{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:32:29Z","timestamp":1789003949810,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.neuroscience.2022.12.014","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T11:23:33Z","timestamp":1671449013000},"page":"14-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Pre-ischaemic Treatment with Enriched Environment Alleviates Acute Neuronal Injury by Inhibiting Endoplasmic Reticulum Stress-dependent Autophagy and Apoptosis"],"prefix":"10.1016","volume":"513","author":[{"given":"Yu","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Ya","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Kun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"ping Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2022.12.014_b0005","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.nlm.2009.05.004","article-title":"A single exposure to an enriched environment stimulates the activation of discrete neuronal populations in the brain of the fos-tau-lacZ mouse","volume":"92","author":"Ali","year":"2009","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0010","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3389\/fpsyg.2019.00466","article-title":"Enriched Environments as a Potential Treatment for Developmental Disorders: A Critical Assessment","volume":"10","author":"Ball","year":"2019","journal-title":"Front Psychol"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0015","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3389\/fnagi.2018.00288","article-title":"Enriched Environment Significantly Reduced Senile Plaques in a Transgenic Mice Model of Alzheimer's Disease, Improving Memory","volume":"10","author":"Balthazar","year":"2018","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0020","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41572-019-0118-8","article-title":"Ischaemic stroke","volume":"5","author":"Campbell","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0025","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1038\/s41598-019-40887-x","article-title":"The tricyclic antidepressant clomipramine inhibits neuronal autophagic flux","volume":"9","author":"Cavaliere","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0030","doi-asserted-by":"crossref","first-page":"6541","DOI":"10.1007\/s11033-022-07494-y","article-title":"Effect of prior exposure to enriched environment on cellular apoptosis after experimental stroke","volume":"49","author":"Chen","year":"2022","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0035","doi-asserted-by":"crossref","first-page":"813","DOI":"10.4103\/1673-5374.297084","article-title":"Enriched environment boosts the post-stroke recovery of neurological function by promoting autophagy","volume":"16","author":"Deng","year":"2021","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0040","doi-asserted-by":"crossref","DOI":"10.3390\/cells9030695","article-title":"ER Stress Responses: An Emerging Modulator for Innate Immunity","volume":"9","author":"Di Conza","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0045","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1177\/17474930211065917","article-title":"World Stroke Organization (WSO): Global Stroke Fact Sheet 2022","volume":"17","author":"Feigin","year":"2022","journal-title":"Int J Stroke"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0050","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12395","article-title":"Pre-ischemia melatonin treatment alleviated acute neuronal injury after ischemic stroke by inhibiting endoplasmic reticulum stress-dependent autophagy via PERK and IRE1 signalings","volume":"62","author":"Feng","year":"2017","journal-title":"J Pineal Res"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0055","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.exer.2018.10.007","article-title":"Pre-ischemic enriched environment increases retinal resilience to acute ischemic damage in adult rats","volume":"178","author":"Gonz\u00e1lez Fleitas","year":"2019","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2022.105295","article-title":"Effects of enriched environment on microglia and functional white matter recovery in rats with post stroke cognitive impairment","volume":"154","author":"Guo","year":"2022","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2019.112564","article-title":"Alleviation of diazepam-induced conditioned place preference and its withdrawal-associated neurobehavioral deficits following pre-exposure to enriched environment in rats","volume":"208","author":"Haider","year":"2019","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0070","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.704334","article-title":"Mechanism of Endoplasmic Reticulum Stress in Cerebral Ischemia","volume":"15","author":"Han","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0075","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S1097-2765(00)80330-5","article-title":"Perk is essential for translational regulation and cell survival during the unfolded protein response","volume":"5","author":"Harding","year":"2000","journal-title":"Mol Cell"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113389","article-title":"Effects of enriched environment on depression and anxiety-like behavior induced by early life stress: A comparison between different periods","volume":"411","author":"Huang","year":"2021","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0085","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18020406","article-title":"Effects of Postnatal Enriched Environment in a Model of Parkinson's Disease in Adult Rats","volume":"18","author":"Jungling","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0090","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41583-019-0120-x","article-title":"Environmental enrichment, new neurons and the neurobiology of individuality","volume":"20","author":"Kempermann","year":"2019","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0095","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0100","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4161\/auto.4600","article-title":"How to interpret LC3 immunoblotting","volume":"3","author":"Mizushima","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0105","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/j.jacc.2019.10.034","article-title":"Management of Acute Ischemic Stroke Due to Large-Vessel Occlusion: JACC Focus Seminar","volume":"75","author":"Ospel","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0110","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jare.2021.01.016","article-title":"protects against cerebral ischemia\/reperfusion injury through endoplasmic reticulum stress and MAPK-mediated mechanisms","volume":"33","author":"Pan","year":"2021","journal-title":"J Adv Res"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0115","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0169-328X(98)00180-6","article-title":"Activation of gadd153 expression through transient cerebral ischemia: evidence that ischemia causes endoplasmic reticulum dysfunction","volume":"60","author":"Paschen","year":"1998","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0120","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cell.2005.07.002","article-title":"Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy","volume":"122","author":"Pattingre","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0125","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.nlm.2010.08.004","article-title":"Distinct