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Res."},{"issue":"9","key":"10.1016\/j.neuroscience.2025.03.033_b0400","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.it.2020.07.004","article-title":"Astrocyte reactivity: subtypes, states and functions in CNS innate immunity[J]","volume":"41","author":"Sofroniew","year":"2020","journal-title":"Trends Immunol."},{"issue":"7638","key":"10.1016\/j.neuroscience.2025.03.033_b0405","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia[J]","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.neuroscience.2025.03.033_b0410","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41593-020-00783-4","article-title":"Reactive astrocyte nomenclature, definitions, and future directions[J]","volume":"24","author":"Escartin","year":"2021","journal-title":"Nat. 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Chem."},{"issue":"43","key":"10.1016\/j.neuroscience.2025.03.033_b0440","doi-asserted-by":"crossref","first-page":"10939","DOI":"10.1523\/JNEUROSCI.2085-06.2006","article-title":"Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism[J]","volume":"26","author":"Yin","year":"2006","journal-title":"J. Neurosci."},{"issue":"7","key":"10.1016\/j.neuroscience.2025.03.033_b0445","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1471-4914(03)00112-6","article-title":"Astrocytes: a cellular player in Abeta clearance and degradation[J]","volume":"9","author":"Gu\u00e9nette","year":"2003","journal-title":"Trends Mol. 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Immunol."},{"issue":"6","key":"10.1016\/j.neuroscience.2025.03.033_b0560","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.immuni.2012.11.001","article-title":"Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia[J]","volume":"37","author":"Greter","year":"2012","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.neuroscience.2025.03.033_b0565","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1046\/j.0953-816x.2001.01661.x","article-title":"Astrocyte-released cytokines induce ramification and outward K+ channel expression in microglia via distinct signalling pathways[J]","volume":"14","author":"Schilling","year":"2001","journal-title":"Eur. J. Neurosci."},{"issue":"5","key":"10.1016\/j.neuroscience.2025.03.033_b0570","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.neuron.2011.07.022","article-title":"Development of a method for the purification and culture of rodent astrocytes[J]","volume":"71","author":"Foo","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2025.03.033_b0575","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.3389\/fimmu.2020.01416","article-title":"Crosstalk between astrocytes and microglia: an overview[J]","volume":"11","author":"Matejuk","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neuroscience.2025.03.033_b0580","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neuroscience.2018.04.003","article-title":"Cell-to-cell communication by extracellular vesicles: focus on microglia[J]","volume":"405","author":"Paolicelli","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2025.03.033_b0585","doi-asserted-by":"crossref","first-page":"910","DOI":"10.3389\/fphar.2017.00910","article-title":"ATP modifies the proteome of extracellular vesicles released by microglia and influences their action on astrocytes[J]","volume":"8","author":"Drago","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuroscience.2025.03.033_b0590","doi-asserted-by":"crossref","unstructured":"Bianco F, Pravettoni E, Colombo A, et al. Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia[J]. Journal of Immunology (Baltimore, Md.: 1950), 2005, 174(11): 7268-7277.","DOI":"10.4049\/jimmunol.174.11.7268"},{"key":"10.1016\/j.neuroscience.2025.03.033_b0595","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jconrel.2020.04.017","article-title":"Astrocyte-derived extracellular vesicles: neuroreparative properties and role in the pathogenesis of neurodegenerative disorders[J]","volume":"323","author":"Upadhya","year":"2020","journal-title":"Journal of Controlled Release: Official Journal of the Controlled Release Society"},{"issue":"1","key":"10.1016\/j.neuroscience.2025.03.033_b0600","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13024-021-00440-9","article-title":"Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model[J]","volume":"16","author":"Clayton","year":"2021","journal-title":"Mol. 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Neurotherapeutics: The Journal of the American Society for Experimental NeuroTherapeutics, 2023, 20(1): 195-206.","DOI":"10.1007\/s13311-022-01308-6"},{"issue":"1","key":"10.1016\/j.neuroscience.2025.03.033_b0645","doi-asserted-by":"crossref","first-page":"24544","DOI":"10.1038\/srep24544","article-title":"High Resolution Dissection of Reactive Glial Nets in Alzheimer\u2019s Disease[J]","volume":"6","author":"Bouvier","year":"2016","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.neuroscience.2025.03.033_b0650","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/NEN.0b013e3182933788","article-title":"Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in alzheimer disease[J]","volume":"72","author":"Serrano-Pozo","year":"2013","journal-title":"J. Neuropathol. Exp. 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Dis."