{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T02:17:05Z","timestamp":1773454625556,"version":"3.50.1"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,16]],"date-time":"2019-03-16T00:00:00Z","timestamp":1552694400000},"content-version":"am","delay-in-days":349,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"US Department of Defense Grant","award":["W81XWH-16-1-0102"],"award-info":[{"award-number":["W81XWH-16-1-0102"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.neuroscience.2018.02.015","type":"journal-article","created":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T12:08:38Z","timestamp":1518869318000},"page":"172-187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Biomaterial Cues to Direct a Pro-regenerative Phenotype in Macrophages and Schwann Cells"],"prefix":"10.1016","volume":"376","author":[{"given":"Melissa R.","family":"Wrobel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harini G.","family":"Sundararaghavan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2018.02.015_b0005","first-page":"405","article-title":"Peripheral nerve conduits: technology update","volume":"7","author":"Arslantunali","year":"2014","journal-title":"Med Devices"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0010","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/jbm.a.20134","article-title":"Quantification of inflammatory cellular responses using real-time polymerase chain reaction","volume":"69","author":"Bailey","year":"2004","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0015","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/ni.2406","article-title":"From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines","volume":"13","author":"Banchereau","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0020","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1002\/jbm.a.34562","article-title":"The effect of surface roughness on RAW 264.7 macrophage phenotype","volume":"101","author":"Barth","year":"2013","journal-title":"J Biomed Mater Res Part A"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0025","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1016\/j.biomaterials.2012.02.050","article-title":"Inducing healing-like human primary macrophage phenotypes by 3D hydrogel coated nanofibres","volume":"33","author":"Bartneck","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0030","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1002\/glia.20753","article-title":"Neuregulin-1, a key axonal signal that drives Schwann cell growth and differentiation","volume":"56","author":"Birchmeier","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0035","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1002\/jbm.a.34104","article-title":"The effects of substrate stiffness on the in vitro activation of macrophages and in vivo host response to poly(ethylene glycol)-based hydrogels","volume":"100","author":"Blakney","year":"2012","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0040","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.toxlet.2012.11.010","article-title":"Dental monomers inhibit LPS-induced cytokine release from the macrophage cell line RAW264.7","volume":"216","author":"Bolling","year":"2013","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0045","series-title":"Basic neurochemistry: principles of molecular, cellular, and medical neurobiology","author":"Brady","year":"2012"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0050","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s10571-007-9215-4","article-title":"Induction of TNF-alpha by LPS in Schwann cell is regulated by MAPK activation signals","volume":"27","author":"Cheng","year":"2007","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0055","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1002\/glia.20740","article-title":"Regulation of Schwann cell function by the extracellular matrix","volume":"56","author":"Chernousov","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0060","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.biomaterials.2007.10.025","article-title":"The effect of the alignment of electrospun fibrous scaffolds on Schwann cell maturation","volume":"29","author":"Chew","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0065","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1016\/j.biomaterials.2009.04.022","article-title":"Thin-film enhanced nerve guidance channels for peripheral nerve repair","volume":"30","author":"Clements","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0070","doi-asserted-by":"crossref","first-page":"7819","DOI":"10.1016\/j.biomaterials.2014.05.065","article-title":"Collagen scaffolds modified with CNTF and bFGF promote facial nerve regeneration in minipigs","volume":"35","author":"Cui","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0075","doi-asserted-by":"crossref","first-page":"E5","DOI":"10.3171\/FOC.2009.26.2.E5","article-title":"Designing ideal conduits for peripheral nerve repair","volume":"26","author":"de Ruiter","year":"2009","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0080","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1089\/ten.tea.2008.0406","article-title":"Collagen I-matrigel scaffolds for enhanced Schwann cell survival and control of three-dimensional cell morphology","volume":"15","author":"Dewitt","year":"2009","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0085","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.biomaterials.2007.08.045","article-title":"Differences between the effect of anisotropic and isotropic laminin and nerve growth factor presenting scaffolds on nerve regeneration across long peripheral nerve