{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T19:12:40Z","timestamp":1786821160053,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Guangdong Provincial Key Laboratory of Brain Function and Disease"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471289"],"award-info":[{"award-number":["81471289"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31371071"],"award-info":[{"award-number":["31371071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601104"],"award-info":[{"award-number":["81601104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771368"],"award-info":[{"award-number":["81771368"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31871019)"],"award-info":[{"award-number":["31871019)"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030313507"],"award-info":[{"award-number":["2017A030313507"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030313862"],"award-info":[{"award-number":["2017A030313862"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Project of Guangzhou City","award":["2014Y2-00500"],"award-info":[{"award-number":["2014Y2-00500"]}]},{"name":"Science and Technology Project of Guangzhou City","award":["201604020141"],"award-info":[{"award-number":["201604020141"]}]},{"name":"Science and Technology Project of Guangzhou City","award":["201704020066"],"award-info":[{"award-number":["201704020066"]}]},{"name":"Science and Technology Project of Guangzhou City","award":["201804020008"],"award-info":[{"award-number":["201804020008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.neuroscience.2018.12.026","type":"journal-article","created":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T20:17:14Z","timestamp":1545682634000},"page":"117-124","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["c-Jun\/Bim Upregulation in Dopaminergic Neurons Promotes Neurodegeneration in the MPTP Mouse Model of Parkinson\u2019s Disease"],"prefix":"10.1016","volume":"399","author":[{"given":"Kunhua","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingtao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3004-9468","authenticated-orcid":false,"given":"Shanshan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2018.12.026_b0005","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1093\/emboj\/21.7.1782","article-title":"Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver","volume":"21","author":"Behrens","year":"2002","journal-title":"EMBO J"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0010","doi-asserted-by":"crossref","first-page":"29368","DOI":"10.1074\/jbc.M702634200","article-title":"Pro-apoptotic Bim induction in response to nerve growth factor deprivation requires simultaneous activation of three different death signaling pathways","volume":"282","author":"Biswas","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0015","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/415922a","article-title":"BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes","volume":"415","author":"Bouillet","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0020","first-page":"182","article-title":"Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease","volume":"119","author":"Brochard","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0025","first-page":"877","article-title":"Suppression of oncogene-induced transformation by a deletion mutant of c-jun","volume":"8","author":"Brown","year":"1993","journal-title":"Oncogene"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0030","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1038\/cdd.2012.42","article-title":"(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD","volume":"19","author":"Chen","year":"2012","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0035","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm3722","article-title":"Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy","volume":"15","author":"Czabotar","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0040","doi-asserted-by":"crossref","first-page":"12535","DOI":"10.1523\/JNEUROSCI.1920-10.2010","article-title":"Pathogenic lysosomal depletion in Parkinson's disease","volume":"30","author":"Dehay","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0045","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pneurobio.2013.10.004","article-title":"Autophagy and apoptosis dysfunction in neurodegenerative disorders","volume":"112","author":"Ghavami","year":"2014","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0050","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev-neuro-071013-014317","article-title":"A mitocentric view of Parkinson's disease","volume":"37","author":"Haelterman","year":"2014","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0055","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1523\/JNEUROSCI.4564-03.2004","article-title":"Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease","volume":"24","author":"Hayley","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0060","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.expneurol.2015.10.010","article-title":"JNK-mediated activation of ATF2 contributes to dopaminergic neurodegeneration in the MPTP mouse model of Parkinson's disease","volume":"277","author":"Huang","year":"2016","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0065","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1073\/pnas.0307453101","article-title":"JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease","volume":"101","author":"Hunot","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Suppl 1","key":"10.1016\/j.neuroscience.2018.12.026_b0070","doi-asserted-by":"crossref","first-page":"S183","DOI":"10.1016\/S1353-8020(11)70057-8","article-title":"Animal models of Parkinson's disease","volume":"18","author":"Jackson-Lewis","year":"2012","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0075","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson's disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0080","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1523\/JNEUROSCI.4181-06.2007","article-title":"Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulin","volume":"27","author":"Li","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0085","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3389\/fnagi.2014.00184","article-title":"SIRT2 enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway","volume":"6","author":"Liu","year":"2014","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0090","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.molcel.2012.05.040","article-title":"Bim inhibits autophagy by recruiting Beclin 1 to microtubules","volume":"47","author":"Luo","year":"2012","journal-title":"Mol Cell"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0095","doi-asserted-by":"crossref","first-page":"8161","DOI":"10.1073\/pnas.0609874104","article-title":"Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease","volume":"104","author":"Perier","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0100","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0105","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0896-6273(03)00355-6","article-title":"JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis","volume":"38","author":"Putcha","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0110","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3389\/fimmu.2013.00161","article-title":"IL-15 fosters age-driven regulatory T cell accrual in the face of declining IL-2 levels","volume":"4","author":"Raynor","year":"2013","journal-title":"Front Immunol"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0115","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1126\/science.1190217","article-title":"BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program","volume":"330","author":"Ren","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0120","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a009365","article-title":"Programmed cell death in Parkinson's disease","volume":"2","author":"Venderova","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0125","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1073\/pnas.051633998","article-title":"Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease","volume":"98","author":"Vila","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0130","doi-asserted-by":"crossref","first-page":"9519","DOI":"10.1523\/JNEUROSCI.21-24-09519.2001","article-title":"Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease","volume":"21","author":"Viswanath","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0135","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/bpa.12267","article-title":"MiR-124 regulates apoptosis and autophagy process in MPTP model of Parkinson's disease by targeting to Bim","volume":"26","author":"Wang","year":"2016","journal-title":"Brain Pathol"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0140","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neures.2003.10.012","article-title":"SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease","volume":"48","author":"Wang","year":"2004","journal-title":"Neurosci Res"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0145","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0896-6273(01)00239-2","article-title":"Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release","volume":"29","author":"Whitfield","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0150","doi-asserted-by":"crossref","first-page":"10433","DOI":"10.1073\/pnas.181182298","article-title":"Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease","volume":"98","author":"Xia","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0155","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1126\/science.1138870","article-title":"Cellular demolition and the rules of engagement","volume":"315","author":"Youle","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2018.12.026_b0160","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.expneurol.2018.01.009","article-title":"Early activation of Egr-1 promotes neuroinflammation and dopaminergic neurodegeneration in an experimental model of Parkinson's disease","volume":"302","author":"Yu","year":"2018","journal-title":"Exp Neurol"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645221830842X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645221830842X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,22]],"date-time":"2019-09-22T04:36:32Z","timestamp":1569126992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030645221830842X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":32,"alternative-id":["S030645221830842X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2018.12.026","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]}}}