{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:54:28Z","timestamp":1790009668795,"version":"4.0.1"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012232","name":"National Key Clinical Specialty Discipline Construction Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012232","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871002"],"award-info":[{"award-number":["81871002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471334"],"award-info":[{"award-number":["81471334"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100981"],"award-info":[{"award-number":["81100981"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ibroneuroscience.org","clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.neuroscience.2024.08.027","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T20:11:08Z","timestamp":1724357468000},"page":"17-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Constipation is associated with emotional and cognitive impairment in patients with Parkinson\u2019s disease: A clinical and brain functional study"],"prefix":"10.1016","volume":"559","author":[{"given":"Meilan","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1889-6541","authenticated-orcid":false,"given":"Oumei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.neuroscience.2024.08.027_b0005","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/BF02056950","article-title":"A constipation scoring system to simplify evaluation and management of constipated patients","volume":"39","author":"Agachan","year":"1996","journal-title":"Dis Colon Rectum."},{"key":"10.1016\/j.neuroscience.2024.08.027_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2020.101905","article-title":"BDNF and Netrin-1 repression by C\/EBP\u03b2 in the gut triggers Parkinson's disease pathologies, associated with constipation and motor dysfunctions","volume":"198","author":"Ahn","year":"2021","journal-title":"Prog Neurobiol."},{"issue":"8","key":"10.1016\/j.neuroscience.2024.08.027_b0015","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S2468-1253(21)00111-4","article-title":"Global prevalence of functional constipation according to the Rome criteria: a systematic review and meta-analysis","volume":"6","author":"Barberio","year":"2021","journal-title":"Lancet Gastroenterol Hepatol."},{"issue":"1","key":"10.1016\/j.neuroscience.2024.08.027_b0020","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41531-021-00191-w","article-title":"Early constipation predicts faster dementia onset in Parkinson's disease","volume":"7","author":"Camacho","year":"2021","journal-title":"NPJ Parkinsons Dis."},{"issue":"11","key":"10.1016\/j.neuroscience.2024.08.027_b0025","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1002\/mds.28246","article-title":"The gut metabolite trimethylamine n-oxide is associated with parkinson's disease severity and progression","volume":"35","author":"Chen","year":"2020","journal-title":"Mov Disord."},{"issue":"5","key":"10.1016\/j.neuroscience.2024.08.027_b0030","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/mdc3.12466","article-title":"The relationship between serotonin-2A receptor and cognitive functions in nondemented parkinson's disease patients with visual hallucinations","volume":"4","author":"Cho","year":"2017","journal-title":"Mov Disord Clin Pract."},{"issue":"8","key":"10.1016\/j.neuroscience.2024.08.027_b0035","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1001\/jamaneurol.2017.1125","article-title":"Association of autonomic dysfunction with disease progression and survival in parkinson disease","volume":"74","author":"De Pablo-Fernandez","year":"2017","journal-title":"JAMA Neurol."},{"issue":"4","key":"10.1016\/j.neuroscience.2024.08.027_b0040","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1093\/cercor\/bhu324","article-title":"The organization of right prefrontal networks reveals common mechanisms of inhibitory regulation across cognitive, emotional, and motor processes","volume":"26","author":"Depue","year":"2016","journal-title":"Cereb Cortex."},{"issue":"2","key":"10.1016\/j.neuroscience.2024.08.027_b0045","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11065-014-9246-9","article-title":"Contributions of the insula to cognition and emotion","volume":"24","author":"Gasquoine","year":"2014","journal-title":"Neuropsychol Rev."},{"key":"10.1016\/j.neuroscience.2024.08.027_b0050","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fncom.2015.00045","article-title":"On the role of spatial phase and phase correlation in vision, illusion, and cognition","volume":"9","author":"Gladilin","year":"2015","journal-title":"Front Comput Neurosci."