{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:03:02Z","timestamp":1792598582411,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["ibroneuroscience.org","clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.neuroscience.2024.11.014","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T21:47:10Z","timestamp":1731102430000},"page":"41-51","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Quantitative assessments of white matter hyperintensities and plasma biomarkers can predict cognitive impairment and cerebral microbleeds in cerebral small vessel disease patients"],"prefix":"10.1016","volume":"564","author":[{"given":"Zhuo","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3018-8924","authenticated-orcid":false,"given":"Xiaohan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yike","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0795-3006","authenticated-orcid":false,"given":"You","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2024.11.014_b0005","doi-asserted-by":"crossref","unstructured":"ALAWODE, D. O. T., HESLEGRAVE, A. J., ASHTON, N. J., KARIKARI, T. K., SIMR\u00e9N, J., MONTOLIU-GAYA, L., PANNEE, J., A, O. C., WESTON, P. S. J., LANTERO-RODRIGUEZ, J., KESHAVAN, A., SNELLMAN, A., GOBOM, J., PATERSON, R. W., SCHOTT, J. M., BLENNOW, K., FOX, N. C. & ZETTERBERG, H. 2021. Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's disease. J Intern Med, 290, 583-601.","DOI":"10.1111\/joim.13332"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0010","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1001\/archneur.63.2.246","article-title":"Association of white matter hyperintensity volume with decreased cognitive functioning: The Framingham Heart Study","volume":"63","author":"Au","year":"2006","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neuroscience.2024.11.014_b0015","doi-asserted-by":"crossref","unstructured":"BACHMANN, D., VON RICKENBACH, B., BUCHMANN, A., H\u00fcLLNER, M., ZUBER, I., STUDER, S., SAAKE, A., RAUEN, K., GRUBER, E., NITSCH, R. M., HOCK, C., TREYER, V. & GIETL, A. 2024. White matter hyperintensity patterns: associations with comorbidities, amyloid, and cognition. Alzheimers Res Ther, 16, 67.","DOI":"10.1186\/s13195-024-01435-6"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0020","doi-asserted-by":"crossref","unstructured":"BRUGULAT-SERRAT, A., SALVAD\u00f3, G., SUDRE, C. H., GRAU-RIVERA, O., SU\u00e1REZ-CALVET, M., FALCON, C., S\u00e1NCHEZ-BENAVIDES, G., GRAMUNT, N., FAURIA, K., CARDOSO, M. J., BARKHOF, F., MOLINUEVO, J. L. & GISPERT, J. D. 2020. Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals. Brain Imaging Behav, 14, 2012-2023.","DOI":"10.1007\/s11682-019-00151-2"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0025","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1212\/WNL.0000000000007654","article-title":"CNS small vessel disease: A clinical review","volume":"92","author":"Cannistraro","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0030","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1093\/geronb\/gbac137","article-title":"Sleep parameters and plasma biomarkers for cognitive impairment evaluation in patients with cerebral small vessel disease","volume":"78","author":"Chen","year":"2023","journal-title":"J. Gerontol. B Psychol. Sci. Soc. Sci."},{"key":"10.1016\/j.neuroscience.2024.11.014_b0035","doi-asserted-by":"crossref","unstructured":"DING, J., SIGUR\u00f0SSON, S., J\u00f3NSSON, P. V., EIRIKSDOTTIR, G., MEIRELLES, O., KJARTANSSON, O., LOPEZ, O. L., VAN BUCHEM, M. A., GUDNASON, V. & LAUNER, L. J. 2017. Space and location of cerebral microbleeds, cognitive decline, and dementia in the community. Neurology, 88, 2089-2097.","DOI":"10.1212\/WNL.0000000000003983"},{"issue":"Suppl 2","key":"10.1016\/j.neuroscience.2024.11.014_b0040","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/jnc.13607","article-title":"Neuroinflammation: the devil is in the details","volume":"139","author":"Disabato","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuroscience.2024.11.014_b0045","doi-asserted-by":"crossref","unstructured":"DUERING, M., KONIECZNY, M. J., TIEDT, S., BAYKARA, E., TULADHAR, A. M., LEIJSEN, E. V., LYRER, P., ENGELTER, S. T., GESIERICH, B., ACHM\u00fcLLER, M., BARRO, C., ADAM, R., EWERS, M., DICHGANS, M., KUHLE, J., DE LEEUW, F. E. & PETERS, N. 2018. Serum Neurofilament Light Chain Levels Are Related to Small Vessel Disease Burden. J Stroke, 20, 228-238.","DOI":"10.5853\/jos.2017.02565"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0050","doi-asserted-by":"crossref","unstructured":"DUERING, M., BIESSELS, G. J., BRODTMANN, A., CHEN, C., CORDONNIER, C., DE LEEUW, F. E., DEBETTE, S., FRAYNE, R., JOUVENT, E., ROST, N. S., TER TELGTE, A., AL-SHAHI