{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T20:49:16Z","timestamp":1782506956240,"version":"3.54.5"},"reference-count":120,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571486"],"award-info":[{"award-number":["31571486"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31270033"],"award-info":[{"award-number":["31270033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["5132003"],"award-info":[{"award-number":["5132003"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Development of High-Caliber Talents","award":["CIT&TCD20130339"],"award-info":[{"award-number":["CIT&TCD20130339"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.neuroscience.2018.07.046","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T22:52:05Z","timestamp":1533941525000},"page":"60-78","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Abnormalities in Prefrontal Cortical Gene Expression Profiles Relevant to Schizophrenia in MK-801-Exposed C57BL\/6 Mice"],"prefix":"10.1016","volume":"390","author":[{"given":"Jialu","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyue","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2018.07.046_b0005","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1523\/JNEUROSCI.16-01-00019.1996","article-title":"Selective alterations in gene expression for NMDA receptor subunits in prefrontal cortex of schizophrenics","volume":"16","author":"Akbarian","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0010","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.biopsych.2005.03.031","article-title":"Deficient hippocampal neuron expression of proteasome, ubiquitin, and mitochondrial genes in multiple schizophrenia cohorts","volume":"58","author":"Altar","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0015","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/mp.2014.171","article-title":"Distinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder","volume":"20","author":"Arion","year":"2015","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0020","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.biopsych.2006.12.021","article-title":"Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia","volume":"62","author":"Arion","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0025","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/schbul\/22.1.5","article-title":"Cognitive impairment in elderly schizophrenia: a dementia (still) lacking distinctive histopathology","volume":"22","author":"Arnold","year":"1996","journal-title":"Schizoph Bull"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0030","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/mp.2008.7","article-title":"Proteomic analysis of membrane microdomain-associated proteins in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder reveals alterations in LAMP, STXBP1 and BASP1 protein expression","volume":"14","author":"Behan","year":"2009","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0035","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.ntt.2010.05.002","article-title":"Comparative analyses of the neurodegeneration induced by the non-competitive NMDA-receptor-antagonist drug MK801 in mice and rats","volume":"32","author":"Bender","year":"2010","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0040","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1038\/sj.npp.1301604","article-title":"Lamina-specific abnormalities of NMDA receptor-associated postsynaptic protein transcripts in the prefrontal cortex in schizophrenia and bipolar disorder","volume":"33","author":"Beneyto","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0045","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.schres.2015.08.010","article-title":"CX3CR1 is dysregulated in blood and brain from schizophrenia patients","volume":"168","author":"Bergon","year":"2015","journal-title":"Schizophr Res"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0050","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s11920-013-0409-9","article-title":"Defining psychosis: the evolution of DSM-5 schizophrenia spectrum disorders","volume":"15","author":"Bhati","year":"2013","journal-title":"Curr Psychiatry Rep"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0055","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nature12743","article-title":"The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition","volume":"503","author":"Bloodgood","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0060","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.2174\/138161212799958576","article-title":"Glutamatergic animal models of schizophrenia","volume":"18","author":"Bondi","year":"2012","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0065","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1460-9568.2005.03875.x","article-title":"New neurons in the dentate gyrus are involved in the expression of enhanced long-term memory following environmental enrichment","volume":"21","author":"Bruel-Jungerman","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0070","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.neuron.2014.07.028","article-title":"Juvenile antioxidant treatment prevents adult deficits in a developmental model of schizophrenia","volume":"83","author":"Cabungcal","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0075","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1046\/j.1471-4159.2003.02193.x","article-title":"Neuron-glia communication: metallothionein expression is specifically up-regulated by astrocytes in response to neuronal injury","volume":"88","author":"Chung","year":"2004","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0080","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1523\/JNEUROSCI.23-08-03336.2003","article-title":"Metallothionein-IIA promotes initial neurite elongation and postinjury reactive neurite growth and facilitates healing after focal cortical brain injury","volume":"23","author":"Chung","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0085","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.schres.2014.12.026","article-title":"The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia","volume":"167","author":"Cohen","year":"2015","journal-title":"Schizophr