{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:08:55Z","timestamp":1779340135511,"version":"3.51.4"},"reference-count":106,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.neuroscience.2026.02.043","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T16:16:08Z","timestamp":1772036168000},"page":"69-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrative analysis of spontaneous brain activity in Parkinson\u2019s disease: associations with gene expression, cell types, and receptor density"],"prefix":"10.1016","volume":"601","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0876-5649","authenticated-orcid":false,"given":"Zhan-Xiang","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4112-9525","authenticated-orcid":false,"given":"Yuan-Zhi","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3021-5956","authenticated-orcid":false,"given":"Xin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2946-3650","authenticated-orcid":false,"given":"Zhi","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.neuroscience.2026.02.043_b0005","doi-asserted-by":"crossref","first-page":"5517","DOI":"10.1002\/hbm.22567","article-title":"The dorsal medial frontal cortex mediates automatic motor inhibition in uncertain contexts: evidence from combined fMRI and EEG studies","volume":"35","author":"Albares","year":"2014","journal-title":"Hum. Brain Mapp."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.02.043_b0010","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s40001-024-01779-7","article-title":"Role of GABA pathway in motor and non-motor symptoms in Parkinson's disease: a bidirectional circuit","volume":"29","author":"Alharbi","year":"2024","journal-title":"Eur. J. Med. Res."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.02.043_b0015","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/s41467-018-03811-x","article-title":"Gene expression links functional networks across cortex and striatum","volume":"9","author":"Anderson","year":"2018","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.neuroscience.2026.02.043_b0020","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/jama.2019.22360","article-title":"Diagnosis and treatment of parkinson disease: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"J. Am. Med. Assoc."},{"issue":"3","key":"10.1016\/j.neuroscience.2026.02.043_b0025","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.neuroimage.2005.02.018","article-title":"Unified segmentation","volume":"26","author":"Ashburner","year":"2005","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.neuroscience.2026.02.043_b0030","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/hbm.22622","article-title":"Cognitive impairment and resting-state network connectivity in Parkinson's disease","volume":"36","author":"Baggio","year":"2015","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neuroscience.2026.02.043_b0035","article-title":"Emerging roles for aberrant astrocytic calcium signals in Parkinson's disease","volume":"12","author":"Bancroft","year":"2021","journal-title":"Front. Physiol."},{"issue":"10","key":"10.1016\/j.neuroscience.2026.02.043_b0040","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1073\/pnas.0911855107","article-title":"Toward discovery science of human brain function","volume":"107","author":"Biswal","year":"2010","journal-title":"PNAS"},{"issue":"10291","key":"10.1016\/j.neuroscience.2026.02.043_b0045","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson's disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.neuroscience.2026.02.043_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2020.102468","article-title":"Functional connectivity between resting-state networks reflects decline in executive function in Parkinson's disease: a longitudinal fMRI study","volume":"28","author":"Boon","year":"2020","journal-title":"Neuroimage Clin"},{"issue":"2","key":"10.1016\/j.neuroscience.2026.02.043_b0055","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson's disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"issue":"10","key":"10.1016\/j.neuroscience.2026.02.043_b0060","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/acn3.246","article-title":"Dopaminergic, serotonergic, and noradrenergic deficits in Parkinson disease","volume":"2","author":"Buddhala","year":"2015","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"7","key":"10.1016\/j.neuroscience.2026.02.043_b0065","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s40263-021-00836-7","article-title":"Relevance of 5-HT(2A) receptor modulation of pyramidal cell excitability for dementia-related psychosis: implications for pharmacotherapy","volume":"35","author":"Burstein","year":"2021","journal-title":"CNS Drugs"},{"key":"10.1016\/j.neuroscience.2026.02.043_b0070","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.neuroimage.2016.12.018","article-title":"Methods for cleaning the BOLD fMRI signal","volume":"154","author":"Caballero-Gaudes","year":"2017","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroscience.2026.02.043_b0075","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3389\/fncel.2014.00211","article-title":"Astrocytic modulation of blood brain barrier: perspectives on Parkinson's disease","volume":"8","author":"Cabezas","year":"2014","journal-title":"Front. Cell. Neurosci."