{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:12:41Z","timestamp":1793779961618,"version":"4.6.1"},"reference-count":105,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Research Foundation of South Africa","award":["111958"],"award-info":[{"award-number":["111958"]}]},{"name":"National Research Foundation of South Africa","award":["106052"],"award-info":[{"award-number":["106052"]}]},{"name":"National Research Foundation of South Africa","award":["96072"],"award-info":[{"award-number":["96072"]}]},{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004477","name":"Stellenbosch University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004477","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.neuroscience.2019.02.020","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T02:25:01Z","timestamp":1551320701000},"page":"1-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":270,"special_numbering":"C","title":["Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review"],"prefix":"10.1016","volume":"406","author":[{"given":"Shameemah","family":"Abrahams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Haylett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glynis","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Carr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Bardien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2019.02.020_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/942981","article-title":"Neurodegenerative shielding by curcumin and its derivatives on brain lesions induced by 6-OHDA model of Parkinson's disease in albino Wistar rats","volume":"2012","author":"Agrawal","year":"2012","journal-title":"Cardiovasc Psychiatry Neurol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0010","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.phrs.2009.12.008","article-title":"Effect of curcumin on brain insulin receptors and memory functions in STZ (ICV) induced dementia model of rat","volume":"61","author":"Agrawal","year":"2010","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0015","doi-asserted-by":"crossref","unstructured":"Albrecht P, Lewerenz J, Dittmer S, Noack R, Maher P, Methner A (2010) Mechanisms of oxidative glutamate toxicity: the glutamate\/cystine antiporter system xc as a neuroprotective drug target. CNS Neurol Disord Targets (formerly Curr Drug Targets-CNS Neurol Disord 9:373\u2013382.","DOI":"10.2174\/187152710791292567"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0020","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jalz.2015.02.003","article-title":"2015 Alzheimer's disease facts and figures","volume":"11","author":"Alzheimer Association","year":"2015","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0025","doi-asserted-by":"crossref","unstructured":"Amara F, Berbenni M, Fragni M, Leoni G, Viggiani S, Ippolito VM, Larocca M, Rossano R, Alberghina L, Riccio P, Colangelo AM (2015) Neuroprotection by cocktails of dietary antioxidants under conditions of nerve growth factor deprivation. Oxid Med Cell Longev:1\u201315.","DOI":"10.1155\/2015\/217258"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0030","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2174\/1570159X13666150703154541","article-title":"Mitochondrial biology and neurological diseases","volume":"14","author":"Arun","year":"2016","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0035","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/541144a","article-title":"Chemists warn against deceptive molecules: spice extract curcumin dupes assays and leads some drug hunters astray","volume":"541","author":"Baker","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0040","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.fct.2014.08.020","article-title":"Curcumin and hesperidin improve cognition by suppressing mitochondrial dysfunction and apoptosis induced by D-galactose in rat brain","volume":"74","author":"Banji","year":"2014","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2013.03.023","article-title":"Curcumin and piperine abrogate lipid and protein oxidation induced by D-galactose in rat brain","volume":"1515","author":"Banji","year":"2013","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0050","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/jcp.0b013e318160862c","article-title":"Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease","volume":"28","author":"Baum","year":"2008","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0055","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1124\/jpet.108.137455","article-title":"Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease","volume":"326","author":"Begum","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0060","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/glia.1109","article-title":"Glial cells as targets for cytotoxic immune mediators","volume":"36","author":"Benn","year":"2001","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0065","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0006-2952(02)01174-7","article-title":"Glutathione, iron and Parkinson's disease","volume":"64","author":"Bharath","year":"2002","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0070","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1093\/hmg\/ddw073","article-title":"A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy","volume":"25","author":"Bott","year":"2016","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0075","doi-asserted-by":"crossref","unstructured":"Braak E, Griffing K, Arai K, Bohl