{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:28:01Z","timestamp":1780072081218,"version":"3.54.0"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.neuroscience.2022.12.012","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T11:29:41Z","timestamp":1672313381000},"page":"53-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Spatial Disorientation Under Dark Conditions Across Development in an Alzheimer\u2019s Disease Mouse Model"],"prefix":"10.1016","volume":"511","author":[{"given":"Ashley A","family":"Blackwell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine M","family":"Jodelka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami I.","family":"Lake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"Hastings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas G.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.neuroscience.2022.12.012_b0005","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1080\/13607863.2019.1566813","article-title":"Vestibular impairment, cognitive decline and Alzheimer's disease: balancing the evidence","volume":"24","author":"Agrawal","year":"2019","journal-title":"Aging Ment Health"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0010","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fnagi.2015.00030","article-title":"Regional and sub-regional differences in hippocampal GABAergic neuronal vulnerability in the TgCRND8 mouse model of Alzheimer's disease","volume":"7","author":"Albuquerque","year":"2015","journal-title":"Front Aging Neurosci"},{"issue":"2","key":"10.1016\/j.neuroscience.2022.12.012_b0015","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.neurobiolaging.2014.08.032","article-title":"Altered brain development in an early-onset murine model of Alzheimer's disease","volume":"36","author":"Allemang-Grand","year":"2015","journal-title":"Neurobiol Aging"},{"issue":"8","key":"10.1016\/j.neuroscience.2022.12.012_b0020","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/hipo.20304","article-title":"Processing idiothetic cues to remember visited locations: hippocampal and vestibular contributions to radial-arm maze performance","volume":"17","author":"Allen","year":"2007","journal-title":"Hippocampus"},{"issue":"1","key":"10.1016\/j.neuroscience.2022.12.012_b0025","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3233\/JAD-150855","article-title":"Spatial Navigation in Preclinical Alzheimer's Disease","volume":"52","author":"Allison","year":"2016","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"10.1016\/j.neuroscience.2022.12.012_b0030","doi-asserted-by":"crossref","first-page":"544","DOI":"10.2353\/ajpath.2006.051107","article-title":"Reduction of amyloid angiopathy and Abeta plaque burden after enriched housing in TgCRND8 mice: involvement of multiple pathways","volume":"169","author":"Ambr\u00e9e","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0035","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1017\/S0959259800002549","article-title":"Ultrastructural and biochemical basis of Alzheimer\u2019s disease","volume":"1","author":"Anderton","year":"1991","journal-title":"Rev Clin Gerontol"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0040","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.gaitpost.2018.12.016","article-title":"Reduced vestibular function is associated with longer, slower steps in healthy adults during normal speed walking","volume":"68","author":"Anson","year":"2019","journal-title":"Gait Posture"},{"issue":"4","key":"10.1016\/j.neuroscience.2022.12.012_b0045","first-page":"1125","article-title":"Effects of acquired vestibular pathology on the organization of mouse exploratory behavior","volume":"239","author":"Banovetz","year":"2021","journal-title":"EBR"},{"issue":"4558","key":"10.1016\/j.neuroscience.2022.12.012_b0050","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1126\/science.7046051","article-title":"The cholinergic hypothesis of geriatric memory dysfunction","volume":"217","author":"Bartus","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0055","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical, cognitive, and biomarker changes in the Dominantly Inherited Alzheimer Network","volume":"367","author":"Bateman","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0060","series-title":"Circular Statistics in Biology","author":"Batschelet","year":"1981"},{"issue":"3","key":"10.1016\/j.neuroscience.2022.12.012_b0065","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1037\/0735-7044.110.3.460","article-title":"Intact spatial learning in both young and aged rats following selective removal of hippocampal cholinergic input","volume":"110","author":"Baxter","year":"1996","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0070","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.nbd.2006.03.012","article-title":"Cholinergic