},{"issue":"6","key":"10.1016\/j.neuroscience.2026.02.043_b0080","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1007\/s11682-019-00160-1","article-title":"Right arcuate fasciculus and superior longitudinal fasciculus abnormalities in primary insomnia","volume":"13","author":"Cai","year":"2019","journal-title":"Brain Imaging Behav."},{"key":"10.1016\/j.neuroscience.2026.02.043_b0085","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fnint.2013.00025","article-title":"Serotonin modulation of cortical neurons and networks","volume":"7","author":"Celada","year":"2013","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.neuroscience.2026.02.043_b0090","first-page":"13","article-title":"DPARSF: a MATLAB toolbox for \u201cpipeline\u201d data analysis of resting-state fMRI","volume":"4","author":"Chao-Gan","year":"2010","journal-title":"Front. Syst. Neurosci."},{"issue":"3","key":"10.1016\/j.neuroscience.2026.02.043_b0095","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1474-4422(06)70373-8","article-title":"Non-motor symptoms of Parkinson's disease: diagnosis and management","volume":"5","author":"Chaudhuri","year":"2006","journal-title":"Lancet Neurol."},{"issue":"10","key":"10.1016\/j.neuroscience.2026.02.043_b0100","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/cns.12464","article-title":"Different patterns of spontaneous brain activity between tremor-dominant and postural instability\/gait difficulty subtypes of Parkinson's disease: a resting-state fMRI study","volume":"21","author":"Chen","year":"2015","journal-title":"CNS Neurosci. Ther."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.02.043_b0105","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/cns.13982","article-title":"Brain energy metabolism: astrocytes in neurodegenerative diseases","volume":"29","author":"Chen","year":"2023","journal-title":"CNS Neurosci. Ther."},{"issue":"Pt 5","key":"10.1016\/j.neuroscience.2026.02.043_b0110","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1093\/brain\/awv051","article-title":"Autism: reduced connectivity between cortical areas involved in face expression, theory of mind, and the sense of self","volume":"138","author":"Cheng","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2026.02.043_b0115","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1273855","article-title":"Unraveling the transcriptomic signatures of Parkinson's disease and major depression using single-cell and bulk data","volume":"15","author":"Christodoulou","year":"2023","journal-title":"Front. Aging Neurosci."},{"issue":"10","key":"10.1016\/j.neuroscience.2026.02.043_b0120","doi-asserted-by":"crossref","DOI":"10.1093\/pnasnexus\/pgad334","article-title":"A unique cell population expressing the Epithelial-Mesenchymal Transition-transcription factor Snail moderates microglial and astrocyte injury responses","volume":"2","author":"Clarkson-Paredes","year":"2023","journal-title":"PNAS Nexus"},{"key":"10.1016\/j.neuroscience.2026.02.043_b0125","doi-asserted-by":"crossref","DOI":"10.3389\/fmmed.2023.1240862","article-title":"Astrocytes in stroke-induced neurodegeneration: a timeline","volume":"3","author":"Collyer","year":"2023","journal-title":"Front. Mol. Med."},{"issue":"Pt 12","key":"10.1016\/j.neuroscience.2026.02.043_b0130","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1093\/brain\/124.12.2503","article-title":"Mechanisms of cognitive set flexibility in Parkinson's disease","volume":"124","author":"Cools","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2026.02.043_b0135","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.freeradbiomed.2013.01.018","article-title":"Parkinson disease: from pathology to molecular disease mechanisms","volume":"62","author":"Dexter","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"24","key":"10.1016\/j.neuroscience.2026.02.043_b0140","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.1007\/s00018-020-03584-x","article-title":"Glial cells in Parkinso\u0144s disease: protective or deleterious?","volume":"77","author":"Domingues","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.02.043_b0145","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1001\/jamaneurol.2017.3299","article-title":"The Parkinson pandemic-a call to action","volume":"75","author":"Dorsey","year":"2018","journal-title":"JAMA Neurol."