{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:59:14Z","timestamp":1790009954946,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.neuroscience.2023.08.005","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T20:55:13Z","timestamp":1692219313000},"page":"116-128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Effect of the Combination of Different Therapies on Oxidative Stress in the Experimental Model of Multiple Sclerosis"],"prefix":"10.1016","volume":"529","author":[{"given":"Bego\u00f1a M.","family":"Escribano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Mu\u00f1oz-Jurado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelio","family":"Luque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Galv\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"LaTorre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0571-5147","authenticated-orcid":false,"given":"Javier","family":"Caballero-Villarraso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana I.","family":"Giraldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Ag\u00fcera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"T\u00fanez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2023.08.005_b0005","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/7905148","article-title":"Oxidative modification of blood serum proteins in multiple sclerosis after interferon beta and melatonin treatment","volume":"2017","author":"Adamczyk-Sowa","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0010","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1973834","article-title":"New insights into the role of oxidative stress mechanisms in the pathophysiology and treatment of multiple sclerosis","volume":"2016","author":"Adamczyk","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fneur.2020.00817","article-title":"Impact of repetitive transcranial magnetic stimulation on neurocognition and oxidative stress in relapsing-remitting multiple sclerosis: A case report","volume":"11","author":"Ag\u00fcera","year":"2020","journal-title":"Front Neurol"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0020","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1080\/1028415X.2019.1659560","article-title":"Effect of omega-3 fatty acids and fish oil supplementation on multiple sclerosis: A systematic review","volume":"24","author":"AlAmmar","year":"2021","journal-title":"Nutr Neurosci"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0025","doi-asserted-by":"crossref","DOI":"10.3390\/nu11020427","article-title":"New insights on the nutrition status and antioxidant capacity in multiple sclerosis patients","volume":"11","author":"Armon-Omer","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0030","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1177\/1352458514533400","article-title":"Glutathione in multiple sclerosis: More than just an antioxidant?","volume":"20","author":"Carvalho","year":"2014","journal-title":"Mult Scler J"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0035","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/907162","article-title":"The antioxidant mechanisms underlying the aged garlic extract- and S-allylcysteine-induced protection","volume":"2012","author":"Col\u00edn-Gonz\u00e1lez","year":"2012","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0040","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/1028415X.2018.1469281","article-title":"The protective effect of extra-virgin olive oil in the experimental model of multiple sclerosis in the rat","volume":"23","author":"Conde","year":"2020","journal-title":"Nutr Neurosci"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0045","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.3390\/nu11102448","article-title":"Extra-virgin olive oil modifies the changes induced in non-nervous organs and tissues by experimental autoimmune encephalomyelitis models","volume":"11","author":"Conde","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0050","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1006\/mcne.1994.1060","article-title":"Comparison between low frequency magnetic field stimulation and nerve growth factor treatment of cultured chromaffin cells, on neurite growth, noradrenaline release, excitable properties, and grafting in nigrostriatal lesioned rats","volume":"5","author":"Drucker-Col\u00edn","year":"1994","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2017.09.025","article-title":"Dose-dependent S-allyl cysteine ameliorates multiple sclerosis disease-related pathology by reducing oxidative stress and biomarkers of dysbiosis in experimental autoimmune encephalomyelitis","author":"Escribano","year":"2017","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0060","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s13311-016-0480-0","article-title":"Lipopolysaccharide binding protein and oxidative stress in a multiple sclerosis model","volume":"14","author":"Escribano","year":"2017","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0065","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jff.2017.12.068","article-title":"Neuroprotective effect of S-allyl cysteine on an experimental model of multiple sclerosis: Antioxidant effects","volume":"42","author":"Escribano","year":"2018","journal-title":"J Funct Foods"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0070","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1042\/BJ20111943","article-title":"Antioxidant and bioenergetic coupling between neurons and astrocytes","volume":"443","author":"Fernandez-Fernandez","year":"2012","journal-title":"Biochem