{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:52:51Z","timestamp":1790247171639,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["170100781"],"award-info":[{"award-number":["170100781"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["1136241"],"award-info":[{"award-number":["1136241"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008710","name":"Dementia Australia Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1141789"],"award-info":[{"award-number":["1141789"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1102012"],"award-info":[{"award-number":["1102012"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1095215"],"award-info":[{"award-number":["1095215"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.neuroscience.2020.01.047","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T16:26:16Z","timestamp":1581438376000},"page":"166-175","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Novel Behavioural Characteristics of Male Human P301S Mutant Tau Transgenic Mice \u2013 A Model for Tauopathy"],"prefix":"10.1016","volume":"431","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6677-5747","authenticated-orcid":false,"given":"Georgia","family":"Watt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Przybyla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Zak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"van Eersel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Ittner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars M.","family":"Ittner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Karl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2020.01.047_b0005","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1177\/1533317506292282","article-title":"Sensory gating in patients with Alzheimer\u2019s disease and their biological children","volume":"21","author":"Ally","year":"2007","journal-title":"Am J Alzheimer's Dis Other Dement"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0010","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jalz.2018.02.001","article-title":"2018 Alzheimer's disease facts and figures","volume":"14","author":"Association","year":"2018","journal-title":"Alzheimer's Dement"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0015","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1136\/jnnp.59.1.61","article-title":"Frontotemporal dementia and Alzheimer's disease: retrospective differentiation using information from informants","volume":"59","author":"Barber","year":"1995","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0020","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1093\/brain\/awx243","article-title":"Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer\u2019s disease","volume":"140","author":"Bejanin","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0025","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/1098-2337(1976)2:1<55::AID-AB2480020107>3.0.CO;2-L","article-title":"The role of endocrines in isolation-induced lntermale fighting in albino laboratory mice. II. Sex steroid influences in aggressive mice","volume":"2","author":"Brain","year":"1976","journal-title":"Aggressive Behav"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0030","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrn2652","article-title":"Tests to assess motor phenotype in mice: a user's guide","volume":"10","author":"Brooks","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0035","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1586\/ern.11.57","article-title":"Loss of motor function in preclinical Alzheimer\u2019s disease","volume":"11","author":"Buchman","year":"2011","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0040","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0168-9525(01)02285-5","article-title":"Genes, models and Alzheimer's disease","volume":"17","author":"Chapman","year":"2001","journal-title":"Trends Genet"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0045","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.3233\/JAD-140921","article-title":"Long-term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimer's disease transgenic mice","volume":"42","author":"Cheng","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0050","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1007\/s00213-014-3478-5","article-title":"Chronic cannabidiol treatment improves social and object recognition in double transgenic APP swe\/PS1\u0394 E9 mice","volume":"231","author":"Cheng","year":"2014","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0055","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1007\/s10571-017-0574-1","article-title":"Tau proteins and tauopathies in Alzheimer\u2019s disease","volume":"38","author":"Chong","year":"2018","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0060","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1037\/0735-7044.122.4.885","article-title":"On the influence of baseline startle reactivity on the indexation of prepulse inhibition","volume":"122","author":"Csomor","year":"2008","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0065","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1096\/fj.11-186650","article-title":"Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice","volume":"25","author":"Dumont","year":"2011","journal-title":"FASEB J"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0070","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0014-2999(03)01273-1","article-title":"A review of 25 years of the social interaction test","volume":"463","author":"File","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0075","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1750-3639.2007.00051.x","article-title":"A decade of tau transgenic animal models and beyond","volume":"17","author":"G\u00f6tz","year":"2007","journal-title":"Brain Pathol"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0080","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.neurobiolaging.2003.11.005","article-title":"Prepulse inhibition in patients with Alzheimer\u2019s disease","volume":"25","author":"Hejl","year":"2004","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0085","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s002130050800","article-title":"Smoking withdrawal, nicotine dependence and prepulse inhibition of the acoustic startle reflex","volume":"141","author":"Kumari","year":"1999","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0090","first-page":"14","article-title":"Psychosis-related disturbances psychosis, agitation and disinhibition in Alzheimer's disease: definitions and treatment options","volume":"61","author":"Lesser","year":"2006","journal-title":"Geriatrics"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0095","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0092-8674(00)80354-2","article-title":"Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1","volume":"90","author":"Lijam","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0100","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF02246439","article-title":"Neonatal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine","volume":"122","author":"Lipska","year":"1995","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0105","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF00177912","article-title":"The use of a plus-maze to measure anxiety in the mouse","volume":"92","author":"Lister","year":"1987","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0110","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.neuron.2013.07.037","article-title":"Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls","volume":"79","author":"Maruyama","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0115","doi-asserted-by":"crossref","first-page":"16066","DOI":"10.1073\/pnas.0504908102","article-title":"Prostaglandin E receptor EP1 controls impulsive behavior under