{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:15:51Z","timestamp":1775150151346,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.neuroscience.2022.06.037","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T11:20:56Z","timestamp":1657020056000},"page":"12-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Mesenchymal Stem Cell-derived Extracellular Vesicle-enclosed microRNA-93 Prevents Hypoxic-ischemic Brain Damage in Rats"],"prefix":"10.1016","volume":"500","author":[{"given":"Xiaoding","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuelai","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guonian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.neuroscience.2022.06.037_b0005","doi-asserted-by":"crossref","first-page":"e77098","DOI":"10.1371\/journal.pone.0077098","article-title":"Involvement of miRNAs in the differentiation of human glioblastoma multiforme stem-like cells","volume":"8","author":"Aldaz","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.neuroscience.2022.06.037_b0010","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12035-013-8504-9","article-title":"Exosomes: a new weapon to treat the central nervous system","volume":"49","author":"Braccioli","year":"2014","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2022.06.037_b0015","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21175986","article-title":"MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases","volume":"21","author":"Catanesi","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.neuroscience.2022.06.037_b0020","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12974-018-1077-9","article-title":"IRE1alpha inhibition decreased TXNIP\/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats","volume":"15","author":"Chen","year":"2018","journal-title":"J Neuroinflamm"},{"issue":"2","key":"10.1016\/j.neuroscience.2022.06.037_b0025","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/ejn.13784","article-title":"Preservation of neuronal functions by exosomes derived from different human neural cell types under ischemic conditions","volume":"47","author":"Deng","year":"2018","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2022.06.037_b0030","doi-asserted-by":"crossref","first-page":"735","DOI":"10.5114\/aoms.2017.71076","article-title":"MicroRNA-135b-5p prevents oxygen-glucose deprivation and reoxygenation-induced neuronal injury through regulation of the GSK-3beta\/Nrf2\/ARE signaling pathway","volume":"14","author":"Duan","year":"2018","journal-title":"Archiv Med Sci: AMS"},{"key":"10.1016\/j.neuroscience.2022.06.037_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresbull.2019.06.004","article-title":"Long non-coding RNA MALAT1 sponges microRNA-429 to regulate apoptosis of hippocampal neurons in hypoxic-ischemic brain damage by regulating WNT1","volume":"152","author":"Fang","year":"2019","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.neuroscience.2022.06.037_b0040","doi-asserted-by":"crossref","first-page":"18587","DOI":"10.1038\/srep18587","article-title":"Endogenous IL-6 of mesenchymal stem cell improves behavioral outcome of hypoxic-ischemic brain damage neonatal rats by supressing apoptosis in astrocyte","volume":"6","author":"Gu","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.neuroscience.2022.06.037_b0045","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.expneurol.2018.09.006","article-title":"Mesenchymal stem cells-derived IL-6 activates AMPK\/mTOR signaling to inhibit the proliferation of reactive astrocytes induced by hypoxic-ischemic brain damage","volume":"311","author":"He","year":"2019","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2022.06.037_b0050","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/jcmm.12040","article-title":"HDAC4\/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia\/reperfusion injury","volume":"17","author":"He","year":"2013","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.neuroscience.2022.06.037_b0055","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/WNR.0000000000001194","article-title":"Effect of erythropoietin on Fas\/FasL expression in brain tissues of neonatal rats with hypoxic-ischemic brain damage","volume":"30","author":"Huang","year":"2019","journal-title":"Neuroreport"},{"issue":"2","key":"10.1016\/j.neuroscience.2022.06.037_b0060","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1021\/ci200584f","article-title":"Exploring inhibitor release pathways in histone deacetylases using random acceleration molecular dynamics simulations","volume":"52","author":"Kalyaanamoorthy","year":"2012","journal-title":"J Chem Inf Model"},{"key":"10.1016\/j.neuroscience.2022.06.037_b0065","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3389\/fnins.2019.01149","article-title":"Progress of Research on Exosomes in the