Res"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166944","article-title":"Transcriptomic analysis shows decreased cortical expression of NR4A1, NR4A2 and RXRB in schizophrenia and provides evidence for nuclear receptor dysregulation","volume":"11","author":"Corley","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046604","article-title":"Npas4: a neuronal transcription factor with a key role in social and cognitive functions relevant to developmental disorders","volume":"7","author":"Coutellier","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0100","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s00702-016-1514-9","article-title":"SNARE complex in developmental psychiatry: neurotransmitter exocytosis and beyond","volume":"123","author":"Cupertino","year":"2016","journal-title":"J Neural Transm"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0105","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.neuropharm.2013.10.001","article-title":"Effects of MK-801 treatment across several pre-clinical analyses including a novel assessment of brain metabolic function utilizing PET and CT fused imaging in live rats","volume":"77","author":"Daya","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0110","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00259-004-1701-z","article-title":"Myocardial beta-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[11C]CGP12388","volume":"32","author":"de Jong","year":"2005","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0115","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11011-011-9234-1","article-title":"Behavioral changes and mitochondrial dysfunction in a rat model of schizophrenia induced by ketamine","volume":"26","author":"de Oliveira","year":"2011","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0120","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12974-015-0302-z","article-title":"Electroacupuncture remediates glial dysfunction and ameliorates neurodegeneration in the astrocytic alpha-synuclein mutant mouse model","volume":"12","author":"Deng","year":"2015","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0125","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1080\/15622970701557993","article-title":"The changes of aggregability of blood platelets in schizophrenia","volume":"10","author":"Dietrich-Muszalska","year":"2009","journal-title":"World J Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0130","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1176\/appi.ajp.158.9.1400","article-title":"N-methyl-d-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia","volume":"158","author":"Dracheva","year":"2001","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0135","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/sj.mp.4001116","article-title":"State-dependent alterations in mitochondrial complex I activity in platelets: a potential peripheral marker for schizophrenia","volume":"7","author":"Dror","year":"2002","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0140","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11920-016-0710-5","article-title":"Dysregulations of Synaptic Vesicle Trafficking in Schizophrenia","volume":"18","author":"Egbujo","year":"2016","journal-title":"Curr Psychiatry Rep"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0145","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00213-004-2109-y","article-title":"Impairment in perceptual attentional set-shifting following PCP administration: a rodent model of set-shifting deficits in schizophrenia","volume":"179","author":"Egerton","year":"2005","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0150","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.physbeh.2011.05.023","article-title":"Anomalies in social behaviors and exploratory activities in an APPswe\/PS1 mouse model of Alzheimer's disease","volume":"104","author":"Filali","year":"2011","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0155","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature12929","article-title":"De novo mutations in schizophrenia implicate synaptic networks","volume":"506","author":"Fromer","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0160","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1038\/nn.4399","article-title":"Gene expression elucidates functional impact of polygenic risk for schizophrenia","volume":"19","author":"Fromer","year":"2016","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0165","doi-asserted-by":"crossref","unstructured":"Gandal MJ, Haney JR, Parikshak NN, Leppa V, Ramaswami G, Hartl C, Schork AJ, Appadurai V, Buil A, Werge TM, Liu C, White KP, CommonMind C, Psych EC, i P-BWG, Horvath S, Geschwind DH (2018) Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science 359:693\u2013697.","DOI":"10.1126\/science.aad6469"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0170","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/archpsyc.57.1.65","article-title":"Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia","volume":"57","author":"Glantz","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0175","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12035-011-8222-0","article-title":"Post-transcriptional trafficking and regulation of neuronal gene expression","volume":"45","author":"Goldie","year":"2012","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0180","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.bbr.2013.06.017","article-title":"Pharmacological disruption of mouse social approach behavior: relevance to negative symptoms of schizophrenia","volume":"252","author":"Hanks","year":"2013","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0185","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1093\/bioinformatics\/btq227","article-title":"FABIA: factor analysis for bicluster