},{"issue":"s1","key":"10.1016\/j.neuroscience.2026.02.043_b0150","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.3233\/JPD-181474","article-title":"The emerging evidence of the Parkinson pandemic","volume":"8","author":"Dorsey","year":"2018","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.neuroscience.2026.02.043_b0155","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3389\/fncir.2013.00170","article-title":"Pathophysiological power of improper tonic GABA(A) conductances in mature and immature models","volume":"7","author":"Egawa","year":"2013","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.neuroscience.2026.02.043_b0160","first-page":"19","article-title":"Clinical applications of resting state functional connectivity","volume":"4","author":"Fox","year":"2010","journal-title":"Front. Syst. Neurosci."},{"issue":"9","key":"10.1016\/j.neuroscience.2026.02.043_b0165","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nrn2201","article-title":"Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging","volume":"8","author":"Fox","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuroscience.2026.02.043_b0170","doi-asserted-by":"crossref","DOI":"10.1007\/s10753-025-02306-4","article-title":"Integrated analysis of single-cell and transcriptome data reveals the role and regulatory mechanisms of neuroinflammation in Parkinson's disease","author":"Geng","year":"2025","journal-title":"Inflammation"},{"issue":"10","key":"10.1016\/j.neuroscience.2026.02.043_b0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077336","article-title":"Altered resting state brain networks in Parkinson's disease","volume":"8","author":"G\u00f6ttlich","year":"2013","journal-title":"PLoS One"},{"issue":"13","key":"10.1016\/j.neuroscience.2026.02.043_b0180","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1073\/pnas.0308627101","article-title":"Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI","volume":"101","author":"Greicius","year":"2004","journal-title":"PNAS"},{"issue":"10","key":"10.1016\/j.neuroscience.2026.02.043_b0185","doi-asserted-by":"crossref","DOI":"10.3390\/ph16101427","article-title":"Modulation of neuron and astrocyte dopamine receptors via receptor-receptor interactions","volume":"16","author":"Guidolin","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"issue":"Pt 12","key":"10.1016\/j.neuroscience.2026.02.043_b0190","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1093\/brain\/aws281","article-title":"Resting state functional connectivity of the striatum in Parkinson's disease","volume":"135","author":"Hacker","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2026.02.043_b0195","doi-asserted-by":"crossref","first-page":"15132","DOI":"10.1038\/ncomms15132","article-title":"Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism","volume":"8","author":"Hasel","year":"2017","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.neuroscience.2026.02.043_b0200","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1152\/physrev.00049.2005","article-title":"Astrocyte control of synaptic transmission and neurovascular coupling","volume":"86","author":"Haydon","year":"2006","journal-title":"Physiol. Rev."},{"issue":"7","key":"10.1016\/j.neuroscience.2026.02.043_b0205","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.amjmed.2019.03.001","article-title":"Parkinson's disease and parkinsonism","volume":"132","author":"Hayes","year":"2019","journal-title":"Am. J. Med."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.02.043_b0210","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12974-022-02496-w","article-title":"The role of toll-like receptors and neuroinflammation in Parkinson's disease","volume":"19","author":"Heidari","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"5","key":"10.1016\/j.neuroscience.2026.02.043_b0215","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/cercor\/bhp178","article-title":"Spatial remapping of cortico-striatal connectivity in Parkinson's disease","volume":"20","author":"Helmich","year":"2010","journal-title":"Cereb. Cortex"},{"issue":"7","key":"10.1016\/j.neuroscience.2026.02.043_b0220","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nri3705","article-title":"Innate immune activation in neurodegenerative disease","volume":"14","author":"Heneka","year":"2014","journal-title":"Nat. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.neuroscience.2026.02.043_b0225","doi-asserted-by":"crossref","first-page":"5815","DOI":"10.1002\/hbm.22587","article-title":"Frequency-dependent neural activity in Parkinson's disease","volume":"35","author":"Hou","year":"2014","journal-title":"Hum. Brain Mapp."