{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:35:03Z","timestamp":1793054103994,"version":"4.5.0"},"reference-count":181,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.neuroscience.2026.07.063","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:39:27Z","timestamp":1785253167000},"page":"335-358","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Non-transgenic rodent models associated with Alzheimer\u2019s disease: applications, evaluations, and perspectives"],"prefix":"10.1016","volume":"612","author":[{"given":"Shu","family":"Xing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuangfei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2026.07.063_b0005","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1007\/s10787-025-01755-5","article-title":"Empagliflozin and memantine combination ameliorates cognitive impairment in scopolamine + heavy metal mixture-induced Alzheimer's disease in rats: role of AMPK\/mTOR, BDNF, BACE-1, neuroinflammation, and oxidative stress","volume":"33","author":"Abdel-Lah","year":"2025","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0010","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1002\/mnfr.201100481","article-title":"Toxicology and risk assessment of acrolein in food","volume":"55","author":"Abraham","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0015","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1093\/jpp\/rgad048","article-title":"Spotlight on Coenzyme Q10 in scopolamine-induced Alzheimer's disease: oxidative stress\/PI3K\/AKT\/GSK 3\u00df\/CREB\/BDNF\/TrKB","volume":"75","author":"Abuelezz","year":"2023","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0020","doi-asserted-by":"crossref","DOI":"10.1515\/bmc-2022-0042","article-title":"\u03b2-Amyloid peptide modulates peripheral immune responses and neuroinflammation in rats","volume":"15","author":"Adhikary","year":"2024","journal-title":"Biomol. Concepts"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0025","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.pharep.2019.04.015","article-title":"The protective effect of metformin in scopolamine-induced learning and memory impairment in rats","volume":"71","author":"Aksoz","year":"2019","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0030","doi-asserted-by":"crossref","unstructured":"Al-Joufi, F.A., et al., 2022. Flavonoid derivatives as potential cholinesterase inhibitors in scopolamine-induced amnesic mice: an in vitro, in vivo and integrated computational approach. Brain Sci., 12.","DOI":"10.3390\/brainsci12060731"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0035","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26125541","article-title":"Beyond transgenic mice: emerging models and translational strategies in Alzheimer's disease","volume":"26","author":"Alexandra Lopes","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0045","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1443552","article-title":"Kojic acid reverses LPS-induced neuroinflammation and cognitive impairment by regulating the TLR4\/NF-\u03baB signaling pathway","volume":"15","author":"Ali","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24043754","article-title":"Alzheimer's Disease: an updated overview of its genetics","volume":"24","author":"Andrade-Guerrero","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0055","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ibneur.2025.01.008","article-title":"Neuroprotective effects of empagliflozin against scopolamine-induced memory impairment and oxidative stress in rats","volume":"18","author":"Anoush","year":"2025","journal-title":"IBRO Neurosci. Rep."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0060","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1007\/s00213-021-05903-x","article-title":"Effects of chronic tramadol administration on cognitive flexibility in mice","volume":"238","author":"Attoh-Mensah","year":"2021","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0065","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neurobiolaging.2019.09.008","article-title":"What electrophysiology tells us about Alzheimer's disease: a window into the synchronization and connectivity of brain neurons","volume":"85","author":"Babiloni","year":"2020","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0070","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s40478-022-01417-5","article-title":"Modeling the early stages of Alzheimer's disease by administering intracerebroventricular injections of human native A\u03b2 oligomers to rats","volume":"10","author":"Baerends","year":"2022","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0075","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40478-025-01930-3","article-title":"Tau oligomers impair memory and synaptic plasticity through the cellular prion protein","volume":"13","author":"Balducci","year":"2025","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0080","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3389\/fnagi.2017.00347","article-title":"Sex differences in the cognitive and hippocampal effects of streptozotocin in an animal model of sporadic AD","volume":"9","author":"Bao","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2022.111812","article-title":"MicroRNA modulation is a potential molecular mechanism for neuroprotective effects