acquisition","volume":"26","author":"Hochreiter","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0190","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.biopsych.2010.07.017","article-title":"Analyzing schizophrenia by DNA microarrays","volume":"69","author":"Horvath","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0195","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.biopsych.2013.06.010","article-title":"Immune system disturbances in schizophrenia","volume":"75","author":"Horvath","year":"2014","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0200","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.biopsych.2014.01.001","article-title":"Schizophrenia as a disorder of molecular pathways","volume":"77","author":"Horvath","year":"2015","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang da","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0210","doi-asserted-by":"crossref","first-page":"428","DOI":"10.6026\/97320630002428","article-title":"DAVID gene ID conversion tool","volume":"2","author":"Huang da","year":"2008","journal-title":"Bioinformation"},{"issue":"Suppl 5","key":"10.1016\/j.neuroscience.2018.07.046_b0215","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1186\/1471-2164-14-S5-S10","article-title":"Analysis of schizophrenia and hepatocellular carcinoma genetic network with corresponding modularity and pathways: novel insights to the immune system","volume":"14","author":"Huang","year":"2013","journal-title":"BMC Genomics"},{"issue":"Suppl 9","key":"10.1016\/j.neuroscience.2018.07.046_b0220","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/1471-2164-15-S9-S6","article-title":"Transcriptome alterations of mitochondrial and coagulation function in schizophrenia by cortical sequencing analysis","volume":"15","author":"Huang","year":"2014","journal-title":"BMC Genomics"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0225","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2013.94","article-title":"Gene expression profiling by mRNA sequencing reveals increased expression of immune\/inflammation-related genes in the hippocampus of individuals with schizophrenia","volume":"3","author":"Hwang","year":"2013","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0230","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.bbr.2009.08.003","article-title":"Nitric oxide modulation of methylphenidate-induced disruption of prepulse inhibition in Swiss mice","volume":"205","author":"Issy","year":"2009","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0235","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/hmg\/ddi022","article-title":"Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis","volume":"14","author":"Iwamoto","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0240","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/j.1476-5381.2011.01386.x","article-title":"Animal models of schizophrenia","volume":"164","author":"Jones","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0245","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.pnpbp.2007.09.008","article-title":"Comparison between intraperitoneal and subcutaneous phencyclidine administration in Sprague-Dawley rats: a locomotor activity and gene induction study","volume":"32","author":"Kalinichev","year":"2008","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0250","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2174\/1871527315666160321105216","article-title":"Global expression studies of schizophrenic brain: a meta-analysis study linking neurological immune system with psychological disorders","volume":"15","author":"Karim","year":"2016","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0255","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.biopsych.2003.12.012","article-title":"Mitochondrial complex I subunits expression is altered in schizophrenia: a postmortem study","volume":"55","author":"Karry","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0260","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1002\/ajmg.b.30781","article-title":"No association between tagging SNPs of SNARE complex genes (STX1A, VAMP2 and SNAP25) and schizophrenia in a Japanese population","volume":"147B","author":"Kawashima","year":"2008","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001763","article-title":"The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity","volume":"12","author":"Kempf","year":"2014","journal-title":"PLoS Biol"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0270","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/mp.2011.154","article-title":"De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia","volume":"17","author":"Kirov","year":"2012","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0275","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1567-133X(01)00003-5","article-title":"Reduced neuropeptide Y mRNA levels in the frontal cortex of people with schizophrenia and bipolar disorder","volume":"1","author":"Kuromitsu","year":"2001","journal-title":"Brain Res Gene Exp Patterns"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0280","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1097\/00001756-200004070-00017","article-title":"Increased levels of expression of an NMDARI splice variant in the superior temporal gyrus in schizophrenia","volume":"11","author":"Le Corre","year":"2000","journal-title":"NeuroReport"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0285","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1196\/annals.1300.007","article-title":"Altered cortical glutamate neurotransmission in schizophrenia: evidence from morphological studies of pyramidal neurons","volume":"1003","author":"Lewis","year":"2003","journal-title":"Ann N Yk Acad Sci"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0290","doi-asserted-by":"crossref","first-page":"10286","DOI":"10.1128\/MCB.25.23.10286-10300.2005","article-title":"The neuroplasticity-associated arc gene is a direct transcriptional target of early growth response (Egr) transcription factors","volume":"25","author":"Li","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0295","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3233\/JAD-150807","article-title":"Integrated