Protection Against Ischemic Brain Injury","volume":"13","author":"Kang","year":"2019","journal-title":"Front Neurosci"},{"issue":"sup1","key":"10.1016\/j.neuroscience.2022.06.037_b0070","doi-asserted-by":"crossref","first-page":"S189","DOI":"10.1517\/14712598.2012.680018","article-title":"Exosomal RNA as biomarkers and the therapeutic potential of exosome vectors","volume":"12","author":"L\u00e4sser","year":"2012","journal-title":"Expert Opin Biol Ther"},{"issue":"6","key":"10.1016\/j.neuroscience.2022.06.037_b0075","doi-asserted-by":"crossref","first-page":"e67411","DOI":"10.1371\/journal.pone.0067411","article-title":"Dynamic Activity of miR-125b and miR-93 during Murine Neural Stem Cell Differentiation In Vitro and in the Subventricular Zone Neurogenic Niche","volume":"8","author":"Lattanzi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2022.06.037_b0080","first-page":"1","article-title":"Role of Phosphorylated HDAC4 in Stroke-Induced Angiogenesis","volume":"2017","author":"Liu","year":"2017","journal-title":"Biomed Res Int"},{"issue":"9","key":"10.1016\/j.neuroscience.2022.06.037_b0085","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1002\/sctm.19-0327","article-title":"Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease","volume":"9","author":"Losurdo","year":"2020","journal-title":"Stem Cells Translat Med"},{"key":"10.1016\/j.neuroscience.2022.06.037_b0090","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jocn.2018.12.003","article-title":"Blood microRNA-93 as an indicator for diagnosis and prediction of functional recovery of acute stroke patients","volume":"62","author":"Ma","year":"2019","journal-title":"J Clin Neurosci"},{"issue":"2","key":"10.1016\/j.neuroscience.2022.06.037_b0095","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1167\/iovs.17-22855","article-title":"Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Promote Neuroprotection in Rodent Models of Glaucoma","volume":"59","author":"Mead","year":"2018","journal-title":"Investig Ophthalmol Visual Sci"},{"issue":"2","key":"10.1016\/j.neuroscience.2022.06.037_b0100","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10571-018-0642-1","article-title":"miR-9 Upregulation Integrates Post-ischemic Neuronal Survival and Regeneration In Vitro","volume":"39","author":"Nampoothiri","year":"2019","journal-title":"Cell Mol Neurobiol"},{"issue":"3","key":"10.1016\/j.neuroscience.2022.06.037_b0105","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s12975-018-0654-7","article-title":"Role of Exosomes as a Treatment and Potential Biomarker for Stroke","volume":"10","author":"Otero-Ortega","year":"2019","journal-title":"Transl Stroke Res"},{"issue":"7","key":"10.1016\/j.neuroscience.2022.06.037_b0110","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1177\/0963689717715168","article-title":"Neural Stem Cell Transplantation Is Associated with Inhibition of Apoptosis, Bcl-xL Upregulation, and Recovery of Neurological Function in a Rat Model of Traumatic Brain Injury","volume":"26","author":"Pang","year":"2017","journal-title":"Cell Transplant"},{"key":"10.1016\/j.neuroscience.2022.06.037_b0115","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s13287-018-1069-9","article-title":"Mesenchymal stem cell-derived extracellular vesicles affect disease outcomes via transfer of microRNAs","volume":"9","author":"Qiu","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.neuroscience.2022.06.037_b0120","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.201211138","article-title":"Extracellular vesicles: exosomes, microvesicles, and friends","volume":"200","author":"Raposo","year":"2013","journal-title":"J Cell Biol"},{"issue":"6","key":"10.1016\/j.neuroscience.2022.06.037_b0125","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1021\/acsnano.9b01004","article-title":"Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders","volume":"13","author":"Riazifar","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.neuroscience.2022.06.037_b0130","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.3892\/mmr.2016.5158","article-title":"TLR2\/NFkappaB signalling regulates endogenous IL-6 release from marrow-derived mesenchymal stromal cells to suppress the apoptosis of PC12 cells injured by oxygen and glucose deprivation","volume":"13","author":"Shi","year":"2016","journal-title":"Mol Med Rep"},{"issue":"2","key":"10.1016\/j.neuroscience.2022.06.037_b0135","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1159\/000486923","article-title":"Effects of MicroRNA-592-5p on Hippocampal Neuron Injury Following Hypoxic-Ischemic Brain Damage in Neonatal Mice - Involvement of PGD2\/DP and PTGDR","volume":"45","author":"Sun","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.neuroscience.2022.06.037_b0140","doi-asserted-by":"crossref","first-page":"113039","DOI":"10.1016\/j.expneurol.2019.113039","article-title":"Early