{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:19:39Z","timestamp":1770272379801,"version":"3.49.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007688","name":"American University of Beirut","doi-asserted-by":"publisher","award":["MPP CFU320105"],"award-info":[{"award-number":["MPP CFU320105"]}],"id":[{"id":"10.13039\/100007688","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.neuroscience.2025.12.017","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T16:03:58Z","timestamp":1765209838000},"page":"96-105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Nitrous oxide promotes exploratory activity and stimulates neurogenesis in a male rat model of post-traumatic stress disorder"],"prefix":"10.1016","volume":"593","author":[{"given":"Batoul","family":"Darwish","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jad El","family":"Masri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Hourieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziad","family":"Nahas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9719-9324","authenticated-orcid":false,"given":"Wassim","family":"Abou-Kheir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3559-457X","authenticated-orcid":false,"given":"Farah","family":"Chamaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.neuroscience.2025.12.017_b0005","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nrn.2017.45","article-title":"Adult hippocampal neurogenesis and cognitive flexibility \u2014 linking memory and mood","volume":"18","author":"Anacker","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuroscience.2025.12.017_b0010","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1146\/annurev-clinpsy-032210-104544","article-title":"The nature and significance of memory disturbance in posttraumatic stress disorder","volume":"7","author":"Brewin","year":"2011","journal-title":"Annu. Rev. Clin. Psychol."},{"issue":"4","key":"10.1016\/j.neuroscience.2025.12.017_b0015","doi-asserted-by":"crossref","first-page":"557","DOI":"10.2174\/1570159X21666230428091433","article-title":"Treatment of posttraumatic stress disorder: a state-of-the-art review","volume":"22","author":"Burback","year":"2024","journal-title":"Curr. Neuropharmacol."},{"issue":"12","key":"10.1016\/j.neuroscience.2025.12.017_b0020","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.2174\/1570159X19666210113152954","article-title":"PTSD in the COVID-19 Era","volume":"19","author":"Chamaa","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.neuroscience.2025.12.017_b0025","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3389\/fncel.2018.00135","article-title":"Nitrous oxide induces prominent cell proliferation in adult rat hippocampal dentate gyrus","volume":"12","author":"Chamaa","year":"2018","journal-title":"Front. Cell. Neurosci."},{"issue":"21","key":"10.1016\/j.neuroscience.2025.12.017_b0030","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.3390\/cells11213413","article-title":"Sustained activation of the anterior thalamic neurons with low doses of kainic acid boosts hippocampal neurogenesis","volume":"11","author":"Chamaa","year":"2022","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.neuroscience.2025.12.017_b0035","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.brs.2015.09.006","article-title":"Thalamic stimulation in awake rats induces neurogenesis in the hippocampal formation","volume":"9","author":"Chamaa","year":"2016","journal-title":"Brain Stimul."},{"issue":"1","key":"10.1016\/j.neuroscience.2025.12.017_b0040","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1038\/s41467-025-57951-y","article-title":"Nitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect","volume":"16","author":"Cichon","year":"2025","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.neuroscience.2025.12.017_b0045","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1093\/ijnp\/pyab052","article-title":"Chronic stress alters astrocyte morphology in mouse prefrontal cortex","volume":"24","author":"Codeluppi","year":"2021","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neuroscience.2025.12.017_b0050","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3389\/fnins.2019.00687","article-title":"Intranigral injection of endotoxin suppresses proliferation of hippocampal progenitor cells","volume":"13","author":"Darwish","year":"2019","journal-title":"Front. Neurosci."},{"issue":"6","key":"10.1016\/j.neuroscience.2025.12.017_b0055","doi-asserted-by":"crossref","first-page":"891","DOI":"10.3390\/biology11060891","article-title":"Urinary tract infections impair adult hippocampal neurogenesis","volume":"11","author":"Darwish","year":"2022","journal-title":"Biology"},{"key":"10.1016\/j.neuroscience.2025.12.017_b0060","doi-asserted-by":"crossref","unstructured":"Frost, E., Rubin, R., 2013. Posterior cranial fossa surgery. Clin. Anesth. Neurosurg., ed. EA Frost (Stoneham, MA: Butterworth-Heinemann, a division of Reed Publishing), 221-244.","DOI":"10.1016\/B978-0-409-90171-9.50015-5"},{"key":"10.1016\/j.neuroscience.2025.12.017_b0065","doi-asserted-by":"crossref","DOI":"10.1038\/s41380-024-02585-7","article-title":"Neurogenesis-dependent remodeling of hippocampal circuits reduces PTSD-like behaviors in adult mice","author":"Fujikawa","year":"2024","journal-title":"Mol. Psychiatry"},{"issue":"5","key":"10.1016\/j.neuroscience.2025.12.017_b0070","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.jpsychires.2010.10.014","article-title":"Reduced hippocampus volume in the mouse model of posttraumatic stress disorder","volume":"45","author":"Golub","year":"2011","journal-title":"J. Psychiatr. Res."