},{"key":"10.1016\/j.neuroscience.2024.08.027_b0055","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.parkreldis.2022.08.001","article-title":"Constipation distinguishes different clinical-biochemical patterns in de novo Parkinson's disease","volume":"102","author":"Grillo","year":"2022","journal-title":"Parkinsonism Relat Disord."},{"issue":"Pt 3","key":"10.1016\/j.neuroscience.2024.08.027_b0060","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1093\/brain\/aws364","article-title":"Distinct illusory own-body perceptions caused by damage to posterior insula and extrastriate cortex","volume":"136","author":"Heydrich","year":"2013","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.neuroscience.2024.08.027_b0065","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases","volume":"55","author":"Hughes","year":"1992","journal-title":"J Neurol Neurosurg Psychiatry."},{"issue":"2","key":"10.1016\/j.neuroscience.2024.08.027_b0070","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2019.04.022","article-title":"Effects of serotonin and slow-release 5-hydroxytryptophan on gastrointestinal motility in a mouse model of depression","volume":"157","author":"Israelyan","year":"2019","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.neuroscience.2024.08.027_b0075","doi-asserted-by":"crossref","first-page":"e13566","DOI":"10.1111\/nmo.13566","article-title":"Sex-related differences in resting-state brain activity and connectivity in the orbital frontal cortex and insula in patients with functional constipation","volume":"31","author":"Jin","year":"2019","journal-title":"Neurogastroenterol Motil."},{"key":"10.1016\/j.neuroscience.2024.08.027_b0080","article-title":"A bidirectional relationship between anxiety, depression and gastrointestinal symptoms in Parkinson's disease","volume":"5","author":"Jones","year":"2021","journal-title":"Clin Park Relat Disord."},{"issue":"3","key":"10.1016\/j.neuroscience.2024.08.027_b0085","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1097\/BSD.0000000000000932","article-title":"propensity score matching: A statistical method","volume":"33","author":"Kane","year":"2020","journal-title":"Clin Spine Surg."},{"issue":"1","key":"10.1016\/j.neuroscience.2024.08.027_b0090","doi-asserted-by":"crossref","first-page":"38","DOI":"10.14802\/jmd.21074","article-title":"Constipation is associated with mild cognitive impairment in patients with de novo parkinson's disease","volume":"15","author":"Kang","year":"2022","journal-title":"J Mov Disord."},{"issue":"1","key":"10.1016\/j.neuroscience.2024.08.027_b0095","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/mds.26866","article-title":"Constipation in parkinson's disease: Subjective symptoms, objective markers, and new perspectives","volume":"32","author":"Knudsen","year":"2017","journal-title":"Mov Disord."},{"issue":"6","key":"10.1016\/j.neuroscience.2024.08.027_b0100","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/nmo.12793","article-title":"Functional neuroimaging studies in functional dyspepsia patients: a systematic review","volume":"28","author":"Lee","year":"2016","journal-title":"Neurogastroenterol Motil."},{"issue":"3","key":"10.1016\/j.neuroscience.2024.08.027_b0105","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3233\/JPD-212570","article-title":"Constipation is associated with development of cognitive impairment in de novo parkinson's disease: A longitudinal analysis of two international cohorts","volume":"11","author":"Leta","year":"2021","journal-title":"J Parkinsons Dis."},{"issue":"23","key":"10.1016\/j.neuroscience.2024.08.027_b0110","doi-asserted-by":"crossref","first-page":"13078","DOI":"10.1073\/pnas.2002737117","article-title":"Multiple areas of the cerebral cortex influence the stomach","volume":"117","author":"Levinthal","year":"2020","journal-title":"Proc Natl Acad Sci U S a."},{"issue":"10","key":"10.1016\/j.neuroscience.2024.08.027_b0115","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/cns.12727","article-title":"Adverse effects produced by different drugs used in the treatment of Parkinson's disease: A mixed treatment comparison","volume":"23","author":"Li","year":"2017","journal-title":"CNS Neurosci Ther."},{"issue":"8","key":"10.1016\/j.neuroscience.2024.08.027_b0120","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.14336\/AD.2021.0418","article-title":"Intestinal inflammation and parkinson's disease","volume":"12","author":"Li","year":"2021","journal-title":"Aging Dis."