J, Bratzke H, Braak H (1999) Neuropathology of Alzheimer's disease: what is new since A. Alzheimer? Eur Arch Psychiatry Clin Neurosci 249 Suppl:14\u201322 Available at: http:\/\/link.springer.com\/10.1007\/PL00014168.","DOI":"10.1007\/PL00014168"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0080","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1179\/1476830511Y.0000000034","article-title":"Curcumin protects against the oxidative damage induced by the pesticide parathion in the hippocampus of the rat brain","volume":"15","author":"Canales-Aguirre","year":"2012","journal-title":"Nutr Neurosci"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0085","doi-asserted-by":"crossref","first-page":"468","DOI":"10.17113\/ftb.52.04.14.3622","article-title":"Curcumin-protected PC12 cells against glutamate-induced oxidative toxicity","volume":"52","author":"Chang","year":"2014","journal-title":"Food Technol Biotechnol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0090","doi-asserted-by":"crossref","first-page":"742","DOI":"10.4103\/1673-5374.230303","article-title":"Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease","volume":"13","author":"Chen","year":"2018","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027865","article-title":"A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease","volume":"6","author":"Chen","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0100","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s10495-006-6715-5","article-title":"Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway*","volume":"11","author":"Chen","year":"2006","journal-title":"Apoptosis"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0105","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s12031-015-0566-x","article-title":"A potent multi-functional neuroprotective derivative of tetramethylpyrazine","volume":"56","author":"Chen","year":"2015","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0110","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1152\/ajpcell.00345.2012","article-title":"Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-\u03baB regulation","volume":"304","author":"Chhunchha","year":"2013","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0115","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.3892\/mmr.2015.4657","article-title":"Curcumin ameliorates dopaminergic neuronal oxidative damage via activation of the Akt\/Nrf2 pathway","volume":"13","author":"Cui","year":"2016","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0120","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neuroscience.2016.07.012","article-title":"Curcumin alleviates oxidative stress and mitochondrial dysfunction in astrocytes","volume":"333","author":"Daverey","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0125","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1158\/1078-0432.CCR-08-0024","article-title":"Phase II trial of curcumin in patients with advanced pancreatic cancer","volume":"14","author":"Dhillon","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0130","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.conb.2007.04.010","article-title":"Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease","volume":"17","author":"Dodson","year":"2007","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0135","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","article-title":"Oxidants, oxidative stress and the biology of ageing","volume":"408","author":"Finkel","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0140","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0197-4580(01)00300-1","article-title":"Phenolic anti-inflammatory antioxidant reversal of A\u03b2-induced cognitive deficits and neuropathology","volume":"22","author":"Frautschy","year":"2001","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0145","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bbr.2017.04.012","article-title":"Neuroprotective effect of three caffeic acid derivatives via ameliorate oxidative stress and enhance PKA\/CREB signaling pathway","volume":"328","author":"Fu","year":"2017","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0150","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s12035-014-9021-1","article-title":"Strategy to suppress oxidative damage-induced neurotoxicity in PC12 cells by curcumin: the role of ROS-mediated DNA damage and the MAPK and AKT pathways","volume":"53","author":"Fu","year":"2016","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0155","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.abb.2015.10.021","article-title":"Oxidative stress, free radicals and protein peroxides","volume":"595","author":"Gebicki","year":"2016","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0160","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1016\/j.bmc.2010.02.029","article-title":"Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: implications for Parkinson's disease","volume":"18","author":"Harish","year":"2010","journal-title":"Bioorganic Med Chem"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0165","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1021\/acs.chemrev.5b00407","article-title":"Superoxide ion: generation and chemical implications","volume":"116","author":"Hayyan","year":"2016","journal-title":"Chem Rev"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0170","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3109\/13880209.2012.717230","article-title":"Continuous exercise training and curcumin attenuate changes in brain-derived