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Neurosci."},{"issue":"6","key":"10.1016\/j.neuroscience.2024.05.005_b0340","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1523\/JNEUROSCI.16-06-01982.1996","article-title":"Evidence for multiple AMPA receptor complexes in hippocampal CA1\/CA2 neurons","volume":"16","author":"Wenthold","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuroscience.2024.05.005_b0345","doi-asserted-by":"crossref","unstructured":"Whiteford, H.A., Ferrari, A.J., Degenhardt, L., Feigin, V., Vos, T., 2016. Global burden of mental, neurological, and substance use disorders: an analysis from the global burden of disease study 2010. In: Patel, V., Chisholm, D., Dua, T., Laxminarayan, R., Medina-Mora, M.E. (Eds.), Mental, Neurological, and Substance Use Disorders: Disease Control Priorities, 3rd ed., vol. 4. https:\/\/doi.org\/10.1596\/978-1-4648-0426-7_ch2.","DOI":"10.1596\/978-1-4648-0426-7_ch2"},{"issue":"1","key":"10.1016\/j.neuroscience.2024.05.005_b0350","doi-asserted-by":"crossref","first-page":"e492","DOI":"10.1038\/tp.2014.131","article-title":"N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6\/1 mouse model of Huntington's disease","volume":"5","author":"Wright","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neuroscience.2024.05.005_b0355","doi-asserted-by":"crossref","first-page":"1181973","DOI":"10.3389\/fimmu.2023.1181973","article-title":"Lipopolysaccharide-induced depression-like model in mice: meta-analysis and systematic evaluation","volume":"14","author":"Yin","year":"2023","journal-title":"Front. 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