{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T10:30:14Z","timestamp":1769941814436,"version":"3.49.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.neuroscience.2017.04.050","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T05:15:19Z","timestamp":1494393319000},"page":"61-70","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Chitinase1 contributed to a potential protection via microglia polarization and A\u03b2 oligomer reduction in D-galactose and aluminum-induced rat model with cognitive impairments"],"prefix":"10.1016","volume":"355","author":[{"given":"Qian","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"L\u00fc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.neuroscience.2017.04.050_b0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/nan.12011","article-title":"Review: activation patterns of microglia and their identification in the human brain","volume":"39","author":"Boche","year":"2013","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"4","key":"10.1016\/j.neuroscience.2017.04.050_b0010","doi-asserted-by":"crossref","first-page":"419","DOI":"10.2174\/156720505774330555","article-title":"Chitin-like polysaccharides in Alzheimer's disease brains","volume":"2","author":"Castellani","year":"2005","journal-title":"Curr Alzheimer Res"},{"issue":"4","key":"10.1016\/j.neuroscience.2017.04.050_b0015","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF03033910","article-title":"The role of novel chitin-like polysaccharides in Alzheimer disease","volume":"12","author":"Castellani","year":"2007","journal-title":"Neurotox Res"},{"issue":"R1","key":"10.1016\/j.neuroscience.2017.04.050_b0020","doi-asserted-by":"crossref","first-page":"R12","DOI":"10.1093\/hmg\/ddq160","article-title":"Molecular mechanisms of neurodegeneration in Alzheimer's disease","volume":"19","author":"Crews","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neuroscience.2017.04.050_b0025","doi-asserted-by":"crossref","first-page":"6362707","DOI":"10.1155\/2016\/6362707","article-title":"Gypenoside attenuates \u03b2-amyloid-induced inflammation in N9 microglial cells via SOCS1 signaling","volume":"2016","author":"Cai","year":"2016","journal-title":"Neural Plast"},{"issue":"Suppl. 3","key":"10.1016\/j.neuroscience.2017.04.050_b0030","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3233\/JAD-2010-100975","article-title":"Alzheimer's disease: a general introduction and patho mechanism","volume":"22","author":"Finder","year":"2010","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"10.1016\/j.neuroscience.2017.04.050_b0035","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1021\/acschemneuro.6b00250","article-title":"Dipeptidyl vinyl sulfone as a novel chemical tool to inhibit HMGB1\/NLRP3-inflammasome and inflamma-miRs in A\u00e2-mediated microglial inflammation","volume":"8","author":"Falc\u00e3o","year":"2017","journal-title":"ACS Chem Neurosci"},{"issue":"9634","key":"10.1016\/j.neuroscience.2017.04.050_b0040","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0140-6736(08)61075-2","article-title":"Long-term effects of Abeta 42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial","volume":"372","author":"Holmes","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.neuroscience.2017.04.050_b0045","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3389\/fimmu.2015.00370","article-title":"The many faces of macrophage activation","volume":"6","author":"Hume","year":"2015","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.neuroscience.2017.04.050_b0050","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol"},{"issue":"10","key":"10.1016\/j.neuroscience.2017.04.050_b0055","doi-asserted-by":"crossref","first-page":"8585","DOI":"10.1074\/jbc.M110.172411","article-title":"Abeta42 neurotoxicity is mediated by ongoing uncleated polymerization process rather than by discrete Abeta 42 species","volume":"286","author":"Jan","year":"2011","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.neuroscience.2017.04.050_b0060","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1574-6976.2002.tb00613.x","article-title":"Dynamics of cell wall structure in Saccharomyces cerevisiae","volume":"26","author":"Klis","year":"2002","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.neuroscience.2017.04.050_b0065","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1750-1326-2-18","article-title":"Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers","volume":"2","author":"Kayed","year":"2007","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.neuroscience.2017.04.050_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1875044301205010001","article-title":"Role of chitotriosidase (chitinase1) under Normal and disease conditions","volume":"5","author":"Kanneganti","year":"2012","journal-title":"J Epithel Biol Pharmacol"},{"issue":"1","key":"10.1016\/j.neuroscience.2017.04.050_b0075","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ajpath.2013.04.003","article-title":"Chitinase inhibition promotes atherosclerosis in hyperlipidemic mice","volume":"183","author":"Kitamoto","year":"2013","journal-title":"Am J