of intranasal insulin administration in amyloid \u03b2eta oligomer induced Alzheimer's like rat model","volume":"164","author":"Bazrgar","year":"2022","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0090","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nature17655","article-title":"Normalizing the environment recapitulates adult human immune traits in laboratory mice","volume":"532","author":"Beura","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0095","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/35049064","article-title":"Recognition memory: what are the roles of the perirhinal cortex and hippocampus?","volume":"2","author":"Brown","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0100","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1007\/s00213-019-05189-0","article-title":"An automated home-cage-based 5-choice serial reaction time task for rapid assessment of attention and impulsivity in rats","volume":"236","author":"Bruinsma","year":"2019","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0105","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neurobiolaging.2020.08.021","article-title":"LTP-like plasticity is impaired in amyloid-positive amnestic MCI but independent of PET-amyloid burden","volume":"96","author":"Buss","year":"2020","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0110","article-title":"Salidroside ameliorates Alzheimer's disease by targeting NLRP3 inflammasome-mediated pyroptosis","volume":"13","author":"Cai","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2024.105987","article-title":"Electrophysiological insights into Alzheimer's disease: a review of human and animal studies","volume":"169","author":"Calvin-Dunn","year":"2025","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0120","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1007\/s00221-022-06472-x","article-title":"Interaction of cholinergic disruption and age on cognitive flexibility in rats","volume":"240","author":"Cammarata","year":"2022","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0125","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature20412","article-title":"The road to restoring neural circuits for the treatment of Alzheimer's disease","volume":"539","author":"Canter","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0130","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/2031407","article-title":"MiR-29c-3p may promote the progression of Alzheimer's disease through BACE1","volume":"2021","author":"Cao","year":"2021","journal-title":"J. Healthc. Eng."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0135","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12950-024-00412-y","article-title":"Locomotor and gait changes in the LPS model of neuroinflammation are correlated with inflammatory cytokines in blood and brain","volume":"21","author":"Carregosa","year":"2024","journal-title":"J. Inflamm. (Lond.)"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0140","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.809541","article-title":"Antioxidant activity of fluoxetine and vortioxetine in a non-transgenic animal model of Alzheimer's disease","volume":"12","author":"Caruso","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0145","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3389\/fnagi.2017.00141","article-title":"Slow and fast neocortical oscillations in the senescence-accelerated mouse model SAMP8","volume":"9","author":"Castano-Prat","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0150","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12974-024-03180-x","article-title":"The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and rescues synaptic\/cognitive functions by modulating DRD1 signaling or directly binding to Abeta","volume":"21","author":"Chae","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0155","doi-asserted-by":"crossref","DOI":"10.3390\/diseases13110359","article-title":"Type 3 diabetes: linking insulin resistance to cognitive decline","volume":"13","author":"Chapple","year":"2025","journal-title":"Diseases"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.106003","article-title":"Acrolein, an endogenous aldehyde induces Alzheimer's disease-like pathologies in mice: a new sporadic AD animal model","volume":"175","author":"Chen","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0165","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.cell.2020.06.038","article-title":"Spatial transcriptomics and in situ sequencing to study Alzheimer's disease","volume":"182","author":"Chen","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0170","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.24272\/j.issn.2095-8137.2022.289","article-title":"Animal models of Alzheimer's disease: applications, evaluation, and perspectives","volume":"43","author":"Chen","year":"2022","journal-title":"Zool. Res."