SALMAN, R., BACKES, W. H., BAE, H. J., BROWN, R., CHABRIAT, H., DE LUCA, A., DECARLI, C., DEWENTER, A., DOUBAL, F. N., EWERS, M., FIELD, T. S., GANESH, A., GREENBERG, S., HELMER, K. G., HILAL, S., JOCHEMS, A. C. C., JOKINEN, H., KUIJF, H., LAM, B. Y. K., LEBENBERG, J., MACINTOSH, B. J., MAILLARD, P., MOK, V. C. T., PANTONI, L., RUDILOSSO, S., SATIZABAL, C. L., SCHIRMER, M. D., SCHMIDT, R., SMITH, C., STAALS, J., THRIPPLETON, M. J., VAN VELUW, S. J., VEMURI, P., WANG, Y., WERRING, D., ZEDDE, M., AKINYEMI, R. O., DEL BRUTTO, O. H., MARKUS, H. S., ZHU, Y. C., SMITH, E. E., DICHGANS, M. & WARDLAW, J. M. 2023. Neuroimaging standards for research into small vessel disease-advances since 2013. Lancet Neurol, 22, 602-618.","DOI":"10.1016\/S1474-4422(23)00131-X"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0055","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.747115","article-title":"Total cerebral small vessel disease burden on MRI correlates with cognitive impairment in outpatients with amnestic disorders","volume":"12","author":"Fan","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neuroscience.2024.11.014_b0060","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.fertnstert.2009.03.029","article-title":"The measurements of RAGE, VEGF, and AGEs in the plasma and follicular fluid of reproductive women: the influence of aging","volume":"94","author":"Fujii","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.neuroscience.2024.11.014_b0065","doi-asserted-by":"crossref","unstructured":"GALEA, I. 2021. The blood-brain barrier in systemic infection and inflammation. Cell Mol Immunol, 18, 2489-2501.","DOI":"10.1038\/s41423-021-00757-x"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0070","doi-asserted-by":"crossref","unstructured":"GARNIER-CRUSSARD, A., BOUGACHA, S., WIRTH, M., DAUTRICOURT, S., SHERIF, S., LANDEAU, B., GONNEAUD, J., DE FLORES, R., DE LA SAYETTE, V., VIVIEN, D., KROLAK-SALMON, P. & CH\u00e9TELAT, G. 2022. White matter hyperintensity topography in Alzheimer's disease and links to cognition. Alzheimers Dement, 18, 422-433.","DOI":"10.1002\/alz.12410"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0075","doi-asserted-by":"crossref","unstructured":"GATTRINGER, T., PINTER, D., ENZINGER, C., SEIFERT-HELD, T., KNEIHSL, M., FANDLER, S., PICHLER, A., BARRO, C., GR\u00f6BKE, S., VOORTMAN, M., PIRPAMER, L., HOFER, E., ROPELE, S., SCHMIDT, R., KUHLE, J., FAZEKAS, F. & KHALIL, M. 2017. Serum neurofilament light is sensitive to active cerebral small vessel disease. Neurology, 89, 2108-2114.","DOI":"10.1212\/WNL.0000000000004645"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0080","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1093\/brain\/awz162","article-title":"White matter hyperintensities: Relationship to amyloid and tau burden","volume":"142","author":"Graff-Radford","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0085","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1212\/WNL.0000000000004643","article-title":"In vivo staging of regional amyloid deposition","volume":"89","author":"Grothe","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0090","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13195-023-01174-0","article-title":"The dynamics of plasma biomarkers across the Alzheimer's continuum","volume":"15","author":"Guo","year":"2023","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.neuroscience.2024.11.014_b0095","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.949763","article-title":"White matter hyperintensities volume and cognition: A meta-analysis","volume":"14","author":"Guo","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neuroscience.2024.11.014_b0100","doi-asserted-by":"crossref","unstructured":"HABES, M., SOTIRAS, A., ERUS, G., TOLEDO, J. B., JANOWITZ, D., WOLK, D. A., SHOU, H., BRYAN, N. R., DOSHI, J., V\u00f6LZKE, H., SCHMINKE, U., HOFFMANN, W., RESNICK, S. M., GRABE, H. J. & DAVATZIKOS, C. 2018. White matter lesions: Spatial heterogeneity, links to risk factors, cognition, genetics, and atrophy. Neurology, 91, e964-e975.","DOI":"10.1212\/WNL.0000000000006116"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0105","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201899430","article-title":"Beclin1-driven autophagy modulates the inflammatory response of microglia via NLRP3","volume":"38","author":"Houtman","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.neuroscience.2024.11.014_b0110","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neubiorev.2020.11.007","article-title":"White matter hyperintensities and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 36 prospective