},{"issue":"11","key":"10.1016\/j.neuroscience.2025.12.017_b0075","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/S0006-3223(99)00247-4","article-title":"Stress and hippocampal neurogenesis","volume":"46","author":"Gould","year":"1999","journal-title":"Biol. Psychiatry"},{"issue":"Pt 3","key":"10.1016\/j.neuroscience.2025.12.017_b0080","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1046\/j.1365-2818.1999.00457.x","article-title":"The efficiency of systematic sampling in stereology\u2013reconsidered","volume":"193","author":"Gundersen","year":"1999","journal-title":"J. Microsc."},{"key":"10.1016\/j.neuroscience.2025.12.017_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.brat.2019.103513","article-title":"The temporal course of over-generalized conditioned threat expectancies in posttraumatic stress disorder","volume":"124","author":"Hammell","year":"2020","journal-title":"Behav. Res. Ther."},{"issue":"5","key":"10.1016\/j.neuroscience.2025.12.017_b0090","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1007\/s11064-015-1549-6","article-title":"Loss of glial cells of the hippocampus in a rat model of post-traumatic stress disorder","volume":"40","author":"Han","year":"2015","journal-title":"Neurochem. Res."},{"issue":"2","key":"10.1016\/j.neuroscience.2025.12.017_b0095","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/HRP.0000000000000328","article-title":"Does hippocampal volume in patients with posttraumatic stress disorder vary by trauma type?","volume":"30","author":"Hinojosa","year":"2022","journal-title":"Harv. Rev. Psychiatry"},{"key":"10.1016\/j.neuroscience.2025.12.017_b0100","doi-asserted-by":"crossref","unstructured":"Hoppen, T.H., Priebe, S., Vetter, I., Morina, N., 2021. Global burden of post-traumatic stress disorder and major depression in countries affected by war between 1989 and 2019: a systematic review and meta-analysis. BMJ Glob. Health, 6(7). DOI: 10.1136\/bmjgh-2021-006303.","DOI":"10.1136\/bmjgh-2021-006303"},{"issue":"12","key":"10.1016\/j.neuroscience.2025.12.017_b0105","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.biopsych.2022.06.016","article-title":"Nitrous oxide, a rapid antidepressant, has ketamine-like effects on excitatory transmission in the adult hippocampus","volume":"92","author":"Izumi","year":"2022","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuroscience.2025.12.017_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2020.116778","article-title":"Ketamine and nitrous oxide: the evolution of NMDA receptor antagonists as antidepressant agents","volume":"412","author":"Kalmoe","year":"2020","journal-title":"J. Neurol. Sci."},{"issue":"9","key":"10.1016\/j.neuroscience.2025.12.017_b0115","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a018812","article-title":"Neurogenesis in the Adult Hippocampus","volume":"7","author":"Kempermann","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"2","key":"10.1016\/j.neuroscience.2025.12.017_b0120","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0022-3565(25)31834-3","article-title":"Tolerance of mice to nitrous oxide","volume":"211","author":"Koblin","year":"1979","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.neuroscience.2025.12.017_b0125","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neuroscience.2007.05.041","article-title":"Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model","volume":"148","author":"Kohda","year":"2007","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.neuroscience.2025.12.017_b0130","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/bcpt.13598","article-title":"Rapid-acting antidepressants and the regulation of TrkB neurotrophic signalling-Insights from ketamine, nitrous oxide, seizures and anaesthesia","volume":"129","author":"Kohtala","year":"2021","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.neuroscience.2025.12.017_b0135","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-1-4939-8994-2_4","article-title":"The elevated plus maze test for measuring anxiety-like behavior in rodents","volume":"1916","author":"Kraeuter","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.neuroscience.2025.12.017_b0140","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-4939-8994-2_10","article-title":"The Y-maze for assessment of spatial working and reference memory in mice","volume":"1916","author":"Kraeuter","year":"2019","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.neuroscience.2025.12.017_b0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0297330","article-title":"Sustained mood improvement with laughing gas exposure (SMILE): Study protocol for a randomized placebo-controlled pilot trial of nitrous oxide for treatment-resistant depression","volume":"19","author":"Ladha","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2025.12.017_b0150","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.neubiorev.2019.09.024","article-title":"Impaired hippocampus-dependent associative learning as a mechanism underlying PTSD: a meta-analysis","volume":"107","author":"Lambert","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuroscience.2025.12.017_b0155","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3389\/fpsyt.2018.00196","article-title":"Single-prolonged stress: a review of two decades of progress in a rodent model of post-traumatic stress disorder","volume":"9","author":"Lisieski","year":"2018","journal-title":"Front. Psych."