{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:57:43Z","timestamp":1787738263059,"version":"build-2784847793"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Bloomington Drosophila Stock Center"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.neuroscience.2019.10.035","type":"journal-article","created":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T05:21:44Z","timestamp":1572672104000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["North Sea Progressive Myoclonus Epilepsy is Exacerbated by Heat, A Phenotype Primarily Associated with Affected Glia"],"prefix":"10.1016","volume":"423","author":[{"given":"Roald A.","family":"Lambrechts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoukje S.","family":"Polet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Hernandez-Pichardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"van Ninhuys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenke A.","family":"Gorter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola A.","family":"Grzeschik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina A.J.","family":"de Koning-Tijssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom J.","family":"de Koning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ody C.M.","family":"Sibon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2019.10.035_b0005","doi-asserted-by":"crossref","unstructured":"Boiss\u00e9 Lomax L et al. (2013) \u2018North Sea\u2019 progressive myoclonus epilepsy: phenotype of subjects with GOSR2 mutation. Brain 136:1146\u20131154 Available at: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23449775. [Accessed February 27, 2019].","DOI":"10.1093\/brain\/awt021"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0010","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1534\/genetics.111.127910","article-title":"Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: A RhoGEF\/Rho-family\/JNK pathway is a central driver of tumorigenesis","volume":"188","author":"Brumby","year":"2011","journal-title":"Genetics"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0015","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.ajhg.2011.04.011","article-title":"A Mutation in the Golgi Qb-SNARE Gene GOSR2 Causes Progressive Myoclonus Epilepsy with Early Ataxia","volume":"88","author":"Corbett","year":"2011","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0020","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1534\/genetics.106.057463","article-title":"Metabolic disruption in Drosophila bang-sensitive seizure mutants","volume":"173","author":"Fergestad","year":"2006","journal-title":"Genetics"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0025","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1083\/jcb.141.7.1489","article-title":"Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs","volume":"141","author":"Hay","year":"1998","journal-title":"J Cell Biol"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0030","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/39923","article-title":"A SNARE involved in protein transport through the Golgi apparatus","volume":"389","author":"Hong","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0035","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/0022-1910(75)90265-6","article-title":"Effects of neurotropic drugs on Drosophila melanogaster","volume":"21","author":"Howard","year":"1975","journal-title":"J Insect Physiol"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroscience.2019.03.057","article-title":"Mechanisms of neurological dysfunction in GOSR2 progressive myoclonus epilepsy, a Golgi SNAREopathy","author":"Jepson","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0045","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1055\/s-0035-1552620","article-title":"Progressive myoclonus epilepsies","volume":"35","author":"K\u00e4lvi\u00e4inen","year":"2015","journal-title":"Semin Neurol"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0050","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1093\/brain\/awv132","article-title":"Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction","volume":"138","author":"Kinghorn","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0055","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/glia.23115","article-title":"The glia of the adult Drosophila nervous system","volume":"65","author":"Kremer","year":"2017","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0060","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0006-8993(02)03431-5","article-title":"Anticonvulsant valproate reduces seizure-susceptibility in mutant Drosophila","volume":"958","author":"Kuebler","year":"2002","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0065","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1136\/practneurol-2014-000994","article-title":"The progressive myoclonic epilepsies","volume":"15","author":"Malek","year":"2015","journal-title":"Pract Neurol"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0070","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1152\/jn.00808.2010","article-title":"Increased persistent Na + current contributes to seizure in the slamdance bang-sensitive Drosophila mutant","volume":"106","author":"Marley","year":"2011","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0075","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/ana.24929","article-title":"Myoclonus epilepsy and ataxia due to KCNC 1 mutation: analysis of 20 cases and K + channel properties","volume":"81","author":"Oliver","year":"2017","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0080","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1534\/genetics.110.123299","article-title":"Drosophila as a model for epilepsy: bss is a gain-of-function mutation in the para sodium channel gene that leads to seizures","volume":"187","author":"Parker","year":"2011","journal-title":"Genetics"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0085","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.celrep.2017.09.004","article-title":"Mutations in membrin\/GOSR2 reveal stringent secretory pathway demands of dendritic growth and synaptic integrity","volume":"21","author":"Praschberger","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0090","doi-asserted-by":"crossref","first-page":"6988","DOI":"10.1073\/pnas.0912105107","article-title":"Pantethine rescues a Drosophila model for pantothenate kinase-associated neurodegeneration","volume":"107","author":"Rana","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0095","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/nn.4184","article-title":"Glia as drivers of abnormal neuronal activity","volume":"19","author":"Robel","year":"2016","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0100","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.pneurobio.2007.10.006","article-title":"From bench to drug: human seizure modeling using Drosophila","volume":"84","author":"Song","year":"2008","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0105","doi-asserted-by":"crossref","first-page":"14145","DOI":"10.1523\/JNEUROSCI.2932-12.2012","article-title":"A Knock-In Model of Human Epilepsy in Drosophila Reveals a Novel Cellular Mechanism Associated with Heat-Induced Seizure","volume":"32","author":"Sun","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0110","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.brainres.2004.05.111","article-title":"Potassium bromide, an anticonvulsant, is effective at alleviating seizures in the Drosophila bang-sensitive mutant bang senseless","volume":"1020","author":"Tan","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2019.10.035_b0115","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/mds.25704","article-title":"Ramsay hunt syndrome: Clinical characterization of progressive myoclonus ataxia caused by GOSR2 mutation","volume":"29","author":"van Egmond","year":"2014","journal-title":"Mov Disord"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452219307274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452219307274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T15:52:10Z","timestamp":1759679530000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452219307274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":23,"alternative-id":["S0306452219307274"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2019.10.035","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"North Sea Progressive Myoclonus Epilepsy is Exacerbated by Heat, A Phenotype Primarily Associated with Affected Glia","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2019.10.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}