},{"issue":"1","key":"10.1016\/j.neuroscience.2024.08.027_b0125","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11682-015-9382-8","article-title":"A pilot fMRI study of the effect of stressful factors on the onset of depression in female patients","volume":"10","author":"Li","year":"2016","journal-title":"Brain Imaging Behav."},{"issue":"7","key":"10.1016\/j.neuroscience.2024.08.027_b0130","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/PSY.0000000000000958","article-title":"Distinct basal brain functional activity and connectivity in the emotional-arousal network and thalamus in patients with functional constipation associated with anxiety and\/or depressive disorders","volume":"83","author":"Li","year":"2021","journal-title":"Psychosom Med."},{"key":"10.1016\/j.neuroscience.2024.08.027_b0135","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.sleep.2021.03.041","article-title":"Altered regional homogeneity and connectivity in cerebellum and visual-motor relevant cortex in Parkinson's disease with rapid eye movement sleep behavior disorder","volume":"82","author":"Liu","year":"2021","journal-title":"Sleep Med."},{"issue":"15","key":"10.1016\/j.neuroscience.2024.08.027_b0140","doi-asserted-by":"crossref","first-page":"4173","DOI":"10.1002\/hbm.25116","article-title":"Differences in directed functional brain connectivity related to age, sex and mental health","volume":"41","author":"Lund","year":"2020","journal-title":"Hum Brain Mapp."},{"issue":"4 Suppl","key":"10.1016\/j.neuroscience.2024.08.027_b0145","first-page":"S63","article-title":"Managing costs and care for chronic idiopathic constipation","volume":"25","author":"McCormick","year":"2019","journal-title":"Am J Manag Care."},{"issue":"4","key":"10.1016\/j.neuroscience.2024.08.027_b0150","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.jpainsymman.2008.04.016","article-title":"A review of the literature on gender and age differences in the prevalence and characteristics of constipation in North America","volume":"37","author":"McCrea","year":"2009","journal-title":"J Pain Symptom Manage."},{"issue":"2\u20133","key":"10.1016\/j.neuroscience.2024.08.027_b0155","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/13546805.2021.1960812","article-title":"Cognition, hallucination severity and hallucination-specific insight in neurodegenerative disorders and eye disease","volume":"27","author":"Montagnese","year":"2022","journal-title":"Cogn Neuropsychiatry."},{"issue":"24","key":"10.1016\/j.neuroscience.2024.08.027_b0160","doi-asserted-by":"crossref","first-page":"9868","DOI":"10.1073\/pnas.87.24.9868","article-title":"Brain magnetic resonance imaging with contrast dependent on blood oxygenation","volume":"87","author":"Ogawa","year":"1990","journal-title":"Proc Natl Acad Sci U S a."},{"issue":"2","key":"10.1016\/j.neuroscience.2024.08.027_b0165","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.parkreldis.2014.11.015","article-title":"Constipation is reduced by beta-blockers and increased by dopaminergic medications in Parkinson's disease","volume":"21","author":"Pagano","year":"2015","journal-title":"Parkinsonism Relat Disord."},{"issue":"5","key":"10.1016\/j.neuroscience.2024.08.027_b0170","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1017\/S0317167100014888","article-title":"Visual hallucinations and cognitive impairment in Parkinson's disease","volume":"40","author":"Park","year":"2013","journal-title":"Can J Neurol Sci."},{"issue":"4","key":"10.1016\/j.neuroscience.2024.08.027_b0175","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.3233\/JAD-191191","article-title":"Brief cognitive tests used in primary care cannot accurately differentiate mild cognitive impairment from subjective cognitive decline","volume":"75","author":"Petrazzuoli","year":"2020","journal-title":"J Alzheimers Dis."},{"key":"10.1016\/j.neuroscience.2024.08.027_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112196","article-title":"Meta-analysis of alcohol induced gut dysbiosis and the resulting behavioral impact","volume":"376","author":"Qamar","year":"2019","journal-title":"Behav Brain Res."},{"key":"10.1016\/j.neuroscience.2024.08.027_b0185","first-page":"3897315","article-title":"Gastrointestinal dysfunction in chinese patients with parkinson's disease","volume":"2019","author":"Qin","year":"2019","journal-title":"Parkinsons Dis."