{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T22:08:09Z","timestamp":1750284489130,"version":"3.37.3"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"am","delay-in-days":353,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R01 EB016101","R01 EB027717-01A1"],"award-info":[{"award-number":["R01 EB016101","R01 EB027717-01A1"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2016220817"],"award-info":[{"award-number":["2016220817"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["P50-MH115874"],"award-info":[{"award-number":["P50-MH115874"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030692","name":"Intramural Research Program, National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01DA045000"],"award-info":[{"award-number":["R01DA045000"]}],"id":[{"id":"10.13039\/100030692","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ibroneuroscience.org","clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.neuroscience.2024.10.047","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T09:30:34Z","timestamp":1730107834000},"page":"261-267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Microdosing of a kappa opioid receptor agonist within proximal nucleus accumbens shell microstructures revealing opposing behavioral outcomes"],"prefix":"10.1016","volume":"563","author":[{"given":"Erin B.","family":"Rousseau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah D.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suman","family":"Guha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sydney S.","family":"Sherman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Cima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena H.","family":"Chartoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2024.10.047_b0005","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.neuron.2015.08.019","article-title":"Distinct subpopulations of nucleus accumbens dynorphin neurons drive aversion and reward","volume":"87","author":"Al-Hasani","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2024.10.047_b0010","doi-asserted-by":"crossref","unstructured":"Amemori, K. I. & Graybiel, A. M. Localized microstimulation of primate pregenual cingulate cortex induces negative decision-making. Nat. Neurosci. 2012 15:5 15, 776\u2013785 (2012).","DOI":"10.1038\/nn.3088"},{"key":"10.1016\/j.neuroscience.2024.10.047_b0015","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.brainres.2009.08.062","article-title":"The dynorphin\/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors","volume":"1314","author":"Bruchas","year":"2010","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2024.10.047_b0020","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.neuron.2019.03.003","article-title":"A Motivational and Neuropeptidergic Hub: Anatomical and Functional Diversity within the Nucleus Accumbens Shell","volume":"102","author":"Castro","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2024.10.047_b0025","doi-asserted-by":"crossref","first-page":"6450","DOI":"10.1523\/JNEUROSCI.0491-06.2006","article-title":"Behavioral and Molecular Effects of Dopamine D1 Receptor Stimulation during Naloxone-Precipitated Morphine Withdrawal","volume":"26","author":"Chartoff","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuroscience.2024.10.047_b0030","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3171\/jns.1999.90.2.0315","article-title":"Variables affecting convection-enhanced delivery to the striatum: a systematic examination of rate of infusion, cannula size, infusate concentration, and tissue-cannula sealing time","volume":"90","author":"Chen","year":"1999","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.neuroscience.2024.10.047_b0035","doi-asserted-by":"crossref","first-page":"1901459","DOI":"10.1002\/smll.201901459","article-title":"Steerable microinvasive probes for localized drug delivery to deep tissue","volume":"15","author":"Cotler","year":"2019","journal-title":"Small"},{"key":"10.1016\/j.neuroscience.2024.10.047_b0040","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aan2742","article-title":"Miniaturized neural system for chronic, local intracerebral drug delivery","volume":"10","author":"Dagdeviren","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neuroscience.2024.10.047_b0045","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1152\/jn.00277.2023","article-title":"Side-by-side regions in dorsolateral prefrontal cortex estimated within the individual respond differentially to domain-specific and domain-flexible processes","volume":"130","author":"DiNicola","year":"2023","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuroscience.2024.10.047_b0050","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuron.2009.11.031","article-title":"Are The Dorsal and Ventral Hippocampus functionally distinct structures?","volume":"65","author":"Fanselow","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2024.10.047_b0055","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bbi.2014.06.009","article-title":"Single episode of mild murine malaria induces neuroinflammation, alters microglial profile, impairs adult neurogenesis, and causes deficits in social and anxiety-like behavior","volume":"42","author":"Guha","year":"2014","journal-title":"Brain, Behav. Immun."