{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:44:24Z","timestamp":1790693064392,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.neuroscience.2018.07.041","type":"journal-article","created":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T22:36:04Z","timestamp":1533076564000},"page":"347-356","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Accumulation of Cholesterol and Homocysteine in the Nigrostriatal Pathway of Brain Contributes to the Dopaminergic Neurodegeneration in Mice"],"prefix":"10.1016","volume":"388","author":[{"given":"Rajib","family":"Paul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankumoni","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banashree Chetia","family":"Phukan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed Khairujjaman","family":"Mazumder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arokiasamy","family":"Justin-Thenmozhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thamilarasan","family":"Manivasagam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallab","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupom","family":"Borah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2018.07.041_b0005","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neuint.2016.10.001","article-title":"Oxidative stress and mitochondrial dysfunction are the underlying events of dopaminergic neurodegeneration in homocysteine rat model of Parkinson's disease","volume":"101","author":"Bhattacharjee","year":"2016","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0010","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.neulet.2016.06.011","article-title":"L-DOPA treatment in MPTP-mouse model of Parkinson's disease potentiates homocysteine accumulation in substantia nigra","volume":"628","author":"Bhattacharjee","year":"2016","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0015","first-page":"47","article-title":"Chronic exposure of homocysteine in mice contributes to dopamine loss by enhancing oxidative stress in nigrostriatum and produces behavioral phenotypes of Parkinson\u2019s disease","volume":"6","author":"Bhattacharjee","year":"2016","journal-title":"Biochem Biophys Rep"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0020","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3389\/fnana.2014.00155","article-title":"Parkinson\u2019s disease: animal models and dopaminergic cell vulnerability","volume":"8","author":"Blesa","year":"2014","journal-title":"Front Neuroanat"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0025","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s10571-007-9213-6","article-title":"Long-term L-DOPA treatment causes indiscriminate increase in dopamine levels at the cost of serotonin synthesis in discrete brain regions of rats","volume":"27","author":"Borah","year":"2007","journal-title":"Cell Mol Neurobiol"},{"issue":"11","key":"10.1016\/j.neuroscience.2018.07.041_b0030","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1186\/1471-2458-11-641","article-title":"Why have total cholesterol levels declined in most developed countries?","volume":"11","author":"Capewell","year":"2011","journal-title":"BMC Public Health"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0035","first-page":"107","article-title":"Homocysteine and Parkinson's disease: a complex relationship","volume":"1","author":"Doherty","year":"2013","journal-title":"J Neurol Disord"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0040","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.freeradbiomed.2016.10.008","article-title":"Contribution of cholesterol and oxysterols to the pathophysiology of Parkinson's disease","volume":"101","author":"Doria","year":"2016","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0045","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1046\/j.0022-3042.2001.00676.x","article-title":"Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease","volume":"80","author":"Duan","year":"2002","journal-title":"J Neurochem"},{"issue":"9385","key":"10.1016\/j.neuroscience.2018.07.041_b0050","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(03)14234-1","article-title":"Dyslipidaemia","volume":"362","author":"Durrington","year":"2003","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.neuroscience.2018.07.041_b0055","doi-asserted-by":"crossref","first-page":"872","DOI":"10.5858\/2007-131-872-HATAO","article-title":"Hyperhomocysteinemia and thrombosis: an overview","volume":"131","author":"Eldibany","year":"2007","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0060","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ejcb.2017.01.002","article-title":"Impact of high cholesterol in a Parkinson's disease model: prevention of lysosomal leakage versus stimulation of \u03b1-synuclein aggregation","volume":"96","author":"Eriksson","year":"2017","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0065","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1475-2891-14-6","article-title":"Role of homocysteine in the development of cardiovascular disease","volume":"14","author":"Ganguly","year":"2015","journal-title":"Nutr J"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-7091-0579-5_1","article-title":"Dopaminergic neurotoxicity of homocysteine and its derivatives in primary mesencephalic cultures","volume":"68","author":"Heider","year":"2004","journal-title":"J Neural Transm Suppl"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0075","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3109\/10715769709065762","article-title":"Hydroxylation of salicylate and phenylalanine as assays for hydroxyl radicals: a cautionary note visited for the third time","volume":"27","author":"Halliwell","year":"1997","journal-title":"Free Radic