gaps","volume":"29","author":"Dodla","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0090","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10753-009-9173-8","article-title":"Cyclin D3\/CDK11(p58) complex involved in Schwann cells proliferation repression caused by lipopolysaccharide","volume":"33","author":"Duan","year":"2010","journal-title":"Inflammation"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0095","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/jbm.a.35894","article-title":"Solubilized extracellular matrix bioscaffolds derived from diverse source tissues differentially influence macrophage phenotype","volume":"105","author":"Dziki","year":"2017","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0100","doi-asserted-by":"crossref","first-page":"e71076","DOI":"10.1371\/journal.pone.0071076","article-title":"Lentiviral vector-mediated gradients of GDNF in the injured peripheral nerve: effects on nerve coil formation, Schwann cell maturation and myelination","volume":"8","author":"Eggers","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0105","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1523\/JNEUROSCI.17-01-00241.1997","article-title":"Actin plays a role in both changes in cell shape and gene-expression associated with Schwann cell myelination","volume":"17","author":"Fernandez-Valle","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0110","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.3390\/brainsci3031182","article-title":"Repair of the peripheral nerve-remyelination that works","volume":"3","author":"Fex Svennigsen","year":"2013","journal-title":"Brain Sci"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0115","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.1016\/j.actbio.2012.11.016","article-title":"Artificial extracellular matrices composed of collagen I and high-sulfated hyaluronan promote phenotypic and functional modulation of human pro-inflammatory M1 macrophages","volume":"9","author":"Franz","year":"2013","journal-title":"Acta Biomater"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0120","doi-asserted-by":"crossref","first-page":"698256","DOI":"10.1155\/2014\/698256","article-title":"Peripheral nerve reconstruction after injury: a review of clinical and experimental therapies","volume":"2014","author":"Grinsell","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0125","doi-asserted-by":"crossref","first-page":"6672","DOI":"10.1016\/j.biomaterials.2012.06.006","article-title":"The influence of substrate stiffness on the behavior and functions of Schwann cells in culture","volume":"33","author":"Gu","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0130","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/jnr.10327","article-title":"Comparative analysis of Schwann cell lines as model systems for myelin gene transcription studies","volume":"69","author":"Hai","year":"2002","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0135","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1089\/ten.tea.2016.0501","article-title":"Activation of macrophages by lipopolysaccharide for assessing the immunomodulatory property of biomaterials","volume":"23","author":"Han","year":"2017","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0140","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1038\/sj.emboj.7600309","article-title":"The Ras\/Raf\/ERK signalling pathway drives Schwann cell dedifferentiation","volume":"23","author":"Harrisingh","year":"2004","journal-title":"EMBO J"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0145","doi-asserted-by":"crossref","first-page":"9330","DOI":"10.1523\/JNEUROSCI.2488-08.2008","article-title":"Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions","volume":"28","author":"Horn","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0150","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.ymthe.2005.01.016","article-title":"Lentiviral-mediated transfer of CNTF to schwann cells within reconstructed peripheral nerve grafts enhances adult retinal ganglion cell survival and axonal regeneration","volume":"11","author":"Hu","year":"2005","journal-title":"Mol Ther"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0155","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cellimm.2013.01.010","article-title":"Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin","volume":"281","author":"Jaguin","year":"2013","journal-title":"Cell Immunol"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0160","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17091494","article-title":"Advances and future applications of augmented peripheral nerve regeneration","volume":"17","author":"Jones","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0165","doi-asserted-by":"crossref","first-page":"13435","DOI":"10.1523\/JNEUROSCI.3257-09.2009","article-title":"Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord","volume":"29","author":"Kigerl","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0170","doi-asserted-by":"crossref","first-page":"e33664","DOI":"10.1371\/journal.pone.0033664","article-title":"The MMP-9\/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration","volume":"7","author":"Kim","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0175","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1016\/j.biomaterials.2008.03.042","article-title":"The role of aligned polymer fiber-based constructs in the bridging of long peripheral nerve gaps","volume":"29","author":"Kim","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0180","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.nano.2011.06.013","article-title":"In vitro and in vivo evaluation of the