},{"issue":"4","key":"10.1016\/j.neuroscience.2024.08.027_b0190","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1055\/s-0043-1771457","article-title":"Constipation in parkinson's disease","volume":"43","author":"Quigley","year":"2023","journal-title":"Semin Neurol."},{"issue":"10","key":"10.1016\/j.neuroscience.2024.08.027_b0195","first-page":"021","article-title":"Gastrointestinal dysfunction in parkinson's disease","volume":"25","author":"Safarpour","year":"2022","journal-title":"Drugs"},{"issue":"1","key":"10.1016\/j.neuroscience.2024.08.027_b0200","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3233\/JPD-212868","article-title":"Constipation predicts cognitive decline in parkinson's disease: Results from the COPPADIS cohort at 2-year follow-up and comparison with a control group","volume":"12","author":"Santos Garc\u00eda","year":"2022","journal-title":"J Parkinsons Dis."},{"issue":"1","key":"10.1016\/j.neuroscience.2024.08.027_b0205","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/cercor\/bhac056","article-title":"Age differences in the functional architecture of the human brain","volume":"33","author":"Setton","year":"2022","journal-title":"Cereb Cortex."},{"key":"10.1016\/j.neuroscience.2024.08.027_b0210","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.770528","article-title":"Region-specific neurovascular decoupling associated with cognitive decline in parkinson's disease","volume":"13","author":"Shang","year":"2021","journal-title":"Front Aging Neurosci."},{"issue":"3","key":"10.1016\/j.neuroscience.2024.08.027_b0215","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0061-20.2020","article-title":"Differential rapid plasticity in auditory and visual responses in the primarily multisensory orbitofrontal cortex","volume":"7","author":"Sharma","year":"2020","journal-title":"eNeuro."},{"issue":"2","key":"10.1016\/j.neuroscience.2024.08.027_b0220","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/cns.13259","article-title":"Altered putamen and cerebellum connectivity among different subtypes of Parkinson's disease","volume":"26","author":"Shen","year":"2020","journal-title":"CNS Neurosci Ther."},{"issue":"1","key":"10.1016\/j.neuroscience.2024.08.027_b0225","doi-asserted-by":"crossref","first-page":"e84705","DOI":"10.1371\/journal.pone.0084705","article-title":"Altered spontaneous brain activity in patients with Parkinson's disease accompanied by depressive symptoms, as revealed by regional homogeneity and functional connectivity in the prefrontal-limbic system","volume":"9","author":"Sheng","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2024.08.027_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2022.103112","article-title":"A systematic review on resting state functional connectivity in patients with neurodegenerative disease and hallucinations","volume":"35","author":"Spinosa","year":"2022","journal-title":"Neuroimage Clin."},{"issue":"7","key":"10.1016\/j.neuroscience.2024.08.027_b0235","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.parkreldis.2015.04.006","article-title":"Alterations in the limbic\/paralimbic cortices of Parkinson's disease patients with hyposmia under resting-state functional MRI by regional homogeneity and functional connectivity analysis","volume":"21","author":"Su","year":"2015","journal-title":"Parkinsonism Relat Disord."},{"issue":"6","key":"10.1016\/j.neuroscience.2024.08.027_b0240","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9061916","article-title":"Distinctive pathophysiology underlying constipation in parkinson's disease: Implications for cognitive inefficiency","volume":"9","author":"Tucker","year":"2020","journal-title":"J Clin Med."},{"issue":"1","key":"10.1016\/j.neuroscience.2024.08.027_b0245","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1162\/jocn_a_00462","article-title":"Beyond the tripartite cognition-emotion-interoception model of the human insular cortex","volume":"26","author":"Uddin","year":"2014","journal-title":"J Cogn Neurosci."},{"issue":"Suppl 1","key":"10.1016\/j.neuroscience.2024.08.027_b0250","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1016\/j.dcn.2011.09.007","article-title":"Brain function during probabilistic learning in relation to IQ and level of education","volume":"2","author":"van den Bos","year":"2012","journal-title":"Dev Cogn Neurosci."},{"issue":"2","key":"10.1016\/j.neuroscience.2024.08.027_b0255","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1037\/h0041665","article-title":"The adaptation and use of Kendall's coefficient of concordance (W) to sociometric-type rankings","volume":"52","author":"Willerman","year":"1955","journal-title":"Psychol Bull."