{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:08:37Z","timestamp":1774008517839,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901142"],"award-info":[{"award-number":["81901142"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012397","name":"Army Medical University","doi-asserted-by":"publisher","award":["2017XYY05"],"award-info":[{"award-number":["2017XYY05"]}],"id":[{"id":"10.13039\/501100012397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.neuroscience.2022.06.009","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T13:10:50Z","timestamp":1654866650000},"page":"27-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["p75NTR Ectodomain Ameliorates Cognitive Deficits and Pathologies in a Rapid Eye Movement Sleep Deprivation Mice Model"],"prefix":"10.1016","volume":"496","author":[{"given":"Yang","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Hao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling-Yi","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Yue","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2022.06.009_b0005","article-title":"Astrocytes as essential time-keepers of the central pacemaker","author":"Astiz","year":"2021","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0010","doi-asserted-by":"crossref","first-page":"10221","DOI":"10.1523\/JNEUROSCI.2757-12.2013","article-title":"p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks","volume":"33","author":"Baeza-Raja","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0015","doi-asserted-by":"crossref","first-page":"11373","DOI":"10.1523\/JNEUROSCI.23-36-11373.2003","article-title":"Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad","volume":"23","author":"Bhakar","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0020","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.neuroscience.2006.06.026","article-title":"Increased apoptosis in rat brain after rapid eye movement sleep loss","volume":"142","author":"Biswas","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0025","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.neulet.2017.04.047","article-title":"Sleep deprivation accelerates the progression of alzheimer's disease by influencing A\u03b2-related metabolism","volume":"650","author":"Chen","year":"2017","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0030","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3233\/JAD-170032","article-title":"Cerebrospinal fluid amyloid-\u03b2 levels are increased in patients with insomnia","volume":"61","author":"Chen","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0035","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/glia.24090","article-title":"Microglia modulate hippocampal synaptic transmission and sleep duration along the light\/dark cycle","volume":"70","author":"Corsi","year":"2022","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0040","doi-asserted-by":"crossref","first-page":"e016047","DOI":"10.1161\/JAHA.119.016047","article-title":"Recombinant extracellular domain (p75ECD) of the neurotrophin receptor p75 attenuates myocardial ischemia-reperfusion injury by inhibiting the p-JNK\/caspase-3 signaling pathway in rat microvascular pericytes","volume":"9","author":"Fang","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0045","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/j.2040-4603.2020.tb00121.x","article-title":"Role of glia in the regulation of sleep in health and disease","volume":"10","author":"Garofalo","year":"2020","journal-title":"Compr Physiol"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0050","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s12035-021-02699-x","article-title":"The effect of sleep deprivation and subsequent recovery period on the synaptic proteome of rat cerebral cortex","volume":"59","author":"Guly\u00e1ssy","year":"2022","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0055","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.cellsig.2012.02.010","article-title":"The impact of sleep deprivation on neuronal and glial signaling pathways important for memory and synaptic plasticity","volume":"24","author":"Havekes","year":"2012","journal-title":"Cell Signal"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0060","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.tins.2012.03.007","article-title":"p75 neurotrophin receptor signaling in nervous system injury and degeneration: paradox and opportunity","volume":"35","author":"Ib\u00e1\u00f1ez","year":"2012","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0065","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S1474-4422(18)30450-2","article-title":"Implications of sleep disturbance and inflammation for Alzheimer's disease dementia","volume":"18","author":"Irwin","year":"2019","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0070","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.freeradbiomed.2018.01.026","article-title":"Circadian control of p75 neurotrophin receptor leads to alternate activation of Nrf2 and c-Rel to reset energy metabolism in astrocytes via brain-derived neurotrophic factor","volume":"119","author":"Ishii","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0075","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ddtec.2016.09.004","article-title":"Translational pharmacokinetics and pharmacodynamics of monoclonal antibodies","volume":"21\u201322","author":"Kamath","year":"2016","journal-title":"Drug Discov Today Technol"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0080","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1126\/science.1180962","article-title":"Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle","volume":"326","author":"Kang","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0085","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2174\/1389200221666200502015203","article-title":"Preclinical study of the pharmacokinetics of p75ECD-Fc, a novel human recombinant protein for treatment of Alzheimer's disease, in Sprague Dawley rats","volume":"21","author":"Kelliny","year":"2020","journal-title":"Curr Drug Metab"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0090","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/sleep\/33.1.37","article-title":"Trends in the prevalence of short sleepers in the USA: 1975\u20132006","volume":"33","author":"Knutson","year":"2010","journal-title":"Sleep"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0095","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00406-019-01075-0","article-title":"Do sleep disturbances contribute to cognitive impairments in schizophrenia spectrum and bipolar disorders?","volume":"270","author":"Laskemoen","year":"2020","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0100","doi-asserted-by":"crossref","first-page":"112905","DOI":"10.1016\/j.bbr.2020.112905","article-title":"Blockage of p75(NTR) ameliorates depressive-like behaviours of mice under chronic unpredictable mild