{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:46:12Z","timestamp":1780541172240,"version":"3.54.1"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["29651"],"award-info":[{"award-number":["29651"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["28988"],"award-info":[{"award-number":["28988"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["157572"],"award-info":[{"award-number":["157572"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["24326"],"award-info":[{"award-number":["24326"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.neuroscience.2020.05.058","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T08:26:20Z","timestamp":1594801580000},"page":"314-328","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Taking Rapid and Intermittent Cocaine Infusions Enhances Both Incentive Motivation for the Drug and Cocaine-induced Gene Regulation in Corticostriatal Regions"],"prefix":"10.1016","volume":"442","author":[{"given":"Ellie-Anna","family":"Minogianis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-No\u00ebl","family":"Samaha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2020.05.058_b0005","article-title":"Sex differences in cocaine self-administration behaviour under long access versus intermittent access conditions","author":"Algallal","year":"2019","journal-title":"Addict Biol"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0010","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00213-017-4773-8","article-title":"High and escalating levels of cocaine intake are dissociable from subsequent incentive motivation for the drug in rats","volume":"235","author":"Allain","year":"2018","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0015","article-title":"Amphetamine maintenance therapy during intermittent cocaine self-administration in rats: reduction of addiction-like behavior is associated with attenuation of psychomotor and dopamine sensitization","author":"Allain","year":"2020","journal-title":"BioRxiv"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0020","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.neubiorev.2015.06.012","article-title":"How fast and how often: The pharmacokinetics of drug use are decisive in addiction","volume":"56","author":"Allain","year":"2015","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2017.01.026","article-title":"Intermittent intake of rapid cocaine injections promotes robust psychomotor sensitization, increased incentive motivation for the drug and mGlu2\/3 receptor dysregulation","author":"Allain","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0030","article-title":"Revisiting long-access versus short-access cocaine self-administration in rats: intermittent intake promotes addiction symptoms independent of session length","author":"Allain","year":"2018","journal-title":"Addict Biol"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0035","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1037\/1064-1297.2.3.244","article-title":"Comparative epidemiology of dependence on tobacco, alcohol, controlled substances, and inhalants: basic findings from the National Comorbidity Survey","volume":"2","author":"Anthony","year":"1994","journal-title":"Exp Clin Psychopharmacol"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0040","series-title":"DSM V diagnostic and statistical manual of mental disorders","author":"APA","year":"2013"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0045","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/npp.2011.10","article-title":"Continuous, but not intermittent, antipsychotic drug delivery intensifies the pursuit of reward cues","volume":"36","author":"B\u00e9dard","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0050","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/cne.903160305","article-title":"Topographical organization and relationship with ventral striatal compartments of prefrontal corticostriatal projections in the rat","volume":"316","author":"Berendse","year":"1992","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0055","unstructured":"Beveridge TJR, Wray P, Brewer A, Shapiro B, Mahoney JJ and Newton TF (2012) Analyzing Human cocaine use patterns to inform animal addiction model development. (Published abstract for the College on Problems of Drug Dependence Annual Meeting, Palm Springs, CA)."},{"key":"10.1016\/j.neuroscience.2020.05.058_b0060","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1007\/s00213-014-3576-4","article-title":"The self-administration of rapidly delivered cocaine promotes increased motivation to take the drug: contributions of prior levels of operant responding and cocaine intake","volume":"231","author":"Bouayad-Gervais","year":"2014","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0065","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/jnc.12452","article-title":"Extended access of cocaine self-administration results in tolerance to the dopamine-elevating and locomotor-stimulating effects of cocaine","volume":"128","author":"Calipari","year":"2014","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0070","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1038\/npp.2013.136","article-title":"Temporal pattern of cocaine intake determines tolerance vs sensitization of cocaine effects at the dopamine transporter","volume":"38","author":"Calipari","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0075","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0028-3908(82)90019-3","article-title":"Topographical distribution of possible glutamatergic pathways from the frontal cortex to the striatum and substantia nigra in rats","volume":"21","author":"Carter","year":"1982","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0080","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/j.1460-9568.1993.tb00959.x","article-title":"Transection of corticostriatal afferents reduces amphetamine-and apomorphine-induced striatal Fos expression and turning behaviour in unilaterally 6-hydroxydopamine-lesioned rats","volume":"5","author":"Cenci","year":"1993","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0085","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3109\/16066359409005547","article-title":"Cocaine use in Amsterdam in non deviant