studies","volume":"120","author":"Hu","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuroscience.2024.11.014_b0115","doi-asserted-by":"crossref","unstructured":"HUSS, A., ABDELHAK, A., MAYER, B., TUMANI, H., M\u00fcLLER, H. P., ALTHAUS, K., KASSUBEK, J., OTTO, M., LUDOLPH, A. C., YILMAZER-HANKE, D. & NEUGEBAUER, H. 2022. Association of Serum GFAP with Functional and Neurocognitive Outcome in Sporadic Small Vessel Disease. Biomedicines, 10.","DOI":"10.3390\/biomedicines10081869"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0120","doi-asserted-by":"crossref","unstructured":"IMBIMBO, B. P., WATLING, M., IMBIMBO, C. & NISTIC\u00f2, R. 2023. Plasma ATN(I) classification and precision pharmacology in Alzheimer's disease. Alzheimers Dement, 19, 4729-4734.","DOI":"10.1002\/alz.13084"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0125","doi-asserted-by":"crossref","unstructured":"JACK, C. R., JR., BENNETT, D. A., BLENNOW, K., CARRILLO, M. C., DUNN, B., HAEBERLEIN, S. B., HOLTZMAN, D. M., JAGUST, W., JESSEN, F., KARLAWISH, J., LIU, E., MOLINUEVO, J. L., MONTINE, T., PHELPS, C., RANKIN, K. P., ROWE, C. C., SCHELTENS, P., SIEMERS, E., SNYDER, H. M. & SPERLING, R. 2018. NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease. Alzheimers Dement, 14, 535-562.","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0130","doi-asserted-by":"crossref","unstructured":"KIM, H. J., PARK, S., CHO, H., JANG, Y. K., SAN LEE, J., JANG, H., KIM, Y., KIM, K. W., RYU, Y. H., CHOI, J. Y., MOON, S. H., WEINER, M. W., JAGUST, W. J., RABINOVICI, G. D., DECARLI, C., LYOO, C. H., NA, D. L. & SEO, S. W. 2018. Assessment of Extent and Role of Tau in Subcortical Vascular Cognitive Impairment Using 18F-AV1451 Positron Emission Tomography Imaging. JAMA Neurol, 75, 999-1007.","DOI":"10.1001\/jamaneurol.2018.0975"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0135","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1212\/WNL.0000000000000505","article-title":"Presence and progression of white matter hyperintensities and cognition: A meta-analysis","volume":"82","author":"Kloppenborg","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0140","doi-asserted-by":"crossref","unstructured":"LAMPE, L., KHARABIAN-MASOULEH, S., KYNAST, J., ARELIN, K., STEELE, C. J., L\u00f6FFLER, M., WITTE, A. V., SCHROETER, M. L., VILLRINGER, A. & BAZIN, P. L. 2019. Lesion location matters: The relationships between white matter hyperintensities on cognition in the healthy elderly. J Cereb Blood Flow Metab, 39, 36-43.","DOI":"10.1177\/0271678X17740501"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0145","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/s41419-020-03137-x","article-title":"Age-related cerebral small vessel disease and inflammaging","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.neuroscience.2024.11.014_b0150","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1177\/0963689718795148","article-title":"Cerebral small vessel disease","volume":"27","author":"Li","year":"2018","journal-title":"Cell Transplant."},{"key":"10.1016\/j.neuroscience.2024.11.014_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2019.100916","article-title":"Inflammation and cerebral small vessel disease: A systematic review","volume":"53","author":"Low","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.neuroscience.2024.11.014_b0160","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.dadm.2016.06.004","article-title":"A blood screening test for Alzheimer's disease","volume":"3","author":"O'Bryant","year":"2016","journal-title":"Alzheimers Dement. (Amst.)"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0165","doi-asserted-by":"crossref","first-page":"e11170","DOI":"10.15252\/emmm.201911170","article-title":"Cerebrospinal fluid and plasma biomarker trajectories with increasing amyloid deposition in Alzheimer's disease","volume":"11","author":"Palmqvist","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.neuroscience.2024.11.014_b0170","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s43856-023-00295-9","article-title":"Integrated algorithm combining plasma biomarkers and cognitive assessments accurately predicts brain \u03b2-amyloid pathology","volume":"3","author":"Pan","year":"2023","journal-title":"Commun. Med. (Lond.)"