{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:39:16Z","timestamp":1792784356683,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"am","delay-in-days":321,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R43EY026281-01"],"award-info":[{"award-number":["R43EY026281-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Michigan's Vision Research Core","award":["NIH P30 EY007003"],"award-info":[{"award-number":["NIH P30 EY007003"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.neuroscience.2018.05.049","type":"journal-article","created":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T19:50:42Z","timestamp":1528487442000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Confirmation of Luteinizing Hormone (LH) in Living Human Vitreous and the Effect of LH Receptor Reduction on Murine Electroretinogram"],"prefix":"10.1016","volume":"385","author":[{"given":"Tammy Z.","family":"Movsas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwoon Y.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Ober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Sigler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenmin M.","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arivalagan","family":"Muthusamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2018.05.049_b0005","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1056\/NEJM199412013312203","article-title":"Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders","volume":"331","author":"Aiello","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ygcen.2013.12.004","article-title":"Luteinizing hormone, insulin like growth factor-1, and epidermal growth factor stimulate vascular endothelial growth factor production in cultured bubaline granulosa cells","volume":"198","author":"Babitha","year":"2014","journal-title":"Gen Comp Endocrinol"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0015","doi-asserted-by":"crossref","first-page":"e111569","DOI":"10.1371\/journal.pone.0111569","article-title":"Standardized full-field electroretinography in the Green Monkey (Chlorocebus sabaeus)","volume":"9","author":"Bouskila","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0020","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s00417-009-1082-x","article-title":"Involvement of Muller glial cells in epiretinal membrane formation","volume":"247","author":"Bringmann","year":"2009","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0025","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/dmrr.415","article-title":"Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives","volume":"19","author":"Caldwell","year":"2003","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0030","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.mce.2006.06.013","article-title":"Increases in luteinizing hormone are associated with declines in cognitive performance","volume":"269","author":"Casadesus","year":"2007","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0035","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.7150\/ijbs.7268","article-title":"Development of a rapid streptavidin capture-based assay for the tyrosine phosphorylated CSF-1R in peripheral blood mononuclear cells","volume":"9","author":"Chaturvedi","year":"2013","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0040","first-page":"606","article-title":"Postmortem endocrine levels in the vitreous humor","volume":"15","author":"Chong","year":"1986","journal-title":"Ann Acad Med Singapore"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0045","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1477-7827-8-102","article-title":"Biological functions of hCG and hCG-related molecules","volume":"8","author":"Cole","year":"2010","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0050","doi-asserted-by":"crossref","first-page":"e52567","DOI":"10.1371\/journal.pone.0052567","article-title":"Chorionic gonadotropin and its receptor are both expressed in human retina, possible implications in normal and pathological conditions","volume":"7","author":"Dukic-Stefanovic","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0055","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0303-7207(01)00698-0","article-title":"Transgenic and knockout mouse models for the study of luteinizing hormone and luteinizing hormone receptor function","volume":"187","author":"Huhtaniemi","year":"2002","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0060","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/353655a0","article-title":"Retinal receptors in rodents maximally sensitive to ultraviolet light","volume":"353","author":"Jacobs","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0065","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/ceo.12732","article-title":"Biochemical analysis of the living human vitreous","volume":"44","author":"Kokavec","year":"2016","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0070","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1172\/JCI65157","article-title":"Targeted deletion of Vegfa in adult mice induces vision loss","volume":"122","author":"Kurihara","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0075","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0149-7634(01)00041-0","article-title":"The neurobiological basis of spontaneous alternation","volume":"26","author":"Lalonde","year":"2002","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0080","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s11095-005-9045-3","article-title":"Fit-for-purpose method development and validation for successful biomarker measurement","volume":"23","author":"Lee","year":"2006","journal-title":"Pharm Res"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0085","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1210\/mend.15.1.0586","article-title":"Targeted disruption of luteinizing hormone\/human chorionic gonadotropin receptor gene","volume":"15","author":"Lei","year":"2001","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0090","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1210\/endo.132.5.8477671","article-title":"Novel expression of human chorionic gonadotropin\/luteinizing hormone receptor gene in brain","volume":"132","author":"Lei","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cca.2017.05.014","article-title":"Antecedents and early correlates of high and low concentrations of angiogenic proteins in extremely preterm newborns","volume":"471","author":"Leviton","year":"2017","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0100","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1093\/humupd\/4.5.532","article-title":"Novel insights into human endometrial paracrinology and embryo-maternal communication by intrauterine microdialysis","volume":"4","author":"Licht","year":"1998","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0105","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0021-9258(18)53881-3","article-title":"Disruption of potential sites for N-linked glycosylation does not impair hormone binding to the lutropin\/choriogonadotropin receptor if Asn-173 is left intact","volume":"268","author":"Liu","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0110","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/pr.2015.15","article-title":"VEGF mRNA and protein concentrations in the developing human