{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:14:53Z","timestamp":1780467293642,"version":"3.54.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.neuroscience.2020.06.023","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T11:26:37Z","timestamp":1592997997000},"page":"274-285","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["The Role of Acid-sensing Ion Channel 3 in the Modulation of Tooth Mechanical Hyperalgesia Induced by Orthodontic Tooth Movement"],"prefix":"10.1016","volume":"442","author":[{"given":"Hong","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengyan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhe","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyue","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2020.06.023_b0005","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1034\/j.1600-0722.2002.11193.x","article-title":"Experience of pain during an orthodontic procedure","volume":"110","author":"Bergius","year":"2002","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0010","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1097\/ALN.0b013e3181eaa58a","article-title":"A role for acid-sensing ion channel 3, but not acid-sensing ion channel 2, in sensing dynamic mechanical stimuli","volume":"113","author":"Borzan","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0015","doi-asserted-by":"crossref","first-page":"8992","DOI":"10.1073\/pnas.122245999","article-title":"A role for ASIC3 in the modulation of high-intensity pain stimuli","volume":"99","author":"Chen","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0020","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12929-018-0448-y","article-title":"Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing","volume":"25","author":"Cheng","year":"2018","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0025","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neuropharm.2015.02.009","article-title":"Acid-Sensing Ion Channels and nociception in the peripheral and central nervous systems","volume":"94","author":"Deval","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0030","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1038\/emboj.2008.213","article-title":"ASIC3, a sensor of acidic and primary inflammatory pain","volume":"27","author":"Deval","year":"2008","journal-title":"EMBO J"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0035","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/ejo\/cjv082","article-title":"The role of periodontal ASIC3 in orofacial pain induced by experimental tooth movement in rats","volume":"38","author":"Gao","year":"2016","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0040","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41368-019-0044-3","article-title":"Transient receptor potential Vanilloid 1-based gene therapy alleviates orthodontic pain in rats","volume":"11","author":"Guo","year":"2019","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0045","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jpain.2008.10.010","article-title":"Acid-sensing ion channel 3 expression in mouse knee joint afferents and effects of carrageenan-induced arthritis","volume":"10","author":"Ikeuchi","year":"2009","journal-title":"J Pain"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0050","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.neulet.2019.03.031","article-title":"IL-10 and CXCL2 in trigeminal ganglia in neuropathic pain","volume":"703","author":"Iwasa","year":"2019","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0055","doi-asserted-by":"crossref","first-page":"7713","DOI":"10.1523\/JNEUROSCI.3359-17.2018","article-title":"Cerebrospinal fluid-contacting neurons sense pH changes and motion in the hypothalamus","volume":"38","author":"Jalalvand","year":"2018","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0060","first-page":"118","article-title":"Pain and discomfort perception among patients undergoing orthodontic treatment: results from one month follow-up study","volume":"14","author":"Kavaliauskiene","year":"2012","journal-title":"Stomatologija"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0070","doi-asserted-by":"crossref","first-page":"31052","DOI":"10.1074\/jbc.M109.052969","article-title":"Identification of neuronal nuclei (NeuN) as Fox-3, a new member of the Fox-1 gene family of splicing factors","volume":"284","author":"Kim","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0075","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/ejo\/cjl081","article-title":"Orthodontic pain: from causes to management\u2013a review","volume":"29","author":"Krishnan","year":"2007","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0080","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1021\/cn100094b","article-title":"ASIC3 channels in multimodal sensory perception","volume":"2","author":"Li","year":"2011","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0085","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/eos.12110","article-title":"Evaluation of pain in rats through facial expression following experimental tooth movement","volume":"122","author":"Liao","year":"2014","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/eos.12326","article-title":"A novel technique of delivering viral vectors to trigeminal ganglia in rats","volume":"125","author":"Long","year":"2017","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.archoralbio.2019.02.002","article-title":"Bite force measurements for objective evaluations of orthodontic tooth movement-induced pain in rats","volume":"101","author":"Long","year":"2019","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0100","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/ijos.2016.24","article-title":"Current advances in orthodontic pain","volume":"8","author":"Long","year":"2016","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0105","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.2319\/010113-2.1","article-title":"Comparison of adverse effects between lingual and labial orthodontic treatment","volume":"83","author":"Long","year":"2013","journal-title":"Angle Orthod"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0110","first-page":"535","article-title":"The effect of nerve growth factor on the expression of BMP-2 in the healing of rabbits' mandibular fracture with partial nerve injury","volume":"30","author":"Lv","year":"2016","journal-title":"Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0115","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1177\/10454411990100030401","article-title":"The Ruffini ending as the primary mechanoreceptor in the periodontal