dysfunction, neuronal damage and axonal loss in TgCRND8 mice","volume":"23","author":"Bellucci","year":"2006","journal-title":"Neurobiol Dis"},{"issue":"3","key":"10.1016\/j.neuroscience.2022.12.012_b0075","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1152\/jn.01260.2003","article-title":"When is vestibular information important during walking?","volume":"92","author":"Bent","year":"2004","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0080","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.neuron.2010.10.013","article-title":"The Genetics of Alzheimer Disease: Back to the Future","volume":"68","author":"Bertram","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2017.02.031","article-title":"Otolith dysfunction alters exploratory movement in mice","volume":"325","author":"Blankenship","year":"2017","journal-title":"Behav Brain Res"},{"issue":"4","key":"10.1016\/j.neuroscience.2022.12.012_b0090","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3109\/00016489409126075","article-title":"Vestibular morphology in relation to age and circling behavior","volume":"114","author":"Bloom","year":"1994","journal-title":"Acta Otolaryngol"},{"issue":"3","key":"10.1016\/j.neuroscience.2022.12.012_b0095","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/6374","article-title":"Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice","volume":"2","author":"Chapman","year":"1999","journal-title":"Nat Neurosci"},{"issue":"24","key":"10.1016\/j.neuroscience.2022.12.012_b0100","doi-asserted-by":"crossref","first-page":"21562","DOI":"10.1074\/jbc.M100710200","article-title":"Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695*","volume":"276","author":"Chishti","year":"2001","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.neuroscience.2022.12.012_b0105","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.neubiorev.2011.03.001","article-title":"Revisiting the cholinergic hypothesis in the development of Alzheimer\u2019s disease","volume":"35","author":"Craig","year":"2011","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0110","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbr.2017.10.012","article-title":"Antisense oligonucleotide therapy rescues disruptions in organization of exploratory movements associated with Usher syndrome type 1C in mice","volume":"338","author":"Donaldson","year":"2018","journal-title":"Behav Brain Res"},{"issue":"2","key":"10.1016\/j.neuroscience.2022.12.012_b0115","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0165-0270(99)00194-6","article-title":"Statistical discrimination of natural modes of motion in rat exploratory behavior","volume":"96","author":"Drai","year":"2000","journal-title":"J Neurosci Methods"},{"issue":"5","key":"10.1016\/j.neuroscience.2022.12.012_b0120","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0149-7634(01)00022-7","article-title":"SEE: a tool for the visualization and analysis of rodent exploratory behavior","volume":"25","author":"Drai","year":"2001","journal-title":"Neurosci Biobehav Rev"},{"issue":"7","key":"10.1016\/j.neuroscience.2022.12.012_b0125","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.neurobiolaging.2003.08.008","article-title":"Inflammation occurs early during the Abeta deposition process in TgCRND8 mice","volume":"25","author":"Dudal","year":"2004","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0130","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000080004","article-title":"Visuospatial Disorientation in Alzheimer\u2019s Disease: Impaired Spatiotemporal Integration in Visual Information Processing","author":"Duffy","year":"2004","journal-title":"Vision Alzheimer\u2019s Dis"},{"issue":"4","key":"10.1016\/j.neuroscience.2022.12.012_b0135","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1152\/jn.00005.2017","article-title":"The role of the hippocampus in navigation is memory","volume":"117","author":"Eichenbaum","year":"2017","journal-title":"J Neurophysiol"},{"issue":"3","key":"10.1016\/j.neuroscience.2022.12.012_b0140","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0166-4328(89)80102-0","article-title":"Home base behavior of rats (Rattus norvegicus) exploring a novel environment","volume":"34","author":"Eilam","year":"1989","journal-title":"Behav Brain Res"},{"issue":"1","key":"10.1016\/j.neuroscience.2022.12.012_b0145","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/msj.20159","article-title":"Transgenic Mouse Models of Alzheimer\u2019s Disease","volume":"77","author":"Elder","year":"2010","journal-title":"Mt Sinai J Med"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0150","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.cub.2006.05.063","article-title":"Resolving