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0175","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.4239\/wjd.v12.i11.1818","article-title":"Organophosphate pesticides and new-onset diabetes mellitus: from molecular mechanisms to a possible therapeutic perspective","volume":"12","author":"Chung","year":"2021","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0180","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212282","article-title":"Nitric oxide-dependent mechanisms underlying MK-801- or scopolamine-induced memory dysfunction in animals: mechanistic studies","volume":"22","author":"Cie\u015blik","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0185","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/509282a","article-title":"Policy: NIH to balance sex in cell and animal studies","volume":"509","author":"Clayton","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0190","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbr.2014.08.002","article-title":"Assessing rodent hippocampal involvement in the novel object recognition task. A review","volume":"285","author":"Cohen","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25116222","article-title":"Rodent models of Alzheimer's disease: past misconceptions and future prospects","volume":"25","author":"Collins","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0200","doi-asserted-by":"crossref","first-page":"21966","DOI":"10.1021\/acs.est.4c07427","article-title":"Organophosphate insecticide malathion induces Alzheimer's disease-like cognitive impairment in mice: evidence of the microbiota-gut-brain axis","volume":"58","author":"Cui","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0205","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25052772","article-title":"Proteomic analysis of a rat streptozotocin model shows dysregulated biological pathways implicated in Alzheimer's disease","volume":"25","author":"da Silva","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.116036","article-title":"Aniba canelilla (Kunth) Mez essential oil and its primary constituent, 1-nitro-2-phenylethane, inhibits acetylcholinesterase and reverse memory impairment in rodents","volume":"303","author":"de Campos","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0215","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s40265-016-0674-0","article-title":"Insulin resistance and neurodegeneration: progress towards the development of new therapeutics for Alzheimer's disease","volume":"77","author":"de la Monte","year":"2017","journal-title":"Drugs"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0220","doi-asserted-by":"crossref","DOI":"10.3390\/biom14111405","article-title":"Navigating Alzheimer's disease mouse models: age-related pathology and cognitive deficits","volume":"14","author":"De Plano","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0225","doi-asserted-by":"crossref","first-page":"G330","DOI":"10.1152\/ajpgi.00224.2023","article-title":"Characterization of mitochondria-associated ER membranes in the enteric nervous system under physiological and pathological conditions","volume":"326","author":"Delfino","year":"2024","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0230","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.brs.2020.05.013","article-title":"LTP-like cortical plasticity predicts conversion to dementia in patients with memory impairment","volume":"13","author":"Di Lorenzo","year":"2020","journal-title":"Brain Stimul."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0235","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3390\/pathophysiology31040047","article-title":"Comparative study of injected Alzheimer's disease models in rats: insights from experimental research","volume":"31","author":"Doumar","year":"2024","journal-title":"Pathophysiology"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105170","article-title":"Exposure to footshock stress downregulates antioxidant genes and increases neuronal apoptosis in an A\u03b2(1-42) rat model of Alzheimer's disease","volume":"150","author":"Faborode","year":"2021","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0245","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s12011-017-0942-1","article-title":"Cortex- and amygdala-dependent learning and nicotinic acetylcholine receptor gene expression is severely impaired in mice orally treated with AlCl(3)","volume":"179","author":"Farhat","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0250","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41582-018-0032-9","article-title":"Sex differences in Alzheimer disease - the gateway to precision medicine","volume":"14","author":"Ferretti","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0255","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1440-1681.2008.04922.x","article-title":"Long-term exposure to extremely low-frequency magnetic fields impairs spatial recognition memory in mice","volume":"35","author":"Fu","year":"2008","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0260","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3389\/fnbeh.2014.00321","article-title":"Longitudinal analysis of the behavioral phenotype in a novel transgenic rat model of early stages of Alzheimer's disease","volume":"8","author":"Galeano","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0265","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/ibra.12092","article-title":"Effect of sulfonamide derivatives of phenylglycine on scopolamine-induced amnesia in rats","volume":"9","author":"Ganeshpurkar","year":"2023","journal-title":"Ibrain"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0270","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9070828","article-title":"Antibody protection against long-term memory loss induced by monomeric