Res"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0080","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bbr.2005.04.011","article-title":"Swim-test as a function of motor impairment in MPTP model of Parkinson's disease: a comparative study in two mouse strains","volume":"163","author":"Haobam","year":"2005","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0085","first-page":"292","article-title":"Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson's disease","volume":"60","author":"Hattori","year":"1993","journal-title":"Adv Neurol"},{"issue":"2","key":"10.1016\/j.neuroscience.2018.07.041_b0090","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/ane.12106","article-title":"Elevated homocysteine levels in levodopa-treated idiopathic Parkinson's disease: a meta-analysis","volume":"128","author":"Hu","year":"2013","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0095","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1212\/01.wnl.0000312511.62699.a8","article-title":"Total cholesterol and the risk of Parkinson disease","volume":"70","author":"Hu","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0100","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1212\/01.wnl.0000247052.18422.e5","article-title":"Body mass index and the risk of Parkinson disease","volume":"67","author":"Hu","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0105","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1080\/14647270802336650","article-title":"Influence of hypercholesterolemia and hypertension on the integrity of the blood\u2013brain barrier in rats","volume":"119","author":"Kalayci","year":"2009","journal-title":"Int J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0110","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1007\/s12272-001-1275-5","article-title":"Neuroprotective effect of benzylideneacetophenone derivative on the MPTP model of neurodegeneration in mice","volume":"31","author":"Kang","year":"2008","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0115","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuroscience.2013.01.032","article-title":"Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson's disease in rats","volume":"236","author":"Karuppagounder","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0120","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1056\/NEJM198804073181402","article-title":"Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implications","volume":"318","author":"Kish","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0125","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.neuro.2005.01.008","article-title":"Effects of homocysteine on the dopaminergic system and behavior in rodents","volume":"26","author":"Lee","year":"2005","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0130","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.15252\/embr.201439225","article-title":"Cholesterol in brain disease: sometimes determinant and frequently implicated","volume":"15","author":"Mart\u00edn","year":"2014","journal-title":"EMBO Rep"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0135","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.lfs.2016.07.020","article-title":"A highly reproducible mice model of chronic kidney disease: Evidences of behavioural abnormalities and blood-brain barrier disruption","volume":"161","author":"Mazumder","year":"2016","journal-title":"Life Sci"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0140","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/S0955-2863(99)00033-9","article-title":"A new HPLC method for the simultaneous determination of oxidized and reduced plasma aminothiols using coulometric electrochemical detection","volume":"10","author":"Melnyk","year":"1999","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0145","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.1523\/JNEUROSCI.5647-06.2007","article-title":"Constitutive Ret activity in knock-in multiple endocrine neoplasia type B mice induces profound elevation of brain dopamine concentration via enhanced synthesis and increases the number of TH-positive cells in the substantia nigra","volume":"27","author":"Mijatovic","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0150","doi-asserted-by":"crossref","first-page":"52961","DOI":"10.1074\/jbc.M406820200","article-title":"Abnormal lipid metabolism in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia","volume":"279","author":"Namekata","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0155","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.nbd.2014.09.012","article-title":"Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease","volume":"73","author":"Nordstr\u00f6m","year":"2015","journal-title":"Neurobiol Dis"},{"issue":"3","key":"10.1016\/j.neuroscience.2018.07.041_b0160","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2014-007404","article-title":"Prevalence and incidence of dyslipidaemia among adults in Africa: a systematic review and meta-analysis protocol","volume":"5","author":"Noubiap","year":"2015","journal-title":"BMJ Open"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008762","article-title":"Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice","volume":"5","author":"Pan-Montojo","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0170","doi-asserted-by":"crossref","first-page":"17922","DOI":"10.1038\/s41598-017-17911-z","article-title":"Global loss of acetylcholinesterase activity with mitochondrial complexes inhibition and inflammation in brain of hypercholesterolemic mice","volume":"7","author":"Paul","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0175","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.bbagen.2016.06.018","article-title":"L-DOPA-induced hyperhomocysteinemia in Parkinson's disease: elephant in