subcultures","volume":"2","author":"Cohen","year":"1994","journal-title":"Addict Res"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0090","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/syn.890180106","article-title":"Acute and chronic cocaine administration differentially alters striatal opioid and nuclear transcription factor mRNAs","volume":"18","author":"Daunais","year":"1994","journal-title":"Synapse"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0095","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/00001756-199305000-00020","article-title":"Cocaine self-administration increases preprodynorphin, but not c-fos, mRNA in rat striatum","volume":"4","author":"Daunais","year":"1993","journal-title":"NeuroReport"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0100","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0361-9230(95)00049-K","article-title":"Short-term cocaine self administration alters striatal gene expression","volume":"37","author":"Daunais","year":"1995","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0105","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/0169-328X(94)90080-9","article-title":"Persistent reduction of immediate early gene mRNA in rat forebrain following single or multiple doses of cocaine","volume":"26","author":"Ennulat","year":"1994","journal-title":"Mol Brain Res"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0110","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1471-4159.2003.01815.x","article-title":"Amphetamine-evoked c-fos mRNA expression in the caudate-putamen: the effects of DA and NMDA receptor antagonists vary as a function of neuronal phenotype and environmental context","volume":"86","author":"Ferguson","year":"2003","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0115","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1471-4159.2004.02712.x","article-title":"Amphetamine-evoked gene expression in striatopallidal neurons: regulation by corticostriatal afferents and the ERK\/MAPK signaling cascade","volume":"91","author":"Ferguson","year":"2004","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0120","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.brainres.2008.02.081","article-title":"The rate of intravenous cocaine administration alters c-fos mRNA expression and the temporal dynamics of dopamine, but not glutamate, overflow in the striatum","volume":"1209","author":"Ferrario","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0125","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.euroneuro.2006.08.005","article-title":"Amphetamine pretreatment accelerates the subsequent escalation of cocaine self-administration behavior","volume":"17","author":"Ferrario","year":"2007","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0130","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.biopsych.2010.06.026","article-title":"Cocaine-insensitive dopamine transporters with intact substrate transport produced by self-administration","volume":"69","author":"Ferris","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0135","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1126\/science.2011738","article-title":"Cocaine addiction: psychology and neurophysiology","volume":"251","author":"Gawin","year":"1991","journal-title":"Science (Washington)"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0140","series-title":"Advances in neuroscience and schizophrenia","first-page":"43","article-title":"The neostriatal mosaic: multiple levels of compartmental organization","author":"Gerfen","year":"1992"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0145","doi-asserted-by":"crossref","first-page":"6912","DOI":"10.1073\/pnas.87.17.6912","article-title":"Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum","volume":"87","author":"Graybiel","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0150","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/s41386-018-0249-8","article-title":"Intermittent intake of rapid cocaine injections promotes the risk of relapse and increases mesocorticolimbic BDNF levels during abstinence","volume":"44","author":"Gueye","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0155","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0166-4328(97)83332-3","article-title":"Neural mechanisms of tolerance to the effects of cocaine","volume":"84","author":"Hammer","year":"1997","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0160","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0306-4522(03)00423-8","article-title":"Ampakines reduce methamphetamine-driven rotation and activate neocortex in a regionally selective fashion","volume":"121","author":"Hess","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0165","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.1073\/pnas.89.13.5764","article-title":"Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine","volume":"89","author":"Hope","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0170","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1146\/annurev.neuro.29.051605.113009","article-title":"Neural mechanisms of addiction: the role of reward-related learning and memory","volume":"29","author":"Hyman","year":"2006","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0175","article-title":"Increased number and activity of a lateral subpopulation of hypothalamic orexin\/hypocretin neurons underlies the expression of an addicted state in rats","author":"James","year":"2018","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0180","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/PL00005483","article-title":"Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli","volume":"146","author":"Jentsch","year":"1999","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0185","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s00213-019-5164-0","article-title":"The transition to cocaine addiction: the importance of pharmacokinetics for preclinical models","volume":"236","author":"Kawa","year":"2019","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0190","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1007\/s00213-016-4393-8","article-title":"Less is more: prolonged intermittent access cocaine self-administration produces