{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T20:29:34Z","timestamp":1794083374090,"version":"4.8.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT 159548"],"award-info":[{"award-number":["PJT 159548"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN 2018-04581"],"award-info":[{"award-number":["RGPIN 2018-04581"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN 2014-05950"],"award-info":[{"award-number":["RGPIN 2014-05950"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001819","name":"International Rett Syndrome Foundation","doi-asserted-by":"publisher","award":["3005"],"award-info":[{"award-number":["3005"]}],"id":[{"id":"10.13039\/100001819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.neuroscience.2019.07.008","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T11:20:19Z","timestamp":1562671219000},"page":"141-153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Cell-Genotype Specific Effects of Mecp2 Mutation on Spontaneous and Nicotinic Acetylcholine Receptor-Evoked Currents in Medial Prefrontal Cortical Pyramidal Neurons in Female Rett Model Mice"],"prefix":"10.1016","volume":"414","author":[{"given":"Azam","family":"Asgarihafshejani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raad","family":"Nashmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry R.","family":"Delaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2019.07.008_bb0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009261","article-title":"Developmental sex differences in nicotinic currents of prefrontal layer VI neurons in mice and rats","volume":"5","author":"Alves","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0010","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"Amir","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0015","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3389\/fncel.2015.00115","article-title":"Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via alpha4beta2* nicotinic receptor activation","volume":"9","author":"Bell","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0020","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/00001756-199105000-00016","article-title":"Steroids inhibit nicotinic acetylcholine receptors","volume":"2","author":"Bertrand","year":"1991","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19010097","article-title":"Motor, somatosensory, viscerosensory and metabolic impairments in a heterozygous female rat model of Rett syndrome","volume":"19","author":"Bhattacherjee","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0030","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1126\/science.281.5378.794","article-title":"Choline, a vital amine","volume":"281","author":"Blusztajn","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0035","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1471-4159.2007.04700.x","article-title":"Nicotinic alpha5 subunit deletion locally reduces high-affinity agonist activation without altering nicotinic receptor numbers","volume":"103","author":"Brown","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0040","first-page":"596","article-title":"Rett syndrome symptomatology of institutionalized adults with mental retardation: comparison of males and females","volume":"95","author":"Burd","year":"1991","journal-title":"Am J Ment Retard"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0045","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2005.12.027","article-title":"The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression","volume":"49","author":"Chang","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0050","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nature09582","article-title":"Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes","volume":"468","author":"Chao","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0055","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1044-7431(03)00026-5","article-title":"Expression of MeCP2 in olfactory receptor neurons is developmentally regulated and occurs before synaptogenesis","volume":"22","author":"Cohen","year":"2003","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0060","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1093\/cercor\/bhh052","article-title":"Cortical cholinergic function and deficits in visual attentional performance in rats following 192 IgG-saporin-induced lesions of the medial prefrontal cortex","volume":"14","author":"Dalley","year":"2004","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0065","doi-asserted-by":"crossref","first-page":"11263","DOI":"10.1523\/JNEUROSCI.1019-09.2009","article-title":"Intact long-term potentiation but reduced connectivity between neocortical layer 5 pyramidal neurons in a mouse model of Rett syndrome","volume":"29","author":"Dani","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0070","doi-asserted-by":"crossref","first-page":"12560","DOI":"10.1073\/pnas.0506071102","article-title":"Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome","volume":"102","author":"Dani","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0075","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.neuron.2012.12.004","article-title":"NMDA receptor regulation prevents regression of visual cortical function in the absence of Mecp2","volume":"76","author":"Durand","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0080","doi-asserted-by":"crossref","first-page":"12629","DOI":"10.1523\/JNEUROSCI.0684-11.2011","article-title":"Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway","volume":"31","author":"Gantz","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0090","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1038\/npp.2010.130","article-title":"Cortico-thalamic connectivity is vulnerable to nicotine exposure during early postnatal development through alpha4\/beta2\/alpha5 nicotinic acetylcholine receptors","volume":"35","author":"Heath","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0095","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0277-17.2017","article-title":"Activation of the medial prefrontal cortex reverses cognitive and respiratory symptoms in a mouse model of Rett syndrome","volume":"4","author":"Howell","year":"2017","journal-title":"eNeuro"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0100","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1017\/cjn.2016.8","article-title":"The incidence and evolution of parkinsonian rigidity in Rett syndrome: a pilot study","volume":"43","author":"Humphreys","year":"2016","journal-title":"Can J Neurol Sci"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0105","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ejpn.2007.02.008","article-title":"Seizures in Rett syndrome: an overview from a one-year calendar study","volume":"11","author":"Jian","year":"2007","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0110","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1097\/WNR.0b013e32832b7324","article-title":"Choline up-regulates BDNF and down-regulates TrkB neurotrophin receptor in rat cortical cell culture","volume":"20","author":"Johansson","year":"2009","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0115","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0165-3806(99)00103-0","article-title":"Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation","volume":"118","author":"Jones","year":"1999","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0120","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/neu.10201","article-title":"The