{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:00:45Z","timestamp":1792641645765,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T00:00:00Z","timestamp":1644710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971425"],"award-info":[{"award-number":["81971425"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY20H040002"],"award-info":[{"award-number":["LY20H040002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771624"],"award-info":[{"award-number":["81771624"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.neuroscience.2022.02.013","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T22:08:41Z","timestamp":1645049321000},"page":"131-142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"special_numbering":"C","title":["Ferroptosis is Involved in Hypoxic-ischemic Brain Damage in Neonatal Rats"],"prefix":"10.1016","volume":"487","author":[{"given":"Wei","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianlei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2022.02.013_b0005","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.ajpath.2017.11.012","article-title":"gammadelta T cells contribute to injury in the developing brain","volume":"188","author":"Albertsson","year":"2018","journal-title":"Am J Pathol"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0010","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1056\/NEJM199912233412607","article-title":"Disorders of iron metabolism","volume":"341","author":"Andrews","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0015","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.mvr.2016.06.003","article-title":"Visualization of perfusion changes with laser speckle contrast imaging using the method of motion history image","volume":"107","author":"Ansari","year":"2016","journal-title":"Microvasc Res"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0020","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.chembiol.2020.03.016","article-title":"Ferroptosis and necroptosis in the kidney","volume":"27","author":"Belavgeni","year":"2020","journal-title":"Cell Chem Biol"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0025","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1093\/infdis\/jiv231","article-title":"Staphylococcus epidermidis Bacteremia induces brain injury in neonatal mice via toll-like receptor 2-dependent and -independent pathways","volume":"212","author":"Bi","year":"2015","journal-title":"J Infect Dis"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0030","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.canlet.2017.12.025","article-title":"Heme oxygenase-1 mediates BAY 11\u20137085 induced ferroptosis","volume":"416","author":"Chang","year":"2018","journal-title":"Cancer Lett"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0035","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12974-018-1077-9","article-title":"IRE1\u03b1 inhibition decreased TXNIP\/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats","volume":"15","author":"Chen","year":"2018","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0040","doi-asserted-by":"crossref","first-page":"e77023","DOI":"10.1371\/journal.pone.0077023","article-title":"Iron accumulates in Huntington's disease neurons: protection by deferoxamine","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0045","doi-asserted-by":"crossref","first-page":"28097","DOI":"10.1074\/jbc.M115.680090","article-title":"Ablation of the ferroptosis inhibitor glutathione peroxidase 4 in neurons results in rapid motor neuron degeneration and paralysis","volume":"290","author":"Chen","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0050","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0055","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nchembio.1416","article-title":"The role of iron and reactive oxygen species in cell death","volume":"10","author":"Dixon","year":"2014","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0060","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3389\/fneur.2012.00144","article-title":"Biomarkers of hypoxic-ischemic encephalopathy in newborns","volume":"3","author":"Douglas-Escobar","year":"2012","journal-title":"Front Neurol"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0065","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/cr.2016.95","article-title":"Ferroptosis is an autophagic cell death process","volume":"26","author":"Gao","year":"2016","journal-title":"Cell Res"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0070","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","article-title":"Glutaminolysis and transferrin regulate ferroptosis","volume":"59","author":"Gao","year":"2015","journal-title":"Mol Cell"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0075","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1038\/sj.leu.2402238","article-title":"Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug","volume":"15","author":"Gout","year":"2001","journal-title":"Leukemia"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0080","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.phrs.2016.01.010","article-title":"Inhalation of growth factors and apo-transferrin to protect and repair the hypoxic-ischemic brain","volume":"109","author":"Guardia Clausi","year":"2016","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0085","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S1474-4422(13)70261-8","article-title":"Mitochondria: hub of injury responses in the developing brain","volume":"13","author":"Hagberg","year":"2014","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0090","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.redox.2017.01.021","article-title":"Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration","volume":"12","author":"Hambright","year":"2017","journal-title":"Redox Biol"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0095","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1073\/pnas.92.7.2539","article-title":"Aceruloplasminemia: molecular characterization of this disorder of iron metabolism","volume":"92","author":"Harris","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0100","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/WNR.0000000000001194","article-title":"Effect of erythropoietin on Fas\/FasL expression in brain tissues of neonatal rats with hypoxic-ischemic brain damage","volume":"30","author":"Huang","year":"2019","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0105","first-page":"143","article-title":"Lipid