{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:06:50Z","timestamp":1766066810965},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300760","81470632"],"award-info":[{"award-number":["81300760","81470632"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.neuroscience.2017.12.044","type":"journal-article","created":{"date-parts":[[2017,12,30]],"date-time":"2017-12-30T11:52:09Z","timestamp":1514634729000},"page":"141-153","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Morphological and Functional Changes of Locus Coeruleus in Patients with Primary Open-Angle Glaucoma and Animal Models"],"prefix":"10.1016","volume":"372","author":[{"given":"Yuxiang","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinwei","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieling","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ketao","family":"Mu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2017.12.044_b0010","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0165-0173(03)00143-7","article-title":"The locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processes","volume":"42","author":"Berridge","year":"2003","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0015","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/mrm.1910340409","article-title":"Functional connectivity in the motor cortex of resting human brain using echo-planar MRI","volume":"34","author":"Biswal","year":"1995","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0030","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1442-9071.2012.02773.x","article-title":"Definition of glaucoma: clinical and experimental concepts","volume":"40","author":"Casson","year":"2012","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0035","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1442-9071.2012.02832.x","article-title":"Diffusion tensor magnetic resonance imaging reveals visual pathway damage that correlates with clinical severity in glaucoma","volume":"41","author":"Chen","year":"2013","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0040","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s00401-016-1609-2","article-title":"Glaucoma: the retina and beyond","volume":"132","author":"Davis","year":"2016","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0045","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00429-010-0283-8","article-title":"Atrophy in the parahippocampal gyrus as an early biomarker of Alzheimer's disease","volume":"215","author":"Ech\u00e1varri","year":"2011","journal-title":"Brain Struct Funct"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0055","doi-asserted-by":"crossref","first-page":"e105931","DOI":"10.1371\/journal.pone.0105931","article-title":"Structural and functional brain changes beyond visual system in patients with advanced glaucoma","volume":"9","author":"Frezzotti","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0060","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1002\/hbm.23330","article-title":"Early changes of brain connectivity in primary open angle glaucoma","volume":"37","author":"Frezzotti","year":"2016","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0065","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1517\/17425250802457609","article-title":"Efficacy, safety, and current applications of brimonidine","volume":"7","author":"Fudemberg","year":"2008","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0080","first-page":"1","article-title":"Considerations in glaucoma therapy: fixed combinations versus their component medications","volume":"4","author":"Higginbotham","year":"2010","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0085","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0304-3940(99)00241-4","article-title":"Stress-induced changes of norepinephrine uptake sites in the locus coeruleus of C57BL\/6J andDBA\/2J mice: a quantitative autoradiographic study using [3H]-tomoxetine","volume":"265","author":"Hwang","year":"1999","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0090","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/cne.21753","article-title":"Entorhinal cortex of the monkey: IV. Topographical and laminar organization of cortical afferents","volume":"509","author":"Insausti","year":"2008","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0100","first-page":"951","article-title":"Essential iris atrophy, pigment dispersion, and glaucoma in DBA\/2J mice","volume":"39","author":"John","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0110","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0891-0618(96)00111-1","article-title":"Dopamine-beta-hydroxylase immunoreactive neurons in the human brain stem","volume":"10","author":"Kitahama","year":"1996","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0115","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000381986","article-title":"Historical evolution of the frontal lobe syndrome","volume":"48","author":"Krudop","year":"2015","journal-title":"Psychopathology"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0120","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/IJG.0000000000000393","article-title":"Assessment of depression, anxiety, and quality of life in Singaporean patients with glaucoma","volume":"25","author":"Lim","year":"2016","journal-title":"J Glaucoma"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0125","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/35084005","article-title":"Neurophysiological investigation of the basis of the fMRI signal","volume":"412","author":"Logothetis","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0130","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0306-4522(86)90155-7","article-title":"Efferent projections of nucleus locus coeruleus: topographic organization of cells of origin demonstrated by three-dimensional reconstruction","volume":"18","author":"Loughlin","year":"1986","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0135","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1097\/IJG.0b013e31816299d4","article-title":"High prevalence of anxiety and depression in patients with primary open-angle glaucoma","volume":"17","author":"Mabuchi","year":"2008","journal-title":"J Glaucoma"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0140","doi-asserted-by":"crossref","DOI":"10.1089\/brain.2016.0432","article-title":"Altered resting-state functional connectivity in the hand motor network in glioma