{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T23:44:41Z","timestamp":1770335081108,"version":"3.49.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.neuroscience.2018.05.045","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T01:26:56Z","timestamp":1528766816000},"page":"121-132","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Short-term Heat Exposure Promotes Hippocampal Neurogenesis via Activation of Angiotensin II Type 1 Receptor in Adult Rats"],"prefix":"10.1016","volume":"385","author":[{"given":"Yuka","family":"Koyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4764-7296","authenticated-orcid":false,"given":"Takao","family":"Mukuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sawako","family":"Hamasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Nakane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Kaidoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2018.05.045_b0005","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.brainres.2008.07.042","article-title":"Hippocampal angiotensin II receptors play an important role in mediating the effect of voluntary exercise on learning and memory in rat","volume":"1232","author":"Akhavan","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0010","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.1210\/endo.142.9.8366","article-title":"Peripheral administration of an angiotensin II AT(1) receptor antagonist decreases the hypothalamic-pituitary-adrenal response to isolation Stress","volume":"142","author":"Armando","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0015","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/0196-9781(96)00030-7","article-title":"Angiotensin II blockade of long-term potentiation at the perforant path-granule cell synapse in vitro","volume":"17","author":"Armstrong","year":"1996","journal-title":"Peptides"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0020","doi-asserted-by":"crossref","first-page":"9","DOI":"10.18553\/jmcp.2007.13.s8-b.9","article-title":"The renin-angiotensin aldosterone system: pathophysiological role and pharmacologic inhibition","volume":"13","author":"Atlas","year":"2007","journal-title":"J Manag Care Pharm"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0025","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12642","article-title":"Heat acclimation and thirst in rats","volume":"3","author":"Barney","year":"2015","journal-title":"Physiol Rep"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0030","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.ajpath.2013.05.031","article-title":"VEGF-A165b is an endogenous neuroprotective splice isoform of vascular endothelial growth factor A in vivo and in vitro","volume":"183","author":"Beazley-Long","year":"2013","journal-title":"Am J Pathol"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0035","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.neuroscience.2010.04.023","article-title":"Chronic high corticosterone reduces neurogenesis in the dentate gyrus of adult male and female rats","volume":"168","author":"Brummelte","year":"2010","journal-title":"Neurosci"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0040","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/ng1395","article-title":"VEGF links hippocampal activity with neurogenesis, learning and memory","volume":"36","author":"Cao","year":"2004","journal-title":"Nat Genet"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0045","doi-asserted-by":"crossref","first-page":"e63488","DOI":"10.1371\/journal.pone.0063488","article-title":"Angiotensin II increased neuronal stem cell proliferation: role of AT2R","volume":"8","author":"Chao","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1460-9568.2004.03813.x","article-title":"Doublecortin expression levels in adult brain reflect neurogenesis","volume":"21","author":"Couillard-Despres","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0055","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1111\/j.1460-9568.2003.03041.x","article-title":"VEGF is necessary for exercise-induced adult hippocampal neurogenesis","volume":"18","author":"Fabel","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0060","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1152\/physrev.1998.78.3.583","article-title":"Angiotensin, thirst, and sodium appetite","volume":"78","author":"Fitzsimons","year":"1998","journal-title":"Physiol Rev"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0065","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.bbi.2010.09.015","article-title":"Angiotensin II Type 1 receptor (AT1) signaling in astrocytes regulates synaptic degeneration-induced leukocyte entry to the central nervous system","volume":"25","author":"F\u00fcchtbauer","year":"2011","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0070","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1097\/00004872-200205000-00026","article-title":"Effects of orally applied candesartan cilexetil on central responses to angiotensin II in conscious rats","volume":"20","author":"Gohlke","year":"2002","journal-title":"J Hypertens"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0075","doi-asserted-by":"crossref","first-page":"351758","DOI":"10.1155\/2012\/351758","article-title":"The angiotensin II type 2 receptor in brain functions: an update","volume":"2012","author":"Guimond","year":"2012","journal-title":"Int J Hypertens"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0080","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.phrs.2017.06.016","article-title":"Brain renin-angiotensin system in the pathophysiology of cardiovascular diseases","volume":"125A","author":"Huber","year":"2017","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0085","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1677\/jme.1.02033","article-title":"Angiotensin II stimulates the synthesis of vascular endothelial growth factor through the p38 mitogen activated protein kinase pathway in cultured mouse podocytes","volume":"36","author":"Kang","year":"2006","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0090","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1002\/sctm.16-0382","article-title":"Angiotensin II causes apoptosis of adult hippocampal neural stem cells and memory impairment through the action on AMPK-PGC1\u03b1 signaling in heart failure","volume":"6","author":"Kim","year":"2017","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0095","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1002\/cne.23732","article-title":"Aging attenuates acquired heat tolerance and hypothalamic neurogenesis in rats","volume":"523","author":"Matsuzaki","year":"2015","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0100","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1161\/hy1201.096573","article-title":"Angiotensin