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.02.043_b0230","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s00415-016-8331-9","article-title":"Default-mode network connectivity in cognitively unimpaired drug-na\u00efve patients with rigidity-dominant Parkinson's disease","volume":"264","author":"Hou","year":"2017","journal-title":"J. Neurol."},{"issue":"2","key":"10.1016\/j.neuroscience.2026.02.043_b0235","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.pneurobio.2011.08.004","article-title":"The serotonergic system in Parkinson's disease","volume":"95","author":"Huot","year":"2011","journal-title":"Prog. Neurobiol."},{"issue":"7","key":"10.1016\/j.neuroscience.2026.02.043_b0240","doi-asserted-by":"crossref","DOI":"10.3390\/cells12071012","article-title":"Microglia mediated neuroinflammation in Parkinson's disease","volume":"12","author":"Isik","year":"2023","journal-title":"Cells"},{"issue":"15","key":"10.1016\/j.neuroscience.2026.02.043_b0245","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1002\/hbm.24710","article-title":"Dopaminergic modulation of motor network compensatory mechanisms in Parkinson's disease","volume":"40","author":"Jastrz\u0119bowska","year":"2019","journal-title":"Hum. Brain Mapp."},{"issue":"46","key":"10.1016\/j.neuroscience.2026.02.043_b0250","doi-asserted-by":"crossref","first-page":"19575","DOI":"10.1073\/pnas.0905884106","article-title":"Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling","volume":"106","author":"Jones","year":"2009","journal-title":"PNAS"},{"issue":"7","key":"10.1016\/j.neuroscience.2026.02.043_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A unique microglia type associated with restricting development of Alzheimer's disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.neuroscience.2026.02.043_b0260","doi-asserted-by":"crossref","first-page":"6009","DOI":"10.1038\/s41467-023-41677-w","article-title":"Patient-specific models link neurotransmitter receptor mechanisms with motor and visuospatial axes of Parkinson's disease","volume":"14","author":"Khan","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuroscience.2026.02.043_b0265","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.semcdb.2020.10.013","article-title":"Crossing boundaries: interplay between the immune system and oligodendrocyte lineage cells","volume":"116","author":"Kirby","year":"2021","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.neuroscience.2026.02.043_b0270","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3389\/fneur.2014.00157","article-title":"Cerebellum in levodopa-induced dyskinesias: the unusual suspect in the motor network","volume":"5","author":"Kishore","year":"2014","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.02.043_b0275","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1152\/japplphysiol.00938.2005","article-title":"Role of astrocytes in cerebrovascular regulation","volume":"100","author":"Koehler","year":"2006","journal-title":"J. Appl. Physiol. (1985)"},{"issue":"3","key":"10.1016\/j.neuroscience.2026.02.043_b0280","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1007\/s12035-024-04419-7","article-title":"Single-cell cortical transcriptomics reveals common and distinct changes in cell-cell communication in Alzheimer's and Parkinson's disease","volume":"62","author":"Le Bars","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"Pt 1","key":"10.1016\/j.neuroscience.2026.02.043_b0285","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/brain\/awt162","article-title":"The role of the posterior cingulate cortex in cognition and disease","volume":"137","author":"Leech","year":"2014","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.neuroscience.2026.02.043_b0290","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2174\/1567205011666140331225335","article-title":"Alzheimer's Disease NeuroImaging I. Altered amplitude of low-frequency fluctuations in early and late mild cognitive impairment and Alzheimer's disease","volume":"11","author":"Liang","year":"2014","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.neuroscience.2026.02.043_b0295","first-page":"24","article-title":"Using coherence to measure regional homogeneity of resting-state FMRI signal","volume":"4","author":"Liu","year":"2010","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.neuroscience.2026.02.043_b0300","doi-asserted-by":"crossref","DOI":"10.3389\/fnetp.2022.817524","article-title":"Spike-timing-dependent plasticity mediated by dopamine and its role in Parkinson's disease pathophysiology","volume":"2","author":"Madadi Asl","year":"2022","journal-title":"Front. Netw. Physiol."