stress","volume":"396","author":"Lin","year":"2021","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0105","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.drudis.2013.07.020","article-title":"Immunity and Alzheimer's disease: immunological perspectives on the development of novel therapies","volume":"18","author":"Liu","year":"2013","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0110","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.1523\/JNEUROSCI.3547-05.2006","article-title":"Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death","volume":"26","author":"Massa","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0115","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1126\/science.1197623","article-title":"Decreased clearance of CNS beta-amyloid in Alzheimer's disease","volume":"330","author":"Mawuenyega","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0120","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3233\/JAD-140036","article-title":"Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in A\u03b2PP(L\/S) transgenic mice","volume":"42","author":"Nguyen","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0125","first-page":"e13028","article-title":"Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathology","author":"Niu","year":"2021","journal-title":"Brain Pathol"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0130","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/nm.3302","article-title":"PDK1 decreases TACE-mediated \u03b1-secretase activity and promotes disease progression in prion and Alzheimer's diseases","volume":"19","author":"Pietri","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0135","doi-asserted-by":"crossref","first-page":"48043","DOI":"10.1074\/jbc.M205324200","article-title":"NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway","volume":"277","author":"Salehi","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0140","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer's disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0145","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.smrv.2017.06.010","article-title":"Sleep disturbances increase the risk of dementia: A systematic review and meta-analysis","volume":"40","author":"Shi","year":"2018","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0150","first-page":"R142","article-title":"Recombinant tumor necrosis factor and interleukin 1 enhance slow-wave sleep","volume":"253","author":"Shoham","year":"1987","journal-title":"Am J Physiol"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0155","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.1073\/pnas.1721694115","article-title":"\u03b2-Amyloid accumulation in the human brain after one night of sleep deprivation","volume":"115","author":"Shokri-Kojori","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0160","first-page":"e829","article-title":"Association of sleep, neuropsychological performance, and gray matter volume with glymphatic function in community-dwelling older adults","volume":"98","author":"Siow","year":"2021","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0165","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.cub.2015.01.016","article-title":"Sleep interacts with a\u03b2 to modulate intrinsic neuronal excitability","volume":"25","author":"Tabuchi","year":"2015","journal-title":"Curr Biol"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0170","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nrneurol.2017.147","article-title":"A systemic view of Alzheimer disease - insights from amyloid-\u03b2 metabolism beyond the brain","volume":"13","author":"Wang","year":"2017","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0175","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1523\/JNEUROSCI.2733-10.2011","article-title":"p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain","volume":"31","author":"Wang","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0180","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/jnc.13616","article-title":"Intramuscular delivery of p75NTR ectodomain by an AAV vector attenuates cognitive deficits and Alzheimer's disease-like pathologies in APP\/PS1 transgenic mice","volume":"138","author":"Wang","year":"2016","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0185","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3233\/JAD-171012","article-title":"Cysteine-rich repeat domains 2 and 4 are amyloid-\u03b2 binding domains of neurotrophin receptor p75NTR and potential targets to block amyloid-\u03b2 neurotoxicity","volume":"63","author":"Wang","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0190","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1523\/JNEUROSCI.2876-18.2019","article-title":"The p75 neurotrophin receptor is an essential mediator of impairments in hippocampal-dependent associative plasticity and memory induced by sleep deprivation","volume":"39","author":"Wong","year":"2019","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0195","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.1241224","article-title":"Sleep drives metabolite clearance from the adult brain","volume":"342","author":"Xie","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0200","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s40478-020-01034-0","article-title":"Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice","volume":"8","author":"Yang","year":"2020","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0205","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1038\/mp.2015.49","article-title":"p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer's disease","volume":"20","author":"Yao","year":"2015","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0210","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1177\/1073858410381532","article-title":"Sink hypothesis and therapeutic strategies for attenuating Abeta levels","volume":"17","author":"Zhang","year":"2011","journal-title":"Neuroscientist"},{"key":"10.1016\/j.neuroscience.2022.06.009_b0215","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1523\/JNEUROSCI.16-09-02901.1996","article-title":"Differential expression of the p75 nerve growth factor receptor in glia and neurons of the rat dorsal root ganglia after peripheral nerve transection","volume":"16","author":"Zhou","year":"1996","journal-title":"J Neurosci"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452222002949?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452222002949?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:11:52Z","timestamp":1759680712000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452222002949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":43,"alternative-id":["S0306452222002949"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2022.06.009","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"p75NTR Ectodomain Ameliorates Cognitive Deficits and Pathologies in a Rapid Eye Movement Sleep Deprivation Mice Model","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2022.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}