},{"issue":"9","key":"10.1016\/j.neuroscience.2025.03.033_b0935","doi-asserted-by":"crossref","first-page":"7487","DOI":"10.1007\/s12035-018-0933-z","article-title":"Regulatory effects of neuroinflammatory responses through brain-derived neurotrophic factor signaling in microglial cells[J]","volume":"55","author":"Lai","year":"2018","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.neuroscience.2025.03.033_b0940","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.cell.2017.10.024","article-title":"Synaptic neurexin complexes: a molecular code for the logic of neural circuits[J]","volume":"171","author":"S\u00fcdhof","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2025.03.033_b0945","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.semcdb.2022.05.028","article-title":"Synapse pathology in alzheimer\u2019s disease[J]","volume":"139","author":"Griffiths","year":"2023","journal-title":"Semin. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.neuroscience.2025.03.033_b0950","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.tins.2023.11.010","article-title":"Complement-mediated synapse loss in Alzheimer\u2019s disease: mechanisms and involvement of risk factors[J]","volume":"47","author":"Wen","year":"2024","journal-title":"Trends Neurosci."},{"issue":"5","key":"10.1016\/j.neuroscience.2025.03.033_b0955","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/ana.410270502","article-title":"Synapse loss in frontal cortex biopsies in alzheimer\u2019s disease: correlation with cognitive severity[J]","volume":"27","author":"DeKosky","year":"1990","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuroscience.2025.03.033_b0960","first-page":"1456","volume":"333","author":"Paolicelli","year":"2011","journal-title":"Synaptic Pruning by Microglia Is Necessary for Normal Brain Development[j]"},{"key":"10.1016\/j.neuroscience.2025.03.033_b0965","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3389\/fnmol.2017.00381","article-title":"Roles of glial cells in sculpting inhibitory synapses and neural circuits[J]","volume":"10","author":"Um","year":"2017","journal-title":"Front. Mol. 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Commun."},{"issue":"7","key":"10.1016\/j.neuroscience.2025.03.033_b1060","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1084\/jem.193.7.855","article-title":"Cd47-signal regulatory protein \u03b1 (Sirp\u03b1) regulates Fc\u03b3 and complement receptor\u2013mediated phagocytosis[J]","volume":"193","author":"Oldenborg","year":"2001","journal-title":"J. Exp. Med."},{"issue":"7847","key":"10.1016\/j.neuroscience.2025.03.033_b1065","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/s41586-020-03060-3","article-title":"Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis[J]","volume":"590","author":"Lee","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2025.03.033_b1070","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12974-023-02752-7","article-title":"Astrocytes display ultrastructural alterations and heterogeneity in the hippocampus of aged APP-PS1 mice and human post-mortem brain samples[J]","volume":"20","author":"St-Pierre","year":"2023","journal-title":"J. Neuroinflammation"},{"issue":"7480","key":"10.1016\/j.neuroscience.2025.03.033_b1075","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nature12776","article-title":"Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways[J]","volume":"504","author":"Chung","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2025.03.033_b1080","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.899251","article-title":"The role of astrocytes in synapse loss in Alzheimer\u2019s disease: a systematic review[J]","volume":"16","author":"Hulshof","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuroscience.2025.03.033_b1085","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.844534","article-title":"A neuron, microglia, and astrocyte triple Co-culture model to study alzheimer\u2019s disease[J]","volume":"14","author":"Luchena","year":"2022","journal-title":"Front. Aging Neurosci."},{"issue":"8","key":"10.1016\/j.neuroscience.2025.03.033_b1090","doi-asserted-by":"crossref","first-page":"5568","DOI":"10.1007\/s12035-019-1467-8","article-title":"Activation of mGluR1 mediates C1q-dependent microglial phagocytosis of glutamatergic synapses in alzheimer\u2019s rodent models[J]","volume":"56","author":"Bie","year":"2019","journal-title":"Mol. Neurobiol."},{"issue":"5","key":"10.1016\/j.neuroscience.2025.03.033_b1095","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1007\/s12035-020-01885-7","article-title":"Amyloid fibril-induced astrocytic glutamate transporter disruption contributes to complement C1q-mediated microglial pruning of glutamatergic synapses[J]","volume":"57","author":"Wu","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuroscience.2025.03.033_b1100","doi-asserted-by":"crossref","unstructured":"Vainchtein I D, Chin G, Cho F S, et al. Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development[J]. Science (New York, N.Y.), 2018, 359(6381): 1269-1273.","DOI":"10.1126\/science.aal3589"},{"issue":"19","key":"10.1016\/j.neuroscience.2025.03.033_b1105","doi-asserted-by":"crossref","first-page":"E2705","DOI":"10.1073\/pnas.1604032113","article-title":"IL-33 ameliorates alzheimer\u2019s disease-like pathology and cognitive decline[J]","volume":"113","author":"Fu","year":"2016","journal-title":"PNAS"},{"issue":"10","key":"10.1016\/j.neuroscience.2025.03.033_b1110","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1002\/glia.23664","article-title":"TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment[J]","volume":"67","author":"Jay","year":"2019","journal-title":"Glia"},{"issue":"25","key":"10.1016\/j.neuroscience.2025.03.033_b1115","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1523\/JNEUROSCI.0829-08.2008","article-title":"Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia\/macrophage phenotype in amyloid precursor protein transgenic mice[J]","volume":"28","author":"Maier","year":"2008","journal-title":"J. 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