C-reactive protein in a mouse model of dementia","volume":"9","author":"Garc\u00eda-Lara","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0275","doi-asserted-by":"crossref","DOI":"10.3390\/ijms251910294","article-title":"Melatonin supplementation alleviates impaired spatial memory by influencing A\u03b2(1-42) metabolism via \u03b3-secretase in the icvA\u03b2(1-42) rat model with pinealectomy","volume":"25","author":"Georgieva","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119766","article-title":"Investigation of alpha-lipoic acid effect on memory impairment considering strain-dependent differences in mice","volume":"281","author":"Ghafour-Boroujerdi","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0285","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3389\/fnagi.2018.00101","article-title":"Theta-gamma coupling and working memory in Alzheimer's dementia and mild cognitive impairment","volume":"10","author":"Goodman","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0290","doi-asserted-by":"crossref","DOI":"10.3390\/cells14161238","article-title":"Adeno-associated viral gene delivery of wild-type human tau induces progressive hyperphosphorylation and neuronal cell death in the hippocampi of middle-aged rats","volume":"14","author":"Gorzek","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.nlm.2018.01.001","article-title":"Rigor and reproducibility in rodent behavioral research","volume":"165","author":"Gulinello","year":"2019","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchemneu.2024.102404","article-title":"Protective effects of myricetin and morin on neurological damage in A\u03b2(1-42)\/Al(3+) -induced Alzheimer's disease model of rats","volume":"137","author":"Guo","year":"2024","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0305","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyaf028","article-title":"Cognitive improvement effects of PF-04957325, a phosphodiesterase-8 inhibitor, in mouse models of Alzheimer's disease via modulating neuroinflammation","volume":"28","author":"Guo","year":"2025","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0310","first-page":"8","article-title":"High-performance voltammetric aptasensing platform for ultrasensitive detection of bisphenol a as an environmental pollutant","author":"Hassani","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0315","doi-asserted-by":"crossref","first-page":"292","DOI":"10.4103\/1735-5362.371585","article-title":"Effects of hydroalcoholic, methanolic, and hexane extracts of brown algae Sargassum angustifolium on scopolamine-induced memory impairment and learning deficit in rodents","volume":"18","author":"Hassanzadeh","year":"2023","journal-title":"Res. Pharm. Sci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0320","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci15030322","article-title":"Murine non-transgenic models of Alzheimer's disease pathology: focus on risk factors","volume":"15","author":"Hern\u00e1ndez-Rodr\u00edguez","year":"2025","journal-title":"Brain Sci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0325","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1007\/s00702-025-02952-w","article-title":"Species-specific sensitivity to intracerebroventricular streptozotocin in rats and mice highlights pathways and proteins relevant to Alzheimer's disease","volume":"132","author":"Homolak","year":"2025","journal-title":"J. Neural Transm. (Vienna)"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0330","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1742-7843.2011.00741.x","article-title":"Protective effect of magnesium-25 carrying porphyrin-fullerene nanoparticles on degeneration of dorsal root ganglion neurons and motor function in experimental diabetic neuropathy","volume":"109","author":"Hosseini","year":"2011","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0335","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.835577","article-title":"Impact of donepezil on brain glucose metabolism assessed using [(18)F]2-fluoro-2-deoxy-D-glucose positron emission tomography imaging in a mouse model of Alzheimer's disease induced by intracerebroventricular injection of amyloid-beta peptide","volume":"16","author":"Hugon","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0340","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s11011-019-00409-0","article-title":"Cortico-hippocampal memory enhancing activity of hesperetin on scopolamine-induced amnesia in mice: role of antioxidant defense system, cholinergic neurotransmission and expression of BDNF","volume":"34","author":"Ishola","year":"2019","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0345","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.573487","article-title":"Sugarcane (Saccharum officinarum L.) top extract ameliorates cognitive decline in senescence model SAMP8 mice: modulation of neural development and energy metabolism","volume":"8","author":"Iwata","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102635","article-title":"Beyond the blur: scopolamine's utility and limits in modeling cognitive disorders across sexes - narrative review","volume":"104","author":"Jagielska","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2026.119775","article-title":"EGFR-Annexin A2 signaling-mediated tauopathy in amyloid-\u03b2 and aluminum chloride-induced Alzheimer's disease and its modulation by the HDAC inhibitor butyrate","volume":"310","author":"Jayaswamy","year":"2026","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0360","first-page":"515","article-title":"Aging, plasminogen activator inhibitor 1, brain cell senescence, and Alzheimer's disease","volume":"14","author":"Jiang","year":"2023","journal-title":"Aging Dis."