AT1 receptor stimulates heat shock protein 27 phosphorylation in vitro and in vivo","volume":"38","author":"Meier","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0105","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.brainres.2014.09.019","article-title":"Systemic angiotensin II and exercise-induced neurogenesis in adult rat hippocampus","volume":"1588","author":"Mukuda","year":"2014","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0110","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.neures.2007.02.005","article-title":"An angiotensin II receptor antagonist suppresses running-enhanced hippocampal neurogenesis in rat","volume":"58","author":"Mukuda","year":"2007","journal-title":"Neurosci Res"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0115","first-page":"11","article-title":"Angiotensin II upregulates the expression of placental growth factor in human vascular endothelial cells and smooth muscle cells","volume":"26","author":"Pan","year":"2010","journal-title":"BMC Cell Biol"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0120","series-title":"The rat brain in stereotaxic coordinates, compact","author":"Paxinos","year":"2009"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0125","first-page":"1255","article-title":"Angiotensin II stimulation of plasminogen activator inhibitor-1 gene expression in astroglial cells from the brain","volume":"130","author":"Rydzewski","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0130","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.phrs.2017.06.017","article-title":"Beneficial effects of angiotensin II receptor blockers in brain disorders","volume":"125A","author":"Saavedra","year":"2017","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0135","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s12975-013-0271-4","article-title":"Heat shock proteins in the brain: role of Hsp70, Hsp 27, and HO-1 (Hsp32) and their therapeutic potential","volume":"4","author":"Sharp","year":"2013","journal-title":"Transl Stroke Res"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0140","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s004240050379","article-title":"The role of angiotensin II in the feedback control of renin gene expression","volume":"434","author":"Shricker","year":"1997","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0145","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1160\/TH08-04-0259","article-title":"Anti-apoptotic roles of plasminogen activator inhibitor-1 as a neurotrophic factor in the central nervous system","volume":"100","author":"Soeda","year":"2008","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0150","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bbi.2012.09.013","article-title":"Daily exercise improves memory, stimulates hippocampal neurogenesis and modulates immune and neuroimmune cytokines in aging rats","volume":"28","author":"Speisman","year":"2013","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0155","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1126\/science.3201232","article-title":"Astrocytes synthesize angiotensinogen in brain","volume":"242","author":"Stornetta","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0160","doi-asserted-by":"crossref","first-page":"14522","DOI":"10.1523\/JNEUROSCI.3673-08.2008","article-title":"Enhanced adult neurogenesis and angiogenesis and altered affective behaviors in mice overexpressing vascular endothelial growth factor 120","volume":"28","author":"Udo","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0165","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1600-0404.1994.tb02748.x","article-title":"Accumulation of blood-borne horseradish peroxidase in medial portions of the mouse hippocampus","volume":"90","author":"Ueno","year":"1994","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0170","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s004010051140","article-title":"Blood-brain barrier permeability in the periventricular areas of the normal mouse brain","volume":"99","author":"Ueno","year":"2000","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0175","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s13311-014-0286-x","article-title":"Angiotensin receptor type 2 activation induces neuroprotection and neurogenesis after traumatic brain injury","volume":"11","author":"Umschweif","year":"2014","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0180","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/jcbfm.2014.93","article-title":"Neuroprotection after traumatic brain injury in heat-acclimated mice involves induced neurogenesis and activation of angiotensin receptor type 2 signaling","volume":"34","author":"Umschweif","year":"2014","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0185","doi-asserted-by":"crossref","first-page":"13427","DOI":"10.1073\/pnas.96.23.13427","article-title":"Running enhances neurogenesis, learning, and long-term potentiation in mice","volume":"96","author":"van Praag","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0190","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1161\/HYPERTENSIONAHA.116.08922","article-title":"Brain renin-angiotensin system: does it exist?","volume":"69","author":"van Thiel","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0195","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1111\/j.1460-9568.2004.03720.x","article-title":"Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition","volume":"20","author":"Vaynman","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0200","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s00380-014-0523-6","article-title":"Humid heat exposure induced oxidative stress and apoptosis in cardiomyocytes through the angiotensin II signaling pathway","volume":"30","author":"Wang","year":"2015","journal-title":"Heart Vessels"},{"key":"10.1016\/j.neuroscience.2018.05.045_b0205","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/0091-3057(93)90265-U","article-title":"Role of angiotensin II and AT1 receptors in hippocampal LTP","volume":"45","author":"Wayner","year":"1993","journal-title":"Pharmacol Biochem Behav"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452218303956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452218303956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T14:02:19Z","timestamp":1661436139000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452218303956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":41,"alternative-id":["S0306452218303956"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2018.05.045","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]}}}