{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:25:36Z","timestamp":1793175936054,"version":"4.5.0"},"reference-count":96,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T00:00:00Z","timestamp":1743292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074513"],"award-info":[{"award-number":["82074513"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.neuroscience.2025.03.063","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T04:34:44Z","timestamp":1743395684000},"page":"364-380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Electroacupuncture ameliorates cognitive impairment and white matter injury in vascular dementia rats via activating HIF-1\u03b1\/VEGF\/VEGFR2 pathway"],"prefix":"10.1016","volume":"573","author":[{"given":"Yihan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanli","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2025.03.063_b0005","article-title":"Safranal Inhibits Angiogenesis via Targeting HIF-1\u03b1\/VEGF Machinery: In Vitro and Ex Vivo Insights","volume":"11","author":"Abdalla","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0010","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.720715","article-title":"Vascular Dementia and Underlying Sex Differences","volume":"13","author":"Akhter","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0015","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcad019","article-title":"Decreased myelin proteins in brain donors exposed to football-related repetitive head impacts","volume":"5","author":"Alosco","year":"2023","journal-title":"Brain Commun."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010100","article-title":"Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: Current Insights into the Disease Pathophysiology, Diagnosis and Management","volume":"22","author":"Ambrosius","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0025","doi-asserted-by":"crossref","first-page":"e2704","DOI":"10.21769\/BioProtoc.2704","article-title":"Common Carotid Arteries Occlusion Surgery in Adult Rats as a Model of Chronic Cerebral Hypoperfusion","volume":"8","author":"Cao","year":"2018","journal-title":"Bio-Protocol"},{"key":"10.1016\/j.neuroscience.2025.03.063_b0030","first-page":"7730","article-title":"Isoflurane-induced postoperative cognitive dysfunction is mediated by Hypoxia-inducible factor-1\u03b1-dependent neuroinflammation in aged rats","volume":"17","author":"Cao","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0035","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nature04478","article-title":"Angiogenesis in life, disease and medicine","volume":"438","author":"Carmeliet","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2025.03.063_b0040","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/28867","article-title":"Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis","volume":"394","author":"Carmeliet","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2025.03.063_b0045","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.2174\/1570159X19666210729123137","article-title":"The Potential Role of Hypoxia-Inducible Factor-1 in the Progression and Therapy of Central Nervous System Diseases","volume":"20","author":"Chen","year":"2022","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0050","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbi.2018.04.009","article-title":"Inhibition of immunoproteasome promotes angiogenesis via enhancing hypoxia-inducible factor-1\u03b1 abundance in rats following focal cerebral ischaemia","volume":"73","author":"Chen","year":"2018","journal-title":"Brain. Behav. Immun."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2019.104566","article-title":"Tamoxifen promotes white matter recovery and cognitive functions in male mice after chronic hypoperfusion","volume":"131","author":"Chen","year":"2019","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0060","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6632411","article-title":"Effect of Methylene Blue on White Matter Injury after Ischemic Stroke","volume":"2021","author":"Cheng","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0065","doi-asserted-by":"crossref","first-page":"6531","DOI":"10.1038\/onc.2017.243","article-title":"Contribution of vascular endothelial growth factor receptor-2 sialylation to the process of angiogenesis","volume":"36","author":"Chiodelli","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.neuroscience.2025.03.063_b0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25084465","article-title":"Detrimental Roles of Hypoxia-Inducible Factor-1\u03b1 in Severe Hypoxic Brain Diseases","volume":"25","author":"Choi","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0075","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.vph.2016.05.011","article-title":"VEGF receptor signal transduction - A brief update","volume":"86","author":"Claesson Welsh","year":"2016","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0080","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5985143","article-title":"Electroacupuncture Increases the Hippocampal Synaptic Transmission Efficiency and Long-Term Plasticity to Improve Vascular Cognitive Impairment","volume":"2022","author":"Dai","year":"2022","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0085","doi-asserted-by":"crossref","unstructured":"de Bortoli, V. C., Zangrossi J\u00fanior, H., de Aguiar Corr\u00eaa, F. M., Almeida, S. de S., and de Oliveira, A. M. (2005). Inhibitory avoidance memory retention in the elevated T-maze is impaired after perivascular manipulation of the common carotid arteries. Life Sci. 76, 2103\u20132114. doi: 10.1016\/j.lfs.2004.10.035.","DOI":"10.1016\/j.lfs.2004.10.035"},{"key":"10.1016\/j.neuroscience.2025.03.063_b0090","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1007\/s12035-016-9915-1","article-title":"Molecular Mechanisms of Vascular Dementia: What Can