incentive-sensitization and addiction-like behavior","volume":"233","author":"Kawa","year":"2016","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0195","article-title":"Incentive and dopamine sensitization produced by intermittent but not long access cocaine self-administration","author":"Kawa","year":"2018","journal-title":"bioRxiv"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0200","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s00213-006-0386-3","article-title":"Contributions of prolonged contingent and noncontingent cocaine exposure to enhanced reinstatement of cocaine seeking in rats","volume":"187","author":"Kippin","year":"2006","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0205","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1460-9568.2005.04195.x","article-title":"Sensitization of the reinforcing effects of self-administered cocaine in rats: effects of dose and intravenous injection speed","volume":"22","author":"Liu","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0210","doi-asserted-by":"crossref","first-page":"5718","DOI":"10.1523\/JNEUROSCI.5248-12.2013","article-title":"The rat prefrontostriatal system analyzed in 3D: evidence for multiple interacting functional units","volume":"33","author":"Mailly","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0215","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s00213-004-1778-x","article-title":"Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats","volume":"175","author":"Mantsch","year":"2004","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0220","doi-asserted-by":"crossref","first-page":"6127","DOI":"10.1073\/pnas.0912955107","article-title":"\u201cControl\u201d laboratory rodents are metabolically morbid: why it matters","volume":"107","author":"Martin","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0225","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0306-4522(89)90128-0","article-title":"The organization of the projection from the cerebral cortex to the striatum in the rat","volume":"29","author":"McGeorge","year":"1989","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0230","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1038\/npp.2013.173","article-title":"The speed of cocaine delivery determines the subsequent motivation to self-administer the drug","volume":"38","author":"Minogianis","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112026","article-title":"Role of the orbitofrontal cortex and the dorsal striatum in incentive motivation for cocaine","volume":"372","author":"Minogianis","year":"2019","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0240","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1523\/JNEUROSCI.13-02-00423.1993","article-title":"Coordinate expression of c-fos and jun B is induced in the rat striatum by cocaine","volume":"13","author":"Moratalla","year":"1993","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0245","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/35053570","article-title":"Molecular basis of long-term plasticity underlying addiction","volume":"2","author":"Nestler","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0250","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.biopsych.2019.01.015","article-title":"Incubation of cocaine craving after intermittent-access self-administration: sex differences and estrous cycle","volume":"85","author":"Nicolas","year":"2019","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0255","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/j.1471-4159.1991.tb11425.x","article-title":"Differences in the pharmacokinetics of cocaine in naive and cocaine-experienced rats","volume":"56","author":"Pan","year":"1991","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0260","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"1986"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0265","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0079-6123(00)26017-2","article-title":"The glutamate hypothesis of reinforcement learning","volume":"126","author":"Pennartz","year":"2000","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0270","doi-asserted-by":"crossref","first-page":"7198","DOI":"10.1523\/JNEUROSCI.0990-17.2017","article-title":"Diverse roads to relapse: a discriminative cue signaling cocaine availability is more effective in renewing cocaine seeking in goal trackers than sign trackers and depends on basal forebrain cholinergic activity","volume":"37","author":"Pitchers","year":"2017","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0275","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.bbr.2016.11.024","article-title":"The ability for cocaine and cocaine-associated cues to compete for attention","volume":"320","author":"Pitchers","year":"2017","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-0270(95)00153-0","article-title":"Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy","volume":"66","author":"Richardson","year":"1996","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0285","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0165-0173(93)90013-P","article-title":"The neural basis of drug craving: an incentive-sensitization theory of addiction","volume":"18","author":"Robinson","year":"1993","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0290","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev.psych.54.101601.145237","article-title":"Addiction","volume":"54","author":"Robinson","year":"2003","journal-title":"Annu Rev Psychol"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0295","first-page":"149","article-title":"Food or fluid restriction in common laboratory animals: balancing welfare considerations with scientific inquiry","volume":"57","author":"Rowland","year":"2007","journal-title":"Comp Med"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0300","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/syn.890180309","article-title":"Amphetamine- and cocaine-induced fos in the rat striatum depends on D2 dopamine receptor activation","volume":"18","author":"Ruskin","year":"1994","journal-title":"Synapse"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0305","doi-asserted-by":"crossref","first-page":"6362","DOI":"10.1523\/JNEUROSCI.1205-04.2004","article-title":"The