TLR4 inhibition reduces hippocampal injury at puberty in a rat model of neonatal hypoxic-ischemic brain damage via regulation of neuroimmunity and synaptic plasticity","volume":"321","author":"Tang","year":"2019","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2022.06.037_b0145","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.3892\/etm.2017.4874","article-title":"MicroRNA-93 inhibits inflammatory responses and cell apoptosis after cerebral ischemia reperfusion by targeting interleukin-1 receptor-associated kinase 4","volume":"14","author":"Tian","year":"2017","journal-title":"Exp Ther Med"},{"issue":"4","key":"10.1016\/j.neuroscience.2022.06.037_b0150","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/jpi.12226","article-title":"Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation","volume":"58","author":"Wei","year":"2015","journal-title":"J Pineal Res"},{"issue":"2","key":"10.1016\/j.neuroscience.2022.06.037_b0155","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/TA.0000000000002563","article-title":"Early Single-Dose Treatment with Exosomes Provides Neuroprotection and Improves Blood-Brain Barrier Integrity in Swine Model of Traumatic Brain Injury and Hemorrhagic Shock","volume":"88","author":"Williams","year":"2020","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.neuroscience.2022.06.037_b0160","first-page":"5295","article-title":"MiR-93 blocks STAT3 to alleviate hepatic injury after ischemia-reperfusion","volume":"22","author":"Xiong","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"10.1016\/j.neuroscience.2022.06.037_b0165","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/jnc.13534","article-title":"Elevated serum miR-93, miR-191, and miR-499 are noninvasive biomarkers for the presence and progression of traumatic brain injury","volume":"137","author":"Yang","year":"2016","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2022.06.037_b0170","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.nbd.2016.03.004","article-title":"Nuclear translocation of histone deacetylase 4 induces neuronal death in stroke","volume":"91","author":"Yuan","year":"2016","journal-title":"Neurobiol Dis"},{"issue":"3","key":"10.1016\/j.neuroscience.2022.06.037_b0175","doi-asserted-by":"crossref","first-page":"e92129","DOI":"10.1371\/journal.pone.0092129","article-title":"The anti-oxidative role of micro-vesicles derived from human Wharton-Jelly mesenchymal stromal cells through NOX2\/gp91(phox) suppression in alleviating renal ischemia-reperfusion injury in rats","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2022.06.037_b0180","doi-asserted-by":"crossref","first-page":"931","DOI":"10.3389\/fneur.2018.00931","article-title":"MicroRNA-21 Overexpression Promotes the Neuroprotective Efficacy of Mesenchymal Stem Cells for Treatment of Intracerebral Hemorrhage","volume":"9","author":"Zhang","year":"2018","journal-title":"Front Neurol"},{"key":"10.1016\/j.neuroscience.2022.06.037_b0185","first-page":"1","article-title":"Neuroprotective Effect of SCM-198 through Stabilizing Endothelial Cell Function","volume":"2019","author":"Zhang","year":"2019","journal-title":"Oxid Med Cell Longev"},{"issue":"4","key":"10.1016\/j.neuroscience.2022.06.037_b0190","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3171\/2014.11.JNS14770","article-title":"Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury","volume":"122","author":"Zhang","year":"2015","journal-title":"J Neurosurg"},{"key":"10.1016\/j.neuroscience.2022.06.037_b0195","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fnins.2019.00016","article-title":"miRNA-7a-2-3p Inhibits Neuronal Apoptosis in Oxygen-Glucose Deprivation (OGD) Model","volume":"13","author":"Zhang","year":"2019","journal-title":"Front Neurosci"},{"issue":"1","key":"10.1016\/j.neuroscience.2022.06.037_b0200","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.bbrc.2018.02.070","article-title":"GAS5 silencing protects against hypoxia\/ischemia-induced neonatal brain injury","volume":"497","author":"Zhao","year":"2018","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452222003402?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452222003402?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:24:56Z","timestamp":1775147096000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452222003402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":40,"alternative-id":["S0306452222003402"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2022.06.037","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesenchymal Stem Cell-derived Extracellular Vesicle-enclosed microRNA-93 Prevents Hypoxic-ischemic Brain Damage in Rats","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2022.06.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}