{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:38:30Z","timestamp":1773203910208,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.neuroscience.2017.03.005","type":"journal-article","created":{"date-parts":[[2017,3,11]],"date-time":"2017-03-11T01:04:08Z","timestamp":1489194248000},"page":"30-38","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Oral administration of corticosterone at stress-like levels drives microglial but not vascular disturbances post-stroke"],"prefix":"10.1016","volume":"352","author":[{"given":"Katarzyna","family":"Zalewska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin Kooi","family":"Ong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah J.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick R.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2017.03.005_b0005","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1161\/01.STR.24.10.1478","article-title":"The influence of depression, social activity, and family stress on functional outcome after stroke","volume":"24","author":"Angeleri","year":"1993","journal-title":"Stroke"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0010","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1161\/STROKEAHA.110.607705","article-title":"Stress worsens endothelial function and ischemic stroke via glucocorticoids","volume":"42","author":"Balkaya","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0015","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1034\/j.1600-079X.2001.300307.x","article-title":"Circadian rhythm of melatonin, corticosterone and phagocytosis: effect of stress","volume":"30","author":"Barriga","year":"2001","journal-title":"J Pineal Res"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0020","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.imlet.2008.06.010","article-title":"The role of CD11b in phagocytosis and dendritic cell development","volume":"120","author":"Chen","year":"2008","journal-title":"Immunol Lett"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0025","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/10253890701638204","article-title":"More appraisal please: a commentary on Pfaff et al. (2007) \u201cRelations between mechanisms of CNS arousal and mechanisms of stress\u201d","volume":"10","author":"Day","year":"2007","journal-title":"Stress"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0030","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1046\/j.1460-9568.2003.02542.x","article-title":"Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobe","volume":"17","author":"de Quervain","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0035","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00401-015-1524-y","article-title":"Microglia-blood vessel interactions: a double-edged sword in brain pathologies","volume":"131","author":"Dudvarski Stankovic","year":"2016","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0040","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neulet.2008.06.085","article-title":"Environmental enrichment, exercise and corticosterone affect endothelial cell proliferation in adult rat hippocampus and prefrontal cortex","volume":"442","author":"Ekstrand","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0045","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0003-9993(96)90164-1","article-title":"Caregiver's burden of patients 3 years after stroke assessed by a novel caregiver burden scale","volume":"77","author":"Elmstahl","year":"1996","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0050","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.nlm.2011.01.006","article-title":"Chronic stress prior to hippocampal stroke enhances post-stroke spatial deficits in the ziggurat task","volume":"95","author":"Faraji","year":"2011","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0055","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.neulet.2009.06.096","article-title":"Stress and corticosterone enhance cognitive recovery from hippocampal stroke in rats","volume":"462","author":"Faraji","year":"2009","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0060","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1001\/jama.1977.03280140052016","article-title":"Prognostic value of the stress response following stroke","volume":"238","author":"Feibel","year":"1977","journal-title":"JAMA"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0070","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/npp.2008.123","article-title":"A History of Corticosterone Exposure Regulates Fear Extinction and Cortical NR2B, GluR2\/3, and BDNF","volume":"34","author":"Gourley","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0075","article-title":"Modeling the persistent, depressive-like state in rodents: Long-lasting effects of prior chronic corticosterone","volume":"59","author":"Gourley","year":"2006","journal-title":"Biol Psychiat"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0080","first-page":"Unit 9 32","article-title":"Recapitulation and reversal of a persistent depression-like syndrome in rodents","volume":"Chapter 9","author":"Gourley","year":"2009","journal-title":"Curr Protoc Neurosci"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0085","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1111\/j.1460-9568.2005.03951.x","article-title":"Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk-1 protein expression","volume":"21","author":"Heine","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0090","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/0269215509346090","article-title":"Psychological distress after stroke and aphasia: the first six months","volume":"24","author":"Hilari","year":"2010","journal-title":"Clin Rehabil"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0095","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.brainres.2010.09.081","article-title":"The effect of stress on stroke recovery in a photothrombotic stroke animal model","volume":"1363","author":"Jin","year":"2010","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0100","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0149-7634(05)80175-7","article-title":"Mechanisms of stress: a dynamic overview of hormonal and behavioral homeostasis","volume":"16","author":"Johnson","year":"1992","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0105","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00401-014-1372-1","article-title":"Perivascular microglia promote blood vessel disintegration in the ischemic penumbra","volume":"129","author":"Jolivel","year":"2015","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2015.02.014","article-title":"Chronic stress exacerbates neuronal loss associated with secondary neurodegeneration and suppresses microglial-like cells following focal motor cortex ischemia in the