Pathol"},{"issue":"11","key":"10.1016\/j.neuroscience.2017.04.050_b0080","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.1073\/pnas.95.11.6448","article-title":"Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins","volume":"95","author":"Lambert","year":"1998","journal-title":"Proc Nat Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2017.04.050_b0085","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.carbpol.2013.09.037","article-title":"Protective effect of Millettia pulchra polysaccharide on cognitive impairment induced by D-galactose in mice","volume":"101","author":"Lin","year":"2014","journal-title":"Carbohydr Polym"},{"issue":"11","key":"10.1016\/j.neuroscience.2017.04.050_b0090","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","article-title":"Macrophagepolarization: tumor-associated macrophages as a paradigm forpolarized M2 mononuclear phagocytes","volume":"23","author":"Mantovani","year":"2002","journal-title":"Trends Immunol"},{"issue":"2","key":"10.1016\/j.neuroscience.2017.04.050_b0095","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s12017-011-8147-9","article-title":"Cerebrospinal fluid microglial markers in Alzheimer\u2019s disease: elevated chitotriosidase activity but lack of diagnostic utility","volume":"13","author":"Mattsson","year":"2011","journal-title":"Neuromolecular Med"},{"issue":"9","key":"10.1016\/j.neuroscience.2017.04.050_b0100","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1111\/j.1572-0241.2006.00680.x","article-title":"Potential role of chitotriosidase gene innonalcoholic fatty liver disease evolution","volume":"101","author":"Malaguarnera","year":"2006","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"10.1016\/j.neuroscience.2017.04.050_b0105","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40348-015-0014-6","article-title":"The role of chitin, chitinases, and chitinase-like proteins in pediatric lung diseases","volume":"2","author":"Mack","year":"2015","journal-title":"Mol Cell Pediatr"},{"issue":"1","key":"10.1016\/j.neuroscience.2017.04.050_b0110","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bbrc.2015.01.073","article-title":"Activation of murine microglialN9 cells is attenuated through cannabinoid receptor CB2 signaling","volume":"458","author":"Ma","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"10.1016\/j.neuroscience.2017.04.050_b0115","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1136\/jnnp.2006.090613","article-title":"Exposure to aluminium and the subsequent development of a disorder with features of Alzheimer's disease","volume":"77","author":"Perl","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"10.1016\/j.neuroscience.2017.04.050_b0120","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrneurol.2010.17","article-title":"Microglia in neurodegenerative disease","volume":"6","author":"Perry","year":"2010","journal-title":"Nat Rev Neurol Nat Rev Neurol"},{"issue":"7","key":"10.1016\/j.neuroscience.2017.04.050_b0125","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/nn.2583","article-title":"Amyloid-beta-induced neuronal dysfunction in Alzheimer\u2019sdisease: from synapses toward neural networks","volume":"13","author":"Palop","year":"2010","journal-title":"Nat Neurosci"},{"issue":"5","key":"10.1016\/j.neuroscience.2017.04.050_b0130","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00281-013-0382-8","article-title":"Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration","volume":"35","author":"Perry","year":"2013","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.neuroscience.2017.04.050_b0135","series-title":"World Alzheimer Report 2015 The global impact of dementia, an analysis of prevalence, incidence, cost and trends","author":"Prince","year":"2015"},{"issue":"2","key":"10.1016\/j.neuroscience.2017.04.050_b0140","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1172\/JCI78464","article-title":"Cross-species translation of the Morris maze for Alzheimer\u2019s disease","volume":"126","author":"Possin","year":"2016","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1016\/j.neuroscience.2017.04.050_b0145","doi-asserted-by":"crossref","first-page":"18340","DOI":"10.1038\/srep18340","article-title":"Chitinases and Imaginal disc growth factors organize the extracellular matrix formation at barrier tissues in insects","volume":"3","author":"Pesch","year":"2016","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.neuroscience.2017.04.050_b0150","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer\u2019s disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.neuroscience.2017.04.050_b0155","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1159\/000362164","article-title":"Increased levels of chitotriosidase and YKL-40 in cerebrospinal fluid from patients with Alzheimer\u2019s disease dement","volume":"4","author":"Ros\u00e9n","year":"2014","journal-title":"Geriatr Cogn Disord Extra"},{"key":"10.1016\/j.neuroscience.2017.04.050_b0160","doi-asserted-by":"crossref","first-page":"791907","DOI":"10.1155\/2015\/791907","article-title":"Chitinases from bacteria to human: properties, applications, and future perspectives","volume":"2015","author":"Rathore","year":"2015","journal-title":"Enzyme