{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:05:32Z","timestamp":1791486332418,"version":"4.3.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005693","name":"Hainan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008111","name":"Hainan Provincial Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008111","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ibroneuroscience.org","clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.neuroscience.2024.04.002","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T16:06:14Z","timestamp":1712678774000},"page":"37-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["The Co-oligomers of A\u03b242 and Human Islet Amyloid Polypeptide Exacerbate Neurotoxicity and Alzheimer-like Pathology at Cellular Level"],"prefix":"10.1016","volume":"547","author":[{"given":"Jiajun","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3246-8209","authenticated-orcid":false,"given":"Feng","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2024.04.002_b0005","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.842582","article-title":"Linking Alzheimer's disease and type 2 diabetes: characterization and inhibition of cytotoxic A\u03b2 and IAPP hetero-aggregates","volume":"9","author":"Al Adem","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0010","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3233\/JAD-161192","article-title":"The link between type 2 diabetes and neurodegeneration: roles for amyloid-\u03b2, amylin, and tau proteins","volume":"59","author":"Bharadwaj","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0015","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.bbamem.2018.03.015","article-title":"Role of the cell membrane interface in modulating production and uptake of Alzheimer's beta amyloid protein","volume":"1860","author":"Bharadwaj","year":"2018","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0020","doi-asserted-by":"crossref","first-page":"10356","DOI":"10.1038\/s41598-020-66602-9","article-title":"Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells","volume":"10","author":"Bharadwaj","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0025","doi-asserted-by":"crossref","first-page":"7852","DOI":"10.1523\/JNEUROSCI.5901-11.2012","article-title":"Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-\u03b21-42 oligomers are revealed in vivo by using a novel animal model","volume":"32","author":"Brouillette","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0030","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/nsmb1345","article-title":"Evidence of fibril-like \u03b2-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's \u03b2-amyloid","volume":"14","author":"Chimon","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0035","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nature13800","article-title":"A three-dimensional human neural cell culture model of Alzheimer's disease","volume":"515","author":"Choi","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2024.04.002_b0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22094592","article-title":"Glutamatergic neurons differentiated from embryonic stem cells: an investigation of differentiation and associated diseases","volume":"22","author":"Chuang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0045","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s10522-020-09860-4","article-title":"Alzheimer's disease: targeting the glutamatergic system","volume":"21","author":"Conway","year":"2020","journal-title":"Biogerontology"},{"key":"10.1016\/j.neuroscience.2024.04.002_b0050","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.neurobiolaging.2007.02.029","article-title":"Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers","volume":"29","author":"De Felice","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuroscience.2024.04.002_b0055","doi-asserted-by":"crossref","first-page":"653","DOI":"10.2174\/156720510793611574","article-title":"Tau, neurodegeneration and Alzheimer's disease","volume":"7","author":"Del Carmen Alonso","year":"2010","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0060","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3233\/JAD-215339","article-title":"novel amylin analogues reduce amyloid-\u03b2 cross-seeding aggregation and neurotoxicity","volume":"87","author":"Dharmaraj","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0065","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00401-016-1662-x","article-title":"Alzheimer's disease: experimental models and reality","volume":"133","author":"Drummond","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0070","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.neuron.2017.02.001","article-title":"Hallmarks of Alzheimer's disease in stem-cell-derived human neurons transplanted into mouse brain","volume":"93","author":"Espuny-Camacho","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2024.04.002_b0075","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1001\/jama.1989.03430180093036","article-title":"Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported","volume":"262","author":"Evans","year":"1989","journal-title":"Jama"},{"key":"10.1016\/j.neuroscience.2024.04.002_b0080","doi-asserted-by":"crossref","first-page":"928","DOI":"10.2174\/1567205011666141107124538","article-title":"Islet amyloid polypeptide (IAPP): a second amyloid in Alzheimer's disease","volume":"11","author":"Fawver","year":"2014","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0085","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/jnc.15030","article-title":"Amyloid-\u03b2 oligomers in cellular models of Alzheimer's disease","volume":"155","author":"Fontana","year":"2020","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0090","doi-asserted-by":"crossref","first-page":"13629","DOI":"10.1523\/JNEUROSCI.1353-14.2014","article-title":"Alzheimer's disease-like pathology induced by amyloid-\u03b2 oligomers in nonhuman primates","volume":"34","author":"Forny-Germano","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0095","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1016\/S0140-6736(20)30689-9","article-title":"Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study","volume":"395","author":"Fortea","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.neuroscience.2024.04.002_b0100","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3233\/JAD-2006-9S323","article-title":"Tau protein, the paired helical filament and Alzheimer's disease","volume":"9","author":"Goedert","year":"2006","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0105","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0361-9230(03)00087-X","article-title":"Advances in the development of biomarkers for Alzheimer's disease: from CSF total tau and Abeta(1\u201342) proteins to phosphorylated tau protein","volume":"61","author":"Hampel","year":"2003","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0110","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.exger.2009.10.010","article-title":"Total and phosphorylated tau protein as biological markers of Alzheimer's disease","volume":"45","author":"Hampel","year":"2010","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0115","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer's disease: the amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2024.04.002_b0120","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2024.04.002_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jalz.2011.10.007","article-title":"National institute on aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease","volume":"8","author":"Hyman","year":"2012","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0130","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10495-011-0656-3","article-title":"\u03b2-Amyloid protein (A\u03b2) and human amylin regulation of apoptotic genes occurs through the amylin receptor","volume":"17","author":"Jhamandas","year":"2012","journal-title":"Apoptosis"},{"key":"10.1016\/j.neuroscience.2024.04.002_b0135","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/ana.22615","article-title":"Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders","volume":"70","author":"Jucker","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0140","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1111\/cbdd.12912","article-title":"Protective effects of \u03b2-sheet breaker \u03b1\/\u03b2-hybrid peptide against amyloid \u03b2-induced neuronal apoptosis in vitro","volume":"89","author":"Kumar","year":"2017","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0145","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40478-016-0299-2","article-title":"Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain","volume":"4","author":"Kurbatskaya","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0150","doi-asserted-by":"crossref","first-page":"16485","DOI":"10.1074\/jbc.R116.714576","article-title":"Cross-interactions between the Alzheimer Disease Amyloid-\u03b2 peptide and other amyloid proteins: a further aspect of the amyloid cascade hypothesis","volume":"291","author":"Luo","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0155","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3389\/fnins.2015.00216","article-title":"Amylin at the interface between metabolic and neurodegenerative disorders","volume":"9","author":"Lutz","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0160","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.ajpath.2014.11.016","article-title":"In vivo seeding and cross-seeding of localized amyloidosis: a molecular link between type 2 diabetes and Alzheimer disease","volume":"185","author":"Oskarsson","year":"2015","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0165","doi-asserted-by":"crossref","first-page":"10166","DOI":"10.1038\/s41598-017-10394-y","article-title":"Small molecule-based lineage switch of human adipose-derived stem cells into neural stem cells and functional GABAergic neurons","volume":"7","author":"Park","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0170","doi-asserted-by":"crossref","first-page":"e94251","DOI":"10.1371\/journal.pone.0094251","article-title":"Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions","volume":"9","author":"Petry","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2024.04.002_b0175","first-page":"11","article-title":"Polyphenols modulate Alzheimer's amyloid beta aggregation in a structure-dependent manner","author":"Phan","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.neuroscience.2024.04.002_b0180","doi-asserted-by":"crossref","DOI":"10.3791\/1071-v","article-title":"Photo-induced cross-linking of unmodified proteins (PICUP) applied to amyloidogenic peptides","author":"Rahimi","year":"2009","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0185","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/s41594-020-0442-4","article-title":"Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-\u03b2 fibrils","volume":"27","author":"R\u00f6der","year":"2020","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0190","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.bbrc.2003.11.014","article-title":"Divergent roles of GSK3 and CDK5 in APP processing","volume":"312","author":"Ryder","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0195","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ebiom.2016.03.035","article-title":"The role of amyloid-\u03b2 oligomers in toxicity, propagation, and immunotherapy","volume":"6","author":"Sengupta","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.neuroscience.2024.04.002_b0200","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.conb.2005.03.014","article-title":"From monkeys to humans: what do we now know about brain homologies?","volume":"15","author":"Sereno","year":"2005","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0205","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.jalz.2018.03.004","article-title":"NIA commentary on the NIA-AA research framework: towards a biological definition of Alzheimer's disease","volume":"14","author":"Silverberg","year":"2018","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0210","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113306","article-title":"Type 2 diabetes mellitus and Alzheimer's disease: role of insulin signalling and therapeutic implications","volume":"19","author":"Tumminia","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0215","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in early Alzheimer's disease","volume":"388","author":"van Dyck","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0220","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.nbd.2015.04.008","article-title":"The role of type 2 diabetes in neurodegeneration","volume":"84","author":"Verdile","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0225","doi-asserted-by":"crossref","first-page":"103207","DOI":"10.1016\/j.isci.2021.103207","article-title":"Synthetic amyloid-\u03b2 oligomers drive early pathological progression of Alzheimer's disease in nonhuman primates","volume":"24","author":"Yue","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.neuroscience.2024.04.002_b0230","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1096\/fj.14-251744","article-title":"The pathogenic mechanism of diabetes varies with the degree of overexpression and oligomerization of human amylin in the pancreatic islet \u03b2 cells","volume":"28","author":"Zhang","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0235","doi-asserted-by":"crossref","first-page":"8923","DOI":"10.18632\/aging.103105","article-title":"Influence of human amylin on the membrane stability of rat primary hippocampal neurons","volume":"12","author":"Zhang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.neuroscience.2024.04.002_b0240","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fnmol.2020.00137","article-title":"Targeting amyloidogenic processing of APP in Alzheimer's disease","volume":"13","author":"Zhao","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neuroscience.2024.04.002_b0245","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.semcdb.2022.03.013","article-title":"Impairments of glutamatergic synaptic transmission in Alzheimer's disease","volume":"139","author":"Zott","year":"2023","journal-title":"Semin. Cell Dev. Biol."}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452224001556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452224001556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T02:21:54Z","timestamp":1717035714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452224001556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":49,"alternative-id":["S0306452224001556"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2024.04.002","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Co-oligomers of A\u03b242 and Human Islet Amyloid Polypeptide Exacerbate Neurotoxicity and Alzheimer-like Pathology at Cellular Level","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2024.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 IBRO. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}