{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T17:45:42Z","timestamp":1774460742266,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.neuroscience.2017.07.051","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T16:31:12Z","timestamp":1501605072000},"page":"95-105","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Differential effects of neonatal SSRI treatments on hypoxia-induced behavioral changes in male and female offspring"],"prefix":"10.1016","volume":"360","author":[{"given":"Reiko","family":"Nagano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Nakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Takeshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2017.07.051_b0005","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ejphar.2010.06.028","article-title":"Time-dependent effects of escitalopram on brain derived neurotrophic factor (BDNF) and neuroplasticity related targets in the central nervous system of rats","volume":"643","author":"Alboni","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0010","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1126\/science.1101678","article-title":"Early-life blockade of the 5HT transporter alters emotional behavior in adult mice","volume":"306","author":"Ansorge","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0015","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0301-0082(03)00112-6","article-title":"Hippocampal modulation of sensorimotor processes","volume":"70","author":"Bast","year":"2003","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0020","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.biopsych.2015.02.036","article-title":"Stress in utero: Prenatal programming of brain plasticity and cognition","volume":"78","author":"Bock","year":"2015","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0025","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.yhbeh.2016.01.017","article-title":"Developmental fluoxetine exposure increases behavioral despair and alters epigenetic regulation of the hippocampal BDNF gene in adult female offspring","volume":"80","author":"Boulle","year":"2016","journal-title":"Horm Behav"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0030","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/npp.2010.151","article-title":"Opponency revisited: competition and cooperation between dopamine and serotonin","volume":"36","author":"Boureau","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0035","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0361-9230(99)00076-3","article-title":"Prenatal hypoxia-ischemia alters expression and activity of nitric oxide synthase in the young rat brain and causes learning deficits","volume":"49","author":"Cai","year":"1999","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0040","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.nbd.2006.06.001","article-title":"Early-life fluoxetine exposure reduced functional deficits after hypoxic-ischemia brain injury in rat pups","volume":"24","author":"Chang","year":"2006","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0045","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.rehab.2014.08.002","article-title":"Monoaminergic drugs for motor recovery after ischemic stroke","volume":"57","author":"Chollet","year":"2014","journal-title":"Ann Phys Rehabil Med"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0050","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/OGX.0000000000000236","article-title":"Infections and brain development","volume":"70","author":"Cordeiro","year":"2015","journal-title":"Obstet Gynecol Surv"},{"key":"10.1016\/j.neuroscience.2017.07.051_b9010","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jchemneu.2014.07.001","article-title":"Differential distribution of hypoxia-inducible factor 1-beta (ARNT or ARNT2) in mouse substantia nigra and ventral tegmental area","volume":"61\u201362","author":"Dela Cruz","year":"2014","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0055","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bbr.2012.03.029","article-title":"Impact of prenatal ischemia on behavior, cognitive abilities and neuroanatomy in adult rats with white matter damage","volume":"232","author":"Delcour","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0060","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s11055-009-9235-2","article-title":"Ontogenic characteristic of behavior in rats subjected to hypoxia on day 14or day18 of embryogenesis","volume":"40","author":"Dubrovskaya","year":"2010","journal-title":"Neurosci Behav Physiol"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2013.04.011","article-title":"Citalopram enhances neurovascular regeneration and sensorimotor functional recovery after ischemic stroke in mice","volume":"247","author":"Espinera","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0070","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neulet.2013.06.023","article-title":"Post-ischemic administration of progesterone reduces caspase-3 activation and DNA fragmentation in the hippocampus following global cerebral ischemia","volume":"550","author":"Espinosa-Garc\u00eda","year":"2013","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0075","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/jnr.20641","article-title":"Complex-environment rearing prevents prenatal hypoxia-induced deficits in hippocampal cellular mechanisms necessary for memory consolidation in the adult Wistar rat","volume":"82","author":"Foley","year":"2005","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0080","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1467-7687.2006.00498.x","article-title":"The effect of prenatal hypoxia on brain development: short- and long-term consequences demonstrated in rodent models","volume":"9","author":"Golan","year":"2006","journal-title":"Dev Sci"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0085","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1159\/000331651","article-title":"Inhibition of X-linked inhibitor of apoptosis with embelin differentially affects male versus female behavioral outcome following neonatal hypoxia-ischemia in rats","volume":"33","author":"Hill","year":"2011","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0090","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neulet.2011.10.055","article-title":"Sex differences in the effects of perinatal anoxia on dopamine function in rats","volume":"506","author":"Laplante","year":"2012","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0095","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.expneurol.2011.03.015","article-title":"Pre- and post-treatments with escitalopram protect against experimental ischemic neuronal damage via regulation of BDNF expression and oxidative stress","volume":"229","author":"Lee","year":"2011","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0100","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/jnr.21829","article-title":"Chronic fluoxetine treatment improves ischemia-induced spatial cognitive deficits through increasing hippocampal neurogenesis after stroke","volume":"87","author":"Li","year":"2009","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0105","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.pneurobio.2012.05.010","article-title":"Fetal stress and programming of hypoxic\/ischemic-sensitive phenotype in the neonatal brain: mechanisms and possible interventions","volume":"98","author":"Li","year":"2012","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0110","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1002\/syn.20954","article-title":"Inhibition of the serotonin transporter induces microglial activation and downregulation of dopaminergic neurons in the substantia nigra","volume":"65","author":"MacGillivray","year":"2011","journal-title":"Synapse"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0115","unstructured":"Machado FC, Vitalle MS, Franco M (2015) Predictors of depression and anxiety symptoms during adolescence: the impact of Birth Weight. Minerva Pediatr ISSN 0026\u20134946 Online ISSN 1827\u20131715."