{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:26:50Z","timestamp":1792985210515,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2013R1A1A2011219"],"award-info":[{"award-number":["NRF-2013R1A1A2011219"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2016R1D1A1B01014190"],"award-info":[{"award-number":["NRF-2016R1D1A1B01014190"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.neuroscience.2017.11.046","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T09:37:00Z","timestamp":1512639420000},"page":"49-59","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["\u03b16 and \u03b21 Integrin Heterodimer Mediates Schwann Cell Interactions with Axons and Facilitates Axonal Regeneration after Peripheral Nerve Injury"],"prefix":"10.1016","volume":"371","author":[{"given":"In Ae","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Joong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uk","family":"Namgung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2017.11.046_b0010","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.neuron.2012.06.021","article-title":"C-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration","volume":"75","author":"Arthur-Farraj","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0015","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1385\/NMM:8:1-2:191","article-title":"Role of integrins in peripheral nerves and hereditary neuropathies","volume":"8","author":"Berti","year":"2006","journal-title":"Neuromol Med"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0020","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1083\/jcb.107.1.353","article-title":"Identification of the major proteins that promote neuronal process outgrowth on Schwann cells in vitro","volume":"107","author":"Bixby","year":"1998","journal-title":"J Cell Biol"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0025","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1136\/jnnp.42.5.436","article-title":"Nerve conduction, tactile sensibility, and the electromyogram after suture or compression of peripheral nerve: a longitudinal study in man","volume":"42","author":"Buchthal","year":"1979","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0030","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1096\/fj.11-199018","article-title":"Vimentin phosphorylation by Cdc2 in Schwann cell controls axon growth via \u03b21-integrin activation","volume":"26","author":"Chang","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0035","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1146\/annurev.neuro.30.051606.094337","article-title":"Peripheral regeneration","volume":"30","author":"Chen","year":"2007","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0040","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1083\/jcb.115.3.843","article-title":"The major laminin receptor of mouse embryonic stem cells is a novel isoform of the alpha6 beta 1 integrin","volume":"115","author":"Cooper","year":"1991","journal-title":"J Cell Biol"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0045","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/1098-1136(20010101)33:1<36::AID-GLIA1004>3.0.CO;2-B","article-title":"Laminin molecules in freeze-treated nerve segments are associated with migrating Schwann cells that display the corresponding alpha6beta1 integrin receptor","volume":"33","author":"Dubov\u00fd","year":"2001","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0050","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1083\/jcb.123.5.1223","article-title":"Axonal regulation of Schwann cell integrin expression suggests a role for alpha 6 beta 4 in myelination","volume":"123","author":"Einheber","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0055","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1044-7431(02)00034-9","article-title":"Involvement of alpha7beta1 integrin in the conditioning-lesion effect on sensory axon regeneration","volume":"22","author":"Ekstr\u00f6m","year":"2003","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0060","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.conb.2014.03.018","article-title":"Integrin signalling and traffic during axon growth and regeneration","volume":"27","author":"Eva","year":"2014","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0065","series-title":"Brain Damage, Brain Repair","first-page":"145","article-title":"Peripheral nerve regeneration","author":"Fawcett","year":"2001"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0070","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1242\/dev.120.5.1287","article-title":"Beta 4 integrin expression in myelinating Schwann cells ispolarized, developmentally regulated and axonally dependent","volume":"120","author":"Feltri","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0075","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1083\/jcb.200109021","article-title":"Conditional disruption of beta 1 integrin in Schwann cells impedes interactions with axons","volume":"156","author":"Feltri","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0080","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1083\/jcb.201205025","article-title":"C-Jun in Schwann cells promotes axonal regeneration and moto neuron survival via paracrine signaling","volume":"198","author":"Fontana","year":"2012","journal-title":"J Cell Biol"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0085","doi-asserted-by":"crossref","first-page":"3886","DOI":"10.1523\/JNEUROSCI.15-05-03886.1995","article-title":"Contributing factors to poor functional recovery after delayed nerve repair: prolonged denervation","volume":"15","author":"Fu","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0090","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1002\/dneu.20950","article-title":"Integrins and the extracellular matrix: key mediators of development and regeneration of the sensory nervous system","volume":"71","author":"Gardiner","year":"2011","journal-title":"Dev Neurobiol"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0095","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.mcn.2007.02.020","article-title":"Preconditioning injury-induced neurite outgrowth of adult rat sensory neurons on fibronectin is mediated by mobilisation of axonal alpha5 integrin","volume":"35","author":"Gardiner","year":"2007","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0100","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/ng0796-370","article-title":"Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice","volume":"13","author":"Georges-Labouesse","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0105","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0960-9822(98)70402-6","article-title":"Essential role of alpha 6 integrins in cortical and retinal lamination","volume":"8","author":"Georges-Labouesse","year":"1998","journal-title":"Curr Biol"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0110","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1126\/science.285.5430.1028","article-title":"Integrin signaling","volume":"285","author":"Giancotti","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0115","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.conb.2013.06.010","article-title":"Signals regulating myelination in peripheral nerves and the Schwann cell response to injury","volume":"23","author":"Glenn","year":"2013","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0120","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1006\/dbio.2001.0213","article-title":"Integrin receptors are required for cell survival and proliferation during development of the peripheral glial lineage","volume":"233","author":"Haack","year":"2001","journal-title":"Dev Biol."