J"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0075","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0076-6879(84)05015-1","article-title":"Assays of glutathione peroxidase","volume":"105","author":"Floh\u00e9","year":"1984","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2008.08.006","article-title":"Glutathione: Overview of its protective roles, measurement, and biosynthesis","volume":"30","author":"Forman","year":"2009","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0085","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1128\/MCB.01191-13","article-title":"Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex Degron and Keap1","volume":"34","author":"Fukutomi","year":"2014","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0090","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1093\/brain\/awr128","article-title":"Oxidative damage in multiple sclerosis lesions","volume":"134","author":"Haider","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0095","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700479","article-title":"Supplementation with docosahexaenoic acid and extra virgin olive oil prevents liver steatosis induced by a high-fat diet in mice through PPAR-\u03b1 and Nrf2 upregulation with concomitant SREBP-1c and NF-kB downregulation","volume":"61","author":"Hern\u00e1ndez-Rodas","year":"2017","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0100","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.freeradbiomed.2008.09.023","article-title":"Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression","volume":"45","author":"van Horssen","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0105","first-page":"47","article-title":"Dietary pattern and risk of multiple sclerosis","volume":"11","author":"Jahromi","year":"2012","journal-title":"Iran J Neurol"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0110","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.gene.2016.03.058","article-title":"Small Maf proteins (MafF, MafG, MafK): History, structure and function","volume":"586","author":"Katsuoka","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0115","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.bbadis.2015.09.018","article-title":"Oxidative stress and its impact on neurons and glia in multiple sclerosis lesions","volume":"1862","author":"Lassmann","year":"2016","journal-title":"Biochim Biophys Acta \u2013 Mol Basis Dis"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0120","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0014-4827(03)00391-4","article-title":"Oxidative stress-induced apoptosis is mediated by ERK1\/2 phosphorylation","volume":"291","author":"Lee","year":"2003","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0125","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0076-6879(90)86141-H","article-title":"Determination of carbonyl content in oxidatively modified proteins","volume":"186","author":"Levine","year":"1990","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0130","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/3908677","article-title":"Repetitive transcranial magnetic stimulation improves neuropathy and oxidative stress levels in rats with experimental cerebral infarction through the Nrf2 signaling pathway","volume":"2021","author":"Liang","year":"2021","journal-title":"Evidence-Based Complement Altern Med"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0135","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202101141","article-title":"S-Allylcysteine potently protects against PhIP-induced DNA damage via Nrf2\/AhR signaling pathway modulation in normal human colonic Mucosal epithelial cells","volume":"66","author":"Lin","year":"2022","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0140","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s12031-017-1022-x","article-title":"Neuroprotective effects of melatonin on experimental allergic encephalomyelitis mice via anti-oxidative stress activity","volume":"64","author":"Long","year":"2018","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0145","doi-asserted-by":"crossref","first-page":"799","DOI":"10.3389\/fnins.2018.00799","article-title":"SIRT3 regulation under cellular stress: Making sense of the ups and downs","volume":"12","author":"Marcus","year":"2018","journal-title":"Front Neurosci"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0150","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1080\/10715762.2017.1324955","article-title":"Effects of transcranial magnetic stimulation on oxidative stress in experimental autoimmune encephalomyelitis","volume":"51","author":"Medina-Fern\u00e1ndez","year":"2017","journal-title":"Free Radic Res"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0155","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.brainresbull.2017.11.018","article-title":"Comparative of transcranial magnetic stimulation and other treatments in experimental autoimmune encephalomyelitis","volume":"137","author":"Medina-Fern\u00e1ndez","year":"2018","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0160","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.lfs.2016.11.011","article-title":"Transcranial magnetic stimulation modifies astrocytosis, cell density and lipopolysaccharide levels in experimental autoimmune encephalomyelitis","volume":"169","author":"Medina-Fern\u00e1ndez","year":"2017","journal-title":"Life Sci"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0165","first-page":"11","article-title":"A review of various antioxidant compounds and their potential utility as complementary therapy in multiple