},{"key":"10.1016\/j.neuroscience.2024.08.027_b0260","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jad.2022.11.058","article-title":"Biomarkers of intestinal permeability and blood-brain barrier permeability in adolescents with major depressive disorder","volume":"323","author":"Wu","year":"2023","journal-title":"J Affect Disord."},{"key":"10.1016\/j.neuroscience.2024.08.027_b0265","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2020.567574","article-title":"Depression is associated with constipation in patients with parkinson's disease","volume":"11","author":"Xiao-Ling","year":"2020","journal-title":"Front Neurol."},{"key":"10.1016\/j.neuroscience.2024.08.027_b0270","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3389\/fnins.2019.00133","article-title":"Inefficient involvement of insula in sensorineural hearing loss","volume":"13","author":"Xu","year":"2019","journal-title":"Front Neurosci."},{"issue":"23337214231215637","key":"10.1016\/j.neuroscience.2024.08.027_b0275","article-title":"Aging is associated with constipation in japanese patients with ulcerative colitis: A post hoc analysis","volume":"9","author":"Yagi","year":"2023","journal-title":"Gerontol Geriatr Med."},{"issue":"1","key":"10.1016\/j.neuroscience.2024.08.027_b0280","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000527513","article-title":"Constipation in parkinson's disease: A systematic review and meta-analysis","volume":"86","author":"Yao","year":"2023","journal-title":"Eur Neurol."},{"issue":"18","key":"10.1016\/j.neuroscience.2024.08.027_b0285","doi-asserted-by":"crossref","first-page":"5985","DOI":"10.1002\/hbm.25663","article-title":"Aberrant functional brain network dynamics in patients with functional constipation","volume":"42","author":"Yin","year":"2021","journal-title":"Hum Brain Mapp."},{"issue":"1","key":"10.1016\/j.neuroscience.2024.08.027_b0290","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41598-017-16790-8","article-title":"Parkinson disease with constipation: clinical features and relevant factors","volume":"8","author":"Yu","year":"2018","journal-title":"Sci Rep."},{"key":"10.1016\/j.neuroscience.2024.08.027_b0295","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3389\/fnhum.2020.00244","article-title":"Gender Differences Are Encoded Differently in the Structure and Function of the Human Brain Revealed by Multimodal MRI","volume":"14","author":"Zhang","year":"2020","journal-title":"Front Hum Neurosci."},{"issue":"1","key":"10.1016\/j.neuroscience.2024.08.027_b0300","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s10286-022-00851-8","article-title":"Resting-state functional magnetic resonance imaging in patients with Parkinson's disease with and without constipation: a prospective study","volume":"32","author":"Zheng","year":"2022","journal-title":"Clin Auton Res."},{"key":"10.1016\/j.neuroscience.2024.08.027_b0305","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.923560","article-title":"Aberrant gray matter volume and functional connectivity in Parkinson's disease with minor hallucination","volume":"14","author":"Zhong","year":"2022","journal-title":"Front Aging Neurosci."},{"issue":"3","key":"10.1016\/j.neuroscience.2024.08.027_b0310","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2174\/1567202616666190618170103","article-title":"Constipation Increases Disability and Decreases Dopamine Levels in the Nigrostriatal System through Gastric Inflammatory Factors in Parkinson's Disease","volume":"16","author":"Zhou","year":"2019","journal-title":"Curr Neurovasc Res."}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452224004135?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452224004135?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T05:30:16Z","timestamp":1734327016000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452224004135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":62,"alternative-id":["S0306452224004135"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2024.08.027","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Constipation is associated with emotional and cognitive impairment in patients with Parkinson\u2019s disease: A clinical and brain functional study","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2024.08.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of International Brain Research Organization (IBRO).","name":"copyright","label":"Copyright"}]}}