expression of methyl CpG binding factor MeCP2 correlates with cellular differentiation in the developing rat brain and in cultured cells","volume":"55","author":"Jung","year":"2003","journal-title":"J Neurobiol"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0125","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/ejhg.2011.145","article-title":"Transgenic complementation of MeCP2 deficiency: phenotypic rescue of Mecp2-null mice by isoform-specific transgenes","volume":"20","author":"Kerr","year":"2012","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0130","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.expneurol.2009.12.007","article-title":"MeCP2 functions largely cell-autonomously, but also non-cell-autonomously, in neuronal maturation and dendritic arborization of cortical pyramidal neurons","volume":"222","author":"Kishi","year":"2010","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0135","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.bbr.2010.11.033","article-title":"Acetylcholine and attention","volume":"221","author":"Klinkenberg","year":"2011","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0140","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jneumeth.2011.04.024","article-title":"A rapid agonist application system for fast activation of ligand-gated ion channels","volume":"198","author":"Komal","year":"2011","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0145","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nm.4274","article-title":"Nicotine reverses hypofrontality in animal models of addiction and schizophrenia","volume":"23","author":"Koukouli","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0150","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1242\/dmm.016030","article-title":"A BDNF loop-domain mimetic acutely reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of Rett syndrome","volume":"7","author":"Kron","year":"2014","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0155","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/sj.npp.1300032","article-title":"Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortex","volume":"28","author":"Lambe","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0160","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.bbrc.2008.10.082","article-title":"Activity-dependent NR2B expression is mediated by MeCP2-dependent epigenetic regulation","volume":"377","author":"Lee","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0165","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbr.2017.05.021","article-title":"MeCP2-deficient mice have reduced alpha4 and alpha6 nicotinic receptor mRNA and altered behavioral response to nicotinic agonists","volume":"330","author":"Leung","year":"2017","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0170","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0092-8674(92)90610-O","article-title":"Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA","volume":"69","author":"Lewis","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0175","first-page":"E1575","article-title":"Excitatory synapses are stronger in the hippocampus of Rett syndrome mice due to altered synaptic trafficking of AMPA-type glutamate receptors","volume":"113","author":"Li","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0180","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1007\/s00439-016-1721-3","article-title":"Whole exome sequencing of Rett syndrome-like patients reveals the mutational diversity of the clinical phenotype","volume":"135","author":"Lucariello","year":"2016","journal-title":"Hum Genet"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0185","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1523\/JNEUROSCI.12-07-02765.1992","article-title":"Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment","volume":"12","author":"Marks","year":"1992","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0190","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0086-18.2018","article-title":"Loss of Mecp2 causes atypical synaptic and molecular plasticity of parvalbumin-expressing interneurons reflecting Rett syndrome-like sensorimotor defects","volume":"5","author":"Morello","year":"2018","journal-title":"eNeuro"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0195","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fncir.2016.00035","article-title":"Inhibitory circuits in cortical layer 5","volume":"10","author":"Naka","year":"2016","journal-title":"Front Neural Circuits"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0200","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1523\/JNEUROSCI.5112-07.2008","article-title":"Cholinergic deafferentation of prefrontal cortex increases sensitivity to cross-modal distractors during a sustained attention task","volume":"28","author":"Newman","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0205","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.1038\/s41467-018-06628-w","article-title":"Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex","volume":"9","author":"Obermayer","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0210","doi-asserted-by":"crossref","first-page":"C508","DOI":"10.1152\/ajpcell.00035.2014","article-title":"Alterations in the cholinergic system of brain stem neurons in a mouse model of Rett syndrome","volume":"307","author":"Oginsky","year":"2014","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0215","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1037\/0735-7044.107.6.1031","article-title":"Nucleus basalis magnocellularis and attention: effects of muscimol infusions","volume":"107","author":"Pang","year":"1993","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0220","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.neuron.2007.08.025","article-title":"Prefrontal acetylcholine release controls cue detection on multiple timescales","volume":"56","author":"Parikh","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0225","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/ana.22154","article-title":"Rett syndrome diagnostic criteria: lessons from the natural history study","volume":"68","author":"Percy","year":"2010","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0230","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neuron.2012.08.036","article-title":"Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior","volume":"76","author":"Picciotto","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0235","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/cercor\/bhr390","article-title":"Layer-specific modulation of the prefrontal cortex by nicotinic acetylcholine receptors","volume":"23","author":"Poorthuis","year":"2013","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0240","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1523\/JNEUROSCI.5012-12.2013","article-title":"Layer-specific interference with cholinergic signaling in the prefrontal cortex by smoking concentrations of nicotine","volume":"33","author":"Poorthuis","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0245","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/380347a0","article-title":"Functional contributions of alpha5 subunit to neuronal acetylcholine receptor channels","volume":"380","author":"Ramirez-Latorre","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0250","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.bbr.2011.03.051","article-title":"Cholinergic