{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:39:21Z","timestamp":1791409161117,"version":"4.3.3"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004263","name":"Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","award":["24\/2551-0001237-0"],"award-info":[{"award-number":["24\/2551-0001237-0"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","award":["23\/2551-0001853-5"],"award-info":[{"award-number":["23\/2551-0001853-5"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior","doi-asserted-by":"publisher","award":["1333\/2023"],"award-info":[{"award-number":["1333\/2023"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["307690\/2021-0"],"award-info":[{"award-number":["307690\/2021-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.neuroscience.2025.01.048","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T07:13:43Z","timestamp":1737962023000},"page":"377-387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Development and applications of a machine learning model for an in-depth analysis of pentylenetetrazol-induced seizure-like behaviors in adult zebrafish"],"prefix":"10.1016","volume":"568","author":[{"given":"Barbara D.","family":"Fontana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela E.","family":"Uchoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana L.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falco L.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e1ssio M.","family":"Resmim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o V.","family":"Borba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Canzian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis B","family":"Rosemberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2025.01.048_b0005","first-page":"1834","article-title":"Preventing human error: The impact of data entry methods on data accuracy and statistical results","volume":"27","author":"Barchard","year":"2011","journal-title":"2009 Fifth Int. Conf. Intell. Comput."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0010","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241612723","article-title":"Optimization of the zebrafish larvae pentylenetetrazol-induced seizure model for the study of caffeine and topiramate interactions","volume":"24","author":"Bartoszek","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0015","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.yebeh.2018.03.019","article-title":"Prodrome in epilepsy","volume":"83","author":"Besag","year":"2018","journal-title":"Epilepsy Behav. EB"},{"key":"10.1016\/j.neuroscience.2025.01.048_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2023.110748","article-title":"Expanding the use of homebase-related parameters to investigate how distinct stressful conditions affect zebrafish behaviors","volume":"125","author":"Borba","year":"2023","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuroscience.2025.01.048_b0025","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2174\/1381612023396654","article-title":"Cognitive and sedative effects of benzodiazepine use","volume":"8","author":"Buffett-Jerrott","year":"2002","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0030","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1021\/cn5000056","article-title":"Classics in chemical neuroscience: diazepam (valium)","volume":"5","author":"Calcaterra","year":"2014","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0035","article-title":"Stress increases susceptibility to pentylenetetrazole-induced seizures in adult zebrafish","volume":"114","author":"Canzian","year":"2021","journal-title":"Epilepsy Behav. EB"},{"key":"10.1016\/j.neuroscience.2025.01.048_b0040","doi-asserted-by":"crossref","DOI":"10.3389\/fepid.2023.1273163","article-title":"Editorial: Epidemiology of epilepsy and seizures","volume":"3","author":"Chen","year":"2023","journal-title":"Front. Epidemiol."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.eplepsyres.2023.107236","article-title":"Chemically-induced epileptic seizures in zebrafish: A systematic review","volume":"197","author":"Chitolina","year":"2023","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0050","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1515\/rns.2011.007","article-title":"Stressing zebrafish for behavioral genetics","volume":"22","author":"Clark","year":"2011","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0055","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24097702","article-title":"Zebrafish as an innovative tool for epilepsy modeling: state of the art and potential future directions","volume":"24","author":"D\u2019Amora","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0060","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s12035-018-1107-8","article-title":"Taurine protects from pentylenetetrazole-induced behavioral and neurochemical changes in zebrafish","volume":"56","author":"Fontana","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neubiorev.2020.06.010","article-title":"Seizing the moment: Zebrafish epilepsy models","volume":"116","author":"Gawel","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0070","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.700253","article-title":"Machine learning in modeling of mouse behavior","volume":"15","author":"Gharagozloo","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0075","doi-asserted-by":"crossref","first-page":"322","DOI":"10.21307\/ane-2020-028","article-title":"Diazepam and electrical stimulation of paleocerebellar cortex inhibits seizures in pentylenetetrazol\u2011kindled rats","volume":"80","author":"Godlevsky","year":"2020","journal-title":"Acta Neurobiol. Exp. (Warsz.)"},{"key":"10.1016\/j.neuroscience.2025.01.048_b0080","first-page":"157","article-title":"Effect of Various Antiepileptic Drugs in Zebrafish PTZ-Seizure Model","volume":"76","author":"Gupta","year":"2014","journal-title":"Indian J. Pharm. Sci."