Head Rotation for Human Bipedalism","volume":"16","author":"Fitzpatrick","year":"2006","journal-title":"Curr Biol"},{"issue":"8","key":"10.1016\/j.neuroscience.2022.12.012_b0155","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1038\/npp.2012.40","article-title":"Reduced tissue levels of noradrenaline are associated with behavioral phenotypes of the TgCRND8 mouse model of Alzheimer's disease","volume":"37","author":"Francis","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0160","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bbr.2005.10.008","article-title":"The septohippocampal cholinergic system and spatial working memory in the Morris water maze","volume":"168","author":"Frielingsdorf","year":"2006","journal-title":"Behav Brain Res"},{"issue":"8","key":"10.1016\/j.neuroscience.2022.12.012_b0165","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.neurobiolaging.2013.02.001","article-title":"Inhibition of SPT reduces AB and tau hyperphosphorylation in a mouse model, a safe therapeutic strategy for Alzheimer\u2019s disease","volume":"34","author":"Geekiyanage","year":"2013","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0170","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0006-291X(84)80190-4","article-title":"Alzheimer\u2019s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein","volume":"120","author":"Glenner","year":"1984","journal-title":"Biochem Biophys Res Commun"},{"issue":"6311","key":"10.1016\/j.neuroscience.2022.12.012_b0175","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/349704a0","article-title":"Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease","volume":"349","author":"Goate","year":"1991","journal-title":"Nature"},{"issue":"1\u20132","key":"10.1016\/j.neuroscience.2022.12.012_b0180","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0166-4328(05)80263-3","article-title":"Stopping behavior: constraints on exploration in rats (Rattus norvegicus)","volume":"53","author":"Golani","year":"1993","journal-title":"Behav Brain Res"},{"issue":"1","key":"10.1016\/j.neuroscience.2022.12.012_b0185","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bbr.2008.03.006","article-title":"Effects of environmental enrichment on exploration, anxiety, and memory in female TgCRND8 Alzheimer mice","volume":"191","author":"G\u00f6rtz","year":"2008","journal-title":"Behav Brain Res"},{"issue":"3","key":"10.1016\/j.neuroscience.2022.12.012_b0190","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3233\/JAD-150587","article-title":"A TgCRND8 Mouse Model of Alzheimer's Disease Exhibits Sexual Dimorphisms in Behavioral Indices of Cognitive Reserve","volume":"51","author":"Granger","year":"2016","journal-title":"J Alzheimers Dis"},{"issue":"7","key":"10.1016\/j.neuroscience.2022.12.012_b0195","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1093\/brain\/awy132","article-title":"The cholinergic system in the pathophysiology and treatment of Alzheimer's disease","volume":"141","author":"Hampel","year":"2018","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.neuroscience.2022.12.012_b0200","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1001\/archneur.1989.00520400045018","article-title":"Spatial disorientation in Alzheimer's disease","volume":"46","author":"Henderson","year":"1989","journal-title":"Arch Neurol"},{"issue":"9","key":"10.1016\/j.neuroscience.2022.12.012_b0205","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1111\/j.1460-9568.2005.04412.x","article-title":"Home bases formed to visual cues but not to self-movement (dead reckoning) cues in exploring hippocampectomized rats","volume":"22","author":"Hines","year":"2005","journal-title":"Eur J Neurosci"},{"issue":"4","key":"10.1016\/j.neuroscience.2022.12.012_b0210","doi-asserted-by":"crossref","first-page":"328","DOI":"10.15252\/emmm.201505846","article-title":"Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides","volume":"8","author":"Hinrich","year":"2016","journal-title":"EMBO Mol Med"},{"issue":"10","key":"10.1016\/j.neuroscience.2022.12.012_b0215","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1073\/pnas.0611314104","article-title":"Spatial navigation deficit in amnestic mild cognitive impairment","volume":"104","author":"Hort","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.neuroscience.2022.12.012_b0220","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.bbr.2004.12.017","article-title":"Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice","volume":"160","author":"Hyde","year":"2005","journal-title":"Behav Brain Res"},{"issue":"7","key":"10.1016\/j.neuroscience.2022.12.012_b0225","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1080\/00207450600936874","article-title":"Stereotypic