peroxidation-dependent cell death regulated by GPx4 and ferroptosis","volume":"403","author":"Imai","year":"2017","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0110","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cell.2017.11.048","article-title":"Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis","volume":"172","author":"Ingold","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0115","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pneurobio.2017.10.006","article-title":"Brain-immune interactions in perinatal hypoxic-ischemic brain injury","volume":"159","author":"Li","year":"2017","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0120","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1002\/glia.23734","article-title":"Neurochemical regulation of the expression and function of glial fibrillary acidic protein in astrocytes","volume":"68","author":"Li","year":"2020","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0125","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1038\/jcbfm.2011.75","article-title":"Lithium-mediated long-term neuroprotection in neonatal rat hypoxia-ischemia is associated with antiinflammatory effects and enhanced proliferation and survival of neural stem\/progenitor cells","volume":"31","author":"Li","year":"2011","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0130","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s12253-015-9946-3","article-title":"Ferroptosis is involved in acetaminophen induced cell death","volume":"21","author":"L\u0151rincz","year":"2015","journal-title":"Pathol Oncol Res"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0135","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/nyas.13008","article-title":"Iron and cancer: recent insights","volume":"1368","author":"Manz","year":"2016","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0140","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.pneurobio.2011.01.005","article-title":"GFAP in health and disease","volume":"93","author":"Middeldorp","year":"2011","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0145","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.phymed.2015.08.002","article-title":"Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells","volume":"22","author":"Ooko","year":"2015","journal-title":"Phytomedicine"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0150","doi-asserted-by":"crossref","first-page":"17982","DOI":"10.1523\/JNEUROSCI.2250-11.2011","article-title":"Iron and iron regulatory proteins in amoeboid microglial cells are linked to oligodendrocyte death in hypoxic neonatal rat periventricular white matter through production of proinflammatory cytokines and reactive oxygen\/nitrogen species","volume":"31","author":"Rathnasamy","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0155","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1021\/ja411006a","article-title":"Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models","volume":"136","author":"Skouta","year":"2014","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0160","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.590789","article-title":"The role of iron, its metabolism and ferroptosis in traumatic brain injury","volume":"14","author":"Tang","year":"2020","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0165","doi-asserted-by":"crossref","DOI":"10.3791\/955-v","article-title":"The hypoxic-ischemic encephalopathy model of perinatal ischemia","author":"Taniguchi","year":"2008","journal-title":"J Vis Exp."},{"key":"10.1016\/j.neuroscience.2022.02.013_b0170","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.canlet.2018.04.021","article-title":"Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT","volume":"428","author":"Wang","year":"2018","journal-title":"Cancer Lett"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0175","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.3892\/etm.2016.3550","article-title":"Insights into the role of iron in immature rat model of hypoxic-ischemic brain injury","volume":"12","author":"Wang","year":"2016","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0180","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.1007\/s12035-018-1403-3","article-title":"Ferroptosis and its role in diverse brain diseases","volume":"56","author":"Weiland","year":"2019","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0185","doi-asserted-by":"crossref","first-page":"5962","DOI":"10.1007\/s12035-015-9488-4","article-title":"Neuroprotective effects of a PSD-95 inhibitor in neonatal hypoxic-ischemic brain injury","volume":"53","author":"Xu","year":"2016","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0190","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nature05859","article-title":"RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels","volume":"447","author":"Yagoda","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0195","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0200","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: death by lipid peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0205","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.freeradbiomed.2012.02.043","article-title":"Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain","volume":"52","author":"Yoo","year":"2012","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.neuroscience.2022.02.013_b0210","doi-asserted-by":"crossref","first-page":"113828","DOI":"10.1016\/j.expneurol.2021.113828","article-title":"Inhibition of TLR4 prevents hippocampal hypoxic-ischemic injury by regulating ferroptosis in neonatal rats","volume":"345","author":"Zhu","year":"2021","journal-title":"Exp Neurol"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452222000677?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452222000677?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:11:12Z","timestamp":1759680672000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452222000677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":42,"alternative-id":["S0306452222000677"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2022.02.013","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ferroptosis is Involved in Hypoxic-ischemic Brain Damage in Neonatal Rats","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2022.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Ltd on behalf of IBRO.","name":"copyright","label":"Copyright"}]}}