analysis of Alzheimer's disease and schizophrenia dataset revealed different expression pattern in learning and memory","volume":"51","author":"Li","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0300","first-page":"53","article-title":"RNA sequencing in schizophrenia","volume":"9","author":"Li","year":"2015","journal-title":"Bioinform Biol Insights"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0305","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.bbr.2011.10.052","article-title":"Consequences of early life MK-801 administration: long-term behavioural effects and relevance to schizophrenia research","volume":"227","author":"Lim","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0310","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s11910-009-0032-7","article-title":"Mitochondrial dynamics and neurodegeneration","volume":"9","author":"Lu","year":"2009","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0315","first-page":"3221","article-title":"Accelerating t-SNE using tree-based algorithms","volume":"15","author":"Maaten","year":"2014","journal-title":"J Mach Learn Res"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0320","first-page":"2579","article-title":"Visualizing Data using t-SNE","volume":"9","author":"Maaten","year":"2008","journal-title":"J Mach Learn Res"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0325","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1741-7015-12-73","article-title":"The endogenous and reactive depression subtypes revisited: integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorder","volume":"12","author":"Malki","year":"2014","journal-title":"BMC Med"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0330","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0893-133X(89)90035-3","article-title":"Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat","volume":"2","author":"Mansbach","year":"1989","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0335","doi-asserted-by":"crossref","first-page":"6063048","DOI":"10.1155\/2017\/6063048","article-title":"Attenuated late-phase arc transcription in the dentate gyrus of mice lacking Egr3","volume":"2017","author":"Maple","year":"2017","journal-title":"Neural Plasticity"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0340","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2018.00023","article-title":"Immediate early genes anchor a biological pathway of proteins required for memory formation, long-term depression and risk for schizophrenia","volume":"12","author":"Marballi","year":"2018","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0345","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1101\/gr.079558.108","article-title":"RNA-seq: an assessment of technical reproducibility and comparison with gene expression arrays","volume":"18","author":"Marioni","year":"2008","journal-title":"Genome Res"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0350","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/102538902900012369","article-title":"Mapping brain response to social stress in rodents with c-fos expression: a review","volume":"5","author":"Martinez","year":"2002","journal-title":"Stress"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0355","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-244X-11-2","article-title":"Markers of thrombogenesis are activated in unmedicated patients with acute psychosis: a matched case control study","volume":"11","author":"Masopust","year":"2011","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0360","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neures.2012.04.004","article-title":"Social isolation stress down-regulates cortical early growth response 1 (Egr-1) expression in mice","volume":"73","author":"Matsumoto","year":"2012","journal-title":"Neurosci Res"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0365","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0920-9964(00)00075-X","article-title":"Evidence for a mitochondrial oxidative phosphorylation defect in brains from patients with schizophrenia","volume":"48","author":"Maurer","year":"2001","journal-title":"Schizophr Res"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0370","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1037\/a0014708","article-title":"Neurocognition in first-episode schizophrenia: a meta-analytic review","volume":"23","author":"Mesholam-Gately","year":"2009","journal-title":"Neuropsychology"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0375","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1002\/dneu.22044","article-title":"Immune system gene dysregulation in autism and schizophrenia","volume":"72","author":"Michel","year":"2012","journal-title":"Dev Neurobiol"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0380","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0092-8674(00)81972-8","article-title":"Mice with reduced NMDA receptor expression display behaviors related to schizophrenia","volume":"98","author":"Mohn","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0385","doi-asserted-by":"crossref","first-page":"W182","DOI":"10.1093\/nar\/gkm321","article-title":"KAAS: an automatic genome annotation and pathway reconstruction server","volume":"35","author":"Moriya","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0390","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.schres.2004.02.016","article-title":"NR3A NMDA receptor subunit mRNA expression in schizophrenia, depression and bipolar disorder","volume":"71","author":"Mueller","year":"2004","journal-title":"Schizophr Res"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0395","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat Methods"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0400","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/FBP.0000000000000229","article-title":"GM1 ganglioside reverses the cognitive deficits induced by MK801 in mice","volume":"27","author":"Ni","year":"2016","journal-title":"Behav