sclerosis","author":"Miller","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0170","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1007\/s12035-020-02212-w","article-title":"Increasing Nrf2 activity as a treatment approach in neuropsychiatry","volume":"58","author":"Morris","year":"2021","journal-title":"Mol Neurobiol"},{"issue":"1","key":"10.1016\/j.neuroscience.2023.08.005_b0175","first-page":"1","article-title":"Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action","volume":"2022","author":"Mu\u00f1oz-Jurado","year":"2022","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0180","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/ana.22344","article-title":"Gut, bugs, and brain: Role of commensal bacteria in the control of central nervous system disease","volume":"69","author":"Ochoa-Rep\u00e1raz","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0185","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.expneurol.2015.11.010","article-title":"Oxidative stress in multiple sclerosis: Central and peripheral mode of action","volume":"277","author":"Ohl","year":"2016","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0190","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7191080","article-title":"Inflammation and oxidative stress in multiple sclerosis: Consequences for therapy development","volume":"2020","author":"Pegoretti","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0195","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1742-2094-7-60","article-title":"Chronic immobilisation stress ameliorates clinical score and neuroinflammation in a MOG-induced EAE in Dark Agouti rats: Mechanisms implicated","volume":"7","author":"P\u00e9rez-Nievas","year":"2010","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0200","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet","volume":"123","author":"Reeves","year":"1993","journal-title":"J Nutr"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0205","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s12640-020-00260-7","article-title":"S-Allylcysteine protects against excitotoxic damage in rat cortical slices via reduction of oxidative damage, activation of Nrf2\/ARE binding, and BDNF preservation","volume":"38","author":"Reyes-Soto","year":"2020","journal-title":"Neurotox Res"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0210","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1006\/niox.2001.0392","article-title":"Anticoagulants and other preanalytical factors interfere in plasma nitrate\/nitrite quantification by the Griess method","volume":"6","author":"Ricart-Jan\u00e9","year":"2002","journal-title":"Nitric Oxide \u2013 Biol Chem"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0215","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/jnc.12986","article-title":"S-allyl cysteine activates the Nrf2-dependent antioxidant response and protects neurons against ischemic injury in vitro and in vivo","volume":"133","author":"Shi","year":"2015","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0220","first-page":"13","article-title":"Oxidative stress related to iron metabolism in relapsing remitting multiple sclerosis patients with low disability","author":"Siotto","year":"2019","journal-title":"Front Neurosci"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0225","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.brs.2012.03.015","article-title":"Extremely low-frequency electromagnetic fields activate the antioxidant pathway Nrf2 in a Huntington\u2019s disease-like rat model","volume":"6","author":"Tasset","year":"2013","journal-title":"Brain Stimul"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0230","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s12031-020-01672-y","article-title":"Oxidative\/nitroxidative stress and multiple sclerosis","volume":"71","author":"Tobore","year":"2021","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0235","doi-asserted-by":"crossref","first-page":"461","DOI":"10.5507\/bp.2016.052","article-title":"Nutrition, oxidative stress and intestinal dysbiosis: Influence of diet on gut microbiota in inflammatory bowel diseases","volume":"160","author":"Tomasello","year":"2016","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0240","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.freeradbiomed.2008.09.001","article-title":"Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease?","volume":"45","author":"de Vries","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0245","first-page":"416","article-title":"S-allyl cysteine ameliorates heat stress-induced oxidative stress by activating Nrf2\/HO-1 signaling pathway in BMECs","author":"Wang","year":"2021","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.neuroscience.2023.08.005_b0250","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.coi.2013.09.009","article-title":"Remote control-triggering of brain autoimmune disease in the gut","volume":"25","author":"Wekerle","year":"2013","journal-title":"Curr Opin Immunol"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452223003470?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452223003470?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:21:19Z","timestamp":1759681279000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452223003470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":50,"alternative-id":["S0306452223003470"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2023.08.005","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of the Combination of Different Therapies on Oxidative Stress in the Experimental Model of Multiple Sclerosis","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2023.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}