inflammatory response to nanoscale grooved substrates","volume":"8","author":"Lamers","year":"2012","journal-title":"Nanomed Nanotechnol Biol Med"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0185","doi-asserted-by":"crossref","first-page":"6655","DOI":"10.1016\/j.bmcl.2009.10.007","article-title":"Factors affecting anti-inflammatory effect of chitooligosaccharides in lipopolysaccharides-induced RAW264.7 macrophage cells","volume":"19","author":"Lee","year":"2009","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0190","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0195","doi-asserted-by":"crossref","first-page":"20140247","DOI":"10.1098\/rsif.2014.0247","article-title":"Three-dimensional traction forces of Schwann cells on compliant substrates","volume":"11","author":"Lopez-Fagundo","year":"2014","journal-title":"J R Soc Interface"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0200","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.devcel.2013.12.002","article-title":"Contrasting the glial response to axon injury in the central and peripheral nervous systems","volume":"28","author":"Lutz","year":"2014","journal-title":"Dev Cell"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0205","doi-asserted-by":"crossref","first-page":"28665","DOI":"10.1021\/acsami.5b10589","article-title":"Micro- and nanopatterned topographical cues for regulating macrophage cell shape and phenotype","volume":"7","author":"Luu","year":"2015","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0210","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.actbio.2010.07.033","article-title":"Phenotypic changes in bone marrow-derived murine macrophages cultured on PEG-based hydrogels activated or not by lipopolysaccharide","volume":"7","author":"Lynn","year":"2011","journal-title":"Acta Biomater"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0215","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1039\/C6BM00425C","article-title":"Convex and concave micro-structured silicone controls the shape, but not the polarization state of human macrophages","volume":"4","author":"Malheiro","year":"2016","journal-title":"Biomater Sci"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0220","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1007\/s10439-014-0991-y","article-title":"Redirection of neurite outgrowth by coupling chondroitin sulfate proteoglycans to polymer membranes","volume":"42","author":"Man","year":"2014","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0225","doi-asserted-by":"crossref","unstructured":"Martinez FO, Gordon S, 2014. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000prime reports 6, 13. 10.12703\/P6-13.","DOI":"10.12703\/P6-13"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0230","doi-asserted-by":"crossref","first-page":"17253","DOI":"10.1073\/pnas.1308887110","article-title":"Modulation of macrophage phenotype by cell shape","volume":"110","author":"McWhorter","year":"2013","journal-title":"P Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0235","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.hcl.2013.04.002","article-title":"Nerve physiology: mechanisms of injury and recovery","volume":"29","author":"Menorca","year":"2013","journal-title":"Hand Clin"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0240","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1159\/000364945","article-title":"M1 and M2 macrophages: the chicken and the egg of immunity","volume":"6","author":"Mills","year":"2014","journal-title":"J Innate Immun"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0245","doi-asserted-by":"crossref","first-page":"055004","DOI":"10.1088\/1748-6041\/9\/5\/055004","article-title":"Schwann cell interactions with polymer films are affected by groove geometry and film hydrophilicity","volume":"9","author":"Mobasseri","year":"2014","journal-title":"Biomed Mater"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0250","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s10439-013-0941-0","article-title":"A perspective on immunomodulation and tissue repair","volume":"42","author":"Mokarram","year":"2014","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0255","doi-asserted-by":"crossref","first-page":"8793","DOI":"10.1016\/j.biomaterials.2012.08.050","article-title":"Effect of modulating macrophage phenotype on peripheral nerve repair","volume":"33","author":"Mokarram","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0260","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/mus.22033","article-title":"Acellular nerve allografts in peripheral nerve regeneration: a comparative study","volume":"44","author":"Moore","year":"2011","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0265","doi-asserted-by":"crossref","first-page":"6247","DOI":"10.1523\/JNEUROSCI.5474-10.2011","article-title":"Astrocytic tissue inhibitor of metalloproteinase-1 (TIMP-1) promotes oligodendrocyte differentiation and enhances CNS myelination","volume":"31","author":"Moore","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0270","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.1016\/j.biomaterials.2011.02.015","article-title":"Role of fibronectin in topographical guidance of neurite extension on electrospun fibers","volume":"32","author":"Mukhatyar","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0275","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.neuron.2011.11.031","article-title":"A central role for the ERK-signaling pathway in controlling Schwann cell plasticity and peripheral nerve regeneration in vivo","volume":"73","author":"Napoli","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0280","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.vascn.2006.08.002","article-title":"Use