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CHI3L1 (YKL-40) and Chit-1 expressing glia in the white matter of ALS, FTLD, and AD correlate to pathology and disease duration. medRxiv. 10.1101\/2025.05.05.25326702.","DOI":"10.1101\/2025.05.05.25326702"},{"issue":"1","key":"10.1016\/j.neuroscience.2026.05.024_b0845","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40478-015-0215-1","article-title":"Incidence and extent of TDP-43 accumulation in aging human brain","volume":"3","author":"Uchino","year":"2015","journal-title":"Acta Neuropathol. Commun."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.05.024_b0850","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/s12974-020-01909-y","article-title":"Chitotriosidase, a biomarker of amyotrophic lateral sclerosis, accentuates neurodegeneration in spinal motor neurons through neuroinflammation","volume":"17","author":"Varghese","year":"2020","journal-title":"J. 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