{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:26:08Z","timestamp":1790792768509,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.neuroscience.2025.05.307","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T20:13:08Z","timestamp":1748635988000},"page":"129-143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["High-frequency repetitive transcranial magnetic stimulation upregulates BDNF expression and promotes synaptogenesis in mouse models of Parkinson\u2019s disease"],"prefix":"10.1016","volume":"579","author":[{"given":"Dongdong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzhao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2025.05.307_b0005","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrneurol.2015.197","article-title":"Pathogenesis of Parkinson disease\u2013the gut-brain axis and environmental factors","volume":"11","author":"Klingelhoefer","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0010","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/S0140-6736(04)16305-8","article-title":"Parkinson's disease","volume":"363","author":"Samii","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.neuroscience.2025.05.307_b0015","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1056\/NEJMra2401857","article-title":"Parkinson's Disease","volume":"391","author":"Tanner","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0020","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41401-020-0371-0","article-title":"Synaptic and cellular plasticity in Parkinson's disease","volume":"41","author":"Chu","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0025","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.tins.2018.11.001","article-title":"Synaptic, mitochondrial, and lysosomal dysfunction in Parkinson's disease","volume":"42","author":"Nguyen","year":"2019","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0030","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0306-4522(91)90180-V","article-title":"Selective retention of MPP+ within the monoaminergic systems of the primate brain following MPTP administration: an in vivo autoradiographic study","volume":"40","author":"Herkenham","year":"1991","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2025.05.307_b0035","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1177\/147323000903700221","article-title":"Axonal degeneration of nigra-striatum dopaminergic neurons induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice","volume":"37","author":"Li","year":"2009","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21031170","article-title":"BDNF as a promising therapeutic agent in Parkinson's disease","volume":"21","author":"Palasz","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0045","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.pharmthera.2013.01.004","article-title":"GDNF, NGF and BDNF as therapeutic options for neurodegeneration","volume":"138","author":"Allen","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0050","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cell.2021.12.003","article-title":"BDNF signaling in context: From synaptic regulation to psychiatric disorders","volume":"185","author":"Wang","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2025.05.307_b0055","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1038\/s41598-017-04232-4","article-title":"Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson's disease","volume":"7","author":"Fang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0060","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3389\/fneur.2018.00285","article-title":"High-frequency repetitive magnetic stimulation enhances the expression of brain-derived neurotrophic factor through activation of Ca(2+)-calmodulin-dependent protein Kinase II-cAMP-response element-binding protein pathway","volume":"9","author":"Baek","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0065","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/jnc.15740","article-title":"High-frequency repetitive magnetic stimulation rescues ischemia-injured neurons through modulation of glial-derived neurotrophic factor present in the astrocyte's secretome","volume":"164","author":"Gava-Junior","year":"2023","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0070","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3389\/fnhum.2015.00303","article-title":"Possible mechanisms underlying the therapeutic effects of transcranial magnetic stimulation","volume":"9","author":"Chervyakov","year":"2015","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0075","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.4103\/1673-5374.389303","article-title":"High-frequency repetitive transcranial magnetic stimulation promotes neural stem cell proliferation after ischemic stroke","volume":"19","author":"Luo","year":"2024","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0080","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00232-001-0138-6","article-title":"The oxidant thimerosal modulates gating behavior of KCNQ1 by interaction with the channel outer shell","volume":"186","author":"Kerst","year":"2002","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0085","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1523\/JNEUROSCI.0750-19.2019","article-title":"Neuroscience and sex\/gender: looking back and forward","volume":"40","author":"Hines","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2024.173875","article-title":"Sex-based differences in neuropsychiatric symptoms are due to estradiol\/ERalpha-dependent transcriptional regulation via the modulation of steroid levels by sirolimus","volume":"245","author":"Koike-Kumagai","year":"2024","journal-title":"Pharmacol. Biochem. Behav"},{"key":"10.1016\/j.neuroscience.2025.05.307_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102308","article-title":"Neuronal SH2B1 attenuates apoptosis in an MPTP mouse model of Parkinson's disease via promoting PLIN4 degradation","volume":"52","author":"Han","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0100","doi-asserted-by":"crossref","first-page":"7521","DOI":"10.1523\/JNEUROSCI.6751-10.2011","article-title":"Long-term effects of repetitive transcranial magnetic stimulation on markers for neuroplasticity: differential outcomes in anesthetized and awake animals","volume":"31","author":"Gersner","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0105","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s12974-020-01843-z","article-title":"Extrasynaptic CaMKIIalpha is involved in the antidepressant effects of ketamine by downregulating GluN2B receptors in an LPS-induced depression model","volume":"17","author":"Tang","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuroscience.2025.05.307_b0110","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0115","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12974-020-01747-y","article-title":"High-frequency repetitive transcranial magnetic stimulation improves functional recovery by inhibiting neurotoxic polarization of astrocytes in ischemic rats","volume":"17","author":"Hong","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuroscience.2025.05.307_b0120","doi-asserted-by":"crossref","first-page":"8622","DOI":"10.18632\/aging.103179","article-title":"Lemon essential oil ameliorates age-associated cognitive dysfunction via modulating hippocampal synaptic density and inhibiting acetylcholinesterase","volume":"12","author":"Liu","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.neuroscience.2025.05.307_b0125","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1007\/s10571-023-01379-9","article-title":"A study on autophagy related biomarkers in Alzheimer's disease based on