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0365","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2025.1640966","article-title":"Abnormal resting-state EEG neural oscillations and functional connectivity in mild cognitive impairment","volume":"17","author":"Jiang","year":"2025","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0370","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1007\/s12035-021-02626-0","article-title":"Kai-Xin-San inhibits tau pathology and neuronal apoptosis in aged SAMP8 mice","volume":"59","author":"Jiao","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0375","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13293-023-00545-4","article-title":"Systematic characterization of a non-transgenic A\u03b2(1-42) amyloidosis model: synaptic plasticity and memory deficits in female and male mice","volume":"14","author":"Jim\u00e9nez-Herrera","year":"2023","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0380","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s13311-022-01325-5","article-title":"Fosgonimeton, a novel positive modulator of the HGF\/MET system, promotes neurotrophic and procognitive effects in models of dementia","volume":"20","author":"Johnston","year":"2023","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0385","doi-asserted-by":"crossref","first-page":"8052","DOI":"10.1021\/acsomega.2c07951","article-title":"Antiamnesic effects of novel phthalimide derivatives in scopolamine-induced memory impairment in mice: a useful therapy for Alzheimer's disease","volume":"8","author":"Karim","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2025.115634","article-title":"Demethyleneberberine attenuates combined cognitive and metabolic dysfunctions in an insulin-resistance-induced Alzheimer's disease rat model: synthesis, in-silico and in-vivo insights","volume":"398","author":"Kaur","year":"2026","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0395","article-title":"Link between aluminum and the pathogenesis of Alzheimer's disease: the integration of the aluminum and amyloid cascade hypotheses","volume":"2011","author":"Kawahara","year":"2011","journal-title":"Int. J. Alzheimers Dis."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0400","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1007\/s12035-021-02460-4","article-title":"Antioxidative and anti-inflammatory effects of kojic acid in A\u03b2-induced mouse model of Alzheimer's disease","volume":"58","author":"Khan","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0405","article-title":"Caffeic acid, a polyphenolic micronutrient rescues mice brains against A\u03b2-induced neurodegeneration and memory impairment","volume":"12","author":"Khan","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0410","doi-asserted-by":"crossref","unstructured":"Khan, I., et al., 2023. Antiamnesic effects of feralolide isolated from Aloe vera resin miller against learning impairments induced in mice. Antioxidants (Basel). 12.","DOI":"10.3390\/antiox12010161"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0415","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s12640-021-00346-w","article-title":"Lacidipine prevents scopolamine-induced memory impairment by reducing brain oxido-nitrosative stress in mice","volume":"39","author":"Khurana","year":"2021","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0420","doi-asserted-by":"crossref","unstructured":"Kim, J., et al., 2021. Donepezil regulates LPS and A\u03b2-stimulated neuroinflammation through MAPK\/NLRP3 inflammasome\/STAT3 signaling. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910637"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0425","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.684344","article-title":"Sorafenib modulates the LPS- and A\u03b2-induced neuroinflammatory response in cells, wild-type mice, and 5xFAD mice","volume":"12","author":"Kim","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177645","article-title":"3',4',7-trihydroxyflavone activates the CREB-BDNF axis and restores scopolamine-induced memory deficit in mice","volume":"999","author":"Kim","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0435","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.neubiorev.2010.04.001","article-title":"The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies","volume":"34","author":"Klinkenberg","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0440","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00702-015-1394-4","article-title":"Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease","volume":"122","author":"Knezovic","year":"2015","journal-title":"J. Neural Transm. (Vienna)"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0445","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s00702-025-02887-2","article-title":"Cholinergic neurotransmission in the brain of streptozotocin-induced rat model of sporadic Alzheimer's disease: long-term follow