Be Learned from Animal Models of Chronic Cerebral Hypoperfusion?","volume":"54","author":"Du","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0095","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/cns.12773","article-title":"Acupuncture inhibits TXNIP-associated oxidative stress and inflammation to attenuate cognitive impairment in vascular dementia rats","volume":"24","author":"Du","year":"2018","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0100","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00401-004-0864-9","article-title":"Experimental cerebral hypoperfusion induces white matter injury and microglial activation in the rat brain","volume":"108","author":"Farkas","year":"2004","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0105","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.632374","article-title":"Dl-3-n-Butylphthalide Alleviates Demyelination and Improves Cognitive Function by Promoting Mitochondrial Dynamics in White Matter Lesions","volume":"13","author":"Feng","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0110","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nm0603-669","article-title":"The biology of VEGF and its receptors","volume":"9","author":"Ferrara","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0115","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/0006-291X(89)92678-8","article-title":"Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells","volume":"161","author":"Ferrara","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0120","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.tins.2008.04.001","article-title":"White matter in learning, cognition and psychiatric disorders","volume":"31","author":"Fields","year":"2008","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0125","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1152\/jn.00221.2016","article-title":"White matter and cognition: making the connection","volume":"116","author":"Filley","year":"2016","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0130","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1177\/0964528420938378","article-title":"Electroacupuncture pretreatment promotes angiogenesis via hypoxia-inducible factor 1\u03b1 and vascular endothelial growth factor in a rat model of chronic myocardial ischemia","volume":"39","author":"Fu","year":"2021","journal-title":"Acupunct. Med."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0135","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1124\/pharmrev.121.000418","article-title":"Therapeutic Opportunities and Delivery Strategies for Brain Revascularization in Stroke, Neurodegeneration, and Aging","volume":"74","author":"Gallego","year":"2022","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0140","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1177\/0271678X17694904","article-title":"The effects of environmental enrichment on white matter pathology in a mouse model of chronic cerebral hypoperfusion","volume":"38","author":"Hase","year":"2018","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0145","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/jnc.14271","article-title":"White matter degeneration in vascular and other ageing-related dementias","volume":"144","author":"Hase","year":"2018","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0150","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neubiorev.2020.11.007","article-title":"White matter hyperintensities and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 36 prospective studies","volume":"120","author":"Hu","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113312","article-title":"Effect of fluoxetine on HIF-1\u03b1- Netrin\/VEGF cascade, angiogenesis and neuroprotection in a rat model of transient middle cerebral artery occlusion","volume":"329","author":"Hu","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0160","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.bbi.2020.10.004","article-title":"Toll-like receptor-2 gene knockout results in neurobehavioral dysfunctions and multiple brain structural and functional abnormalities in mice","volume":"91","author":"Hu","year":"2021","journal-title":"Brain. Behav. Immun."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0165","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1002\/ptr.7487","article-title":"Trilobatin promotes angiogenesis after cerebral ischemia-reperfusion injury via SIRT7\/VEGFA signaling pathway in rats","volume":"36","author":"Huang","year":"2022","journal-title":"Phytother. Res."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0170","article-title":"Family caregiving in dementia and its impact on quality of life and economic burden in Japan-web based survey","volume":"8","author":"Igarashi","year":"2020","journal-title":"J. Mark. Access Heal. Policy"},{"key":"10.1016\/j.neuroscience.2025.03.063_b0175","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1474-4422(19)30290-X","article-title":"Dementia in China: epidemiology, clinical management, and research advances","volume":"19","author":"Jia","year":"2020","journal-title":"Lancet. Neurol."