bioinformatics","volume":"43","author":"Li","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2024.108511","article-title":"Identification of key mitochondria-related genes and their relevance to the immune system linking Parkinson's disease and primary Sjogren's syndrome through integrated bioinformatics analyses","volume":"175","author":"Zong","year":"2024","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2023.112111","article-title":"Cross-sectional study and bioinformatics analysis to reveal the correlations of osteoporosis in patients with Parkinson's disease","volume":"173","author":"Ma","year":"2023","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166814","article-title":"Identification of Clec7a as the therapeutic target of rTMS in alleviating Parkinson's disease: targeting neuroinflammation","volume":"1869","author":"Chen","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"issue":"Suppl 1","key":"10.1016\/j.neuroscience.2025.05.307_b0145","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.parkreldis.2004.10.012","article-title":"Pathogenesis of nigral cell death in Parkinson's disease","volume":"11","author":"Przedborski","year":"2005","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0150","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19103155","article-title":"BDNF, brain, and regeneration: insights from Zebrafish","volume":"19","author":"Lucini","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0155","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.brainresbull.2020.11.005","article-title":"Proteolytic cleavage of proBDNF to mBDNF in neuropsychiatric and neurodegenerative diseases","volume":"166","author":"Wang","year":"2021","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0160","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/s41582-022-00681-2","article-title":"The microbiome-gut-brain axis in Parkinson disease - from basic research to the clinic","volume":"18","author":"Tan","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0165","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12929-015-0166-7","article-title":"Neurotensin-polyplex-mediated brain-derived neurotrophic factor gene delivery into nigral dopamine neurons prevents nigrostriatal degeneration in a rat model of early Parkinson's disease","volume":"22","author":"Hernandez-Chan","year":"2015","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0170","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jad.2022.11.059","article-title":"Effects of neuronavigation-guided rTMS on serum BDNF, TrkB and VGF levels in depressive patients with suicidal ideation","volume":"323","author":"Pan","year":"2023","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0175","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1177\/1545968319834898","article-title":"rTMS ameliorates prenatal stress-induced cognitive deficits in male-offspring rats associated with BDNF\/TrkB signaling pathway","volume":"33","author":"Shang","year":"2019","journal-title":"Neurorehabil. Neural Repair"},{"key":"10.1016\/j.neuroscience.2025.05.307_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2022.114857","article-title":"Brain-derived neurotrophic factor (BDNF) as a biomarker of treatment response in patients with treatment resistant depression (TRD): a systematic review & meta-analysis","volume":"317","author":"Meshkat","year":"2022","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brs.2016.11.009","article-title":"Neurobiological after-effects of non-invasive brain stimulation","volume":"10","author":"Cirillo","year":"2017","journal-title":"Brain Stimul."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0190","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.clinph.2019.11.002","article-title":"Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): an update (2014-2018)","volume":"131","author":"Lefaucheur","year":"2020","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0195","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3389\/fnhum.2018.00215","article-title":"Mechanisms of transcranial magnetic stimulation treating on post-stroke depression","volume":"12","author":"Duan","year":"2018","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0200","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s12974-022-02501-2","article-title":"Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4\/NFkappaB\/NLRP3 signaling pathway in cerebral ischemic mice","volume":"19","author":"Luo","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuroscience.2025.05.307_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102354","article-title":"High frequency repetitive transcranial magnetic stimulation alleviates cognitive deficits in 3xTg-AD mice by modulating the PI3K\/Akt\/GLT-1 axis","volume":"54","author":"Cao","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0210","doi-asserted-by":"crossref","first-page":"12280","DOI":"10.1073\/pnas.1614042113","article-title":"Identification of the SNARE complex mediating the exocytosis of NMDA receptors","volume":"113","author":"Gu","year":"2016","journal-title":"PNAS"},{"key":"10.1016\/j.neuroscience.2025.05.307_b0215","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S0022-3565(24)35164-X","article-title":"High-affinity interaction of (des-Tyrosyl)dynorphin A(2-17) with NMDA receptors","volume":"291","author":"Tang","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0220","doi-asserted-by":"crossref","first-page":"E59","DOI":"10.1503\/jpn.230090","article-title":"Pharmacological adjuncts and transcranial magnetic stimulation-induced synaptic plasticity: a systematic review","volume":"49","author":"Sohn","year":"2024","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113210","article-title":"Cognitive improvement and synaptic deficit attenuation by a multifunctional carbazole-based cyanine in AD mice model through regulation of Ca(2+)\/CaMKII\/CREB signaling pathway","volume":"327","author":"Chen","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0230","doi-asserted-by":"crossref","first-page":"10097","DOI":"10.1039\/D3FO03987K","article-title":"Fermented soybean foods (natto) ameliorate age-related cognitive decline by hippocampal TAAR1-mediated activation of the CaMKII\/CREB\/BDNF signaling pathway in senescence-accelerated mouse prone 8 (SAMP8)","volume":"14","author":"Zheng","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.neuroscience.2025.05.307_b0235","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0896-6273(00)81010-7","article-title":"Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism","volume":"20","author":"Tao","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2025.05.307_b0240","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.2147\/NDT.S465898","article-title":"Repetitive transcranial magnetic stimulation alleviates MPTP-induced Parkinson's Disease symptoms by regulating CaMKII-CREB-BMAL1 pathway in mice model","volume":"20","author":"Chen","year":"2024","journal-title":"Neuropsychiatr. Dis. Treat."}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452225006712?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452225006712?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T15:53:06Z","timestamp":1751557986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452225006712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":48,"alternative-id":["S0306452225006712"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2025.05.307","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-frequency repetitive transcranial magnetic stimulation upregulates BDNF expression and promotes synaptogenesis in mouse models of Parkinson\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2025.05.307","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}