patterns of Fos immunoreactivity in striatum and hippocampus induced by different kinds of novelty in mice","volume":"94","author":"Rinaldi","year":"2010","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0130","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cell.2007.12.017","article-title":"How IRE1 reacts to ER stress","volume":"132","author":"Ron","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0135","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tibs.2015.01.002","article-title":"UPR, autophagy, and mitochondria crosstalk underlies the ER stress response","volume":"40","author":"Senft","year":"2015","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0140","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1002\/jcp.25785","article-title":"Crosstalk of autophagy and apoptosis: Involvement of the dual role of autophagy under ER stress","volume":"232","author":"Song","year":"2017","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0145","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13024-017-0183-y","article-title":"Endoplasmic reticulum stress and inflammation in the central nervous system","volume":"12","author":"Sprenkle","year":"2017","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0150","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s10020-020-00236-5","article-title":"Acupuncture protects against cerebral ischemia-reperfusion injury via suppressing endoplasmic reticulum stress-mediated autophagy and apoptosis","volume":"26","author":"Sun","year":"2020","journal-title":"Mol Med (Cambridge Mass)"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0155","first-page":"1249","article-title":"Subcellular stress response and induction of molecular chaperones and folding proteins after transient global ischemia in rats","author":"Truettner","year":"2009","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0160","doi-asserted-by":"crossref","first-page":"766","DOI":"10.4161\/auto.27954","article-title":"Hepatitis C virus core protein activates autophagy through EIF2AK3 and ATF6 UPR pathway-mediated MAP1LC3B and ATG12 expression","volume":"10","author":"Wang","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0165","doi-asserted-by":"crossref","first-page":"246","DOI":"10.2174\/1566524020666200726221735","article-title":"The Melatonin and Enriched Environment Ameliorated Low Protein-Induced Intrauterine Growth Retardation by IGF-1 And mtor Signaling Pathway and Autophagy Inhibition in Rats","volume":"21","author":"Wang","year":"2021","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0170","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S1474-4422(18)30500-3","article-title":"Stroke in China: advances and challenges in epidemiology, prevention, and management","volume":"18","author":"Wu","year":"2019","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0175","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.brainres.2013.02.052","article-title":"Enriched environment preconditioning induced brain ischemic tolerance without reducing infarct volume and edema: the possible role of enrichment-related physical activity increase","volume":"1508","author":"Xie","year":"2013","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0180","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neuint.2014.02.001","article-title":"Endoplasmic reticulum stress in cerebral ischemia","volume":"68","author":"Xin","year":"2014","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0185","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1172\/JCI26373","article-title":"Endoplasmic reticulum stress: cell life and death decisions","volume":"115","author":"Xu","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0190","doi-asserted-by":"crossref","first-page":"8469","DOI":"10.1128\/MCB.19.12.8469","article-title":"BCL-2 is phosphorylated and inactivated by an ASK1\/Jun N-terminal protein kinase pathway normally activated at G(2)\/M","volume":"19","author":"Yamamoto","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0195","first-page":"1538","article-title":"Neuroprotective effects of prior exposure to enriched environment on cerebral ischemia\/reperfusion injury in rats: the possible molecular mechanism","author":"Yu","year":"2013","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0200","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.neuro.2013.09.002","article-title":"Prior exposure to enriched environment reduces nitric oxide synthase after transient MCAO in rats","volume":"39","author":"Yu","year":"2013","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105091","article-title":"The three-phase enriched environment paradigm promotes neurovascular restorative and prevents learning impairment after ischemic stroke in rats","volume":"146","author":"Zhan","year":"2020","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0210","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.brainres.2016.11.001","article-title":"Effect of enriched environment on angiogenesis and neurological functions in rats with focal cerebral ischemia","volume":"1655","author":"Zhang","year":"2017","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0215","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neuroscience.2011.01.018","article-title":"Exercise preconditioning and brain ischemic tolerance","volume":"177","author":"Zhang","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0220","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.brainres.2018.02.030","article-title":"Enriched environment promotes post-stroke neurogenesis through NF-\u03baB-mediated secretion of IL-17A from astrocytes","volume":"1687","author":"Zhang","year":"2018","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0225","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/00207454.2020.1797722","article-title":"Enriched environment improves post-stroke cognitive impairment and inhibits neuroinflammation and oxidative stress by activating Nrf2-ARE pathway","volume":"131","author":"Zhang","year":"2021","journal-title":"Int J Neurosci"},{"key":"10.1016\/j.neuroscience.2022.12.014_b0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2017.10.016","article-title":"Chrysophanol inhibits endoplasmic reticulum stress in cerebral ischemia and reperfusion mice","volume":"818","author":"Zhao","year":"2018","journal-title":"Eur J Pharmacol"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452222006224?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452222006224?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:16:25Z","timestamp":1759680985000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452222006224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":46,"alternative-id":["S0306452222006224"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2022.12.014","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pre-ischaemic Treatment with Enriched Environment Alleviates Acute Neuronal Injury by Inhibiting Endoplasmic Reticulum Stress-dependent Autophagy and Apoptosis","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2022.12.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Ltd on behalf of IBRO.","name":"copyright","label":"Copyright"}]}}