{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T12:36:02Z","timestamp":1774874162565,"version":"3.50.1"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.neuroscience.2019.08.048","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T13:00:12Z","timestamp":1567515612000},"page":"122-132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Characterization of the Basic Membrane Properties of Neurons of the Rat Dorsal Motor Nucleus of the Vagus in Paraquat-Induced Models of Parkinsonism"],"prefix":"10.1016","volume":"418","author":[{"given":"C.","family":"Bove","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.H.","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.A.","family":"Travagli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2019.08.048_bb0005","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nn.3648","article-title":"A solution to dependency: using multilevel analysis to accommodate nested data","volume":"17","author":"Aarts","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0010","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41531-018-0066-0","article-title":"Ingestion of subthreshold doses of environmental toxins induces ascending parkinsonism in the rat","volume":"4","author":"Anselmi","year":"2018","journal-title":"Naturepj Parkinson's Disease"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0015","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1053\/j.gastro.2017.08.069","article-title":"A Nigro-vagal pathway controls gastric motility and is affected in a rat model of parkinsonism","volume":"153","author":"Anselmi","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0020","first-page":"2714","article-title":"GABA-dependent generation of ectopic action potentials in the rat hippocampus","volume":"10","author":"Avoli","year":"1998","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0025","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.brainres.2005.05.073","article-title":"Characterization of neurons of the nucleus tractus solitarius pars centralis","volume":"1052","author":"Baptista","year":"2005","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0030","doi-asserted-by":"crossref","first-page":"R711","DOI":"10.1152\/ajpregu.00138.2014","article-title":"cAMP-dependent insulin modulation of synaptic inhibition in neurons of the dorsal motor nucleus of the vagus is altered in diabetic mice","volume":"307","author":"Blake","year":"2014","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"10.1016\/j.neuroscience.2019.08.048_bb0035","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1152\/ajpgi.00076.2019","article-title":"Altered gastric tone and motility response to brainstem dopamine in a rat model of parkinsonism","volume":"317","author":"Bove","year":"2019","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0040","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1152\/jn.00056.2019","article-title":"Neurophysiology of the brain stem in Parkinson's disease","volume":"121","author":"Bove","year":"2019","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0045","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson's disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0050","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00702-002-0808-2","article-title":"Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen","volume":"110","author":"Braak","year":"2003","journal-title":"J Neural Transm (Vienna)"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0055","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1469-7793.1999.0521t.x","article-title":"Electrophysiological and morphological heterogeneity of rat dorsal vagal neurones which project to specific areas of the gastrointestinal tract","volume":"517","author":"Browning","year":"1999","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0060","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.autneu.2006.01.019","article-title":"Short-term receptor trafficking in the dorsal vagal complex: an overview","volume":"126-127","author":"Browning","year":"2006","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0065","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/j.2040-4603.2014.tb00587.x","article-title":"Central nervous system control of gastrointestinal motility and secretion and modulation of gastrointestinal functions","volume":"4","author":"Browning","year":"2014","journal-title":"Compr Physiol"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0070","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1007\/s00415-012-6801-2","article-title":"Gastrointestinal manifestations in Parkinson's disease: prevalence and occurrence before motor symptoms","volume":"260","author":"Cersosimo","year":"2013","journal-title":"J Neurol"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0075","doi-asserted-by":"crossref","unstructured":"Chandra, R., Hiniker, A., Kuo, Y.M., Nussbaum, R.L. & Liddle, R.A. (2017) Alpha-Synuclein in gut endocrine cells and its implications for Parkinson's disease. JCI Insight, 2.","DOI":"10.1172\/jci.insight.92295"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0080","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1152\/jn.00432.2014","article-title":"Functional segregation of voltage-activated calcium channels in motoneurons of the dorsal motor nucleus of the vagus","volume":"114","author":"Cooper","year":"2015","journal-title":"J Neurophysiol"},{"issue":"Suppl 1","key":"10.1016\/j.neuroscience.2019.08.048_bb0085","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1016\/j.parkreldis.2017.07.033","article-title":"Neuropathology of Parkinson disease","volume":"46","author":"Dickson","year":"2018","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0090","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1474-4422(15)00007-1","article-title":"Gastrointestinal