},{"key":"10.1016\/j.neuroscience.2024.10.047_b0060","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2019.00689","article-title":"Tissue response to neural implants: The use of model systems toward new design solutions of implantable microelectrodes","volume":"13","author":"Gulino","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuroscience.2024.10.047_b0065","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3171\/2009.7.JNS09652","article-title":"Image-guided convection-enhanced delivery of muscimol to the primate brain","volume":"112","author":"Heiss","year":"2010","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.neuroscience.2024.10.047_b0070","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1021\/cn500256e","article-title":"Brain tissue responses to neural implants impact signal sensitivity and intervention strategies","volume":"6","author":"Kozai","year":"2015","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.neuroscience.2024.10.047_b0075","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s13311-017-0520-4","article-title":"Convection-enhanced delivery","volume":"14","author":"Mehta","year":"2017","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.neuroscience.2024.10.047_b0080","doi-asserted-by":"crossref","unstructured":"Muschamp, John W et al. \u201cActivation of CREB in the nucleus accumbens shell produces anhedonia and resistance to extinction of fear in rats.\u201d J. Neurosc. Official J. Soc. Neurosci. vol. 31,8 (2011): 3095-103. doi:10.1523\/JNEUROSCI.5973-10.2011.","DOI":"10.1523\/JNEUROSCI.5973-10.2011"},{"key":"10.1016\/j.neuroscience.2024.10.047_b0085","doi-asserted-by":"crossref","unstructured":"Park, S. et al. Adaptive and multifunctional hydrogel hybrid probes for long-term sensing and modulation of neural activity. Nat. Commun. 2021 12:1 12, 1\u201312 (2021).","DOI":"10.1038\/s41467-021-23802-9"},{"key":"10.1016\/j.neuroscience.2024.10.047_b0090","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.cell.2016.03.047","article-title":"Targeting Neural Circuits","volume":"165","author":"Rajasethupathy","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2024.10.047_b0095","doi-asserted-by":"crossref","first-page":"7254","DOI":"10.1073\/pnas.1804372115","article-title":"Focal, remote-controlled, chronic chemical modulation of brain microstructures","volume":"115","author":"Ramadi","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.neuroscience.2024.10.047_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/jcs.50.1.1","article-title":"Anomalous preferences of cultured macrophages for hydrophobic and roughened substrata","volume":"50","author":"Rich","year":"1981","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.neuroscience.2024.10.047_b0105","doi-asserted-by":"crossref","unstructured":"Schwerdt, H. N. et al. Cellular-scale probes enable stable chronic subsecond monitoring of dopamine neurochemicals in a rodent model. Commun. Biol. 2018 1:1 1, 1\u201311 (2018).","DOI":"10.1038\/s42003-018-0147-y"},{"key":"10.1016\/j.neuroscience.2024.10.047_b0110","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1109\/TBME.2008.2003261","article-title":"In Vivo penetration mechanics and mechanical properties of mouse brain tissue at micrometer scales","volume":"56","author":"Sharp","year":"2009","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"10.1016\/j.neuroscience.2024.10.047_b0115","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1039\/C6LC01411A","article-title":"A three dimensional in vitro glial scar model to investigate the local strain effects from micromotion around neural implants","volume":"17","author":"Spencer","year":"2017","journal-title":"Lab. Chip"},{"key":"10.1016\/j.neuroscience.2024.10.047_b0120","doi-asserted-by":"crossref","unstructured":"Spencer, K. C. et al. Characterization of mechanically matched hydrogel coatings to improve the biocompatibility of neural implants. Sci. Rep. 2017 7:1 7, 1\u201316 (2017).","DOI":"10.1038\/s41598-017-02107-2"},{"key":"10.1016\/j.neuroscience.2024.10.047_b0125","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/cne.24381","article-title":"Brain maps 4.0-Structure of the rat brain: An open access atlas with global nervous system nomenclature ontology and flatmaps","volume":"526","author":"Swanson","year":"2018","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neuroscience.2024.10.047_b0130","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0006-8993(03)03023-3","article-title":"Brain responses to micro-machined silicon devices","volume":"983","author":"Szarowski","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.neuroscience.2024.10.047_b0135","article-title":"Micro\/nanosystems for controllable drug delivery to the brain","volume":"5","author":"Tian","year":"2024","journal-title":"Innovation"},{"key":"10.1016\/j.neuroscience.2024.10.047_b0140","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/exnr.1998.6983","article-title":"Cerebral astrocyte response to micromachined silicon implants","volume":"156","author":"Turner","year":"1999","journal-title":"Exp. Neurol."}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452224005645?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452224005645?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T05:32:55Z","timestamp":1734586375000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452224005645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":28,"alternative-id":["S0306452224005645"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2024.10.047","relation":{},"ISSN":["0306-4522"],"issn-type":[{"type":"print","value":"0306-4522"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microdosing of a kappa opioid receptor agonist within proximal nucleus accumbens shell microstructures revealing opposing behavioral outcomes","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2024.10.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}