patients","author":"Mallela","year":"2016","journal-title":"Brain Connect"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0145","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1023\/B:BEBM.0000028121.61962.6a","article-title":"Effect of locus coeruleus stimulation on ocular hypertension and pathology of pulmonary surfactant during chronic emotional stress","volume":"137","author":"Myagkov","year":"2004","journal-title":"Bull Exp Biol Med"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0150","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1023\/B:NEAB.0000003252.77752.40","article-title":"The correcting influence of the locus ceruleus on ophthalmic hypertension of hypothalamic origin","volume":"34","author":"Myagkov","year":"2004","journal-title":"Neurosci Behav Physiol"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0155","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1007\/s00702-016-1596-4","article-title":"Tyrosine hydroxylase (TH), its cofactor tetrahydrobiopterin (BH4), other catecholamine-related enzymes, and their human genes in relation to the drug and gene therapies of Parkinson\u2019s disease (PD): historical overview and future prospects","volume":"123","author":"Nagatsu","year":"2016","journal-title":"J Neural Transm"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0160","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3940(84)90139-3","article-title":"Increased projection from the locus coeruleus to the lateral geniculate nucleus and visual cortex in young adult rats following unilateral enucleation","volume":"49","author":"Nakamura","year":"1984","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0165","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.coph.2012.08.004","article-title":"Brain involvement in glaucoma: advanced neuroimaging for understanding and monitoring a new target for therapy","volume":"13","author":"Nucci","year":"2013","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0170","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0002-9394(73)90556-4","article-title":"Effect of L-norepinephrine and adrenergic potentiators on the aqueous humor dynamics of man","volume":"76","author":"Pollack","year":"1973","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0175","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/S0140-6736(10)61423-7","article-title":"Glaucoma","volume":"377","author":"Quigley","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0180","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/nn.3458","article-title":"Developmental origins of central norepinephrine neuron diversity","volume":"16","author":"Robertson","year":"2013","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0185","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0006-8993(84)90185-9","article-title":"Changes in projection from locus coeruleus to lateral geniculate nucleus following ablation of visual cortex in adult rats","volume":"321","author":"Sakaguchi","year":"1984","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0190","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1167\/iovs.09-3947","article-title":"The microbead occlusion model: a paradigm for induced ocular hypertension in rats and mice","volume":"51","author":"Sappington","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0195","doi-asserted-by":"crossref","first-page":"R1051","DOI":"10.1016\/j.cub.2015.09.039","article-title":"Organization of the locus coeruleus-norepinephrine system","volume":"25","author":"Schwarz","year":"2015","journal-title":"Curr Biol"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0200","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0091-3057(91)90591-O","article-title":"Alterations of central norepinephrine, dopamine and serotonin in several strains of mice following acute stressor exposure","volume":"38","author":"Shanks","year":"1991","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0205","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/hbm.20580","article-title":"Neuronal correlates of spontaneous fluctuations in fMRI signals in monkey visual cortex: implications for functional connectivity at rest","volume":"29","author":"Shmuel","year":"2008","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0210","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1176\/appi.neuropsych.260401","article-title":"Insular cortex: structural and functional neuroanatomy","volume":"26","author":"Shura","year":"2014","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0215","doi-asserted-by":"crossref","first-page":"e89493","DOI":"10.1371\/journal.pone.0089493","article-title":"Altered spontaneous brain activity in primary open angle glaucoma: a resting-state functional magnetic resonance imaging study","volume":"9","author":"Song","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0230","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/IJG.0b013e3182952213","article-title":"Effect of 0.04% AR-13324, a ROCK, and norepinephrine transporter inhibitor, on aqueous humor dynamics in normotensive monkey eyes","volume":"24","author":"Wang","year":"2015","journal-title":"J Glaucoma"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0235","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/cne.902170406","article-title":"The distribution of neocortical projection neurones in the locus coeruleus","volume":"217","author":"Waterhouse","year":"1983","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0250","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.exer.2006.03.014","article-title":"A rat model of glaucoma induced by episcleral vein ligation","volume":"83","author":"Yu","year":"2006","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.neuroscience.2017.12.044_b0255","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/j.neuroimage.2009.09.037","article-title":"The oscillating brain: complex and reliable","volume":"49","author":"Zuo","year":"2010","journal-title":"Neuroimage"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645221730934X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645221730934X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T20:53:24Z","timestamp":1535144004000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030645221730934X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":39,"alternative-id":["S030645221730934X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2017.12.044","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]}}}