circling behavior in mice with vestibular dysfunction: asymmetrical effects of intrastriatal microinjection of a dopamine agonist","volume":"117","author":"Ishiguro","year":"2007","journal-title":"Int J Neurosci"},{"issue":"1","key":"10.1016\/j.neuroscience.2022.12.012_b0230","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/epirev\/mxn008","article-title":"Dementia of the Alzheimer Type","volume":"30","author":"Jalbert","year":"2008","journal-title":"Epidemiol Rev"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0235","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/35050110","article-title":"Ab peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease","volume":"408","author":"Janus","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0240","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1006\/nbdi.2002.0557","article-title":"Long-term potentiation is increased in the CA1 area of the hippocampus of APPswe\/ind CRND8 mice","volume":"11","author":"Jolas","year":"2002","journal-title":"Neurobiol Dis"},{"issue":"11","key":"10.1016\/j.neuroscience.2022.12.012_b0245","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1111\/j.1460-9568.2004.03739.x","article-title":"Sexually dimorphic effects of hippocampal cholinergic deafferentation in rats","volume":"20","author":"Jonasson","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0250","series-title":"Principles of Neural Science","author":"Kandel","year":"2000"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0255","first-page":"165","article-title":"The lost Alzheimer\u2019s and related disorders search subject: new research and perspectives","volume":"1998","author":"Koester","year":"2015"},{"issue":"2","key":"10.1016\/j.neuroscience.2022.12.012_b0260","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1037\/a0030162","article-title":"Analysis of movement kinematics on analogous spatial learning tasks demonstrates conservation of direction and distance estimation across humans (Homo sapiens) and rats (Rattus norvegicus)","volume":"127","author":"K\u00f6ppen","year":"2013","journal-title":"J Comparat Psychol"},{"issue":"2","key":"10.1016\/j.neuroscience.2022.12.012_b0265","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3233\/JAD-2011-110830","article-title":"Hippocampal GABAergic neurons are susceptible to amyloid-\u03b2 toxicity in vitro and are decreased in number in the Alzheimer's disease TgCRND8 mouse model","volume":"29","author":"Krantic","year":"2012","journal-title":"J Alzheimers Dis"},{"issue":"5","key":"10.1016\/j.neuroscience.2022.12.012_b0270","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/geronb\/53B.5.P294","article-title":"The Gerontological Society of America Wandering: A Significant Problem Among Community Residing Individuals with Alzheimer's Disease","volume":"53","author":"Logsdon","year":"1998","journal-title":"J Gerontol: Psychol Sci"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0275","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1601-183X.2004.00104.x","article-title":"Working memory impairment in a transgenic amyloid precursor protein TgCRND8 mouse model of Alzheimer\u2019s disease","volume":"4","author":"Lovasic","year":"2005","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0280","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neulet.2011.10.056","article-title":"A\u03b2 plaque-associated glial reaction as a determinant of apoptopic neuronal death and cortical gliogenesis: A study in APP mutant mice","volume":"506","author":"Luccarini","year":"2012","journal-title":"Neurosci Lett"},{"issue":"20","key":"10.1016\/j.neuroscience.2022.12.012_b0285","doi-asserted-by":"crossref","first-page":"6736","DOI":"10.1523\/JNEUROSCI.5075-13.2014","article-title":"\u03b1-Melanocyte stimulating hormone prevents GABAergic neuronal loss and improves cognitive function in Alzheimer's disease","volume":"34","author":"Ma","year":"2014","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0290","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0166-4328(98)00100-4","article-title":"Homing with locale, taxon, and dead reckoning strategies by foraging rats: sensory hierarchy in spatial navigation","volume":"99","author":"Maaswinkel","year":"1999","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0295","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3389\/fnagi.2016.00327","article-title":"Phenotypic Alterations in Hippocampal NPY- and PV-Expressing Interneurons in a Presymptomatic Transgenic Mouse Model of Alzheimer\u2019s Disease","volume":"8","author":"Mahar","year":"2017","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0300","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbr.2007.05.026","article-title":"Selective