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0180","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","article-title":"Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway","volume":"30","author":"Kaelin","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neuroscience.2025.03.063_b0185","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00401-016-1571-z","article-title":"Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer\u2019s disease","volume":"131","author":"Kalaria","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0190","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12975-017-0555-1","article-title":"Chronic Remote Ischemic Conditioning Is Cerebroprotective and Induces Vascular Remodeling in a VCID Model","volume":"9","author":"Khan","year":"2018","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0195","doi-asserted-by":"crossref","DOI":"10.3390\/cells8111424","article-title":"Oligodendrocytes in Development, Myelin Generation and Beyond","volume":"8","author":"Kuhn","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.neuroscience.2025.03.063_b0200","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1126618","article-title":"Cerebral white matter lesions and regional blood flow are associated with reduced cognitive function in early-stage cognitive impairment","volume":"15","author":"Kuroda","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0205","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/stem.3344","article-title":"Niche-dependent inhibition of neural stem cell proliferation and oligodendrogenesis is mediated by the presence of myelin basic protein","volume":"39","author":"Lakshman","year":"2021","journal-title":"Stem Cells"},{"key":"10.1016\/j.neuroscience.2025.03.063_b0210","article-title":"Efficacy of acupuncture in animal models of vascular dementia: A systematic review and network meta-analysis","volume":"14","author":"Li","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0215","article-title":"Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways","volume":"10","author":"Li","year":"2021","journal-title":"Biol. Open"},{"key":"10.1016\/j.neuroscience.2025.03.063_b0220","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/4894881","article-title":"Electroacupuncture Promotes the Survival of the Grafted Human MGE Neural Progenitors in Rats with Cerebral Ischemia by Promoting Angiogenesis and Inhibiting Inflammation","volume":"2021","author":"Li","year":"2021","journal-title":"Neural Plast."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0225","article-title":"Naoluo Xintong Decoction Ameliorates Cerebral Ischemia-Reperfusion Injury by Promoting Angiogenesis through Activating the HIF-1\u03b1\/VEGF Signaling Pathway in Rats","volume":"2022","author":"Li","year":"2022","journal-title":"Evid. Based. Complement. Alternat. Med."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0230","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.616236","article-title":"Comprehensive Evaluation of White Matter Damage and Neuron Death and Whole-Transcriptome Analysis of Rats With Chronic Cerebral Hypoperfusion","volume":"14","author":"Li","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0235","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1111\/cns.13918","article-title":"Zinc improves neurological recovery by promoting angiogenesis via the astrocyte-mediated HIF-1\u03b1\/VEGF signaling pathway in experimental stroke","volume":"28","author":"Li","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0240","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1007\/s10571-020-00890-7","article-title":"Missense Variants in Hypoxia-Induced VEGFA\/VEGFR2 Signaling Predict the Outcome of Large Artery Atherosclerotic Stroke","volume":"41","author":"Li","year":"2021","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0245","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7190495","article-title":"Effect and Neuroimaging Mechanism of Electroacupuncture for Vascular Cognitive Impairment No Dementia: Study Protocol for a Randomized, Assessor-Blind, Controlled Clinical Trial","volume":"2020","author":"Lin","year":"2020","journal-title":"Evid. Based. Complement. Alternat. Med."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0250","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/bpa.12628","article-title":"Knockdown of HIF-1\u03b1 impairs post-ischemic vascular reconstruction in the brain via deficient homing and sprouting bmEPCs","volume":"28","author":"Liu","year":"2018","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0255","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet (london, England)"},{"key":"10.1016\/j.neuroscience.2025.03.063_b0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnagi.2020.582904","article-title":"Acupuncture Improves White Matter Perfusion and Integrity in Rat Model of Vascular Dementia: An MRI-Based Imaging Study","volume":"12","author":"Ma","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0265","doi-asserted-by":"crossref","DOI":"10.3791\/61941","article-title":"Microdissection of Mouse Brain into Functionally and Anatomically Different Regions","author":"Meyerhoff","year":"2021","journal-title":"J. vis. Exp."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0270","article-title":"Mechanoregulation of Vascular Endothelial Growth Factor Receptor 2 in Angiogenesis","volume":"8","author":"Miller","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0275","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/S0140-6736(15)00463-8","article-title":"Vascular dementia","volume":"386","author":"O\u2019Brien","year":"2015","journal-title":"Lancet."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0280","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s12975-019-00734-7","article-title":"Treadmill Exercise Suppresses Cognitive Decline and Increases White Matter Oligodendrocyte Precursor Cells in a Mouse Model of Prolonged Cerebral Hypoperfusion","volume":"11","author":"Ohtomo","year":"2020","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0285","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.conb.2021.04.005","article-title":"Neurovascular crosstalk coordinates the central nervous system development","volume":"69","author":"Peguera","year":"2021","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0290","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3389\/fimmu.2017.00529","article-title":"Myelin Oligodendrocyte Glycoprotein: Deciphering a Target in Inflammatory Demyelinating Diseases","volume":"8","author":"Peschl","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0295","doi-asserted-by":"crossref","first-page":"437","DOI":"10.31887\/DCNS.2016.18.4\/cepperson","article-title":"Considering