},{"key":"10.1016\/j.neuroscience.2017.11.046_b0125","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1242\/jcs.03322","article-title":"Cdc2-mediated Schwann cell migration during peripheral nerve regeneration","volume":"120","author":"Han","year":"2007","journal-title":"J Cell Sci"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0130","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1432-1033.1991.tb16140.x","article-title":"Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes","volume":"199","author":"Hogervorst","year":"1991","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0135","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1083\/jcb.121.1.179","article-title":"Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunit","volume":"121","author":"Hogervorst","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0140","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/ncpneuro0262","article-title":"Mechanisms of Disease: what factors limit the success of peripheral nerve regeneration in humans?","volume":"2","author":"H\u00f6ke","year":"2006","journal-title":"Nat Clin Pract Neurol"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0145","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1038\/sj.emboj.7600847","article-title":"PKCepsilon-mediated phosphorylation of vimentin controls integrin recycling and motility","volume":"24","author":"Ivaska","year":"2005","journal-title":"EMBO J"},{"issue":"7","key":"10.1016\/j.neuroscience.2017.11.046_b0150","doi-asserted-by":"crossref","first-page":"a020487","DOI":"10.1101\/cshperspect.a020487","article-title":"Schwann cells: development and role in nerve repair","volume":"7","author":"Jessen","year":"2015","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0155","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1242\/jcs.103.3.743","article-title":"Altered glycosylation and cell surface expression of beta 1 integrin receptors during keratinocyte activation","volume":"103","author":"Kim","year":"1992","journal-title":"J Cell Sci"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0160","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.expneurol.2007.05.027","article-title":"Integrin signaling is integral to regeneration","volume":"209","author":"Lemons","year":"2008","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0165","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1096\/fj.12-227132","article-title":"Nuclear monomeric integrin \u03b1v in cancer cells is a coactivator regulated by thyroid hormone","volume":"27","author":"Lin","year":"2013","journal-title":"FASEB J"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0170","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuron.2014.06.007","article-title":"Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases","volume":"83","author":"Mei","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0175","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0180","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000370324","article-title":"The role of Schwann cell-axon interaction in peripheral nerve regeneration","volume":"200","author":"Namgung","year":"2014","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0185","doi-asserted-by":"crossref","first-page":"6714","DOI":"10.1523\/JNEUROSCI.0326-08.2008","article-title":"Alpha6beta4 integrin and dystroglycan cooperate to stabilize the myelin sheath","volume":"28","author":"Nodari","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0190","doi-asserted-by":"crossref","first-page":"17995","DOI":"10.1523\/JNEUROSCI.3179-13.2013","article-title":"\u03916\u03b21 and \u03b17\u03b21 integrins are required in Schwann cells to sort axons","volume":"33","author":"Pellegatta","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0195","doi-asserted-by":"crossref","first-page":"5520","DOI":"10.1523\/JNEUROSCI.23-13-05520.2003","article-title":"Expression of laminin receptors in schwann cell differentiation: evidence for distinct roles","volume":"23","author":"Previtali","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0200","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1128\/MCB.24.4.1505-1515.2004","article-title":"Protein kinaseB\/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3and alpha 5 beta 1 integrins","volume":"24","author":"Roberts","year":"2004","journal-title":"Mol Cell Biol."},{"key":"10.1016\/j.neuroscience.2017.11.046_b0205","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1249\/01.mss.0000227311.00976.68","article-title":"Involvement of Cdc2 in axonal regeneration enhanced by exercise training in rats","volume":"38","author":"Seo","year":"2006","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2013.11.007","article-title":"Dynamic regulation of SCG10 in regenerating axons after injury","volume":"252","author":"Shin","year":"2014","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0215","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nn.3281","article-title":"A role for Schwann cell-derived neuregulin-1 in remyelination","volume":"16","author":"Stassart","year":"2013","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0220","doi-asserted-by":"crossref","first-page":"10183","DOI":"10.1073\/pnas.88.22.10183","article-title":"Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains","volume":"88","author":"Tamura","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0225","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1006\/exnr.1996.0030","article-title":"Basic behavior of migratory Schwann cells in peripheral nerve regeneration","volume":"137","author":"Torigoe","year":"1996","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0230","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/BF01260889","article-title":"The fate of Schwann cells isolated from axonal contact","volume":"7","author":"Weinberg","year":"1978","journal-title":"J Neurocytol"},{"key":"10.1016\/j.neuroscience.2017.11.046_b0235","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1523\/JNEUROSCI.20-05-01822.2000","article-title":"Impaired axonal regeneration in alpha7 integrin-deficient mice","volume":"20","author":"Werner","year":"2000","journal-title":"J Neurosci"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452217308618?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452217308618?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T15:43:58Z","timestamp":1759679038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452217308618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":46,"alternative-id":["S0306452217308618"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2017.11.046","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b16 and \u03b21 Integrin Heterodimer Mediates Schwann Cell Interactions with Axons and Facilitates Axonal Regeneration after Peripheral Nerve Injury","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2017.11.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}