the room","volume":"1860","author":"Paul","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0180","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.lfs.2015.07.031","article-title":"The potential physiological crosstalk and interrelationship between two sovereign endogenous amines, melatonin and homocysteine","volume":"139","author":"Paul","year":"2015","journal-title":"Life Sci"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0185","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neuint.2015.07.025","article-title":"Cholesterol \u2013 A putative endogenous contributor towards Parkinson's disease","volume":"90","author":"Paul","year":"2015","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0190","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neuint.2017.01.021","article-title":"Hypercholesterolemia causes psychomotor abnormalities in mice and alterations in cortico-striatal biogenic amine neurotransmitters: Relevance to Parkinson's disease","volume":"108","author":"Paul","year":"2017","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171285","article-title":"Cholesterol contributes to dopamine-neuronal loss in MPTP mouse model of Parkinson\u2019s disease: involvement of mitochondrial dysfunctions and oxidative stress","volume":"12","author":"Paul","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0200","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.lfs.2017.11.016","article-title":"Melatonin protects against behavioral deficits, dopamine loss and oxidative stress in homocysteine model of Parkinson's disease","volume":"192","author":"Paul","year":"2018","journal-title":"Life Sci"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0205","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.freeradbiomed.2013.05.042","article-title":"Reprint of: revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abuse","volume":"62","author":"Perfeito","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0210","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0063951","article-title":"Opening of the blood-brain barrier before cerebral pathology in mild hyperhomocysteinemia","volume":"8","author":"Rhodehouse","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0220","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"issue":"6","key":"10.1016\/j.neuroscience.2018.07.041_b0225","doi-asserted-by":"crossref","first-page":"897","DOI":"10.4103\/1673-5374.208560","article-title":"On the role of endogenous neurotoxins and neuroprotection in Parkinson's disease","volume":"12","author":"Segura-Aguilar","year":"2017","journal-title":"Neural Regen Res"},{"issue":"5","key":"10.1016\/j.neuroscience.2018.07.041_b0230","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/bcpt.12424","article-title":"Hyperhomocysteinemia: impact on neurodegenerative diseases","volume":"117","author":"Sharma","year":"2015","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050496","article-title":"Elevated homocysteine by levodopa is detrimental to neurogenesis in parkinsonian model","volume":"7","author":"Shin","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0240","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.pbb.2006.05.017","article-title":"Rats with unilateral median forebrain bundle, but not striatal or nigral, lesions by the neurotoxins MPP+ or rotenone display differential sensitivity to amphetamine and apomorphine","volume":"84","author":"Sindhu","year":"2006","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JPD-150769","article-title":"Retrograde axonal degeneration in Parkinson disease","volume":"6","author":"Tagliaferro","year":"2016","journal-title":"J Parkinsons Dis"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0250","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/jnr.22201","article-title":"Melatonin treatment potentiates neurodegeneration in a rat rotenone Parkinson\u2019s disease model","volume":"88","author":"Tapias","year":"2010","journal-title":"J Neurosci Res"},{"issue":"3","key":"10.1016\/j.neuroscience.2018.07.041_b0255","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.jacl.2015.11.010","article-title":"A review of low-density lipoprotein cholesterol, treatment strategies, and its impact on cardiovascular disease morbidity and mortality","volume":"10","author":"Wadhera","year":"2016","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.neuroscience.2018.07.041_b9000","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1172\/JCI11596","article-title":"Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways","volume":"107","author":"Werstuck","year":"2001","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.neuroscience.2018.07.041_b0260","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2174\/092986710790149774","article-title":"Elevated homocysteine levels in Parkinson's disease: is there anything besides L-dopa treatment?","volume":"17","author":"Zoccolella","year":"2010","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.neuroscience.2018.07.041_b0265","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1016\/S0024-3205(98)00196-9","article-title":"Effect of homocysteine and cholesterol in raising plasma homocysteine, cholesterol and triglyceride levels","volume":"62","author":"Zulli","year":"1998","journal-title":"Life Sci."}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452218305165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452218305165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T10:59:54Z","timestamp":1661684394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452218305165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":54,"alternative-id":["S0306452218305165"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2018.07.041","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]}}}