dysfunction in Parkinson's disease","volume":"14","author":"Fasano","year":"2015","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0095","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1152\/jn.00551.2014","article-title":"Voltage gating by molecular subunits of Na+ and K+ ion channels: higher-dimensional cubic kinetics, rate constants, and temperature","volume":"113","author":"Fohlmeister","year":"2015","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0100","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrneurol.2012.242","article-title":"100 years of Lewy pathology","volume":"9","author":"Goedert","year":"2013","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0105","doi-asserted-by":"crossref","first-page":"10817","DOI":"10.1073\/pnas.0903603106","article-title":"Development regulates a switch between post- and presynaptic strengthening in response to activity deprivation","volume":"106","author":"Han","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0110","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.parkreldis.2009.08.007","article-title":"A timeline for Parkinson's disease","volume":"16","author":"Hawkes","year":"2010","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0115","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1212\/WNL.39.10.1314","article-title":"Epidemiologic study of Parkinson's disease in Hong Kong","volume":"39","author":"Ho","year":"1989","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0120","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00401-014-1343-6","article-title":"Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats","volume":"128","author":"Holmqvist","year":"2014","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0125","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0006-3495(63)86827-7","article-title":"Phase plane trajectories of the muscle spike potential","volume":"3","author":"Jenerick","year":"1963","journal-title":"Biophys J"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0130","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jns.2009.08.020","article-title":"Gastrointestinal dysfunction in Parkinson's disease","volume":"289","author":"Jost","year":"2010","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0135","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1523\/JNEUROSCI.1079-16.2016","article-title":"Mutant alpha-Synuclein overexpression induces stressless pacemaking in vagal motoneurons at risk in Parkinson's disease","volume":"37","author":"Lasser-Katz","year":"2017","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0140","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1152\/jn.1999.82.4.1895","article-title":"Dendritic voltage-gated ion channels regulate the action potential firing mode of hippocampal CA1 pyramidal neurons","volume":"82","author":"Magee","year":"1999","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0145","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1113\/jphysiol.1995.sp020862","article-title":"Characterization of single voltage-gated Na+ and Ca2+ channels in apical dendrites of rat CA1 pyramidal neurons","volume":"487","author":"Magee","year":"1995","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0150","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.brainres.2003.10.076","article-title":"Morphological differences between planes of section do not influence the electrophysiological properties of identified rat dorsal motor nucleus of the vagus neurons","volume":"1003","author":"Martinez-Pena y Valenzuela, I.M., Browning, K.N. & Travagli, R.A.","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0155","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0928-4257(00)80058-3","article-title":"Retrograde effects on synaptic transmission at the Ia\/motoneuron connection","volume":"93","author":"Mendell","year":"1999","journal-title":"J Physiol Paris"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0160","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0896-6273(01)00500-1","article-title":"Inactivity produces increases in neurotransmitter release and synapse size","volume":"32","author":"Murthy","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0165","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3390\/ijerph13090881","article-title":"Environmental exposures and Parkinson's disease","volume":"13","author":"Nandipati","year":"2016","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0170","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1365-2982.2008.01162.x","article-title":"Parkinson's disease and the gut: a well known clinical association in need of an effective cure and explanation","volume":"20","author":"Natale","year":"2008","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0175","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.nbd.2012.06.005","article-title":"Alpha-synuclein transgenic mice display age-related slowing of gastrointestinal motility associated with transgene expression in the vagal system","volume":"48","author":"Noorian","year":"2012","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0180","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0896-6273(00)80624-8","article-title":"Activity-dependent modulation of synaptic AMPA receptor accumulation","volume":"21","author":"O'Brien","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008762","article-title":"Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice","volume":"5","author":"Pan-Montojo","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0190","series-title":"Oral administration of rotenone using a gavage and image analysis of alpha-synuclein inclusions in the enteric nervous system","author":"Pan-Montojo","year":"2010"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0195","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.parkreldis.2015.10.011","article-title":"Gastric