{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:39:32Z","timestamp":1790707172924,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,15]],"date-time":"2019-06-15T00:00:00Z","timestamp":1560556800000},"content-version":"am","delay-in-days":318,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DE023846"],"award-info":[{"award-number":["R01 DE023846"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.neuroscience.2018.05.048","type":"journal-article","created":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T19:50:39Z","timestamp":1528487439000},"page":"290-299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Roles of TRPV1 and TRPA1 in Spontaneous Pain from Inflamed Masseter Muscle"],"prefix":"10.1016","volume":"384","author":[{"given":"Sheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Brigoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongseuk","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisha","family":"Karley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man-Kyo","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2018.05.048_b0005","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1113\/jphysiol.2007.133231","article-title":"Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization","volume":"583","author":"Akopian","year":"2007","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0010","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1111\/bph.12092","article-title":"The contribution of the endogenous TRPV1 ligands 9-HODE and 13-HODE to nociceptive processing and their role in peripheral inflammatory pain mechanisms","volume":"168","author":"Alsalem","year":"2013","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0015","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1523\/JNEUROSCI.5369-07.2008","article-title":"Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress","volume":"28","author":"Andersson","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0020","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.neuroscience.2015.09.042","article-title":"The role of TRPA1 in muscle pain and mechanical hypersensitivity under inflammatory conditions in rats","volume":"310","author":"Asgar","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0025","first-page":"122","article-title":"Effect of peripheral NMDA receptor blockade with ketamine on chronic myofascial pain in temporomandibular disorder patients: a randomized, double-blinded, placebo-controlled trial","volume":"22","author":"Castrillon","year":"2008","journal-title":"J Orofac Pain"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0030","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/978-94-007-0265-3_33","article-title":"Role of TRP channels in pain sensation","volume":"704","author":"Chung","year":"2011","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0035","doi-asserted-by":"crossref","DOI":"10.1177\/1744806916668526","article-title":"Transcriptome analysis of trigeminal ganglia following masseter muscle inflammation in rats","volume":"12","author":"Chung","year":"2016","journal-title":"Mol Pain"},{"issue":"Suppl.","key":"10.1016\/j.neuroscience.2018.05.048_b0040","first-page":"9","article-title":"Experimental tooth clenching. A model for studying mechanisms of muscle pain","author":"Dawson","year":"2013","journal-title":"Swed Dent J"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0045","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13075-015-0905-x","article-title":"Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner","volume":"18","author":"Fernandes","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0050","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1007\/s00424-014-1497-z","article-title":"Direct evidence for functional TRPV1\/TRPA1 heteromers","volume":"466","author":"Fischer","year":"2014","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0055","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.pain.2008.08.013","article-title":"TRP channels and ASICs mediate mechanical hyperalgesia in models of inflammatory muscle pain and delayed onset muscle soreness","volume":"140","author":"Fujii","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0060","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1124\/mol.113.085548","article-title":"Mechanisms of transient receptor potential vanilloid 1 activation and sensitization by allyl isothiocyanate","volume":"84","author":"Gees","year":"2013","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0065","doi-asserted-by":"crossref","first-page":"32879","DOI":"10.1074\/jbc.M603220200","article-title":"Cannabinoid WIN 55,212\u20132 regulates TRPV1 phosphorylation in sensory neurons","volume":"281","author":"Jeske","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0070","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nmeth.1455","article-title":"Coding of facial expressions of pain in the laboratory mouse","volume":"7","author":"Langford","year":"2010","journal-title":"Nat Methods"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0075","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.pupt.2015.08.003","article-title":"Interaction between TRPA1 and TRPV1: Synergy on pulmonary sensory nerves","volume":"35","author":"Lee","year":"2015","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0080","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.jpain.2007.06.009","article-title":"A systematic review of measures used to assess chronic musculoskeletal pain in clinical and randomized controlled clinical trials","volume":"8","author":"Litcher-Kelly","year":"2007","journal-title":"J Pain"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0085","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/S0278-2391(97)90077-X","article-title":"Submasseteric abscess caused by a dentigerous cyst mimicking a parotitis: report of two cases","volume":"55","author":"Mandel","year":"1997","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0090","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/nn.3811","article-title":"Reward and motivation in pain and pain