eye","volume":"77","author":"Ma","year":"2015","journal-title":"Pediatr Res"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0115","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10633-008-9155-4","article-title":"ISCEV Standard for full-field clinical electroretinography (2008 update)","volume":"118","author":"Marmor","year":"2009","journal-title":"Doc Ophthalmol"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0120","series-title":"Williams textbook of endocrinology","author":"Melmed","year":"2011"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0125","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/prca.201400133","article-title":"Vitreous humor in the pathologic scope: insights from proteomic approaches","volume":"9","author":"Monteiro","year":"2015","journal-title":"Proteomics Clin Appl"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0130","doi-asserted-by":"crossref","DOI":"10.1080\/02713683.2018.1467932","article-title":"Vitreous levels of luteinizing hormone and VEGF are strongly correlated in healthy mammalian eyes","author":"Movsas","year":"2018","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0135","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1559-0275-11-29","article-title":"Proteomic analysis of human vitreous humor","volume":"11","author":"Murthy","year":"2014","journal-title":"Clin Proteomics"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.forsciint.2016.10.005","article-title":"Precision of estimating the time since death by vitreous potassium-comparison of 5 different equations","volume":"269","author":"Ortmann","year":"2016","journal-title":"Forensic Sci Int"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0145","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1172\/JCI24562","article-title":"Fertility in luteinizing hormone receptor-knockout mice after wild-type ovary transplantation demonstrates redundancy of extragonadal luteinizing hormone action","volume":"115","author":"Pakarainen","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0150","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1146\/annurev.bi.50.070181.002341","article-title":"Glycoprotein hormones: structure and function","volume":"50","author":"Pierce","year":"1981","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0155","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0303-7207(01)00694-3","article-title":"Consequences of targeted inactivation of LH receptors","volume":"187","author":"Rao","year":"2002","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0160","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1007\/s00125-010-1697-9","article-title":"Progression of diabetic retinopathy during pregnancy in women with type 2 diabetes","volume":"53","author":"Rasmussen","year":"2010","journal-title":"Diabetologia"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0165","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.diabet.2014.04.005","article-title":"Serum and intraocular concentrations of erythropoietin and vascular endothelial growth factor in patients with type 2 diabetes and proliferative retinopathy","volume":"40","author":"Semeraro","year":"2014","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0170","doi-asserted-by":"crossref","first-page":"872978","DOI":"10.1155\/2012\/872978","article-title":"Usefulness of the vitreous fluid analysis in the translational research of diabetic retinopathy","volume":"2012","author":"Simo-Servat","year":"2012","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0175","doi-asserted-by":"crossref","first-page":"e0127567","DOI":"10.1371\/journal.pone.0127567","article-title":"Proteomic insight into the molecular function of the vitreous","volume":"10","author":"Skeie","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0180","article-title":"Gonadotropin regulation by pulsatile GnRH: signaling and gene expression","author":"Stamatiades","year":"2017","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0185","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/343560","article-title":"Pathophysiology of diabetic retinopathy","volume":"2013","author":"Tarr","year":"2013","journal-title":"ISRN Ophthalmol"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0190","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0024-3205(98)00367-1","article-title":"Localization of receptors for luteinizing hormone\/chorionic gonadotropin in neural retina","volume":"63","author":"Thompson","year":"1998","journal-title":"Life Sci"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0195","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1095\/biolreprod.114.123711","article-title":"Angiogenesis in the primate ovulatory follicle is stimulated by luteinizing hormone via prostaglandin E2","volume":"92","author":"Trau","year":"2015","journal-title":"Biol Reprod"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0200","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jri.2009.11.008","article-title":"Human chorionic gonadotropin: a hormone with immunological and angiogenic properties","volume":"85","author":"Tsampalas","year":"2010","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0205","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.preteyeres.2008.09.002","article-title":"Vascular endothelial growth factor and diabetic complications","volume":"27","author":"Wirostko","year":"2008","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0210","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1074\/mcp.M300038-MCP200","article-title":"Proteome analysis of human vitreous proteins","volume":"2","author":"Yamane","year":"2003","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0215","doi-asserted-by":"crossref","first-page":"573","DOI":"10.4155\/bio.14.297","article-title":"A clinical biomarker assay to quantitate thymic stromal lymphopoietin in human plasma at sub-pg\/ml level","volume":"7","author":"Zhao","year":"2015","journal-title":"Bioanalysis"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0220","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1210\/endo-119-3-1159","article-title":"Evidence for the presence of luteinizing hormone\/human chorionic gonadotropin-binding sites in the porcine uterus","volume":"119","author":"Ziecik","year":"1986","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuroscience.2018.05.049_b0225","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12014-018-9187-z","article-title":"Change of ranibizumab-induced human vitreous protein profile in patients with proliferative diabetic retinopathy based on proteomics analysis","volume":"15","author":"Zou","year":"2018","journal-title":"Clin Proteomics"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452218304081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452218304081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T15:44:43Z","timestamp":1759679083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452218304081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":45,"alternative-id":["S0306452218304081"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2018.05.049","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Confirmation of Luteinizing Hormone (LH) in Living Human Vitreous and the Effect of LH Receptor Reduction on Murine Electroretinogram","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2018.05.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}