hippocampal cholinergic deafferentation impairs self-movement cue use during a food hoarding task","volume":"183","author":"Martin","year":"2007","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0305","series-title":"Principles of Behavioral and Cognitive Psychology","author":"Mesulam","year":"2000"},{"issue":"4","key":"10.1016\/j.neuroscience.2022.12.012_b0310","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1155\/NP.2005.299","article-title":"Genetic Mouse Models of Alzheimer\u2019s disease","volume":"12","author":"Mineur","year":"2005","journal-title":"Neural Plast"},{"issue":"1","key":"10.1016\/j.neuroscience.2022.12.012_b0315","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3233\/JAD-142646","article-title":"Vestibular Function Impairment in Alzheimer's Disease","volume":"47","author":"Nakamagoe","year":"2015","journal-title":"J Alzheimers Dis"},{"issue":"10","key":"10.1016\/j.neuroscience.2022.12.012_b0320","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1136\/jnnp.74.10.1398","article-title":"A study of stereotypic behaviours in Alzheimer's disease and frontal and temporal variant frontotemporal dementia","volume":"74","author":"Nyatsanza","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.beproc.2021.104437","article-title":"Organization of exploratory behavior under dark conditions in female and male rats","author":"Osterlund Oltmanns","year":"2021","journal-title":"Behav Process"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.beproc.2022.104713","article-title":"Age-related changes in the organization of spontaneously occurring behaviors","author":"Osterlund Oltmanns","year":"2022","journal-title":"Behav Process"},{"issue":"16","key":"10.1016\/j.neuroscience.2022.12.012_b0335","doi-asserted-by":"crossref","first-page":"9572","DOI":"10.1073\/pnas.1133381100","article-title":"Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits","volume":"100","author":"Palop","year":"2003","journal-title":"Proc Natl Acad Sci"},{"issue":"4","key":"10.1016\/j.neuroscience.2022.12.012_b0340","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1365-2990.1978.tb00545.x","article-title":"Changes in brain cholinesterases in senile dementia of Alzheimer type","volume":"4","author":"Perry","year":"1978","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"6359","key":"10.1016\/j.neuroscience.2022.12.012_b0345","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1126\/science.aap8002","article-title":"The molecular basis of Alzheimer\u2019s plaques","volume":"358","author":"Pospich","year":"2017","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.neuroscience.2022.12.012_b0350","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1080\/13554791003730600","article-title":"Visual spatial cognition in neurodegenerative disease","volume":"16","author":"Possin","year":"2010","journal-title":"Neurocase"},{"issue":"11","key":"10.1016\/j.neuroscience.2022.12.012_b0355","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1007\/s00415-012-6528-0","article-title":"Stereotypic behaviors in degenerative dementias","volume":"259","author":"Prioni","year":"2012","journal-title":"J Neurol"},{"issue":"1","key":"10.1016\/j.neuroscience.2022.12.012_b0360","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.bbr.2008.02.005","article-title":"Wheel-running in a transgenic mouse model of Alzheimer's disease: protection or symptom?","volume":"190","author":"Richter","year":"2008","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0365","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.neurobiolaging.2018.02.025","article-title":"Motor coordination and synaptic plasticity deficits are associated with increased cerebellar activity of NADPH oxidase, CAMKII, and PKC at preplaque stage in the TgCRND8 mouse model of Alzheimer\u2019s disease","volume":"68","author":"Russo","year":"2018","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113577","article-title":"Differential organization of open field behavior in mice following acute or chronic simulated GCR exposure","volume":"416","author":"Schaeffer","year":"2022","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0375","series-title":"The biology of cholinesterases","author":"Silver","year":"1974"},{"issue":"10","key":"10.1016\/j.neuroscience.2022.12.012_b0380","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1002\/cne.23536","article-title":"Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer's disease mouse model","volume":"522","author":"Steele","year":"2014","journal-title":"J Comp Neurol"},{"issue":"1\u20132","key":"10.1016\/j.neuroscience.2022.12.012_b0385","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0165-0270(95)00050-X","article-title":"A phase plane representation of rat exploratory