Pharmacol"},{"issue":"Pt B","key":"10.1016\/j.neuroscience.2018.07.046_b0405","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.nlm.2016.07.034","article-title":"Memory deficits with intact cognitive control in the methylazoxymethanol acetate (MAM) exposure model of neurodevelopmental insult","volume":"134","author":"O'Reilly","year":"2016","journal-title":"Neurobiol Learn Memory"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0410","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090801","article-title":"Biclustering methods: biological relevance and application in gene expression analysis","volume":"9","author":"Oghabian","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0415","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.pnpbp.2012.05.009","article-title":"Differential effects of antipsychotics on hippocampal presynaptic protein expressions and recognition memory in a schizophrenia model in mice","volume":"39","author":"Ozdemir","year":"2012","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0420","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.bbr.2012.11.022","article-title":"Characterization of gene-environment interactions by behavioral profiling of selectively bred rats: the effect of NMDA receptor inhibition and social isolation","volume":"240","author":"Petrovszki","year":"2013","journal-title":"Behav Brain Res"},{"issue":"684\u2013697","key":"10.1016\/j.neuroscience.2018.07.046_b0425","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/sj.mp.4001532","article-title":"Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress","volume":"9","author":"Prabakaran","year":"2004","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0430","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nature12975","article-title":"A polygenic burden of rare disruptive mutations in schizophrenia","volume":"506","author":"Purcell","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0435","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neubiorev.2014.11.005","article-title":"Mitochondrial dysfunction in schizophrenia: pathways, mechanisms and implications","volume":"48","author":"Rajasekaran","year":"2015","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0440","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0306-4522(96)00382-X","article-title":"Transient increases in catecholaminergic activity in medial prefrontal cortex and nucleus accumbens shell during novelty","volume":"76","author":"Rebec","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0445","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/S1734-1140(13)71499-3","article-title":"Effect of combined treatment with mirtazapine and risperidone on the MK-801-induced changes in the object recognition test in mice","volume":"65","author":"Rog\u00f3\u017c","year":"2013","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0450","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061278","article-title":"Contribution of NMDA receptor hypofunction in prefrontal and cortical excitatory neurons to schizophrenia-like phenotypes","volume":"8","author":"Rompala","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0455","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.biopsych.2005.08.029","article-title":"A pharmacological model for psychosis based on N-methyl-D-aspartate receptor hypofunction: molecular, cellular, functional and behavioral abnormalities","volume":"59","author":"Rujescu","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0460","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/00008877-199501000-00009","article-title":"Distinct effects of d-amphetamine and phencyclidine on the social behaviour of rats","volume":"6","author":"Sams-Dodd","year":"1995","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0465","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1001\/archpsyc.1991.01810310036007","article-title":"Neuropsychological function in schizophrenia. Selective impairment in memory and learning","volume":"48","author":"Saykin","year":"1991","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0470","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature13595","article-title":"Biological insights from 108 schizophrenia-associated genetic loci","volume":"511","author":"Schizophrenia Working Group of the Psychiatric Genomics C","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0475","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protocols"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0480","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.cellsig.2008.06.013","article-title":"Erythropoietin receptor-mediated Egr-1 activation: structural requirements and functional implications","volume":"20","author":"Schulze","year":"2008","journal-title":"Cell Signal"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0485","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.conb.2014.02.011","article-title":"Nogo limits neural plasticity and recovery from injury","volume":"27","author":"Schwab","year":"2014","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0490","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2015.115","article-title":"Schizophrenia: a tale of two critical periods for prefrontal cortical development","volume":"5","author":"Selemon","year":"2015","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0495","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0168-0102(97)00095-3","article-title":"Stress-induced expression of immediate early genes in the brain and peripheral organs of the rat","volume":"29","author":"Senba","year":"1997","journal-title":"Neurosci Res"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0500","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.nbd.2011.03.001","article-title":"The first decade and beyond of transcriptional profiling in schizophrenia","volume":"45","author":"Sequeira","year":"2012","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0505","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1179\/war.1999.17.1.101","article-title":"\u201cThe womb of a woman