neurotrophic factor and oxidative stress induced by lead acetate in the hippocampus of male rats","volume":"51","author":"Hosseinzadeh","year":"2013","journal-title":"Pharm Biol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0175","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.fct.2011.04.004","article-title":"Dual effects of curcumin on neuronal oxidative stress in the presence of Cu(II)","volume":"49","author":"Huang","year":"2011","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0180","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.euroneuro.2009.02.002","article-title":"Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT)","volume":"19","author":"Ishrat","year":"2009","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0185","first-page":"1025","article-title":"Piperine augments the protective effect of curcumin against lipopolysaccharide-induced neurobehavioral and neurochemical deficits in mice","volume":"39","author":"Jangra","year":"2016","journal-title":"Inflammation"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0190","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neulet.2016.10.050","article-title":"Curcumin attenuates paraquat-induced cell death in human neuroblastoma cells through modulating oxidative stress and autophagy","volume":"636","author":"Jaroonwitchawan","year":"2017","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/236182","article-title":"CNB-001 a novel curcumin derivative, guards dopamine neurons in MPTP model of Parkinson's disease","volume":"2014","author":"Jayaraj","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0200","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s12031-013-0075-8","article-title":"Neuroprotective effect of CNB-001, a novel pyrazole derivative of curcumin on biochemical and apoptotic markers against rotenone-induced SK-N-SH cellular model of Parkinson's disease","volume":"51","author":"Jayaraj","year":"2013","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2016.07.005","article-title":"Oxidative stress: a major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson's disease and Alzheimer's disease","volume":"147","author":"Jiang","year":"2016","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0210","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1248\/bpb.34.1194","article-title":"Activation of nuclear factor erythroid 2-related factor 2 cytoprotective signaling by curcumin protect primary spinal cord astrocytes against oxidative toxicity","volume":"34","author":"Jiang","year":"2011","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0215","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0140-6736(16)31460-X","article-title":"Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990\u20132015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","author":"Kassebaum","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0220","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pbb.2016.09.002","article-title":"Neuroprotective effect of curcumin as evinced by abrogation of rotenone-induced motor deficits, oxidative and mitochondrial dysfunctions in mouse model of Parkinson's disease","volume":"150\u2013151","author":"Khatri","year":"2016","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0225","doi-asserted-by":"crossref","unstructured":"Kocher A, Schiborr C, Behnam D, Frank J (2015) The oral bioavailability of curcuminoids in healthy humans is markedly enhanced by micellar solubilisation but not further improved by simultaneous ingestion of sesamin , ferulic acid , naringenin and xanthohumol. J Funct Foods 14:183\u2013191 Available at: https:\/\/doi.org\/10.1016\/j.jff.2015.01.045.","DOI":"10.1016\/j.jff.2015.01.045"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0230","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.biomag.2012.03.007","article-title":"Spinal muscular atrophy: an oxidative stress response counteracted with curcumin","volume":"2","author":"K\u00f6stel","year":"2012","journal-title":"Biomed Aging Pathol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0235","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1080\/10286020.2010.544253","article-title":"Protective effect of curcumin (Curcuma longa) against d-galactose-induced senescence in mice","volume":"13","author":"Kumar","year":"2011","journal-title":"J Asian Nat Prod Res"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0240","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1016\/S0140-6736(09)60492-X","article-title":"Parkinson's disease","volume":"373","author":"Lees","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0245","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2147\/CIA.S158513","article-title":"Oxidative stress, aging, and diseases","volume":"13","author":"Liguori","year":"2018","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0250","doi-asserted-by":"crossref","first-page":"8370","DOI":"10.1523\/JNEUROSCI.21-21-08370.2001","article-title":"The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse","volume":"21","author":"Lim","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0255","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.pnpbp.2010.12.022","article-title":"Curcumin enhances neuronal survival in N-methyl-d-aspartic acid toxicity by inducing RANTES expression in astrocytes via PI-3K and MAPK signaling pathways","volume":"35","author":"Lin","year":"2011","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0260","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.phrs.2011.01.004","article-title":"Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for