up","volume":"132","author":"Knezovic","year":"2025","journal-title":"J. Neural Transm. (Vienna)"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0450","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s12035-025-05417-z","article-title":"Targeted nanoparticles for drug delivery across the blood-brain barrier in early and late stages of Alzheimer's disease: a review","volume":"63","author":"Kochman","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0455","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046196","article-title":"In vivo cross-sectional characterization of cerebral alterations induced by intracerebroventricular administration of streptozotocin","volume":"7","author":"Kraska","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0460","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22041779","article-title":"Mechanisms of the procognitive effects of xanthotoxin and umbelliferone on LPS-induced amnesia in mice","volume":"22","author":"Kurach","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0465","doi-asserted-by":"crossref","first-page":"11416","DOI":"10.1523\/JNEUROSCI.1195-14.2014","article-title":"Amyloid-\u03b2-induced action potential desynchronization and degradation of hippocampal gamma oscillations is prevented by interference with peptide conformation change and aggregation","volume":"34","author":"Kurudenkandy","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0470","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s12035-023-03570-x","article-title":"Suv39h1 silencing recovers memory decline in scopolamine-induced amnesic mouse model","volume":"61","author":"Kushwaha","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0475","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212158","article-title":"Tau cleavage contributes to cognitive dysfunction in strepto-zotocin-induced sporadic Alzheimer's disease (sAD) mouse model","volume":"22","author":"Latina","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0480","doi-asserted-by":"crossref","first-page":"25800","DOI":"10.1073\/pnas.2008762117","article-title":"Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease","volume":"117","author":"Lau","year":"2020","journal-title":"PNAS"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0485","article-title":"Idebenone regulates A\u03b2 and LPS-induced neurogliosis and cognitive function through inhibition of NLRP3 inflammasome\/IL-1\u03b2 axis activation","volume":"13","author":"Lee","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0490","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106725","article-title":"Inhibition of CDK4\/6 regulates AD pathology, neuroinflammation and cognitive function through DYRK1A\/STAT3 signaling","volume":"190","author":"Lee","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0495","article-title":"Age-dependent elevation of Nr4a1 attenuates PI3K\/AKT\/GSK3\u03b2 pathway and mediates tau hyperphosphorylation and cognitive impairments","author":"Lei","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0500","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119567","article-title":"Isoliensinine ameliorates cognitive dysfunction in AlCl(3)\/D-gal-induced Alzheimer's disease-like mice by inhibiting the calcium signaling pathway","volume":"344","author":"Li","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0505","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1690192","article-title":"Sporoderm-removed ganoderma lucidum spore powder (S-GLSP) alleviates neuroinflammation injury by regulating microglial polarization through inhibition of NLRP3 inflammasome activation","volume":"16","author":"Li","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0510","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.bbrc.2020.03.110","article-title":"Propane-2-sulfonic acid octadec-9-enyl-amide alleviates scopolamine-induced spatial learning and memory deficits in mice","volume":"529","author":"Li","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0515","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2025.138339","article-title":"Modeling Alzheimer's disease in mice: gonadectomy combined with bilateral hippocampus dentate gyrus injection of A\u03b2(1-42) oligomers","volume":"865","author":"Li","year":"2025","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0520","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1093\/brain\/awaf038","article-title":"The landscape of autosomal-dominant Alzheimer's disease: global distribution and age of onset","volume":"148","author":"Liu","year":"2025","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0525","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175443","article-title":"Dopamine D2 receptor agonist bromocriptine ameliorates A\u03b2(1-42)-induced memory deficits and neuroinflammation in mice","volume":"938","author":"Liu","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0530","doi-asserted-by":"crossref","first-page":"65778","DOI":"10.18632\/oncotarget.19473","article-title":"Protective effect of resveratrol against light-induced retinal degeneration in aged SAMP8 mice","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0535","doi-asserted-by":"crossref","DOI":"10.3390\/ijms27010169","article-title":"Micro- and nanoplastics and functional nutrients in human health: epigenetic mechanisms and cellular resilience signaling