sex and gender in Alzheimer disease and other dementias","volume":"18","author":"Podcasy","year":"2016","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neubiorev.2014.01.001","article-title":"Female mice liberated for inclusion in neuroscience and biomedical research","volume":"40","author":"Prendergast","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0305","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.7150\/thno.68304","article-title":"Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment","volume":"12","author":"Rajeev","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.neuroscience.2025.03.063_b0310","doi-asserted-by":"crossref","DOI":"10.1038\/s41582-018-0112-x","article-title":"Myelin oligodendrocyte glycoprotein antibodies in neurological disease","volume":"15","author":"Reindl","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0315","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0166-4328(02)00090-6","article-title":"Persistent impairment of gait performances and working memory after bilateral common carotid artery occlusion in the adult Wistar rat","volume":"136","author":"Sarti","year":"2002","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0320","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0092-8674(01)00518-9","article-title":"HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus","volume":"107","author":"Semenza","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2025.03.063_b0325","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0955-0674(00)00194-0","article-title":"HIF-1 and mechanisms of hypoxia sensing","volume":"13","author":"Semenza","year":"2001","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0330","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8840319","article-title":"An Enriched Environment Enhances Angiogenesis Surrounding the Cingulum in Ischaemic Stroke Rats","volume":"2020","author":"Shen","year":"2020","journal-title":"Neural Plast."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0335","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/161439","article-title":"Acupuncture for Vascular Dementia: A Pragmatic Randomized Clinical Trial","volume":"2015","author":"Shi","year":"2015","journal-title":"ScientificWorldJournal."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0340","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s11655-013-1323-4","article-title":"Effects of acupuncture on Chinese medicine syndromes of vascular dementia","volume":"20","author":"Shi","year":"2014","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0345","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1177\/1947601911423031","article-title":"Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti-and Pro-Angiogenic Therapies","volume":"2","author":"Shibuya","year":"2011","journal-title":"Genes Cancer"},{"key":"10.1016\/j.neuroscience.2025.03.063_b0350","doi-asserted-by":"crossref","first-page":"10198","DOI":"10.3390\/ijms241210198","article-title":"Abnormal Spontaneous Discharges of Primary Sensory Neurons and Pain Behavior in a Rat Model of Vascular Dementia","volume":"24","author":"Song","year":"2023","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0355","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.1038\/s41467-020-18920-9","article-title":"Brain disconnections link structural connectivity with function and behaviour","volume":"11","author":"Thiebaut de Schotten","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0360","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1080\/14737175.2016.1198257","article-title":"Therapeutic options and management of polyneuropathy associated with anti-MAG antibodies","volume":"16","author":"Vallat","year":"2016","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0365","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41401-021-00637-0","article-title":"Triptolide protects against white matter injury induced by chronic cerebral hypoperfusion in mice","volume":"43","author":"Wan","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0370","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuropharm.2018.11.025","article-title":"Neuroprotective effect of l-serine against white matter demyelination by harnessing and modulating inflammation in mice","volume":"146","author":"Wang","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2025.03.063_b0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111183","article-title":"Knockdown of Smox protects the integrity of the blood-brain barrier through antioxidant effect and Nrf2 pathway activation in stroke","volume":"126","author":"Wang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153300","article-title":"Catalpol protects vascular structure and promotes angiogenesis in cerebral ischemic rats by targeting HIF-1\u03b1\/VEGF","volume":"78","author":"Wang","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.neuroscience.2025.03.063_b0385","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1177\/0271678X211065391","article-title":"Oligodendrocyte precursor cell transplantation promotes angiogenesis and remyelination via Wnt\/\u03b2-catenin pathway in a mouse model of middle cerebral artery occlusion","volume":"42","author":"Wang","year":"2022","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0390","doi-asserted-by":"crossref","first-page":"9255","DOI":"10.1111\/jcmm.15570","article-title":"D1 receptor-mediated endogenous tPA upregulation contributes to blood-brain barrier injury after acute ischaemic stroke","volume":"24","author":"Wang","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0395","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s11011-019-00489-y","article-title":"Electroacupuncture ameliorates learning and memory deficits via hippocampal 5-HT1A receptors and the PKA signaling pathway in