behavior","volume":"62","author":"Tchernichovski","year":"1995","journal-title":"J Neurosci Methods"},{"issue":"5","key":"10.1016\/j.neuroscience.2022.12.012_b0390","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1212\/WNL.52.5.958","article-title":"Visual loss and getting lost in Alzheimer\u2019s disease","volume":"52","author":"Tetewsky","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0395","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.neurobiolaging.2003.09.004","article-title":"Age- and sex-dependent development of adrenocortical hyperactivity in a transgenic mouse model of Alzheimer\u2019s disease","volume":"25","author":"Touma","year":"2004","journal-title":"Neurobiol Aging"},{"issue":"1","key":"10.1016\/j.neuroscience.2022.12.012_b0400","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3233\/JAD-201017","article-title":"Egocentric and Allocentric Spatial Memory in Mild Cognitive Impairment with Real-World and Virtual Navigation Tasks: A Systematic Review","volume":"79","author":"Tuena","year":"2021","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"10.1016\/j.neuroscience.2022.12.012_b0405","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1101\/lm.63504","article-title":"Extensive lesions of cholinergic basal forebrain neurons do not impair spatial working memory","volume":"11","author":"Vuckovich","year":"2004","journal-title":"Learn Mem"},{"issue":"1","key":"10.1016\/j.neuroscience.2022.12.012_b0410","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.bbr.2011.03.049","article-title":"Spatial learning and memory impairment and increased locomotion in a transgenic amyloid precursor protein mouse model of Alzheimer's disease","volume":"222","author":"Walker","year":"2011","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0415","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.lmot.2017.03.004","article-title":"Sequential organization of movement kinematics is associated with spatial orientation across scales and species","volume":"58","author":"Wallace","year":"2017","journal-title":"Learn Motiv"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0420","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0165-0270(01)00489-7","article-title":"Quantification of a single exploratory trip reveals hippocampal formation mediated dead reckoning","volume":"113","author":"Wallace","year":"2002","journal-title":"J Neurosci Methods"},{"issue":"3","key":"10.1016\/j.neuroscience.2022.12.012_b0425","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s10071-006-0023-x","article-title":"Movement characteristics support a role for dead reckoning in organizing exploratory behavior","volume":"9","author":"Wallace","year":"2006","journal-title":"Anim Cogn"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0430","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fgene.2014.00088","article-title":"Using mice to model Alzheimer\u2019s dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models","volume":"5","author":"Webster","year":"2014","journal-title":"Front Genet"},{"issue":"8","key":"10.1016\/j.neuroscience.2022.12.012_b0435","doi-asserted-by":"crossref","first-page":"5779","DOI":"10.1523\/JNEUROSCI.15-08-05779.1995","article-title":"Rats with fimbria-fornix lesions display a place response in a swimming pool: a dissociation between getting there and knowing where","volume":"15","author":"Whishaw","year":"1995","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.neuroscience.2022.12.012_b0440","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0006-8993(91)91199-B","article-title":"Immunolesioning: selective destruction of neurons using immunotoxin to rat NGF receptor","volume":"562","author":"Wiley","year":"1991","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2022.12.012_b0445","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1146\/annurev-neuro-080317-061725","article-title":"What Happens with the Circuit in Alzheimer's Disease in Mice and Humans?","volume":"41","author":"Zott","year":"2018","journal-title":"Annu Rev Neurosci"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452222006200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452222006200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:16:55Z","timestamp":1759681015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452222006200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":89,"alternative-id":["S0306452222006200"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2022.12.012","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spatial Disorientation Under Dark Conditions Across Development in an Alzheimer\u2019s Disease Mouse Model","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2022.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}