of a murine cell line for identification of human nitric oxide synthase inhibitors","volume":"55","author":"Naureckiene","year":"2007","journal-title":"J Pharmacol Toxicol Methods"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0285","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.biocel.2014.09.006","article-title":"Reduced inflammatory activity of RAW 264.7 macrophages on titania nanotube modified Ti surface","volume":"55","author":"Neacsu","year":"2014","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0290","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1089\/ten.teb.2011.0240","article-title":"Biomaterials for the development of peripheral nerve guidance conduits","volume":"18","author":"Nectow","year":"2012","journal-title":"Tissue Eng Part B, Rev"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0295","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/mus.25225","article-title":"Gene expression analysis at multiple time-points identifies key genes for nerve regeneration","volume":"55","author":"Pan","year":"2017","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0300","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1615\/CritRevBiomedEng.v39.i2.20","article-title":"Biomedical engineering strategies for peripheral nerve repair: surgical applications, state of the art, and future challenges","volume":"39","author":"Pfister","year":"2011","journal-title":"Crit Rev Biomed Eng"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0305","doi-asserted-by":"crossref","first-page":"7768","DOI":"10.1073\/pnas.84.21.7768","article-title":"Release of autocrine growth factor by primary and immortalized Schwann cells","volume":"84","author":"Porter","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0310","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jim.2015.03.013","article-title":"Interleukin-10 conjugated electrospun polycaprolactone (PCL) nanofibre scaffolds for promoting alternatively activated (M2) macrophages around the peripheral nerve in vivo","volume":"420","author":"Potas","year":"2015","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0315","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1007\/s11064-011-0664-2","article-title":"TNF-alpha expression in Schwann Cells is Induced by LPS and NF-kappa B-dependent pathways","volume":"37","author":"Qin","year":"2012","journal-title":"Neurochem Res"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0320","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1166\/jbn.2015.1921","article-title":"Topographic cue from electrospun scaffolds regulate myelin-related gene expressions in schwann cells","volume":"11","author":"Radhakrishnan","year":"2015","journal-title":"J Biomed Nanotechnol"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0325","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1742-2094-8-109","article-title":"Wallerian degeneration: the innate-immune response to traumatic nerve injury","volume":"8","author":"Rotshenker","year":"2011","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0330","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1021\/bm200248h","article-title":"Effect of electrospun fiber diameter and alignment on macrophage activation and secretion of proinflammatory cytokines and chemokines","volume":"12","author":"Saino","year":"2011","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0335","unstructured":"Salitsky A, 1983. The raw 264.7 cell line: a valid candidate for studying macrophage activation, Microbiology and Immunology. Hahnemann University, Philadelphia, PA."},{"key":"10.1016\/j.neuroscience.2018.02.015_b0340","doi-asserted-by":"crossref","first-page":"10173","DOI":"10.1021\/am402827g","article-title":"Engineered nanotopography on electrospun PLLA microfibers modifies RAW 264.7 cell response","volume":"5","author":"Schaub","year":"2013","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0345","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.intimp.2016.05.017","article-title":"Isocyperol, isolated from the rhizomes of Cyperus rotundus, inhibits LPS-induced inflammatory responses via suppression of the NF-kappaB and STAT3 pathways and ROS stress in LPS-stimulated RAW 264.7 cells","volume":"38","author":"Seo","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0350","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1111\/j.1742-4658.2008.06577.x","article-title":"Lipopolysaccharide-evoked activation of p38 and JNK leads to an increase in ICAM-1 expression in Schwann cells of sciatic nerves","volume":"275","author":"Shen","year":"2008","journal-title":"FEBS J"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0355","doi-asserted-by":"crossref","first-page":"8605","DOI":"10.1016\/j.biomaterials.2014.06.060","article-title":"The promotion of a constructive macrophage phenotype by solubilized extracellular matrix","volume":"35","author":"Sicari","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0360","doi-asserted-by":"crossref","first-page":"1242974","DOI":"10.1126\/science.1242974","article-title":"Beyond stem cells: self-renewal of differentiated macrophages","volume":"342","author":"Sieweke","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0365","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1186\/1471-2164-9-633","article-title":"A comprehensive collection of experimentally validated primers for polymerase chain reaction quantitation of murine transcript abundance","volume":"9","author":"Spandidos","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0370","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.mattod.2015.01.019","article-title":"Biomaterial