Res"},{"key":"10.1016\/j.neuroscience.2017.04.050_b0165","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1749-6632.2000.tb05554.x","article-title":"Toward a comprehensive theory for Alzheimer\u2019s disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid \u03b2-protein","volume":"924","author":"Selkoe","year":"2000","journal-title":"Ann NY Acad Sci"},{"issue":"07","key":"10.1016\/j.neuroscience.2017.04.050_b0170","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0072-9752(07)01223-7","article-title":"Biochemistry and molecular biology of amyloid beta-protein and the mechanism of Alzheimer's disease","volume":"89","author":"Selkoe","year":"2008","journal-title":"Handb Clin Neurol"},{"issue":"1","key":"10.1016\/j.neuroscience.2017.04.050_b0175","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jneuroim.2008.03.021","article-title":"Different content of chitin-like polysaccharides in multiple sclerosis and Alzheimer's disease brains","volume":"197","author":"Sotgiu","year":"2008","journal-title":"J Neuroimmunol"},{"issue":"19","key":"10.1016\/j.neuroscience.2017.04.050_b0180","doi-asserted-by":"crossref","first-page":"5092","DOI":"10.1182\/blood-2010-09-306993","article-title":"Activin A skewsmacrophage polarization by promoting a proinflamatory phenotype and inhibiting the acquisition of anti-inflamatory macrophage markers","volume":"117","author":"Sierra-Filardi","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.neuroscience.2017.04.050_b0185","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1742-2094-9-115","article-title":"A comparative review of cell culture systems for the study of microglial biology in Alzheimer's disease","volume":"9","author":"Stansley","year":"2012","journal-title":"J Neuroinflammation"},{"issue":"2","key":"10.1016\/j.neuroscience.2017.04.050_b0190","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jalz.2015.06.1893","article-title":"Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer\u2019s disease patients","volume":"12","author":"Siemers","year":"2016","journal-title":"Alzheimers Dement"},{"issue":"11","key":"10.1016\/j.neuroscience.2017.04.050_b0195","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1093\/intimm\/dxh328","article-title":"Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity","volume":"17","author":"van Eijk","year":"2005","journal-title":"Int Immunol"},{"issue":"6880","key":"10.1016\/j.neuroscience.2017.04.050_b0200","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/416535a","article-title":"Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long\u2014termpotentiation in vivo","volume":"416","author":"Walsh","year":"2002","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.neuroscience.2017.04.050_b0205","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1212\/WNL.0b013e318247caa1","article-title":"Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease","volume":"78","author":"Watabe-Rudolph","year":"2012","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.neuroscience.2017.04.050_b0210","first-page":"587","article-title":"Effects of puerarin on D-galactose-induced memory deficits in mice","volume":"23","author":"Xu","year":"2002","journal-title":"Acta Pharmacol Sin"},{"issue":"3","key":"10.1016\/j.neuroscience.2017.04.050_b0215","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s12264-011-1028-2","article-title":"Combined administration of D-galactose and aluminium induces Alzheimer-like lesions in brain","volume":"27","author":"Xiao","year":"2011","journal-title":"Neurosci Bull"},{"issue":"7","key":"10.1016\/j.neuroscience.2017.04.050_b0220","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1007\/s11064-016-1874-4","article-title":"Time-dependent increase of chitinase1 in APP\/PS1 double transgenic mice","volume":"41","author":"Xiao","year":"2016","journal-title":"Neurochem Res"},{"issue":"9","key":"10.1016\/j.neuroscience.2017.04.050_b0225","doi-asserted-by":"crossref","first-page":"992","DOI":"10.15252\/emmm.201606370","article-title":"TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance","volume":"8","author":"Xiang","year":"2016","journal-title":"EMBO Mol Med"},{"issue":"1","key":"10.1016\/j.neuroscience.2017.04.050_b0230","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.gene.2005.05.006","article-title":"Volecularcloning and functional characterization of mouse chitotriosidase","volume":"357","author":"Zheng","year":"2005","journal-title":"Gene"},{"issue":"25","key":"10.1016\/j.neuroscience.2017.04.050_b0235","doi-asserted-by":"crossref","first-page":"10601","DOI":"10.1073\/pnas.0701096104","article-title":"Attenuation of neuroinflammation and Alzheimer\u2019s disease pathology by liver x receptors","volume":"104","author":"Zelcer","year":"2007","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452217303184?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452217303184?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,2]],"date-time":"2018-09-02T01:25:24Z","timestamp":1535851524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452217303184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":47,"alternative-id":["S0306452217303184"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2017.04.050","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]}}}