{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:59:06Z","timestamp":1788328746660,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["10-MALZ-10502"],"award-info":[{"award-number":["10-MALZ-10502"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005413","name":"Universit\u00e9 Paris Descartes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005413","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.neuroscience.2018.11.022","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T00:53:08Z","timestamp":1542934388000},"page":"175-186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["GLS1 Mutant Mice Display Moderate Alterations of Hippocampal Glutamatergic Neurotransmission Associated with Specific Adaptive Behavioral Changes"],"prefix":"10.1016","volume":"396","author":[{"given":"Patrick","family":"Dutar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Tolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Kervern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Carcenac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Carola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius","family":"Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Savasta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Darmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4936-3334","authenticated-orcid":false,"given":"Justine","family":"Masson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2018.11.022_b0005","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1523\/JNEUROSCI.5196-09.2010","article-title":"VGLUT3 (vesicular glutamate transporter type 3) contribution to the regulation of serotonergic transmission and anxiety","volume":"30","author":"Amilhon","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0010","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0165-0270(01)00374-0","article-title":"The LTP Program: a data acquisition program for on-line analysis of long-term potentiation and other synaptic events","volume":"108","author":"Anderson","year":"2001","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0015","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2014.125","article-title":"Hippocampal and behavioral dysfunctions in a mouse model of environmental stress: normalization by agomelatine","volume":"4","author":"Boulle","year":"2014","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0020","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0006-8993(89)91533-3","article-title":"Glutaminase inhibition and the release of neurotransmitter glutamate from synaptosomes","volume":"476","author":"Bradford","year":"1989","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0025","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1038\/mp.2016.262","article-title":"Hippocampal subfield volumes in mood disorders","volume":"22","author":"Cao","year":"2017","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0030","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1096\/fj.08-106450","article-title":"AMPA receptor subunit 1 (GluR-A) knockout mice model the glutamate hypothesis of depression","volume":"22","author":"Chourbaji","year":"2008","journal-title":"FASEB J"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0035","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1177\/42.6.7910617","article-title":"Glutamate immunoreactivity in rat cerebral cortex is reversibly abolished by 6-diazo-5-oxo-L-norleucine (DON), an inhibitor of phosphate-activated glutaminase","volume":"42","author":"Conti","year":"1994","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0040","doi-asserted-by":"crossref","DOI":"10.3390\/ph9010009","article-title":"Cognitive dysfunction in major depressive disorder. A translational review in animal models of the disease","volume":"9","author":"Darcet","year":"2016","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0045","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neuropharm.2012.06.027","article-title":"Hippocampal long-term depression mediates spatial reversal learning in the Morris water maze","volume":"64","author":"Dong","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0050","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1126\/science.1222939","article-title":"Synaptic dysfunction in depression: potential therapeutic targets","volume":"338","author":"Duman","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0055","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/jcbfm.2012.22","article-title":"Brain slices from glutaminase-deficient mice metabolize less glutamine: a cellular metabolomic study with carbon 13 NMR","volume":"32","author":"El Hage","year":"2012","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0060","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1038\/npp.2009.58","article-title":"Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia","volume":"34","author":"Gaisler-Salomon","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0065","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/hipo.22014","article-title":"Synaptic underpinnings of altered hippocampal function in glutaminase-deficient mice during maturation","volume":"22","author":"Gaisler-Salomon","year":"2012","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0070","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.biopsych.2009.02.027","article-title":"Increased vulnerability to depressive-like behavior of mice with decreased expression of VGLUT1","volume":"66","author":"Garcia-Garcia","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0075","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.brainresrev.2009.05.005","article-title":"Emerging role of glutamate in the pathophysiology of major depressive disorder","volume":"61","author":"Hashimoto","year":"2009","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0080","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/j.euroneuro.2014.10.003","article-title":"Glutaminase1 heterozygous mice show enhanced trace fear conditioning and Arc\/Arg3.1 expression in hippocampus and cingulate cortex","volume":"24","author":"Hazan","year":"2014","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0085","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neuint.2003.08.016","article-title":"Intercellular