relief","volume":"17","author":"Navratilova","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0095","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1744-8069-7-4","article-title":"Transient inflammation-induced ongoing pain is driven by TRPV1 sensitive afferents","volume":"7","author":"Okun","year":"2011","journal-title":"Mol Pain"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0100","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.pain.2012.01.022","article-title":"Afferent drive elicits ongoing pain in a model of advanced osteoarthritis","volume":"153","author":"Okun","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0065751","article-title":"TRPV1 and TRPV4 play pivotal roles in delayed onset muscle soreness","volume":"8","author":"Ota","year":"2013","journal-title":"PLoS One"},{"issue":"843","key":"10.1016\/j.neuroscience.2018.05.048_b0110","first-page":"e841","article-title":"Brain activity for chronic knee osteoarthritis: dissociating evoked pain from spontaneous pain","volume":"15","author":"Parks","year":"2011","journal-title":"Eur J Pain"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0115","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.pain.2007.06.005","article-title":"Homologous and heterologous desensitization of capsaicin and mustard oil responses utilize different cellular pathways in nociceptors","volume":"135","author":"Ruparel","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0120","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1744-8069-8-73","article-title":"The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain","volume":"8","author":"Ruparel","year":"2012","journal-title":"Mol Pain"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0125","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1111\/j.1460-9568.2009.06702.x","article-title":"TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1","volume":"29","author":"Salas","year":"2009","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0130","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.pain.2008.08.002","article-title":"Behavioral differentiation between itch and pain in mouse","volume":"139","author":"Shimada","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0135","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1124\/mol.113.088997","article-title":"Modulation of transient receptor vanilloid 1 activity by transient receptor potential ankyrin 1","volume":"85","author":"Spahn","year":"2014","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0140","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1006\/bbrc.1996.0033","article-title":"Significance and immunoassay of 9- and 13-hydroxyoctadecadienoic acids","volume":"218","author":"Spindler","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0145","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/ALN.0000000000001756","article-title":"Hydrogen peroxide induces muscle nociception via transient receptor potential ankyrin 1 receptors","volume":"127","author":"Sugiyama","year":"2017","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0150","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/brain\/aww038","article-title":"TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes\/macrophages and oxidative stress","volume":"139","author":"Trevisan","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0155","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.freeradbiomed.2014.04.021","article-title":"TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout","volume":"72","author":"Trevisan","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0160","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.ejphar.2012.10.014","article-title":"Role of TRPV1 and TRPA1 in visceral hypersensitivity to colorectal distension during experimental colitis in rats","volume":"698","author":"Vermeulen","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0165","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.jpain.2017.06.005","article-title":"Spontaneous and bite-evoked muscle pain are mediated by a common nociceptive pathway with differential contribution by TRPV1","volume":"18","author":"Wang","year":"2017","journal-title":"J Pain"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0170","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/ALN.0b013e31825adb0e","article-title":"Transient receptor potential ankyrin 1 ion channel contributes to guarding pain and mechanical hypersensitivity in a rat model of postoperative pain","volume":"117","author":"Wei","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0175","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.neuron.2014.12.065","article-title":"Tmem100 is a regulator of TRPA1-TRPV1 complex and contributes to persistent pain","volume":"85","author":"Weng","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0180","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1097\/ALN.0b013e31817302b3","article-title":"Effect of AMG0347, a transient receptor potential type V1 receptor antagonist, and morphine on pain behavior after plantar incision","volume":"108","author":"Wu","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuroscience.2018.05.048_b0185","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1016\/j.pain.2013.06.040","article-title":"TRPV1 channels make major contributions to behavioral hypersensitivity and spontaneous activity in nociceptors after spinal cord injury","volume":"154","author":"Wu","year":"2013","journal-title":"Pain"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645221830407X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645221830407X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T15:45:08Z","timestamp":1759679108000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030645221830407X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":37,"alternative-id":["S030645221830407X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2018.05.048","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Roles of TRPV1 and TRPA1 in Spontaneous Pain from Inflamed Masseter Muscle","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2018.05.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}