},{"key":"10.1016\/j.neuroscience.2017.07.051_b0120","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/sj.npp.1300823","article-title":"Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry","volume":"31","author":"Maciag","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0125","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/sj.npp.1301554","article-title":"Divergent plasticity of prefrontal cortex networks","volume":"33","author":"Moghaddam","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0130","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1527-3458.2008.00040.x","article-title":"Therapeutic potential of fluoxetine in neurological disorders","volume":"14","author":"Mostert","year":"2008","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0135","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.neures.2007.12.005","article-title":"Prenatal dexamethasone exposure affects anxiety-like behaviour and neuroendocrine systems in an age-dependent manner","volume":"60","author":"Nagano","year":"2008","journal-title":"Neurosci Res"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0140","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.neuropharm.2012.03.027","article-title":"Early intervention with fluoxetine reverses abnormalities in the serotonergic system and behavior of rats exposed prenatally to dexamethasone","volume":"63","author":"Nagano","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-3806(01)00138-9","article-title":"Influence of mild hypothermia on delayed mitochondrial dysfunction after transient intrauterine ischemia in the immature rat brain","volume":"128","author":"Nakai","year":"2001","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0150","doi-asserted-by":"crossref","first-page":"e1603001","DOI":"10.1126\/sciadv.1603001","article-title":"Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice","volume":"3","author":"Nakai","year":"2017","journal-title":"Sci Adv"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0155","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0006-3223(01)01145-3","article-title":"Second-generation SSRIs: Human monoamine transporter binding profile of escitalopram and R-fluoxetine","volume":"50","author":"Owens","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2017.07.051_b9015","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/NEN.0b013e31828b48b3","article-title":"Vulnerability of the mesencephalic dopaminergic neurons of the human neonate to prolonged perinatal hypoxia: an immunohistochemical study of tyrosine hydroxylase expression in autopsy material","volume":"72","author":"Pagida","year":"2013","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0160","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.neuropharm.2011.04.019","article-title":"Tracing the development of psychosis and its prevention: what can be learned from animal models","volume":"62","author":"Piontkewitz","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0165","doi-asserted-by":"crossref","first-page":"e24003","DOI":"10.1371\/journal.pone.0024003","article-title":"Fluoxetine during development reverses the effects of prenatal stress on depressive-like behavior and hippocampal neurogenesis in adolescence","volume":"6","author":"Rayen","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0170","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pbb.2010.04.007","article-title":"Effects of fluoxetine and PCPA on isolation-induced morphine self-administration and startle reactivity","volume":"96","author":"Raz","year":"2010","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0175","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ijdevneu.2011.04.004","article-title":"The biological basis of injury and neuroprotection in the fetal and neonatal brain","volume":"29","author":"Rees","year":"2011","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0180","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pbb.2013.04.004","article-title":"Prenatal hypoxia, habituation memory and oxidative stress","volume":"107","author":"Sab","year":"2013","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0185","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.brainres.2013.02.040","article-title":"Are the consequences of neonatal hypoxia-ischemia dependent on animals' sex and brain lateralization?","volume":"1507","author":"Sanches","year":"2013","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2017.07.051_b9020","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/mp.2011.183","article-title":"An environmental analysis of genes associated with schizophrenia: hypoxia and vascular factors as interacting elements in the neurodevelopmental model","volume":"17","author":"Schmidt-Kastner","year":"2012","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0190","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.neuroscience.2015.08.034","article-title":"Genomic approach to selective vulnerability of the hippocampus in brain ischemia-hypoxia","volume":"309","author":"Schmidt-Kastner","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0195","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.expneurol.2014.01.003","article-title":"Sex differences in behavioral outcome following neonatal hypoxia ischemia: Insights from a clinical meta-analysis and a rodent model of induced hypoxic ischemic brain injury","volume":"254","author":"Smith","year":"2014","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0200","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ijdevneu.2016.08.007","article-title":"Perinatal exposure to the selective serotonin reuptake inhibitor citalopram alters spatial learning and memory, anxiety, depression, and startle in Sprague-Dawley rats","volume":"54","author":"Sprowles","year":"2016","journal-title":"Int J Devl Neurosci"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0205","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000047125","article-title":"Prenatal influence of ischemia-hypoxia-induced intrauterine growth retardation on brain development and behavioral activity in rats","volume":"80","author":"Tashima","year":"2001","journal-title":"Biol Neonate"},{"issue":"Pt2","key":"10.1016\/j.neuroscience.2017.07.051_b0210","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.expneurol.2015.09.003","article-title":"Sex differences in cell genesis, hippocampal volume and behavioral outcomes in a rat model of neonatal HI","volume":"275","author":"Waddell","year":"2016","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0215","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/s12035-013-8444-4","article-title":"Gestational hypoxia induces sex-differential methylation of Crhr1 linked to anxiety-like behavior","volume":"48","author":"Wang","year":"2013","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0220","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.pharep.2014.12.003","article-title":"Evaluation of the role of NMDA receptor function in antidepressant-like activity. A new study with citalopram and fluoxetine in the forced swim test in mice","volume":"67","author":"Wolak","year":"2015","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.neuroscience.2017.07.051_b0225","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1152\/jappl.2002.92.1.195","article-title":"Testosterone increases neurotoxicity of glutamate in vitro and ischemia-reperfusion injury in an animal model","volume":"92","author":"Yang","year":"2002","journal-title":"J Appl Physiol"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452217305286?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452217305286?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T08:01:08Z","timestamp":1656403268000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452217305286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":48,"alternative-id":["S0306452217305286"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2017.07.051","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]}}}