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0085","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.pnpbp.2003.09.026","article-title":"Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice","volume":"28","author":"Hansen","year":"2004","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuroscience.2025.01.048_b0090","doi-asserted-by":"crossref","first-page":"E5351","DOI":"10.1073\/pnas.1515982112","article-title":"Automated measurement of mouse social behaviors using depth sensing, video tracking, and machine learning","volume":"112","author":"Hong","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0095","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"496","author":"Howe","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2025.01.048_b0100","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0197-0186(00)00013-9","article-title":"Mechanisms of action of valproate: a commentatory","volume":"37","author":"Johannessen","year":"2000","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0105","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1527-3458.2003.tb00249.x","article-title":"Valproate: past, present, and future","volume":"9","author":"Johannessen","year":"2003","journal-title":"CNS Drug Rev."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0110","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1577\/T08-075.1","article-title":"An evaluation of data entry error and proofing methods for fisheries data","volume":"138","author":"Johnson","year":"2009","journal-title":"Trans. Am. Fish. Soc."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0115","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.yebeh.2018.12.019","article-title":"Effects of enalapril and losartan alone and in combination with sodium valproate on seizures, memory, and cardiac changes in rats","volume":"92","author":"Joshi","year":"2019","journal-title":"Epilepsy Behav. EB"},{"key":"10.1016\/j.neuroscience.2025.01.048_b0120","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1352\/0895-8017(2002)107<0376:BBSERA>2.0.CO;2","article-title":"Benzodiazepine behavioral side effects: review and implications for individuals with mental retardation","volume":"107","author":"Kalachnik","year":"2002","journal-title":"Am. J. Ment. Retard. AJMR"},{"key":"10.1016\/j.neuroscience.2025.01.048_b0125","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1089\/zeb.2012.0861","article-title":"Towards a comprehensive catalog of zebrafish behavior 1.0 and beyond","volume":"10","author":"Kalueff","year":"2013","journal-title":"Zebrafish"},{"key":"10.1016\/j.neuroscience.2025.01.048_b0130","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2022.1044492","article-title":"Using deep learning to study emotional behavior in rodent models","volume":"16","author":"Kuo","year":"2022","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2023.109783","article-title":"The effects of valproic acid neurotoxicity on aggressive behavior in zebrafish autism model","volume":"275","author":"Li","year":"2024","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0140","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/s41593-018-0209-y","article-title":"DeepLabCut: markerless pose estimation of user-defined body parts with deep learning","volume":"21","author":"Mathis","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054515","article-title":"Seizures induced by pentylenetetrazole in the adult zebrafish: a detailed behavioral characterization","volume":"8","author":"Mussulini","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.neuroscience.2025.01.048_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115655","article-title":"Effects of new antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish","volume":"427","author":"Pier\u00f3g","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0155","doi-asserted-by":"crossref","first-page":"619","DOI":"10.2147\/NDT.S2118","article-title":"Subchronic treatment with antiepileptic drugs modifies pentylenetetrazol-induced seizures in mice: Its correlation with benzodiazepine receptor binding","volume":"4","author":"Rocha","year":"2008","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.nlm.2024.107963","article-title":"Contextual fear conditioning in zebrafish: Influence of different shock frequencies, context, and pharmacological modulation on behavior","volume":"214","author":"Santos","year":"2024","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0165","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.yebeh.2019.03.014","article-title":"Signs and symptoms of the postictal period in epilepsy: A systematic review and meta-analysis","volume":"94","author":"Subota","year":"2019","journal-title":"Epilepsy Behav. EB"},{"key":"10.1016\/j.neuroscience.2025.01.048_b0170","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/epi.12094","article-title":"Tonic phase of a generalized convulsive seizure is an independent predictor of postictal generalized EEG suppression","volume":"54","author":"Tao","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2025.01.048_b0175","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10050951","article-title":"Multimodal Characterization of Seizures in Zebrafish Larvae","volume":"10","author":"Turrini","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.neuroscience.2025.01.048_b0180","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0022-3565(25)20987-9","article-title":"Modulation of GABA-gated chloride ion flux in rat brain by acute and chronic benzodiazepine administration","volume":"246","author":"Yu","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuroscience.2025.01.048_b0185","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.seizure.2021.12.003","article-title":"Combined effects of levetiracetam and sodium valproate on paediatric patients with epilepsy: a systematic review and meta-analysis","volume":"95","author":"Zhu","year":"2022","journal-title":"Seizure"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452225000582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452225000582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:39:42Z","timestamp":1777264782000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452225000582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":37,"alternative-id":["S0306452225000582"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2025.01.048","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and applications of a machine learning model for an in-depth analysis of pentylenetetrazol-induced seizure-like behaviors in adult zebrafish","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2025.01.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}