rate of cocaine administration alters gene regulation and behavioral plasticity: implications for addiction","volume":"24","author":"Samaha","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0310","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026481","article-title":"Cues paired with either rapid or slower self-administered cocaine injections acquire similar conditioned rewarding properties","volume":"6","author":"Samaha","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0315","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neulet.2007.12.024","article-title":"The orbital cortex in rats topographically projects to central parts of the caudate\u2013putamen complex","volume":"432","author":"Schilman","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0320","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1093\/cercor\/10.3.272","article-title":"Reward processing in primate orbitofrontal cortex and basal ganglia","volume":"10","author":"Schultz","year":"2000","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0325","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1046\/j.1360-0443.2002.00114.x","article-title":"Temporal progression of cocaine dependence symptoms in the US National Comorbidity Survey","volume":"97","author":"Shaffer","year":"2002","journal-title":"Addiction"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0330","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1523\/JNEUROSCI.2604-17.2017","article-title":"Amphetamine reverses escalated cocaine intake via restoration of dopamine transporter conformation","volume":"38","author":"Siciliano","year":"2018","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0335","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1300\/J069v21n01_04","article-title":"A comparison of patterns of methamphetamine and cocaine use","volume":"21","author":"Simon","year":"2001","journal-title":"J Addict Dis"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0340","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1523\/JNEUROSCI.2458-17.2017","article-title":"Are cocaine-seeking \u201chabits\u201d necessary for the development of addiction-like behavior in rats?","volume":"38","author":"Singer","year":"2018","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0345","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0014-4886(91)90171-8","article-title":"Striatal C-fos induction by drugs and stress in neonatally dopamine-depleted rats given nigral transplants: importance of NMDA activation and relevance to sensitization phenomena","volume":"113","author":"Snyder-Keller","year":"1991","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0350","doi-asserted-by":"crossref","first-page":"5066","DOI":"10.1523\/JNEUROSCI.13-12-05066.1993","article-title":"Cocaine-induced c-fos messenger RNA is inversely related to dynorphin expression in striatum","volume":"13","author":"Steiner","year":"1993","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0355","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/19525","article-title":"Relative reward preference in primate orbitofrontal cortex","volume":"398","author":"Tremblay","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0360","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/(SICI)1098-2396(199904)32:1<51::AID-SYN7>3.0.CO;2-E","article-title":"Dopamine D3 receptor antisense administration reduces basal c-fos and NGFI-B mRNA levels in the rat forebrain","volume":"32","author":"Tremblay","year":"1999","journal-title":"Synapse"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0365","doi-asserted-by":"crossref","first-page":"11346","DOI":"10.1523\/JNEUROSCI.2524-10.2010","article-title":"Rats markedly escalate their intake and show a persistent susceptibility to reinstatement only when cocaine is injected rapidly","volume":"30","author":"Wakabayashi","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0370","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1046\/j.1460-9568.2003.02922.x","article-title":"Neuronal activity in primate dorsolateral and orbital prefrontal cortex during performance of a reward preference task","volume":"18","author":"Wallis","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0375","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.138.3537.143","article-title":"Experimental morphine addiction: method for automatic intravenous injections in unrestrained rats","volume":"138","author":"Weeks","year":"1962","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0380","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1073\/pnas.88.4.1291","article-title":"Cocaine induces striatal c-fos-immunoreactive proteins via dopaminergic D1 receptors","volume":"88","author":"Young","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0385","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1038\/npp.2011.165","article-title":"Brain-cocaine concentrations determine the dose self-administered by rats on a novel behaviorally dependent dosing schedule","volume":"36","author":"Zimmer","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2020.05.058_b0390","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1038\/npp.2012.37","article-title":"The motivation to self-administer is increased after a history of spiking brain levels of cocaine","volume":"37","author":"Zimmer","year":"2012","journal-title":"Neuropsychopharmacology"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452220303882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452220303882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:40:26Z","timestamp":1778632826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452220303882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":78,"alternative-id":["S0306452220303882"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2020.05.058","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.04.22.055715","asserted-by":"object"}]},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Taking Rapid and Intermittent Cocaine Infusions Enhances Both Incentive Motivation for the Drug and Cocaine-induced Gene Regulation in Corticostriatal Regions","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2020.05.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}