mouse","author":"Jones","year":"2015","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0115","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.brainres.2008.01.032","article-title":"Delayed recovery and exaggerated infarct size by post-lesion stress in a rat model of focal cerebral stroke","volume":"1201","author":"Kirkland","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0120","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.neuroscience.2015.09.061","article-title":"A combined cumulative threshold spectra and digital reconstruction analysis reveal structural alterations of microglia within the prefrontal cortex following low-dose LPS administration","volume":"310","author":"Kongsui","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0125","first-page":"203","article-title":"Some remarks on the growth-rate and angiogenesis of microvessels in ischemic stroke. Morphometric and immunocytochemical studies","volume":"44","author":"Krupinski","year":"1993","journal-title":"Patol Pol"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0130","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1161\/01.STR.25.9.1794","article-title":"Role of angiogenesis in patients with cerebral ischemic stroke","volume":"25","author":"Krupinski","year":"1994","journal-title":"Stroke"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0135","doi-asserted-by":"crossref","DOI":"10.3791\/50370","article-title":"Photothrombotic ischemia: a minimally invasive and reproducible photochemical cortical lesion model for mouse stroke studies","author":"Labat-gest","year":"2013","journal-title":"J Vis Exp"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0140","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S1474-4422(09)70150-4","article-title":"Motor recovery after stroke: a systematic review","volume":"8","author":"Langhorne","year":"2009","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0145","doi-asserted-by":"crossref","first-page":"16074","DOI":"10.1073\/pnas.1110444108","article-title":"Glucocorticoids are critical regulators of dendritic spine development and plasticity in vivo","volume":"108","author":"Liston","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1310\/YA8Q-EQK9-00EF-EUG7","article-title":"Psychological stress and coping: framework for poststroke psychosocial care","volume":"9","author":"Lyon","year":"2002","journal-title":"Top Stroke Rehabil"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0155","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1086\/508828","article-title":"Baseline and stress-induced plasma corticosterone concentrations of mice selectively bred for high voluntary wheel running","volume":"80","author":"Malisch","year":"2007","journal-title":"Physiol Biochem Zool"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0160","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1111\/j.1460-9568.2005.04285.x","article-title":"Modulation of motor function by stress: a novel concept of the effects of stress and corticosterone on behavior","volume":"22","author":"Metz","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0165","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s00213-012-2844-4","article-title":"Persistent effects of prior chronic exposure to corticosterone on reward-related learning and motivation in rodents","volume":"225","author":"Olausson","year":"2013","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0170","article-title":"Chronic stress exposure following photothrombotic stroke is associated with increased levels of Amyloid beta accumulation and altered oligomerisation at sites of thalamic secondary neurodegeneration in mice","author":"Ong","year":"2016","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0175","series-title":"The mouse brain in stereotaxic coordinates","author":"Paxinos","year":"2004"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0180","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2174\/156720210792231813","article-title":"Pathophysiology of the vascular wall and its relevance for cerebrovascular disorders in aged rodents","volume":"7","author":"Popa-Wagner","year":"2010","journal-title":"Curr Neurovasc Res"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0185","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1242\/dev.01037","article-title":"Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development","volume":"131","author":"Poschl","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0190","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1191\/0748233703th182oa","article-title":"Corticosterone in drinking water: altered kinetics of a single oral dose of corticosterone and concentrations of plasma sodium, albumin, globulin, and total protein","volume":"19","author":"Pung","year":"2003","journal-title":"Toxicol Ind Health"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0195","doi-asserted-by":"crossref","first-page":"14971","DOI":"10.1074\/jbc.M600236200","article-title":"Up-regulation of microglial CD11b expression by nitric oxide","volume":"281","author":"Roy","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0200","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/2040-7378-2-13","article-title":"Functional assessments in the rodent stroke model","volume":"2","author":"Schaar","year":"2010","journal-title":"Exp Transl Stroke Med"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0205","doi-asserted-by":"crossref","first-page":"e46625","DOI":"10.1371\/journal.pone.0046625","article-title":"Inhibition of proliferation, migration and proteolysis contribute to corticosterone-mediated inhibition of angiogenesis","volume":"7","author":"Shikatani","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0210","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jneuroim.2009.01.016","article-title":"Microglial activation is inhibited by corticosterone in dopaminergic neurodegeneration","volume":"208","author":"Sugama","year":"2009","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0215","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.bbi.2010.02.001","article-title":"Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions","volume":"24","author":"Tynan","year":"2010","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.neuroscience.2017.03.005_b0220","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1365-2648.1995.tb02541.x","article-title":"On Being a Stroke Patient","volume":"21","author":"Tyson","year":"1995","journal-title":"J Adv Nurs"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452217301628?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452217301628?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T12:30:06Z","timestamp":1535977806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452217301628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":43,"alternative-id":["S0306452217301628"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2017.03.005","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}