.neuroscience.2012.09.061","article-title":"Differential involvement of dorsal raphe subnuclei in the regulation of anxiety- and panic-related defensive behaviors","volume":"227","author":"Spiacci","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0260","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/S0006-3223(99)00246-2","article-title":"The noradrenergic system in pathological anxiety: a focus on panic with relevance to generalized anxiety and phobias","volume":"46","author":"Sullivan","year":"1999","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0265","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0006-8993(01)03121-3","article-title":"Functional and pharmacological characterization of the modulatory role of serotonin on the firing activity of locus coeruleus norepinephrine neurons","volume":"922","author":"Szabo","year":"2001","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0270","first-page":"R1371","article-title":"Differential control of ventilation among inbred strains of mice","volume":"267","author":"Tankersley","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0275","doi-asserted-by":"crossref","first-page":"10247","DOI":"10.1523\/JNEUROSCI.1680-14.2014","article-title":"The bed nucleus of the stria terminalis is critical for anxiety-related behavior evoked by CO2 and acidosis","volume":"34","author":"Taugher","year":"2014","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0280","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0166-4328(94)90072-8","article-title":"Effect of environmental stressors on time course, variability and form of self-grooming in the rat: handling, social contact, defeat, novelty, restraint and fur moistening","volume":"65","author":"Van Erp","year":"1994","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0285","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0006-8993(83)90011-2","article-title":"Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices","volume":"289","author":"Vandermaelen","year":"1983","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0290","doi-asserted-by":"crossref","first-page":"e572","DOI":"10.1038\/tp.2015.67","article-title":"Acid-base dysregulation and chemosensory mechanisms in panic disorder: a translational update","volume":"5","author":"Vollmer","year":"2015","journal-title":"Transl Psychiatry"},{"issue":"7","key":"10.1016\/j.neuroscience.2017.01.003_b0295","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.biopsych.2016.04.022","article-title":"Microglial acid sensing regulates carbon dioxide evoked fear","volume":"80","author":"Vollmer","year":"2016","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2017.01.003_b0300","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.cell.2009.10.029","article-title":"The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior","volume":"139","author":"Ziemann","year":"2009","journal-title":"Cell"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645221730009X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645221730009X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T07:54:55Z","timestamp":1656402895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030645221730009X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":58,"alternative-id":["S030645221730009X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2017.01.003","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]}}}