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.02.043_b0305","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13024-023-00699-0","article-title":"Unravelling cell type-specific responses to Parkinson's disease at single cell resolution","volume":"19","author":"Martirosyan","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neuroscience.2026.02.043_b0310","article-title":"Reactive astrogliosis in the era of single-cell transcriptomics","volume":"17","author":"Matusova","year":"2023","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuroscience.2026.02.043_b0315","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fnana.2020.00026","article-title":"Interactions between the serotonergic and other neurotransmitter systems in the basal ganglia: role in Parkinson's disease and adverse effects of L-DOPA","volume":"14","author":"Mu\u00f1oz","year":"2020","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.neuroscience.2026.02.043_b0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2023.147898","article-title":"Astrocytic transcription factors REST, YY1, and putative microRNAs in Parkinson's disease and advanced therapeutic strategies","volume":"892","author":"Nassar","year":"2024","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.neuroscience.2026.02.043_b0325","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.1038\/s41467-023-40968-6","article-title":"Astrocyte reactivity and inflammation-induced depression-like behaviors are regulated by Orai1 calcium channels","volume":"14","author":"Novakovic","year":"2023","journal-title":"Nat. Commun."},{"issue":"Pt 1","key":"10.1016\/j.neuroscience.2026.02.043_b0330","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/brain\/awt316","article-title":"Disrupted brain network topology in Parkinson's disease: a longitudinal magnetoencephalography study","volume":"137","author":"Olde Dubbelink","year":"2014","journal-title":"Brain"},{"issue":"5","key":"10.1016\/j.neuroscience.2026.02.043_b0335","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s10072-012-1250-3","article-title":"Gray matter atrophy in Parkinson's disease with dementia: evidence from meta-analysis of voxel-based morphometry studies","volume":"34","author":"Pan","year":"2013","journal-title":"Neurol. Sci."},{"issue":"7851","key":"10.1016\/j.neuroscience.2026.02.043_b0340","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s41586-021-03272-1","article-title":"Reset of hippocampal-prefrontal circuitry facilitates learning","volume":"591","author":"Park","year":"2021","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.neuroscience.2026.02.043_b0345","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuron.2011.08.009","article-title":"Role of astrocytes in neurovascular coupling","volume":"71","author":"Petzold","year":"2011","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.neuroscience.2026.02.043_b0350","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41582-023-00809-y","article-title":"Single-cell and spatial transcriptomics: deciphering brain complexity in health and disease","volume":"19","author":"Piwecka","year":"2023","journal-title":"Nat. Rev. Neurol."},{"issue":"12","key":"10.1016\/j.neuroscience.2026.02.043_b0355","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson's disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov. Disord."},{"issue":"13","key":"10.1016\/j.neuroscience.2026.02.043_b0360","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/mds.25945","article-title":"The prevalence of Parkinson's disease: a systematic review and meta-analysis","volume":"29","author":"Pringsheim","year":"2014","journal-title":"Mov. Disord."},{"issue":"Pt 10","key":"10.1016\/j.neuroscience.2026.02.043_b0365","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1093\/brain\/awv215","article-title":"Clinical correlates of raphe serotonergic dysfunction in early Parkinson's disease","volume":"138","author":"Qamhawi","year":"2015","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.neuroscience.2026.02.043_b0370","doi-asserted-by":"crossref","DOI":"10.3390\/biom13040692","article-title":"Large-scale integration of single-cell RNA-Seq data reveals astrocyte diversity and transcriptomic modules across six central nervous system disorders","volume":"13","author":"Qian","year":"2023","journal-title":"Biomolecules"},{"issue":"6301","key":"10.1016\/j.neuroscience.2026.02.043_b0375","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1126\/science.aag2590","article-title":"How neuroinflammation contributes to neurodegeneration","volume":"353","author":"Ransohoff","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2026.02.043_b0380","article-title":"5-HT2A receptor binding in the frontal cortex of Parkinson's disease patients and alpha-synuclein overexpressing mice: a postmortem