based modulation of macrophage polarization: a review and suggested design principles","volume":"18","author":"Sridharan","year":"2015","journal-title":"Mater Today"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0375","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.brainres.2015.09.025","article-title":"Schwann cells and their transcriptional network: Evolution of key regulators of peripheral myelination","volume":"1641","author":"Stolt","year":"2016","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0380","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1021\/bm200415g","article-title":"Gradients with depth in electrospun fibrous scaffolds for directed cell behavior","volume":"12","author":"Sundararaghavan","year":"2011","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0385","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1089\/ten.teb.2012.0275","article-title":"Experimental and clinical evidence for use of decellularized nerve allografts in peripheral nerve gap reconstruction","volume":"19","author":"Szynkaruk","year":"2013","journal-title":"Tissue Eng Part B, Rev"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0390","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1046\/j.1471-4159.1994.63051646.x","article-title":"Biochemical and cellular properties of three immortalized Schwann cell lines expressing different levels of the myelin-associated glycoprotein","volume":"63","author":"Toda","year":"1994","journal-title":"J Neurochem"},{"issue":"Suppl 1","key":"10.1016\/j.neuroscience.2018.02.015_b0395","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1007\/s10875-014-0015-6","article-title":"Molecules involved in the crosstalk between immune- and peripheral nerve Schwann cells","volume":"34","author":"Tzekova","year":"2014","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0400","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.tibtech.2016.03.009","article-title":"Engineering immunomodulatory biomaterials to tune the inflammatory response","volume":"34","author":"Vishwakarma","year":"2016","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0405","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s11064-008-9801-y","article-title":"Role of mitogen-activated protein kinase cascades in inducible nitric oxide synthase expression by lipopolysaccharide in a rat schwann cell line","volume":"34","author":"Wang","year":"2009","journal-title":"Neurochem Res"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0410","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ab.2008.04.036","article-title":"Standardization of real-time PCR gene expression data from independent biological replicates","volume":"379","author":"Willems","year":"2008","journal-title":"Anal Biochem"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0415","doi-asserted-by":"crossref","first-page":"025016","DOI":"10.1088\/1748-605X\/aa61d1","article-title":"Positive and negative cues for modulating neurite dynamics and receptor expression","volume":"12","author":"Wrobel","year":"2017","journal-title":"Biomed Mater"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0420","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/2211-5463.12101","article-title":"Rabbit M1 and M2 macrophages can be induced by human recombinant GM-CSF and M-CSF","volume":"6","author":"Yamane","year":"2016","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0425","doi-asserted-by":"crossref","first-page":"7158","DOI":"10.1523\/JNEUROSCI.5812-11.2012","article-title":"P38 MAPK activation promotes denervated Schwann cell phenotype and functions as a negative regulator of Schwann cell differentiation and myelination","volume":"32","author":"Yang","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0430","doi-asserted-by":"crossref","first-page":"9572","DOI":"10.1523\/JNEUROSCI.21-24-09572.2001","article-title":"Schwann cells express active agrin and enhance aggregation of acetylcholine receptors on muscle fibers","volume":"21","author":"Yang","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0435","doi-asserted-by":"crossref","first-page":"99","DOI":"10.4161\/cbt.26718","article-title":"M-CSF cooperating with NFkappaB induces macrophage transformation from M1 to M2 by upregulating c-Jun","volume":"15","author":"Yang","year":"2014","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0440","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.bbrc.2007.05.042","article-title":"Chitosan oligosaccharide (COS) inhibits LPS-induced inflammatory effects in RAW 264.7 macrophage cells","volume":"358","author":"Yoon","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2018.02.015_b0445","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/mabi.201500336","article-title":"Tuning the mechanical properties of poly(ethylene glycol) microgel-based scaffolds to increase 3D Schwann cell proliferation","volume":"16","author":"Zhou","year":"2016","journal-title":"Macromol Biosci"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452218301325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452218301325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T15:44:13Z","timestamp":1759679053000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452218301325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":89,"alternative-id":["S0306452218301325"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2018.02.015","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomaterial Cues to Direct a Pro-regenerative Phenotype in Macrophages and Schwann Cells","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2018.02.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}