{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:10:06Z","timestamp":1787314206567,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.neuroscience.2020.10.016","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T02:14:14Z","timestamp":1604110454000},"page":"13-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Key Roles of Cyclooxygenase 2-Protein Kinase A-Hyperpolarization-activated Cyclic Nucleotide-gated Channel 3 Pathway in the Regulation of Oxytocin Neuronal Activity in Lactating Rats with Intermittent Pup-Deprivation"],"prefix":"10.1016","volume":"452","author":[{"given":"Dongyang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwei","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2020.10.016_b0005","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.theriogenology.2016.11.022","article-title":"Effects of ZD7288, a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker, on term-pregnant rat uterine contractility in vitro","volume":"90","author":"Alotaibi","year":"2017","journal-title":"Theriogenology"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0010","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12666","article-title":"Electrophysiological properties of identified oxytocin and vasopressin neurones","volume":"31","author":"Armstrong","year":"2019","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0015","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1212\/WNL.0b013e31827dec42","article-title":"HCN channels: function and clinical implications","volume":"80","author":"Benarroch","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0020","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0306-4530(01)00019-1","article-title":"Brief vs. long maternal separations in infancy: contrasting relationships with adult maternal behavior and lactation levels of aggression and anxiety","volume":"26","author":"Boccia","year":"2001","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0025","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1089\/dna.2013.2021","article-title":"Novel role of KT5720 on regulating hyperpolarization-activated cyclic nucleotide-gated channel activity and dorsal root ganglion neuron excitability","volume":"32","author":"Cheng","year":"2013","journal-title":"DNA Cell Biol"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0030","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ceca.2012.02.002","article-title":"Segregation of calcium signalling mechanisms in magnocellular neurones and terminals","volume":"51","author":"Dayanithi","year":"2012","journal-title":"Cell Calcium"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0035","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0079-6123(08)00414-7","article-title":"Neural mechanisms underlying the milk ejection burst and reflex","volume":"170","author":"Hatton","year":"2008","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0040","doi-asserted-by":"crossref","DOI":"10.4172\/2167-0501.1000211","article-title":"Model Roles of the hypothalamo-Neurohypophysial System in Neuroscience Study","volume":"5","author":"Hou","year":"2016","journal-title":"Biochem Pharmacol (Los Angel)"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0045","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1523\/JNEUROSCI.5198-07.2008","article-title":"Oxytocin-induced postinhibitory rebound firing facilitates bursting activity in oxytocin neurons","volume":"28","author":"Israel","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0050","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1152\/physrev.00031.2017","article-title":"The oxytocin receptor: from intracellular signaling to behavior","volume":"98","author":"Jurek","year":"2018","journal-title":"Physiol Rev"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tjog.2018.11.002","article-title":"The effect of mother-infant skin to skin contact on success and duration of first breastfeeding: A systematic review and meta-analysis","volume":"58","author":"Karimi","year":"2019","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0060","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1210\/en.2008-1611","article-title":"Antagonism of oxytocin prevents suckling- and estradiol-induced, but not progesterone-induced, secretion of prolactin","volume":"150","author":"Kennett","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0065","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1365-4362.1992.tb02705.x","article-title":"Systemic ketoconazole treatment for Fusarium leg ulcers","volume":"31","author":"Landau","year":"1992","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0070","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1113\/jphysiol.1975.sp011064","article-title":"Factors governing the periodic activation of supraoptic and paraventricular neurosecretory cells during suckling in the rat","volume":"250","author":"Lincoln","year":"1975","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0075","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1046\/j.1365-2826.2003.01052.x","article-title":"Central blockade of oxytocin receptors during late gestation disrupts systemic release of oxytocin during suckling in rats","volume":"15","author":"Lipschitz","year":"2003","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0080","first-page":"002","article-title":"Pulsatile but not tonic secretion of oxytocin plays the role of anti-precancerous lesions of the mammary glands in rat dams separated from the pups during lactation","volume":"1","author":"Liu","year":"2016","journal-title":"M J Neuro"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0085","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3389\/fnins.2019.00122","article-title":"Effects of intranasal oxytocin on pup deprivation-evoked aberrant maternal behavior and hypogalactia in rat dams and the underlying mechanisms","volume":"13","author":"Liu","year":"2019","journal-title":"Front Neurosci"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0090","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1046\/j.1523-536x.2001.00013.x","article-title":"Postpartum maternal oxytocin release by newborns: effects of infant hand massage and sucking","volume":"28","author":"Matthiesen","year":"2001","journal-title":"Birth"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0095","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1210\/endo-129-4-1814","article-title":"Coexpression of vasopressin and oxytocin in hypothalamic supraoptic neurons of lactating rats","volume":"129","author":"Mezey","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0100","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4992\/jjpsy.58.233","article-title":"The effects of mother-infant separation upon nursing and suckling behaviors of the rat","volume":"58","author":"Miyamoto","year":"1987","journal-title":"Shinrigaku Kenkyu"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0105","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0169-328X(00)00155-8","article-title":"Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain","volume":"81","author":"Monteggia","year":"2000","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0110","doi-asserted-by":"crossref","first-page":"11320","DOI":"10.1523\/JNEUROSCI.1588-16.2016","article-title":"Nitric