metabolic compartmentation in the brain: past, present and future","volume":"45","author":"Hertz","year":"2004","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0090","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1046\/j.1601-1848.2001.00005.x","article-title":"Behavioral profiles of inbred strains on novel olfactory, spatial and emotional tests for reference memory in mice","volume":"1","author":"Holmes","year":"2002","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0095","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.yebeh.2014.09.038","article-title":"Kainate-induced epileptogenesis alters circular hole board learning strategy but not the performance of C57BL\/6J mice","volume":"41","author":"Hubens","year":"2014","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0100","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.bbr.2011.12.012","article-title":"Sensorimotor gating, working and social memory deficits in mice with reduced expression of the vesicular glutamate transporter VGLUT1","volume":"228","author":"Inta","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0105","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/1570159X14666160321123221","article-title":"Therapeutic modulation of glutamate receptors in major depressive disorder","volume":"15","author":"Jaso","year":"2017","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0110","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.neuroscience.2015.02.044","article-title":"Altered nociception in mice with genetically induced hypoglutamatergic tone","volume":"293","author":"Kayser","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0115","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/pcn.12463","article-title":"Cognitive dysfunction in major depression and bipolar disorder: Assessment and treatment options","volume":"71","author":"MacQueen","year":"2017","journal-title":"Psychiatry Clin Neurosci"},{"key":"10.1016\/j.neuroscience.2018.11.022_b9000","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.biopsych.2007.05.028","article-title":"Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors","volume":"63","author":"Maeng","year":"2008","journal-title":"Biol. psychiat."},{"key":"10.1016\/j.neuroscience.2018.11.022_b0120","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1523\/JNEUROSCI.4241-05.2006","article-title":"Mice lacking brain\/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth","volume":"26","author":"Masson","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0125","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/hipo.1092","article-title":"Neurogranin null mutant mice display performance deficits on spatial learning tasks with anxiety related components","volume":"11","author":"Miyakawa","year":"2001","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0130","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0092-8674(00)81972-8","article-title":"Mice with reduced NMDA receptor expression display behaviors related to schizophrenia","volume":"98","author":"Mohn","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0135","first-page":"167","article-title":"Influence of a chronic ultramild stress procedure on decision-making in mice","volume":"25","author":"Pardon","year":"2000","journal-title":"J Psychiatry Neurosci"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0140","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0006-8993(96)00776-7","article-title":"Role of adrenal steroid mineralocorticoid and glucocorticoid receptors in long-term potentiation in the CA1 field of hippocampal slices","volume":"738","author":"Pavlides","year":"1996","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0145","doi-asserted-by":"crossref","DOI":"10.1002\/0471142301.ns0936s54","article-title":"Open-space forced swim model of depression for mice","author":"Stone","year":"2011","journal-title":"Curr Protoc Neurosci"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0150","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2015.183","article-title":"Brain plasticity and cognitive functions after ethanol consumption in C57BL\/6J mice","volume":"5","author":"Stragier","year":"2015","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0155","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1460-9568.2006.05259.x","article-title":"Enhanced anxiety, depressive-like behaviour and impaired recognition memory in mice with reduced expression of the vesicular glutamate transporter 1 (VGLUT1)","volume":"25","author":"Tordera","year":"2007","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0160","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00406-014-0509-5","article-title":"Impact of adolescent GluA1 AMPA receptor ablation in forebrain excitatory neurons on behavioural correlates of mood disorders","volume":"264","author":"Vogt","year":"2014","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0165","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/sj.mp.4002056","article-title":"Mice lacking the AMPA GluR1 receptor exhibit striatal hyperdopaminergia and 'schizophrenia-related' behaviors","volume":"13","author":"Wiedholz","year":"2008","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.neuroscience.2018.11.022_b0170","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature17998","article-title":"NMDAR inhibition-independent antidepressant actions of ketamine metabolites","volume":"533","author":"Zanos","year":"2016","journal-title":"Nature"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645221830753X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645221830753X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T15:48:21Z","timestamp":1759679301000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030645221830753X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":35,"alternative-id":["S030645221830753X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2018.11.022","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GLS1 Mutant Mice Display Moderate Alterations of Hippocampal Glutamatergic Neurotransmission Associated with Specific Adaptive Behavioral Changes","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2018.11.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}