{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:21:33Z","timestamp":1789849293891,"version":"4.0.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.neuroscience.2017.02.029","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T00:46:17Z","timestamp":1487810777000},"page":"252-263","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["MiR-146a promotes remyelination in a cuprizone model of demyelinating injury"],"prefix":"10.1016","volume":"348","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng Gang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanton B.","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Chopp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2017.02.029_b0005","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10517-015-2903-z","article-title":"Cuprizone model as a tool for preclinical studies of the efficacy of multiple sclerosis diagnosis and therapy","volume":"159","author":"Abakumova","year":"2015","journal-title":"Bull Exp Biol Med"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0010","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.4049\/jimmunol.1200728","article-title":"Next-generation sequencing identifies microRNAs that associate with pathogenic autoimmune neuroinflammation in rats","volume":"190","author":"Bergman","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0015","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/jnc.13745","article-title":"The oligodendrocyte-specific antibody \u2018CC1\u2019 binds Quaking 7","volume":"139","author":"Bin","year":"2016","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0020","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.4049\/jimmunol.1401459","article-title":"CXCL10 triggers early microglial activation in the cuprizone model","volume":"194","author":"Clarner","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0025","series-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen","year":"1988"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0030","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature12647","article-title":"A regenerative approach to the treatment of multiple sclerosis","volume":"502","author":"Deshmukh","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0035","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/jemt.20577","article-title":"A simple protocol for paraffin-embedded myelin sheath staining with osmium tetroxide for light microscope observation","volume":"71","author":"Di Scipio","year":"2008","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0040","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.expneurol.2008.04.039","article-title":"Thyroid hormones promote differentiation of oligodendrocyte progenitor cells and improve remyelination after cuprizone-induced demyelination","volume":"212","author":"Franco","year":"2008","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0045","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nrn2480","article-title":"Remyelination in the CNS: from biology to therapy","volume":"9","author":"Franklin","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0050","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/brain\/awl075","article-title":"Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research","volume":"129","author":"Gold","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0055","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1126\/science.1218071","article-title":"Glial progenitor cell-based treatment and modeling of neurological disease","volume":"338","author":"Goldman","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0060","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nri978","article-title":"Alternative activation of macrophages","volume":"3","author":"Gordon","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0065","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cellsig.2007.08.009","article-title":"IRAK1: a critical signaling mediator of innate immunity","volume":"20","author":"Gottipati","year":"2008","journal-title":"Cell Signal"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0070","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fncel.2014.00073","article-title":"Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned","volume":"8","author":"Gudi","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0075","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jneuroim.2011.10.006","article-title":"MiRNA profiling for biomarker discovery in multiple sclerosis: from microarray to deep sequencing","volume":"248","author":"Guerau-de-Arellano","year":"2012","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0080","doi-asserted-by":"crossref","first-page":"14189","DOI":"10.1523\/JNEUROSCI.4453-08.2008","article-title":"Recovery from chronic demyelination by thyroid hormone therapy: myelinogenesis induction and assessment by diffusion tensor magnetic resonance imaging","volume":"28","author":"Harsan","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0085","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0165-5728(98)00168-4","article-title":"Microglial\/macrophage accumulation during cuprizone-induced demyelination in C57BL\/6 mice","volume":"92","author":"Hiremath","year":"1998","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0090","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.4049\/jimmunol.0900707","article-title":"MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2","volume":"183","author":"Hou","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0095","doi-asserted-by":"crossref","first-page":"5295","DOI":"10.1073\/pnas.1321427111","article-title":"T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation","volume":"111","author":"Inoue","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0100","doi-asserted-by":"crossref","first-page":"13435","DOI":"10.1523\/JNEUROSCI.3257-09.2009","article-title":"Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord","volume":"29","author":"Kigerl","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0105","first-page":"40","article-title":"Experimental demyelination caused by primary oligodendrocyte dystrophy. Regional distribution of the lesions in the nervous system of mice [corrected]","volume":"58","author":"Komoly","year":"2005","journal-title":"Ideggyogy Sz"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0110","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1073\/pnas.89.5.1894","article-title":"Insulin-like growth factor I gene expression is induced in astrocytes during experimental demyelination","volume":"89","author":"Komoly","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0115","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1093\/brain\/awr014","article-title":"Enhancing remyelination in disease\u2013can we wrap it up?","volume":"134","author":"Kotter","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0120","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/ana.22415","article-title":"The complex world of oligodendroglial differentiation inhibitors","volume":"69","author":"Kremer","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0125","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1093\/brain\/awn096","article-title":"Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis","volume":"131","author":"Kuhlmann","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0130","doi-asserted-by":"crossref","first-page":"11720","DOI":"10.1523\/JNEUROSCI.1932-08.2008","article-title":"Identification of dynamically regulated microRNA and mRNA networks in developing