study","volume":"2016","author":"Rasmussen","year":"2016","journal-title":"Parkinsons Dis"},{"issue":"1","key":"10.1016\/j.neuroscience.2026.02.043_b0385","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016508","article-title":"Extrasynaptic GABA(A) receptors and tonic inhibition in rat auditory thalamus","volume":"6","author":"Richardson","year":"2011","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.neuroscience.2026.02.043_b0390","article-title":"Astrocytic oxidative\/nitrosative stress contributes to Parkinson's disease pathogenesis: the dual role of reactive astrocytes","volume":"8","author":"Rizor","year":"2019","journal-title":"Antioxidants (Basel)"},{"issue":"4","key":"10.1016\/j.neuroscience.2026.02.043_b0395","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S1474-4422(06)70411-2","article-title":"Epidemiological, clinical, and genetic characteristics of early-onset parkinsonism","volume":"5","author":"Schrag","year":"2006","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.02.043_b0400","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1038\/s41467-020-17051-5","article-title":"Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders","volume":"11","author":"Seidlitz","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuroscience.2026.02.043_b0405","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.neuroimage.2011.07.012","article-title":"Apathy, depression, and motor symptoms have distinct and separable resting activity patterns in idiopathic Parkinson disease","volume":"81","author":"Skidmore","year":"2013","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.neuroscience.2026.02.043_b0410","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1093\/brain\/awab446","article-title":"Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state","volume":"145","author":"Smaji\u0107","year":"2022","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.neuroscience.2026.02.043_b0415","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.neuroimage.2008.08.039","article-title":"Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies","volume":"44","author":"Stoodley","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroscience.2026.02.043_b0420","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3389\/fnagi.2017.00176","article-title":"Targeting microglial activation states as a therapeutic avenue in Parkinson's disease","volume":"9","author":"Subramaniam","year":"2017","journal-title":"Front. Aging Neurosci."},{"issue":"6","key":"10.1016\/j.neuroscience.2026.02.043_b0425","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.parkreldis.2012.03.018","article-title":"Resting-state brain connectivity in patients with Parkinson's disease and freezing of gait","volume":"18","author":"Tessitore","year":"2012","journal-title":"Parkinsonism Relat. Disord."},{"issue":"23","key":"10.1016\/j.neuroscience.2026.02.043_b0430","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252312613","article-title":"Decoding neurodegeneration: a review of molecular mechanisms and therapeutic advances in Alzheimer's, Parkinson\u2019s, and ALS","volume":"25","author":"Toader","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.neuroscience.2026.02.043_b0435","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrneurol.2013.132","article-title":"Advances in the genetics of Parkinson disease","volume":"9","author":"Trinh","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neuroscience.2026.02.043_b0440","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fnins.2013.00137","article-title":"A multi-site resting state fMRI study on the amplitude of low frequency fluctuations in schizophrenia","volume":"7","author":"Turner","year":"2013","journal-title":"Front. Neurosci."},{"issue":"3","key":"10.1016\/j.neuroscience.2026.02.043_b0445","article-title":"Brain entropy mapping using fMRI","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2026.02.043_b0450","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.3389\/fphys.2018.01093","article-title":"Abnormal spontaneous brain activity in early Parkinson's disease with mild cognitive impairment: a resting-State fMRI study","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.neuroscience.2026.02.043_b0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2024.111110","article-title":"Alterations of regional homogeneity and functional connectivity in different hoehn and yahr stages of Parkinson's disease","volume":"218","author":"Wang","year":"2024","journal-title":"Brain Res. Bull."