parkinsonism","volume":"63","author":"Liu","year":"2011","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0265","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/0973-7847.70902","article-title":"Free radicals, antioxidants and functional foods: impact on human health","volume":"4","author":"Lobo","year":"2010","journal-title":"Pharmacogn Rev"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0275","unstructured":"Lunn MR, Wang CH (2008) Spinal muscular atrophy. Semin 2120 www.thelancet.com 371 Available at: https:\/\/s3.amazonaws.com\/academia.edu.documents\/42185862\/Spinal_muscular_atrophy20160205-7989-ndai1.pdf?AWSAccessKeyId=AKIAIWOWYYGZ2Y53UL3A&Expires=1515445551&Signature=y%252FBGfWTcgspJP3FZ%252B%252BBCRDDNynE%253D&response-content-disposition=inline%253B."},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0280","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1124\/mol.56.2.254","article-title":"Intrastriatal dopamine injection induces apoptosis through oxidation involved activation of transcription factors AP-1 and NF-\u03baB in rats","volume":"56","author":"Luo","year":"1999","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0285","first-page":"189","article-title":"Neuroprotective effect of curcumin against cholesterol induced neuroinflammation in in-vitro and in-vivo models","volume":"7","author":"Manogaran","year":"2015","journal-title":"J Pharm Sci Res"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0290","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00726-013-1503-3","article-title":"Small molecules interacting with a-synuclein: antiaggregating and cytoprotective properties","volume":"45","author":"Marchiani","year":"2013","journal-title":"Amino Acids"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0295","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/WNR.0b013e328341e141","article-title":"Tetrahydrocurcumin confers protection against amyloid \u03b2-induced toxicity","volume":"22","author":"Mishra","year":"2011","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0300","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1139\/jpn.0603","article-title":"Brain imaging and cognitive dysfunctions in Huntington's disease","volume":"31","author":"Montoya","year":"2006","journal-title":"J Psychiatry Neurosci"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0305","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3233\/JAD-170354","article-title":"The natural product curcumin as a potential coadjuvant in Alzheimer's treatment","volume":"60","author":"Morales","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0310","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1007\/s11064-017-2323-8","article-title":"The neuroprotective effect of curcumin against nicotine-induced neurotoxicity is mediated by CREB\u2013BDNF signaling pathway","volume":"42","author":"Motaghinejad","year":"2017","journal-title":"Neurochem Res"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0315","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11010-010-0621-4","article-title":"Glutamoyl diester of the dietary polyphenol curcumin offers improved protection against peroxynitrite-mediated nitrosative stress and damage of brain mitochondria in vitro: implications for Parkinson's disease","volume":"347","author":"Mythri","year":"2011","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0320","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1254\/jphs.12143FP","article-title":"In vivo brain oxidative stress model induced by microinjection of sodium nitroprusside in mice","volume":"120","author":"Nazari","year":"2012","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0325","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1039\/C4FO00009A","article-title":"Potential protective effect of highly bioavailable curcumin on an oxidative stress model induced by microinjection of sodium nitroprusside in mice brain","volume":"5","author":"Nazari","year":"2014","journal-title":"Food Funct"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0330","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1021\/acs.jmedchem.6b00975","article-title":"The essential medicinal chemistry of curcumin","volume":"60","author":"Nelson","year":"2017","journal-title":"J Med Chem"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0335","unstructured":"NIH (2018) ClinicalTrials.gov. Available at: https:\/\/clinicaltrials.gov\/search?term=curcumin [Accessed November 9, 2018]."},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0340","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.2174\/0929867322666151029104611","article-title":"Curcumin: a natural lead for potential new drug candidates","volume":"22","author":"Oliveira","year":"2015","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0345","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.neuro.2009.07.016","article-title":"Curcumin enhances paraquat-induced apoptosis of N27 mesencephalic cells via the generation of reactive oxygen species","volume":"30","author":"Ortiz-Ortiz","year":"2009","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0350","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1080\/09687688.2017.1318224","article-title":"Curcumin inhibits oxidative stress-induced TRPM2 channel activation, calcium ion entry and apoptosis values in SH-SY5Y neuroblastoma cells: involvement of transfection procedure","volume":"33","author":"\u00d6z","year":"2016","journal-title":"Mol Membr