oligodendrocytes","volume":"28","author":"Lau","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0135","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s12035-011-8231-z","article-title":"MicroRNAs: novel regulators of oligodendrocyte differentiation and potential therapeutic targets in demyelination-related diseases","volume":"45","author":"Li","year":"2012","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0140","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-3083.2010.02383.x","article-title":"MicroRNA-146a and human disease","volume":"71","author":"Li","year":"2010","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0145","article-title":"MicroRNA-146a promotes oligodendrogenesis in stroke","author":"Liu","year":"2016","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0150","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0155","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.cell.2010.08.012","article-title":"Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses","volume":"142","author":"Lu","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0160","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/jmcb\/mjr007","article-title":"MicroRNAs in NF-kappaB signaling","volume":"3","author":"Ma","year":"2011","journal-title":"J Mol Cell Biol"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0165","doi-asserted-by":"crossref","first-page":"810","DOI":"10.7150\/ijms.8647","article-title":"Expression, regulation and function of microRNAs in multiple sclerosis","volume":"11","author":"Ma","year":"2014","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0170","doi-asserted-by":"crossref","first-page":"5989","DOI":"10.1128\/MCB.00541-09","article-title":"An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2","volume":"29","author":"Maitra","year":"2009","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0175","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1749-6632.2009.04849.x","article-title":"Toll-like receptors in multiple sclerosis mouse experimental models","volume":"1173","author":"Marta","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2008.05570.x","article-title":"The life, death, and replacement of oligodendrocytes in the adult CNS","volume":"107","author":"McTigue","year":"2008","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0185","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1177\/1352458510379243","article-title":"Altered M1\/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration","volume":"17","author":"Mikita","year":"2011","journal-title":"Mult Scler"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0190","first-page":"75","article-title":"Role of toll-like receptors in multiple sclerosis","volume":"2","author":"Miranda-Hernandez","year":"2013","journal-title":"Am J Clin Exp Immunol"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0195","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nn.3469","article-title":"M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination","volume":"16","author":"Miron","year":"2013","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0200","doi-asserted-by":"crossref","first-page":"e11769","DOI":"10.1371\/journal.pone.0011769","article-title":"Effects of fumaric acids on cuprizone induced central nervous system de- and remyelination in the mouse","volume":"5","author":"Moharregh-Khiabani","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0205","doi-asserted-by":"crossref","first-page":"34590","DOI":"10.1074\/jbc.M109.056317","article-title":"MiR-146a is critical for endotoxin-induced tolerance: IMPLICATION IN INNATE IMMUNITY","volume":"284","author":"Nahid","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0210","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature14335","article-title":"Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo","volume":"522","author":"Najm","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0215","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.1016\/j.febslet.2011.04.037","article-title":"Mediators of oligodendrocyte differentiation during remyelination","volume":"585","author":"Patel","year":"2011","journal-title":"FEBS Lett"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0220","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nature01552","article-title":"Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis","volume":"422","author":"Pluchino","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0225","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.neubiorev.2014.10.004","article-title":"Cellular and molecular neuropathology of the cuprizone mouse model: clinical relevance for multiple sclerosis","volume":"47","author":"Praet","year":"2014","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0230","doi-asserted-by":"crossref","first-page":"e62232","DOI":"10.1371\/journal.pone.0062232","article-title":"MicroRNA-146a is upregulated by and negatively regulates TLR2 signaling","volume":"8","author":"Quinn","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0235","doi-asserted-by":"crossref","first-page":"19508","DOI":"10.1074\/jbc.M113.529966","article-title":"Thymosin beta4 up-regulation of microRNA-146a promotes oligodendrocyte differentiation and suppression of the Toll-like proinflammatory pathway","volume":"289","author":"Santra","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0240","doi-asserted-by":"crossref","first-page":"11555","DOI":"10.1073\/pnas.1006496107","article-title":"Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2","volume":"107","author":"Sloane","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0245","first-page":"807426","article-title":"MicroRNAs and Multiple Sclerosis","volume":"2011","author":"Tufekci","year":"2011","journal-title":"Autoimmune Dis"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0250","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1161\/CIRCRESAHA.110.227496","article-title":"The art of microRNA research","volume":"108","author":"van Rooij","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0255","doi-asserted-by":"crossref","first-page":"173656","DOI":"10.1155\/2015\/173656","article-title":"Therapeutic benefit of extended thymosin beta4 treatment is independent of blood glucose level in mice with diabetic peripheral neuropathy","volume":"2015","author":"Wang","year":"2015","journal-title":"J Diabetes Res"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0260","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1084\/jem.20112218","article-title":"MiR-146a controls the resolution of T cell responses in mice","volume":"209","author":"Yang","year":"2012","journal-title":"J Exp Med"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0265","doi-asserted-by":"crossref","first-page":"e48141","DOI":"10.1371\/journal.pone.0048141","article-title":"Sildenafil enhances neurogenesis and oligodendrogenesis in ischemic brain of middle-aged mouse","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2017.02.029_b0270","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.nbd.2016.01.010","article-title":"Thymosin beta4 promotes oligodendrogenesis in the demyelinating central nervous system","volume":"88","author":"Zhang","year":"2016","journal-title":"Neurobiol Dis"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452217301124?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452217301124?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T11:33:15Z","timestamp":1572953595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452217301124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":54,"alternative-id":["S0306452217301124"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2017.02.029","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}