},{"issue":"10","key":"10.1016\/j.neuroscience.2025.12.017_b0160","doi-asserted-by":"crossref","first-page":"6680","DOI":"10.1007\/s12035-015-9571-x","article-title":"NOX2 mediated-parvalbumin interneuron loss might contribute to anxiety-like and enhanced fear learning behavior in a rat model of post-traumatic stress disorder","volume":"53","author":"Liu","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.neuroscience.2025.12.017_b0165","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.biopsych.2017.09.006","article-title":"Smaller hippocampal volume in posttraumatic stress disorder: a multisite ENIGMA-PGC study: subcortical volumetry results from posttraumatic stress disorder consortia","volume":"83","author":"Logue","year":"2018","journal-title":"Biol. Psychiatry"},{"issue":"9","key":"10.1016\/j.neuroscience.2025.12.017_b0170","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a021303","article-title":"Regulation of adult neurogenesis and plasticity by (early) stress, glucocorticoids, and inflammation","volume":"7","author":"Lucassen","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.neuroscience.2025.12.017_b0175","unstructured":"Mann, S.K., Marwaha, R., Torrico, T.J., 2024. Posttraumatic stress disorder. In StatPearls. StatPearls Publishing Copyright \u00a9 2024, StatPearls Publishing LLC."},{"key":"10.1016\/j.neuroscience.2025.12.017_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbtep.2021.101714","article-title":"Association between spatial working memory and Re-experiencing symptoms in PTSD","volume":"75","author":"Mathew","year":"2022","journal-title":"J. Behav. Ther. Exp. Psychiatry"},{"issue":"10394","key":"10.1016\/j.neuroscience.2025.12.017_b0190","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/S0140-6736(23)00950-9","article-title":"Treatments for major depression","volume":"401","author":"Myles","year":"2023","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.neuroscience.2025.12.017_b0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pscychresns.2015.01.002","article-title":"A systematic review and meta-analysis of magnetic resonance imaging measurement of structural volumes in posttraumatic stress disorder","volume":"232","author":"O'Doherty","year":"2015","journal-title":"Psychiatry Res."},{"issue":"1","key":"10.1016\/j.neuroscience.2025.12.017_b0200","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s41235-022-00386-6","article-title":"PTSD is associated with impaired event processing and memory for everyday events","volume":"7","author":"Pitts","year":"2022","journal-title":"Cogn. Res. Princ. Implic."},{"key":"10.1016\/j.neuroscience.2025.12.017_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2021.120092","article-title":"Nitrous oxide: an emerging novel treatment for treatment-resistant depression","volume":"434","author":"Quach","year":"2022","journal-title":"J. Neurol. Sci."},{"issue":"8","key":"10.1016\/j.neuroscience.2025.12.017_b0210","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1038\/npp.2017.32","article-title":"Hippocampus glutamate and N-acetyl aspartate markers of excitotoxic neuronal compromise in posttraumatic stress disorder","volume":"42","author":"Rosso","year":"2017","journal-title":"Neuropsychopharmacology"},{"issue":"5634","key":"10.1016\/j.neuroscience.2025.12.017_b0215","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.neuroscience.2025.12.017_b0220","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/hipo.23087","article-title":"New neurons restore structural and behavioral abnormalities in a rat model of PTSD","volume":"29","author":"Schoenfeld","year":"2019","journal-title":"Hippocampus"},{"issue":"1","key":"10.1016\/j.neuroscience.2025.12.017_b0225","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.euroneuro.2013.11.007","article-title":"Intranasal neuropeptide Y reverses anxiety and depressive-like behavior impaired by single prolonged stress PTSD model","volume":"24","author":"Serova","year":"2014","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neuroscience.2025.12.017_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2024.110903","article-title":"Prolonged stress response induced by chronic stress and corticosterone exposure causes adult neurogenesis inhibition and astrocyte loss in mouse hippocampus","volume":"208","author":"Shin","year":"2024","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuroscience.2025.12.017_b0235","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.bbi.2019.05.042","article-title":"Microglial cell hyper-ramification and neuronal dendritic spine loss in the hippocampus and medial prefrontal