stress","volume":"102","author":"Matsuoka","year":"2005","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0120","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.bcp.2014.01.013","article-title":"New perspectives on the role of tau in Alzheimer's disease. Implications for therapy","volume":"88","author":"Medina","year":"2014","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0125","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.neuroscience.2009.10.036","article-title":"Pathways from the ventral hippocampus and caudal amygdala to forebrain regions that regulate sensorimotor gating in the rat","volume":"165","author":"Miller","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0130","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1601-1848.2004.00076.x","article-title":"Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice","volume":"3","author":"Moy","year":"2004","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0135","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/gbb.12370","article-title":"Reduced acoustic startle response and peripheral hearing loss in the 5xFAD mouse model of Alzheimer's disease","volume":"16","author":"O'Leary","year":"2017","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0140","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1601-183X.2005.00165.x","article-title":"Impaired spatial reference memory and increased exploratory behavior in P301L tau transgenic mice","volume":"5","author":"Pennanen","year":"2006","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0145","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1034\/j.1601-183X.2002.10306.x","article-title":"Difference in anxiety and sensitization of the acoustic startle response between the two inbred mouse strains BALB\/cAN and DBA\/2N","volume":"1","author":"Plappert","year":"2002","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0150","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.neuron.2006.08.005","article-title":"Mice deficient for the vesicular acetylcholine transporter are myasthenic and have deficits in object and social recognition","volume":"51","author":"Prado","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0155","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neulet.2016.08.007","article-title":"Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia","volume":"631","author":"Przybyla","year":"2016","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0160","first-page":"203","article-title":"Impulsivity, disinhibition, and risk taking in addiction","volume":"1","author":"Reynolds","year":"2013","journal-title":"Comprehensive Addict Behav Disord"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0165","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.pnpbp.2005.03.004","article-title":"(+)-MK-801 induced social withdrawal in rats; a model for negative symptoms of schizophrenia","volume":"29","author":"Rung","year":"2005","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0170","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1017\/S1461145713000321","article-title":"The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress","volume":"16","author":"Sachs","year":"2013","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0175","doi-asserted-by":"crossref","first-page":"153","DOI":"10.31887\/DCNS.2007.9.2\/msilveri","article-title":"Frontotemporal dementia to Alzheimer's disease","volume":"9","author":"Silveri","year":"2007","journal-title":"Dial Clin Neurosci"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0180","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1136\/jnnp.70.3.323","article-title":"Distinct behavioural profiles in frontotemporal dementia and semantic dementia","volume":"70","author":"Snowden","year":"2001","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0185","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s002130100799","article-title":"Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges","volume":"156","author":"Swerdlow","year":"2001","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0190","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.neuroscience.2003.08.028","article-title":"The ventral hippocampal regulation of prepulse inhibition and its disruption by apomorphine in rats are not mediated via the fornix","volume":"123","author":"Swerdlow","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021050","article-title":"P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating","volume":"6","author":"Takeuchi","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0200","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1440-1819.2006.01460.x","article-title":"Prepulse inhibition of acoustic startle response in mild cognitive impairment and mild dementia of Alzheimer type","volume":"60","author":"Ueki","year":"2006","journal-title":"Psychiatry Clin Neurosci"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0205","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bbr.2012.12.008","article-title":"Observations in THY-Tau22 mice that resemble behavioral and psychological signs and symptoms of dementia","volume":"242","author":"Van der Jeugd","year":"2013","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0210","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.nlm.2016.01.007","article-title":"Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia","volume":"130","author":"Van Der Jeugd","year":"2016","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0215","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/nan.12233","article-title":"Early-onset axonal pathology in a novel P301S-tau transgenic mouse model of frontotemporal dementia","volume":"41","author":"van Ersel","year":"2015","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0220","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0166-4328(00)00240-0","article-title":"Behavioural analysis of four mouse strains in an anxiety test battery","volume":"115","author":"Van Gaalen","year":"2000","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0225","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.bbr.2012.05.007","article-title":"Sensorimotor gating and memory deficits in an APP\/PS1 double transgenic mouse model of Alzheimer's disease","volume":"233","author":"Wang","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0230","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.bbr.2005.05.013","article-title":"The expression of prepulse inhibition of the acoustic startle reflex as a function of three pulse stimulus intensities, three prepulse stimulus intensities, and three levels of startle responsiveness in C57BL6\/J mice","volume":"163","author":"Yee","year":"2005","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0235","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1212\/01.wnl.0000324920.96835.95","article-title":"Apathy and disinhibition in frontotemporal dementia: insights into their neural correlates","volume":"71","author":"Zamboni","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2020.01.047_b0240","doi-asserted-by":"crossref","first-page":"43506","DOI":"10.18632\/oncotarget.16490","article-title":"The associations between the MAPT polymorphisms and Alzheimer\u2019s disease risk: a meta-analysis","volume":"8","author":"Zhou","year":"2017","journal-title":"Oncotarget"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452220300774?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452220300774?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:04:34Z","timestamp":1778511874000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452220300774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":48,"alternative-id":["S0306452220300774"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2020.01.047","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel Behavioural Characteristics of Male Human P301S Mutant Tau Transgenic Mice \u2013 A Model for Tauopathy","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2020.01.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}