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.02.043_b0460","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13024-022-00524-0","article-title":"Solving neurodegeneration: common mechanisms and strategies for new treatments","volume":"17","author":"Wareham","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neuroscience.2026.02.043_b0465","article-title":"Htr2a gene and 5-HT(2A) receptor expression in the cerebral cortex studied using genetically modified mice","volume":"4","author":"Weber","year":"2010","journal-title":"Front. Neurosci."},{"issue":"Pt 2","key":"10.1016\/j.neuroscience.2026.02.043_b0470","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1113\/jphysiol.2004.076042","article-title":"The influence of normal human ageing on automatic movements","volume":"562","author":"Wu","year":"2005","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.neuroscience.2026.02.043_b0475","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1093\/brain\/aws360","article-title":"The cerebellum in Parkinson\u2019s disease","volume":"136","author":"Wu","year":"2013","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.neuroscience.2026.02.043_b0480","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.neulet.2009.05.046","article-title":"Changes of functional connectivity of the motor network in the resting state in Parkinson's disease","volume":"460","author":"Wu","year":"2009","journal-title":"Neurosci. Lett."},{"issue":"9","key":"10.1016\/j.neuroscience.2026.02.043_b0485","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1002\/hbm.21118","article-title":"Functional connectivity of cortical motor areas in the resting state in Parkinson's disease","volume":"32","author":"Wu","year":"2011","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neuroscience.2026.02.043_b0490","article-title":"Altered spontaneous brain activity in cortical and subcortical regions in Parkinson's disease","volume":"2016","author":"Xiang","year":"2016","journal-title":"Parkinsons Dis"},{"issue":"1","key":"10.1016\/j.neuroscience.2026.02.043_b0495","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.neuroimage.2007.01.054","article-title":"Amplitude of low frequency fluctuation within visual areas revealed by resting-state functional MRI","volume":"36","author":"Yang","year":"2007","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.neuroscience.2026.02.043_b0500","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.neuroimage.2006.11.047","article-title":"Role of hyperactive cerebellum and motor cortex in Parkinson's disease","volume":"35","author":"Yu","year":"2007","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroscience.2026.02.043_b0505","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3389\/fnhum.2014.00503","article-title":"Amplitude differences in high-frequency fMRI signals between eyes open and eyes closed resting states","volume":"8","author":"Yuan","year":"2014","journal-title":"Front. Hum. Neurosci."},{"issue":"2","key":"10.1016\/j.neuroscience.2026.02.043_b0510","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.braindev.2006.07.002","article-title":"Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI","volume":"29","author":"Zang","year":"2007","journal-title":"Brain Dev."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.02.043_b0515","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.neuroimage.2003.12.030","article-title":"Regional homogeneity approach to fMRI data analysis","volume":"22","author":"Zang","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroscience.2026.02.043_b0520","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.08440","article-title":"Network structure of brain atrophy in de novo Parkinson's disease","volume":"4","author":"Zeighami","year":"2015","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.neuroscience.2026.02.043_b0525","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuroscience.2026.02.043_b0530","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.neuroimage.2012.10.017","article-title":"Toward reliable characterization of functional homogeneity in the human brain: preprocessing, scan duration, imaging resolution and computational space","volume":"65","author":"Zuo","year":"2013","journal-title":"Neuroimage"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452226001466?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452226001466?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:19:00Z","timestamp":1779337140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452226001466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":106,"alternative-id":["S0306452226001466"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2026.02.043","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative analysis of spontaneous brain activity in Parkinson\u2019s disease: associations with gene expression, cell types, and receptor density","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2026.02.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}