belongs to the motherland\u201d: press images of Israeli women in wartime, 1967\u20131973","volume":"17","author":"Shachar","year":"1999","journal-title":"War Soc"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0510","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1158\/1541-7786.MCR-09-0454","article-title":"Transcription factor Egr-1 is essential for maximal matrix metalloproteinase-9 transcription by tumor necrosis factor alpha","volume":"8","author":"Shin","year":"2010","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0515","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neuroscience.2015.06.059","article-title":"Neural circuit dysfunction in schizophrenia: Insights from animal models","volume":"321","author":"Sigurdsson","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0520","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.neuropharm.2012.07.042","article-title":"Influence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autism","volume":"68","author":"Silverman","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0525","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1046\/j.1471-4159.1998.71062454.x","article-title":"Expression of NMDAR1, GluR1, GluR7, and KA1 glutamate receptor mRNAs is decreased in frontal cortex of \u201cneuroleptic-free\u201d schizophrenics: evidence on reversible up-regulation by typical neuroleptics","volume":"71","author":"Sokolov","year":"1998","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0530","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1176\/appi.ajp.2017.17030283","article-title":"Psychiatric Genomics: An Update and an Agenda","volume":"175","author":"Sullivan","year":"2018","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0535","doi-asserted-by":"crossref","first-page":"D362","DOI":"10.1093\/nar\/gkw937","article-title":"The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible","volume":"45","author":"Szklarczyk","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0540","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nn.4216","article-title":"Adult mouse cortical cell taxonomy revealed by single cell transcriptomics","volume":"19","author":"Tasic","year":"2016","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0545","doi-asserted-by":"crossref","DOI":"10.4238\/gmr16019532","article-title":"CASE-REPORT Dysregulation of gene expression in a patient with depressive disorder after transient ischemic attack confirmed by a neurophysiological neuromarker","volume":"16","author":"Trystula","year":"2017","journal-title":"Genet Mol Res"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0550","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0361-9230(01)00522-6","article-title":"Application of cDNA microarrays to examine gene expression differences in schizophrenia","volume":"55","author":"Vawter","year":"2001","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0555","doi-asserted-by":"crossref","first-page":"D433","DOI":"10.1093\/nar\/gki005","article-title":"STRING: known and predicted protein-protein associations, integrated and transferred across organisms","volume":"33","author":"von Mering","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0560","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1471-2164-14-102","article-title":"Biclustering reveals breast cancer tumour subgroups with common clinical features and improves prediction of disease recurrence","volume":"14","author":"Wang","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0565","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/mp.2012.137","article-title":"Molecular evidence of N-methyl-d-aspartate receptor hypofunction in schizophrenia","volume":"18","author":"Weickert","year":"2013","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0570","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/nature13716","article-title":"Synaptic dysregulation in a human iPS cell model of mental disorders","volume":"515","author":"Wen","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0575","doi-asserted-by":"crossref","first-page":"W720","DOI":"10.1093\/nar\/gkl167","article-title":"KOBAS server: a web-based platform for automated annotation and pathway identification","volume":"34","author":"Wu","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0580","article-title":"Transcriptome sequencing revealed significant alteration of cortical promoter usage and splicing in schizophrenia","volume":"7","author":"Wu","year":"2012","journal-title":"PLoS one"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0585","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1002\/ar.22942","article-title":"White matter injuries induced by MK-801 in a mouse model of schizophrenia based on NMDA antagonism","volume":"297","author":"Xiu","year":"2014","journal-title":"Anat Rec"},{"issue":"Suppl 8","key":"10.1016\/j.neuroscience.2018.07.046_b0590","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1471-2164-13-S8-S2","article-title":"RNA-Seq analysis implicates dysregulation of the immune system in schizophrenia","volume":"13","author":"Xu","year":"2012","journal-title":"BMC Genomics"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0595","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex","volume":"34","author":"Zhang","year":"2014","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.07.046_b0600","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00702-014-1180-8","article-title":"Glutamate as a neurotransmitter in the healthy brain","volume":"121","author":"Zhou","year":"2014","journal-title":"J Neural Trans"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452218305219?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452218305219?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:34:00Z","timestamp":1571704440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452218305219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":120,"alternative-id":["S0306452218305219"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2018.07.046","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]}}}