motor dysfunctions in Parkinson's disease: current pre-clinical evidence. Parkinsonism","volume":"21","author":"Pellegrini","year":"2015","journal-title":"Relat Disord"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0200","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1111\/nmo.12933","article-title":"Intestinal dysfunction in Parkinson's disease: lessons learned from translational studies and experimental models","volume":"28","author":"Pellegrini","year":"2016","journal-title":"Neurogastroenterol Motil"},{"issue":"Suppl 1","key":"10.1016\/j.neuroscience.2019.08.048_bb0205","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1468-1331.2008.02056.x","article-title":"Non-motor symptoms in Parkinson's disease","volume":"15","author":"Poewe","year":"2008","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0210","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrn.2017.25","article-title":"The two-century journey of Parkinson disease research","volume":"18","author":"Przedborski","year":"2017","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0215","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1113\/jphysiol.1975.sp011151","article-title":"Functional and structural changes in mammalian sympathetic neurones following interruption of their axons","volume":"252","author":"Purves","year":"1975","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0220","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1152\/jn.1992.68.5.1834","article-title":"Potassium currents contributing to action potential repolarization and the afterhyperpolarization in rat vagal motoneurons","volume":"68","author":"Sah","year":"1992","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0225","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrn.2017.91","article-title":"Non-motor features of Parkinson disease","volume":"18","author":"Schapira","year":"2017","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0230","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/367069a0","article-title":"Active propagation of somatic action potentials into neocortical pyramidal cell dendrites","volume":"367","author":"Stuart","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0235","doi-asserted-by":"crossref","first-page":"13586","DOI":"10.1523\/JNEUROSCI.5069-13.2014","article-title":"Mutant alpha-synuclein enhances firing frequencies in dopamine substantia nigra neurons by oxidative impairment of A-type potassium channels","volume":"34","author":"Subramaniam","year":"2014","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0240","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/BF01104033","article-title":"Quantitative electron microscopy on the injured hypoglossal nucleus in the rat","volume":"2","author":"Sumner","year":"1973","journal-title":"J Neurocytol"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0245","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nrgastro.2016.76","article-title":"Vagal neurocircuitry and its influence on gastric motility","volume":"13","author":"Travagli","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0250","first-page":"G531","article-title":"Glutamate and GABA-mediated synaptic currents in neurons of the rat dorsal motor nucleus of the vagus","volume":"260","author":"Travagli","year":"1991","journal-title":"Am J Physiol"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0255","first-page":"G508","article-title":"Effects of thyrotropin-releasing hormone on neurons in rat dorsal motor nucleus of the vagus, in vitro","volume":"263","author":"Travagli","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0260","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1152\/jn.00207.2011","article-title":"Changes in action potential features during focal seizure discharges in the entorhinal cortex of the in vitro isolated Guinea pig brain","volume":"106","author":"Trombin","year":"2011","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0265","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/36103","article-title":"Activity-dependent scaling of quantal amplitude in neocortical neurons","volume":"391","author":"Turrigiano","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0270","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/2051-5960-1-2","article-title":"The prion hypothesis in Parkinson's disease: Braak to the future","volume":"1","author":"Visanji","year":"2013","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0275","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1523\/JNEUROSCI.5217-04.2005","article-title":"Postsynaptic expression of homeostatic plasticity at neocortical synapses","volume":"25","author":"Wierenga","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2019.08.048_bb0280","doi-asserted-by":"crossref","first-page":"14024","DOI":"10.1523\/JNEUROSCI.2081-11.2011","article-title":"Functional plasticity of central TRPV1 receptors in brainstem dorsal vagal complex circuits of streptozotocin-treated hyperglycemic mice","volume":"31","author":"Zsombok","year":"2011","journal-title":"J Neurosci"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645221930630X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645221930630X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T15:50:48Z","timestamp":1759679448000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030645221930630X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":56,"alternative-id":["S030645221930630X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2019.08.048","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of the Basic Membrane Properties of Neurons of the Rat Dorsal Motor Nucleus of the Vagus in Paraquat-Induced Models of Parkinsonism","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2019.08.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}