Biol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0355","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1007\/s11064-008-9608-x","article-title":"Early anti-oxidative and anti-proliferative curcumin effects on neuroglioma cells suggest therapeutic targets","volume":"33","author":"Panchal","year":"2008","journal-title":"Neurochem Res"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0360","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.pestbp.2012.07.006","article-title":"Neuroprotective properties of phytochemicals against paraquat-induced oxidative stress and neurotoxicity in Drosophila melanogaster","volume":"104","author":"Park","year":"2012","journal-title":"Pestic Biochem Physiol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0365","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3390\/molecules21030264","article-title":"Curcumin and health","volume":"21","author":"Pulido-Moran","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0370","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s12906-017-1720-5","article-title":"Neuroprotective effect of demethoxycurcumin, a natural derivative of curcumin on rotenone induced neurotoxicity in SH-SY 5Y neuroblastoma cells","volume":"17","author":"Ramkumar","year":"2017","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0375","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s10522-013-9466-z","article-title":"Protective effect of curcuminoids on age-related mitochondrial impairment in female Wistar rat brain","volume":"15","author":"Rastogi","year":"2014","journal-title":"Biogerontology"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0380","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1179\/1476830512Y.0000000011","article-title":"Neuroprotective effect of \u03b1-mangostin and curcumin against iodoacetate-induced cell death","volume":"15","author":"Reyes-Fermin","year":"2012","journal-title":"Nutr Neurosci"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0385","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/alzrt146","article-title":"Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study","volume":"4","author":"Ringman","year":"2012","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0390","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1523\/JNEUROSCI.20-07-02589.2000","article-title":"Phenotypic knockout of nerve growth factor in adult transgenic mice reveals severe deficits in basal forebrain cholinergic neurons, cell death in the spleen, and skeletal muscle dystrophy","volume":"20","author":"Ruberti","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0395","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejphar.2015.11.046","article-title":"Downstream modulation of extrinsic apoptotic pathway in streptozotocin-induced Alzheimer's dementia in rats: erythropoietin versus curcumin","volume":"770","author":"Samy","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0400","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s12017-013-8261-y","article-title":"Curcumin nanoparticles attenuate neurochemical and neurobehavioral deficits in experimental model of Huntington's disease","volume":"16","author":"Sandhir","year":"2014","journal-title":"Neuromolecular Med"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0405","doi-asserted-by":"crossref","unstructured":"Sarkar B, Dhiman M, Mittal S, Mantha AK (2017) Curcumin revitalizes amyloid beta (25\u201335)-induced and organophosphate pesticides pestered neurotoxicity in SH-SY5Y and IMR-32 cells via activation of APE1 and Nrf2. Metab Brain Dis:1\u201317.","DOI":"10.1007\/s11011-017-0093-2"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0410","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/mnfr.201300724","article-title":"The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased","volume":"58","author":"Schiborr","year":"2014","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0415","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/neuro.14.001.2009","article-title":"Differential effects of iodoacetamide and iodoacetate on glycolysis and glutathione metabolism of cultured astrocytes","volume":"1","author":"Schmidt","year":"2009","journal-title":"Front Neuroenergetics"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0420","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3233\/JAD-2010-091528","article-title":"Severe motor neuron degeneration in the spinal cord of the Tg2576 mouse model of Alzheimer disease","volume":"21","author":"Seo","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0425","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4103\/0973-1296.126663","article-title":"Curcumin attenuates neurotoxicity induced by fluoride: an in vivo evidence","volume":"10","author":"Sharma","year":"2014","journal-title":"Pharmacogn Mag"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0430","doi-asserted-by":"crossref","first-page":"167","DOI":"10.22159\/ijpps.2016v8i12.15141","article-title":"Neuroprotective activity of novel CUR-CA-THIONE and its oxidative stress study","volume":"8","author":"Shelat","year":"2016","journal-title":"Int J Pharm Pharm Sci"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0435","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neulet.2007.01.060","article-title":"Curcumin attenuates the kainic acid-induced hippocampal cell death in the mice","volume":"416","author":"Shin","year":"2007","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0440","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s12640-011-9249-8","article-title":"Curcumin