oxide modulates HCN channels in magnocellular neurons of the supraoptic nucleus of rats by an S-nitrosylation-dependent mechanism","volume":"36","author":"Pires da Silva","year":"2016","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0115","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neulet.2004.10.033","article-title":"Neuromedin U receptor-2 mRNA and HCN channels mRNA expression in NMU-sensitive neurons in rat hypothalamic paraventricular nucleus","volume":"374","author":"Qiu","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0120","doi-asserted-by":"crossref","DOI":"10.1111\/j.1469-445X.2000.tb00018.x","article-title":"Pre- and postsynaptic modulation of the electrical activity of rat supraoptic neurones","author":"Shibuya","year":"2000","journal-title":"Exp Physiol"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0125","doi-asserted-by":"crossref","first-page":"C75","DOI":"10.1152\/ajpcell.00024.2008","article-title":"PGE2 potentiates tonicity-induced COX-2 expression in renal medullary cells in a positive feedback loop involving EP2-cAMP-PKA signaling","volume":"296","author":"Steinert","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0130","first-page":"E634","article-title":"ERK2 mediates oxytocin-stimulated PGE2 synthesis","volume":"274","author":"Strakova","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0135","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1046\/j.1365-2826.1998.00282.x","article-title":"Actions of prostaglandin E2 on rat supraoptic neurones","volume":"10","author":"Sutarmo Setiadji","year":"1998","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0140","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00441-018-2883-1","article-title":"Neuromodulation of maternal circuits by oxytocin","volume":"375","author":"Valtcheva","year":"2019","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0145","series-title":"The physiology of reproduction","first-page":"1131","article-title":"Milk ejection and its control","author":"Wakerley","year":"1994"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0150","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3389\/fnmol.2017.00262","article-title":"Oxytocin rapidly changes astrocytic GFAP plasticity by differentially modulating the expressions of pERK 1\/2 and protein kinase A","volume":"10","author":"Wang","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0155","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.21474\/IJAR01\/947","article-title":"Suckling-induced burst discharges of supraoptic oxytocin neurons in rats: prostaglandin mediation of oxytocin actions","volume":"4","author":"Wang","year":"2016","journal-title":"Int J Adv Res"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0160","first-page":"252","article-title":"Oxytocin, lactation and postpartum depression","volume":"3","author":"Wang","year":"2009","journal-title":"Front Neurosci"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0165","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.brainres.2004.10.046","article-title":"Burst firing of oxytocin neurons in male rat hypothalamic slices","volume":"1032","author":"Wang","year":"2005","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0170","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1523\/JNEUROSCI.5346-06.2007","article-title":"Dominant role of betagamma subunits of G-proteins in oxytocin-evoked burst firing","volume":"27","author":"Wang","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0175","doi-asserted-by":"crossref","first-page":"13822","DOI":"10.1523\/JNEUROSCI.4119-07.2007","article-title":"Interaction of extracellular signal-regulated protein kinase 1\/2 with actin cytoskeleton in supraoptic oxytocin neurons and astrocytes: role in burst firing","volume":"27","author":"Wang","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0180","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1523\/JNEUROSCI.4669-08.2009","article-title":"Astrocytic plasticity and patterned oxytocin neuronal activity: dynamic interactions","volume":"29","author":"Wang","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0185","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1677\/joe.0.1440463","article-title":"Effects of hemitransection of the midbrain on milk-ejection burst of oxytocin neurones in lactating rat","volume":"144","author":"Wang","year":"1995","journal-title":"J Endocrinol"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0190","doi-asserted-by":"crossref","first-page":"R1191","DOI":"10.1152\/ajpregu.00725.2005","article-title":"Autofeedback effects of progressively rising oxytocin concentrations on supraoptic oxytocin neuronal activity in slices from lactating rats","volume":"290","author":"Wang","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0195","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/glia.22453","article-title":"Hyposmolality differentially and spatiotemporally modulates levels of glutamine synthetase and serine racemase in rat supraoptic nucleus","volume":"61","author":"Wang","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0200","doi-asserted-by":"crossref","first-page":"10412","DOI":"10.1523\/JNEUROSCI.0021-11.2011","article-title":"PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons","volume":"31","author":"Ying","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0205","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1210\/en.2002-221039","article-title":"Extracellular signal-regulated kinase 1\/2 activation by myometrial oxytocin receptor involves Galpha(q)Gbetagamma and epidermal growth factor receptor tyrosine kinase activation","volume":"144","author":"Zhong","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuroscience.2020.10.016_b0210","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1210\/me.2006-0220","article-title":"Oxytocin receptors differentially signal via Gq and Gi proteins in pregnant and nonpregnant rat uterine myocytes: implications for myometrial contractility","volume":"21","author":"Zhou","year":"2007","journal-title":"Mol Endocrinol"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452220306679?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452220306679?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:00:53Z","timestamp":1759680053000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452220306679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":42,"alternative-id":["S0306452220306679"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2020.10.016","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Key Roles of Cyclooxygenase 2-Protein Kinase A-Hyperpolarization-activated Cyclic Nucleotide-gated Channel 3 Pathway in the Regulation of Oxytocin Neuronal Activity in Lactating Rats with Intermittent Pup-Deprivation","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2020.10.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}