cortex in a mouse model of PTSD","volume":"80","author":"Smith","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuroscience.2025.12.017_b0240","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3389\/fphar.2017.00615","article-title":"Using the single prolonged stress model to examine the pathophysiology of PTSD","volume":"8","author":"Souza","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuroscience.2025.12.017_b0245","doi-asserted-by":"crossref","DOI":"10.1177\/1744806916679166","article-title":"Hippocampal activation of microglia may underlie the shared neurobiology of comorbid posttraumatic stress disorder and chronic pain","volume":"12","author":"Sun","year":"2016","journal-title":"Mol. Pain"},{"issue":"1","key":"10.1016\/j.neuroscience.2025.12.017_b0250","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41398-024-02928-6","article-title":"Molecular signatures of astrocytes and microglia maladaptive responses to acute stress are rescued by a single administration of ketamine in a rodent model of PTSD","volume":"14","author":"Valenza","year":"2024","journal-title":"Transl. Psychiatry"},{"issue":"4","key":"10.1016\/j.neuroscience.2025.12.017_b0255","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.20l13393","article-title":"Does nitrous oxide help veterans with posttraumatic stress disorder? a case series","volume":"81","author":"Varias","year":"2020","journal-title":"J. Clin. Psychiatry"},{"issue":"1","key":"10.1016\/j.neuroscience.2025.12.017_b0260","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12974-018-1054-3","article-title":"Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats","volume":"15","author":"Wang","year":"2018","journal-title":"J. Neuroinflammation"},{"issue":"3","key":"10.1016\/j.neuroscience.2025.12.017_b0265","article-title":"Pharmacotherapy for post traumatic stress disorder (PTSD)","volume":"3","author":"Williams","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.neuroscience.2025.12.017_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2021.100391","article-title":"Translational relevance of behavioral, neural, and electroencephalographic profiles in a mouse model of post-traumatic stress disorder","volume":"15","author":"Xi","year":"2021","journal-title":"Neurobiol. Stress"},{"key":"10.1016\/j.neuroscience.2025.12.017_b0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.107710","article-title":"Potential link between antidepressant-like effects of ketamine and promotion of adult neurogenesis in the ventral hippocampus of mice","volume":"158","author":"Yamada","year":"2019","journal-title":"Neuropharmacology"},{"issue":"5","key":"10.1016\/j.neuroscience.2025.12.017_b0280","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1213\/00000539-198105000-00001","article-title":"Fast oscillatory EEG activity induced by analgesic concentrations of nitrous oxide in man","volume":"60","author":"Yamamura","year":"1981","journal-title":"Anesth. Analg."},{"issue":"4","key":"10.1016\/j.neuroscience.2025.12.017_b0285","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/mp.2017.255","article-title":"Mechanisms of ketamine action as an antidepressant","volume":"23","author":"Zanos","year":"2018","journal-title":"Mol. Psychiatry"},{"issue":"5","key":"10.1016\/j.neuroscience.2025.12.017_b0290","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.13874","article-title":"Trends in diagnosed posttraumatic stress disorder and acute stress disorder in US College students, 2017-2022","volume":"7","author":"Zhai","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.neuroscience.2025.12.017_b0295","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1756-6606-7-11","article-title":"Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders","volume":"7","author":"Zhang","year":"2014","journal-title":"Mol. Brain"},{"issue":"1","key":"10.1016\/j.neuroscience.2025.12.017_b0300","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41398-021-01707-x","article-title":"Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume","volume":"11","author":"Zheng","year":"2021","journal-title":"Transl. Psychiatry"},{"issue":"4","key":"10.1016\/j.neuroscience.2025.12.017_b0305","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.bpsgos.2023.01.005","article-title":"Underlying hippocampal mechanism of posttraumatic stress disorder treatment outcome: evidence from two clinical trials","volume":"3","author":"Zilcha-Mano","year":"2023","journal-title":"Biol. Psych. Glob. Open Sci."}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452225011649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452225011649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:05:31Z","timestamp":1770224731000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452225011649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":60,"alternative-id":["S0306452225011649"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2025.12.017","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitrous oxide promotes exploratory activity and stimulates neurogenesis in a male rat model of post-traumatic stress disorder","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2025.12.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}