ligament: its morphology, cytochemical features, regeneration, and development","volume":"10","author":"Maeda","year":"1999","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0120","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1177\/0333102416673204","article-title":"Different processing of meningeal and cutaneous pain information in the spinal trigeminal nucleus caudalis","volume":"37","author":"Melin","year":"2017","journal-title":"Cephalalgia"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0125","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s10753-014-9972-4","article-title":"Inhibition of peripheral nociceptors by aminoglycosides produces analgesia in inflammatory pain models in the rat","volume":"38","author":"Mercado","year":"2015","journal-title":"Inflammation"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0130","doi-asserted-by":"crossref","first-page":"372","DOI":"10.17712\/nsj.2016.4.20160278","article-title":"MRI findings in a case of spinal cord Wallerian degeneration following trauma","volume":"21","author":"Mittal","year":"2016","journal-title":"Neurosciences (Riyadh)"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0135","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1744-8069-6-9","article-title":"Alteration of primary afferent activity following inferior alveolar nerve transection in rats","volume":"6","author":"Nakagawa","year":"2010","journal-title":"Mol Pain"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0140","doi-asserted-by":"crossref","first-page":"137","DOI":"10.14712\/23362936.2019.1","article-title":"The effect of sensory innervation on the inorganic component of bones and teeth; experimental denervation \u2013 review","volume":"119","author":"Nemec","year":"2018","journal-title":"Prague Med Rep"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0145","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/S0896-6273(01)00547-5","article-title":"The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice","volume":"32","author":"Price","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0150","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neulet.2010.11.023","article-title":"Detection of acid-sensing ion channel 3 (ASIC3) in periodontal Ruffini endings of mouse incisors","volume":"488","author":"Rahman","year":"2011","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0155","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.sdentj.2014.11.002","article-title":"Pain and discomfort perceived during the initial stage of active fixed orthodontic treatment","volume":"27","author":"Rakhshan","year":"2015","journal-title":"Saudi Dent J"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0160","first-page":"325","article-title":"The spinal trigeminal nucleus\u2013considerations on the structure of the nucleus caudalis","volume":"63","author":"Rusu","year":"2004","journal-title":"Folia Morphol (Warsz)"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2016.09.032","article-title":"Participation of peripheral TRPV1, TRPV4, TRPA1 and ASIC in a magnesium sulfate-induced local pain model in rat","volume":"339","author":"Srebro","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0170","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.physbeh.2014.11.042","article-title":"TRPA1, NMDA receptors and nitric oxide mediate mechanical hyperalgesia induced by local injection of magnesium sulfate into the rat hind paw","volume":"139","author":"Srebro","year":"2015","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0175","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1177\/0022034513509280","article-title":"Nitric oxide signaling contributes to ectopic orofacial neuropathic pain","volume":"92","author":"Sugiyama","year":"2013","journal-title":"J Dent Res"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0180","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1902\/jop.2013.130039","article-title":"Toll-like receptor 4 expression in trigeminal neurons is increased during ligature-induced periodontitis in rats","volume":"85","author":"Vindis","year":"2014","journal-title":"J Periodontol"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0185","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nrn3529","article-title":"Acid-sensing ion channels in pain and disease","volume":"14","author":"Wemmie","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0190","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.45851","article-title":"A valve-like mechanism controls desensitization of functional mammalian isoforms of acid-sensing ion channels","volume":"8","author":"Wu","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0195","first-page":"91","article-title":"Orthodontic tooth movement and expression of calcium regulating hormone","volume":"22","author":"Yamamoto","year":"2012","journal-title":"Clin Calcium"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0200","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S8756-3282(00)00282-9","article-title":"Inferior alveolar nerve transection inhibits increase in osteoclast appearance during experimental tooth movement","volume":"26","author":"Yamashiro","year":"2000","journal-title":"Bone"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0205","doi-asserted-by":"crossref","first-page":"730","DOI":"10.2319\/090213-643.1","article-title":"Chemokine ligand 2 in the trigeminal ganglion regulates pain induced by experimental tooth movement","volume":"84","author":"Yang","year":"2014","journal-title":"Angle Orthod"},{"key":"10.1016\/j.neuroscience.2020.06.023_b0210","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1590\/1678-775720160150","article-title":"The effect of capsaicin on expression patterns of CGRP in trigeminal ganglion and trigeminal nucleus caudalis following experimental tooth movement in rats","volume":"24","author":"Zhou","year":"2016","journal-title":"J Appl Oral Sci"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452220304012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452220304012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T15:58:57Z","timestamp":1759679937000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452220304012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":42,"alternative-id":["S0306452220304012"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2020.06.023","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Role of Acid-sensing Ion Channel 3 in the Modulation of Tooth Mechanical Hyperalgesia Induced by Orthodontic Tooth Movement","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2020.06.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}