attenuates aluminum-induced oxidative stress and mitochondrial dysfunction in rat brain","volume":"20","author":"Sood","year":"2011","journal-title":"Neurotox Res"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0445","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.bcp.2018.05.016","article-title":"Nano-delivery systems for encapsulation of dietary polyphenols: an experimental approach for neurodegenerative diseases and brain tumors","volume":"154","author":"Squillaro","year":"2018","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0450","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1248\/bpb.30.1732","article-title":"Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus","volume":"30","author":"Sumanont","year":"2007","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0455","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.pbb.2013.02.002","article-title":"Neurobiological and pharmacological validity of curcumin in ameliorating memory performance of senescence-accelerated mice","volume":"105","author":"Sun","year":"2013","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0460","first-page":"682","article-title":"Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats","volume":"131","author":"Suresh","year":"2010","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0465","doi-asserted-by":"crossref","unstructured":"Suzuki YJ, Carini M, Butterfield DA (2010) Protein Carbonylation. Antioxid Redox Signal 12:323\u2013325 Available at: http:\/\/www.liebertonline.com\/doi\/abs\/10.1089\/ars.2009.2887.","DOI":"10.1089\/ars.2009.2887"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0470","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0475","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1007\/s00204-017-1939-4","article-title":"High bioavailability curcumin: an anti-inflammatory and neurosupportive bioactive nutrient for neurodegenerative diseases characterized by chronic neuroinflammation","volume":"91","author":"Ullah","year":"2017","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0480","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.bcp.2003.10.018","article-title":"Dietary compounds prevent oxidative damage and nitric oxide production by cells involved in demyelinating disease","volume":"67","author":"Van Meeteren","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0485","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.neuint.2016.11.003","article-title":"Dopamine exacerbates mutant huntingtin toxicity via oxidative-mediated inhibition of autophagy in SH-SY5Y neuroblastoma cells: beneficial effects of anti-oxidant therapeutics","volume":"101","author":"Vidoni","year":"2016","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0490","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1471-2202-11-57","article-title":"Curcumin reduces \u03b1-synuclein induced cytotoxicity in Parkinson's disease cell model","volume":"11","author":"Wang","year":"2010","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0495","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3390\/biom5020472","article-title":"Biological activities of reactive oxygen and nitrogen species: oxidative stress versus signal transduction","volume":"5","author":"Weidinger","year":"2015","journal-title":"Biomolecules"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0500","series-title":"Neurological disorders: public health challenges","author":"WHO","year":"2006"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0505","series-title":"The molecular and cellular basis of neurodegenerative diseases: underlying mechanisms","year":"2018"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0510","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.nbd.2012.05.020","article-title":"Neurobiology of disease LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: suppression by curcumin","volume":"47","author":"Yang","year":"2012","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0515","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s12192-016-0695-3","article-title":"Curcumin exerts anti-inflammatory and antioxidative properties in 1-methyl-4-phenylpyridinium ion (MPP+)-stimulated mesencephalic astrocytes by interference with TLR4 and downstream signaling pathway","volume":"21","author":"Yu","year":"2016","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0520","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.intimp.2009.12.004","article-title":"Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK\/NF-\u03baB signaling pathways in N9 microglia induced by lipopolysaccharide","volume":"10","author":"Zhang","year":"2010","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.neuroscience.2019.02.020_bb0525","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.foodchem.2011.04.089","article-title":"Curcumin protects mouse neuroblastoma neuro-2A cells against hydrogen-peroxide-induced oxidative stress","volume":"129","author":"Zhao","year":"2011","journal-title":"Food Chem"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452219301228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452219301228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T15:47:33Z","timestamp":1759679253000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452219301228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":105,"alternative-id":["S0306452219301228"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2019.02.020","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2019.02.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}