{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:49:34Z","timestamp":1792795774715,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.neuroscience.2020.10.019","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T02:13:52Z","timestamp":1604110432000},"page":"207-215","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Microglia-Astrocyte Cross Talk through IL-18\/IL-18R Signaling Modulates Migraine-like Behavior in Experimental Models of Migraine"],"prefix":"10.1016","volume":"451","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4846-757X","authenticated-orcid":false,"given":"Qiaoyu","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4017-4529","authenticated-orcid":false,"given":"Zuneng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheman","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2020.10.019_b0005","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0010","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1742-2094-7-9","article-title":"Interleukin 18 in the CNS","volume":"7","author":"Alboni","year":"2010","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0015","first-page":"657","article-title":"The mast cell - neurofibromatosis connection","volume":"33","author":"Antonopoulos","year":"2019","journal-title":"J Biol Regul Homeost Agents"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0020","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/cvr\/cvs226","article-title":"Interleukin-18: a potent pro-inflammatory cytokine in atherosclerosis","volume":"96","author":"Badimon","year":"2012","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0025","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41419-019-1716-9","article-title":"Microglia-derived TNF-\u03b1 mediates endothelial necroptosis aggravating blood brain-barrier disruption after ischemic stroke","volume":"10","author":"Chen","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0030","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.jpain.2012.06.007","article-title":"Role of P2X7 receptor-mediated IL-18\/IL-18R signaling in morphine tolerance: multiple glial-neuronal dialogues in the rat spinal cord","volume":"13","author":"Chen","year":"2012","journal-title":"J Pain"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0035","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0040","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020412","article-title":"The blood-brain barrier","volume":"7","author":"Daneman","year":"2015","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0045","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/s41582-019-0216-y","article-title":"Does inflammation have a role in migraine?","volume":"15","author":"Edvinsson","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0050","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1189\/jlb.5RU0714-360RR","article-title":"Context-dependent role of IL-18 in cancer biology and counter-regulation by IL-18BP","volume":"97","author":"Fabbi","year":"2015","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0055","first-page":"2286","article-title":"A new comorbidity model and the common pathological mechanisms of migraine and epilepsy","volume":"9","author":"Fan","year":"2017","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0060","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1177\/0333102417703764","article-title":"Region-specific disruption of the blood-brain barrier following repeated inflammatory dural stimulation in a rat model of chronic trigeminal allodynia","volume":"38","author":"Fried","year":"2018","journal-title":"Cephalalgia"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0065","first-page":"1","article-title":"Interleukin-1 family cytokines and mast cells: activation and inhibition","volume":"33","author":"Gallenga","year":"2019","journal-title":"J Biol Regul Homeost Agents"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0070","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1152\/physrev.00034.2015","article-title":"Pathophysiology of migraine: a disorder of sensory processing","volume":"97","author":"Goadsby","year":"2017","journal-title":"Physiol Rev"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0075","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12974-019-1459-7","article-title":"Microglial NLRP3 inflammasome activation mediates IL-1\u03b2 release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model","volume":"16","author":"He","year":"2019","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0080","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/head.13529","article-title":"CGRP and the trigeminal system in migraine","volume":"59","author":"Iyengar","year":"2019","journal-title":"Headache"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0085","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/1073858418783959","article-title":"Microglia-astrocyte crosstalk: an intimate molecular conversation","volume":"25","author":"Jha","year":"2019","journal-title":"Neuroscientist"},{"issue":"Suppl 1","key":"10.1016\/j.neuroscience.2020.10.019_b0090","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.pain.2013.06.022","article-title":"Glia and pain: is chronic pain a gliopathy?","volume":"154","author":"Ji","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0095","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s10194-016-0631-z","article-title":"Valproate ameliorates nitroglycerin-induced migraine in trigeminal nucleus caudalis in rats through inhibition of NF-\u043aB","volume":"17","author":"Li","year":"2016","journal-title":"J Headache Pain"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0100","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jpain.2017.10.003","article-title":"IL-18 contributes to bone cancer pain by regulating glia cells and neuron interaction","volume":"19","author":"Liu","year":"2018","journal-title":"J Pain"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0105","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.lfs.2011.05.011","article-title":"Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system","volume":"89","author":"Liu","year":"2011","journal-title":"Life Sci"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0110","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1177\/0333102419861710","article-title":"Basal astrocyte and microglia activation in the central nervous system of Familial Hemiplegic Migraine Type I mice","volume":"39","author":"Magni","year":"2019","journal-title":"Cephalalgia"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0115","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.immuni.2019.03.012","article-title":"Interleukin-1 and related cytokines in the regulation of inflammation and immunity","volume":"50","author":"Mantovani","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0120","doi-asserted-by":"crossref","first-page":"12775","DOI":"10.1523\/JNEUROSCI.3512-08.2008","article-title":"Interleukin-18-mediated microglia\/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury","volume":"28","author":"Miyoshi","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0125","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.mcn.2015.12.013","article-title":"Blockade of IL-18 signaling diminished neuropathic pain and enhanced the efficacy of morphine and buprenorphine","volume":"71","author":"Pilat","year":"2016","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0130","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00281-018-0676-y","article-title":"Neurogenic inflammation and its role in migraine","volume":"40","author":"Ramachandran","year":"2018","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0135","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/ana.10159","article-title":"Nuclear factor-kappaB as a molecular target for migraine therapy","volume":"51","author":"Reuter","year":"2002","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0140","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fncel.2018.00072","article-title":"An inflammation-centric view of neurological disease: beyond the neuron","volume":"12","author":"Skaper","year":"2018","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0145","doi-asserted-by":"crossref","DOI":"10.1177\/1744806918754612","article-title":"Inhibition of toll-like receptor 4 alleviates hyperalgesia induced by acute dural inflammation in experimental migraine","volume":"14","author":"Su","year":"2018","journal-title":"Mol Pain"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0150","first-page":"1663","article-title":"Factors adversely influencing neurodevelopment","volume":"33","author":"Theoharides","year":"2019","journal-title":"J Biol Regul Homeost Agents"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0155","doi-asserted-by":"crossref","first-page":"7950","DOI":"10.1523\/JNEUROSCI.5250-14.2015","article-title":"Delayed activation of spinal microglia contributes to the maintenance of bone cancer pain in female Wistar rats via P2X7 receptor and IL-18","volume":"35","author":"Yang","year":"2015","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0160","doi-asserted-by":"crossref","first-page":"5202","DOI":"10.1007\/s12035-018-1428-7","article-title":"Microglia receptors in animal models of traumatic brain injury","volume":"56","author":"Younger","year":"2019","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0165","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.neuroscience.2018.12.006","article-title":"Inhibition of nerve growth factor signaling alleviates repeated dural stimulation-induced hyperalgesia in rats","volume":"398","author":"Zhou","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2020.10.019_b0170","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452220306771?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452220306771?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:02:27Z","timestamp":1759680147000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452220306771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":34,"alternative-id":["S0306452220306771"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2020.10.019","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microglia-Astrocyte Cross Talk through IL-18\/IL-18R Signaling Modulates Migraine-like Behavior in Experimental Models of Migraine","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2020.10.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}