rats with ischemic stroke","volume":"35","author":"Wang","year":"2020","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0400","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2020.579470","article-title":"The Impact of Age on the Association Between Physical Activity and White Matter Integrity in Cognitively Healthy Older Adults","volume":"12","author":"Wolf","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0405","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20191006","article-title":"Houshiheisan promotes angiogenesis via HIF-1\u03b1\/VEGF and SDF-1\/CXCR4 pathways: in vivo and in vitro","volume":"39","author":"Xiang","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2022.137015","article-title":"Effect of Hyperbaric oxygen on myelin injury and repair after hypoxic-ischemic brain damage in adult rat","volume":"794","author":"Xue","year":"2023","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0415","author":"Yang","year":"2019","journal-title":"Effectiveness of Acupuncture for Vascular Cognitive Impairment No Dementia: a Randomized Controlled Trial."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0420","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/cns.13834","article-title":"Proteomic analysis of the effects of caffeine in a neonatal rat model of hypoxic-ischemic white matter damage","volume":"28","author":"Yang","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0425","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1781","article-title":"Standardizing therapeutic parameters of acupuncture in vascular dementia rats","volume":"10","author":"Yang","year":"2020","journal-title":"Brain Behav."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0430","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2022.909512","article-title":"Acupuncture at GV20 and ST36 Improves the Recovery of Behavioral Activity in Rats Subjected to Cerebral Ischemia\/Reperfusion Injury","volume":"16","author":"Yang","year":"2022","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0435","doi-asserted-by":"crossref","DOI":"10.3390\/cells10051161","article-title":"Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and \u03b2-Amyloid Accumulation in an APP\/tau\/PS1 Mouse Model of Alzheimer\u2019s Disease","volume":"10","author":"Ye","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.neuroscience.2025.03.063_b0440","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.neuint.2016.12.001","article-title":"Mechanisms of acupuncture on vascular dementia\u2014A review of animal studies","volume":"107","author":"Ye","year":"2017","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0445","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1177\/0271678X211010354","article-title":"Connexin43 promotes angiogenesis through activating the HIF-1\u03b1\/VEGF signaling pathway under chronic cerebral hypoperfusion","volume":"41","author":"Yu","year":"2021","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0450","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11164742","article-title":"A Study on the Pathogenesis of Vascular Cognitive Impairment and Dementia: The Chronic Cerebral Hypoperfusion Hypothesis","volume":"11","author":"Yu","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0455","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000021242","article-title":"The effect of scalp electroacupuncture combined with Memantine in patients with vascular dementia: A retrospective study","volume":"99","author":"Yue","year":"2020","journal-title":"Medicine (baltimore)."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0460","doi-asserted-by":"crossref","first-page":"74","DOI":"10.7150\/thno.35841","article-title":"Microglia exacerbate white matter injury via complement C3\/C3aR pathway after hypoperfusion","volume":"10","author":"Zhang","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.neuroscience.2025.03.063_b0465","first-page":"1","article-title":"Curcumin Derivative Cur20 Attenuated Cerebral Ischemic Injury by Antioxidant Effect and HIF-1\u03b1\/VEGF\/TFEB-Activated Angiogenesis","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0470","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1038\/s41467-020-15656-4","article-title":"Glial type specific regulation of CNS angiogenesis by HIF\u03b1-activated different signaling pathways","volume":"11","author":"Zhang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0475","doi-asserted-by":"crossref","first-page":"818","DOI":"10.3109\/00207454.2014.880435","article-title":"Comparison of cognitive performance between two rat models of vascular dementia","volume":"124","author":"Zhang","year":"2014","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.neuroscience.2025.03.063_b0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113574","article-title":"Activin A improves the neurological outcome after ischemic stroke in mice by promoting oligodendroglial ACVR1B-mediated white matter remyelination","volume":"337","author":"Zheng","year":"2021","journal-title":"Exp. Neurol."}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452225002659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452225002659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:29:04Z","timestamp":1778538544000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452225002659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":96,"alternative-id":["S0306452225002659"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2025.03.063","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Electroacupuncture ameliorates cognitive impairment and white matter injury in vascular dementia rats via activating HIF-1\u03b1\/VEGF\/VEGFR2 pathway","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2025.03.063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of International Brain Research Organization (IBRO).","name":"copyright","label":"Copyright"}]}}