hypofunction in MeCP2-308 mice: beneficial neurobehavioural effects of neonatal choline supplementation","volume":"221","author":"Ricceri","year":"2011","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0255","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3389\/fncel.2015.00145","article-title":"Genotype-specific effects of Mecp2 loss-of-function on morphology of layer V pyramidal neurons in heterozygous female Rett syndrome model mice","volume":"9","author":"Rietveld","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0260","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1124\/mol.63.5.1059","article-title":"The nicotinic acetylcholine receptor subunit alpha 5 mediates short-term effects of nicotine in vivo","volume":"63","author":"Salas","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0265","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrn2635","article-title":"Phasic acetylcholine release and the volume transmission hypothesis: time to move on","volume":"10","author":"Sarter","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0270","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1093\/cercor\/bhv002","article-title":"Mechanisms of functional hypoconnectivity in the medial prefrontal cortex of Mecp2 null mice","volume":"26","author":"Sceniak","year":"2016","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0275","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0165-3806(91)90094-Y","article-title":"Progestin receptor cells in mouse cerebral cortex during early postnatal development: a comparison with preoptic area and central hypothalamus using autoradiography with [125I]progestin","volume":"59","author":"Shughrue","year":"1991","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0280","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1210\/endo.130.6.1597162","article-title":"Progestin target cell distribution in forebrain and midbrain regions of the 8-day postnatal mouse brain","volume":"130","author":"Shughrue","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0290","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1124\/mol.106.030445","article-title":"Ca2+ permeability of the (alpha4)3(beta2)2 stoichiometry greatly exceeds that of (alpha4)2(beta2)3 human acetylcholine receptors","volume":"71","author":"Tapia","year":"2007","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0295","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/ng0296-205","article-title":"The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse","volume":"12","author":"Tate","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0300","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1111\/ejn.12622","article-title":"Cholinergic excitation in mouse primary vs. associative cortex: region-specific magnitude and receptor balance","volume":"40","author":"Tian","year":"2014","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0305","doi-asserted-by":"crossref","first-page":"9949","DOI":"10.1073\/pnas.89.20.9949","article-title":"Progesterone modulates a neuronal nicotinic acetylcholine receptor","volume":"89","author":"Valera","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0310","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1523\/JNEUROSCI.14-01-00167.1994","article-title":"Basal forebrain lesions in monkeys disrupt attention but not learning and memory","volume":"14","author":"Voytko","year":"1994","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0315","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0006-8993(90)90248-A","article-title":"The distribution of mRNA encoded by a new member of the neuronal nicotinic acetylcholine receptor gene family (alpha 5) in the rat central nervous system","volume":"526","author":"Wada","year":"1990","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0320","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1086\/302690","article-title":"Rett syndrome and beyond: recurrent spontaneous and familial MECP2 mutations at CpG hotspots","volume":"65","author":"Wan","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0335","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0301-0082(96)00059-7","article-title":"Rett syndrome: neurobiological changes underlying specific symptoms","volume":"51","author":"Wenk","year":"1997","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0330","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1471-4159.2008.05768.x","article-title":"Neurochemical changes in a mouse model of Rett syndrome: changes over time and in response to perinatal choline nutritional supplementation","volume":"108","author":"Ward","year":"2009","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0340","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1055\/s-2007-973476","article-title":"Altered cholinergic function in the basal forebrain of girls with Rett syndrome","volume":"30","author":"Wenk","year":"1999","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0345","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.conb.2017.08.018","article-title":"Cortical inhibitory interneurons control sensory processing","volume":"46","author":"Wood","year":"2017","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0350","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.1113\/JP274450","article-title":"EEA1 restores homeostatic synaptic plasticity in hippocampal neurons from Rett syndrome mice","volume":"595","author":"Xu","year":"2017","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0355","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.bbrc.2010.02.156","article-title":"Pontine norepinephrine defects in Mecp2-null mice involve deficient expression of dopamine beta-hydroxylase but not a loss of catecholaminergic neurons","volume":"394","author":"Zhang","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0360","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/cr.2016.48","article-title":"Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via alpha7 receptor in hippocampus","volume":"26","author":"Zhang","year":"2016","journal-title":"Cell Res"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0365","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bbr.2017.01.023","article-title":"Selective preservation of cholinergic MeCP2 rescues specific Rett-syndrome-like phenotypes in MeCP2(stop) mice","volume":"322","author":"Zhou","year":"2017","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2019.07.008_bb0370","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/ana.410250109","article-title":"Cerebrospinal fluid biogenic amines and biopterin in Rett syndrome","volume":"25","author":"Zoghbi","year":"1989","journal-title":"Ann Neurol"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452219304786?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452219304786?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T15:27:16Z","timestamp":1778686036000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452219304786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":71,"alternative-id":["S0306452219304786"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2019.07.008","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cell-Genotype Specific Effects of Mecp2 Mutation on Spontaneous and Nicotinic Acetylcholine Receptor-Evoked Currents in Medial Prefrontal Cortical Pyramidal Neurons in Female Rett Model Mice","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2019.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}