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0175","doi-asserted-by":"crossref","first-page":"e2535","DOI":"10.1212\/WNL.0000000000201186","article-title":"Association of data-driven white matter hyperintensity spatial signatures with distinct cerebral small vessel disease etiologies","volume":"99","author":"Phuah","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0180","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nrneurol.2015.10","article-title":"White matter hyperintensities, cognitive impairment and dementia: An update","volume":"11","author":"Prins","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neuroscience.2024.11.014_b0185","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/STROKEAHA.120.030302","article-title":"Association of plasma neurofilament light with small vessel disease burden in nondemented elderly: A longitudinal study","volume":"52","author":"Qu","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0190","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.843953","article-title":"Cerebral small vessel disease: neuroimaging features, biochemical markers, influencing factors, pathological mechanism and treatment","volume":"13","author":"Ren","year":"2022","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neuroscience.2024.11.014_b0195","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/acn3.51066","article-title":"Relation of plasma \u03b2-amyloid, clusterin, and tau with cerebral microbleeds: Framingham Heart Study","volume":"7","author":"Romero","year":"2020","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.neuroscience.2024.11.014_b0200","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1037\/neu0000718","article-title":"Periventricular and deep abnormal white matter differ in associations with cognitive performance at midlife","volume":"35","author":"Sanderson-Cimino","year":"2021","journal-title":"Neuropsychology"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0205","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1212\/WNL.0b013e3182661f2b","article-title":"Trajectory of white matter hyperintensity burden preceding mild cognitive impairment","volume":"79","author":"Silbert","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0210","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/imr.13121","article-title":"Targetability of the neurovascular unit in inflammatory diseases of the central nervous system","volume":"311","author":"Smith","year":"2022","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.neuroscience.2024.11.014_b0215","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.neuroscience.2024.11.014_b0220","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.661838","article-title":"Blood-brain barrier dysfunction amplifies the development of neuroinflammation: Understanding of cellular events in brain microvascular endothelial cells for prevention and treatment of BBB dysfunction","volume":"15","author":"Takata","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuroscience.2024.11.014_b0225","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1093\/brain\/awh253","article-title":"Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI","volume":"127","author":"Werring","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0230","doi-asserted-by":"crossref","first-page":"8506","DOI":"10.18632\/aging.103154","article-title":"White matter hyperintensities associated with progression of cerebral small vessel disease: A 7-year Chinese urban community study","volume":"12","author":"Xia","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.neuroscience.2024.11.014_b0235","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.mcn.2016.08.003","article-title":"MCP-1-mediated activation of microglia promotes white matter lesions and cognitive deficits by chronic cerebral hypoperfusion in mice","volume":"78","author":"Yuan","year":"2017","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neuroscience.2024.11.014_b0240","doi-asserted-by":"crossref","first-page":"1096808","DOI":"10.3389\/fnagi.2023.1096808","article-title":"Value of white matter hyperintensity volume and total white matter volume for evaluating cognitive impairment in patients with cerebral small-vessel disease","volume":"15","author":"Zhang","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neuroscience.2024.11.014_b0245","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1084\/jem.20160844","article-title":"Soluble TREM2 induces inflammatory responses and enhances microglial survival","volume":"214","author":"Zhong","year":"2017","journal-title":"J. Exp. Med."}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452224005967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452224005967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T10:36:42Z","timestamp":1734086202000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452224005967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":49,"alternative-id":["S0306452224005967"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2024.11.014","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative assessments of white matter hyperintensities and plasma biomarkers can predict cognitive impairment and cerebral microbleeds in cerebral small vessel disease patients","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2024.11.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}