in brain insulin resistance and the risk of Alzheimer's disease","volume":"27","author":"Lombardo","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0540","doi-asserted-by":"crossref","DOI":"10.3390\/biom13081173","article-title":"Adenosine A(2A) receptor up-regulation pre-dates deficits of synaptic plasticity and of memory in mice exposed to A\u03b2(1-42) to model early Alzheimer's disease","volume":"13","author":"Lopes","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0545","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212280","article-title":"Epigenetic mechanisms in memory and cognitive decline associated with aging and Alzheimer's disease","volume":"22","author":"Maity","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0550","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1093\/jpp\/rgaf036","article-title":"Investigating the neuroprotective role of Synta-66 in type-2 diabetes mellitus-induced dementia in rats","volume":"77","author":"Mannan","year":"2025","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0555","article-title":"The effects of soy on scopolamine-induced spatial learning and memory impairments are comparable to the effects of estradiol","volume":"39","author":"Marefati","year":"2019","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0560","doi-asserted-by":"crossref","DOI":"10.3389\/fnsyn.2023.1129036","article-title":"Alzheimer's disease as a synaptopathy: evidence for dysfunction of synapses during disease progression","volume":"15","author":"Meftah","year":"2023","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0565","doi-asserted-by":"crossref","first-page":"5426","DOI":"10.1007\/s12035-023-03397-6","article-title":"Mdivi-1 rescues memory decline in scopolamine-induced amnesic male mice by ameliorating mitochondrial dynamics and hippocampal plasticity","volume":"60","author":"Mishra","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0570","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1007\/s10787-025-01754-6","article-title":"Chaperone-mediated autophagy, heat shock protein 70, and serotonin: novel targets of beta-hydroxybutyrate in HFFD\/LPS-induced sporadic Alzheimer's disease model","volume":"33","author":"Mohamed","year":"2025","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0575","doi-asserted-by":"crossref","DOI":"10.3390\/cells12131799","article-title":"LRRK2 kinase inhibition attenuates neuroinflammation and cytotoxicity in animal models of Alzheimer's and Parkinson's disease-related neuroinflammation","volume":"12","author":"Mutti","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0580","doi-asserted-by":"crossref","DOI":"10.1093\/toxres\/tfaf031","article-title":"Coenzyme Q10 alleviates AlCl3 and D-galactose induced Alzheimer via modulating oxidative burden and TLR-4\/MAPK pathways and regulation microRNA in rat brain","volume":"14","author":"Nawar","year":"2025","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0585","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1001\/jamaneurol.2017.2188","article-title":"Apolipoprotein E genotype and sex risk factors for Alzheimer disease: a meta-analysis","volume":"74","author":"Neu","year":"2017","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0590","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s13293-025-00788-3","article-title":"Consideration of sex as a biological variable over the history of the 5xFAD Alzheimer's disease mouse model","volume":"16","author":"Neuharth","year":"2025","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0595","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.pestbp.2013.04.003","article-title":"On the biochemical and molecular mechanisms by which malathion induces dysfunction in pancreatic islets in vivo and in vitro","volume":"106","author":"Nili-Ahmadabadi","year":"2013","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0600","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.ibneur.2025.04.006","article-title":"Natural polyphenol mangiferin delays neuronal cell senescence by inhibiting neuroinflammation mediated by microglial activation","volume":"18","author":"Nong","year":"2025","journal-title":"IBRO Neurosci. Rep."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0605","doi-asserted-by":"crossref","DOI":"10.1093\/stmcls\/sxae091","article-title":"Senescence accelerated mouse-prone 8: a model of neuroinflammation and aging with features of sporadic Alzheimer's disease","volume":"43","author":"Ong","year":"2025","journal-title":"Stem Cells"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0610","doi-asserted-by":"crossref","DOI":"10.1016\/j.nlm.2021.107443","article-title":"Touchscreen cognitive testing: cross-species translation and co-clinical trials in neurodegenerative and neuropsychiatric disease","volume":"182","author":"Palmer","year":"2021","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0615","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1089\/rej.2010.1020","article-title":"D-galactose effectiveness in modeling aging and therapeutic antioxidant treatment in mice","volume":"13","author":"Parameshwaran","year":"2010","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0620","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1150940","article-title":"Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation by modulating NLRP3, DYRK1A, and GSK3\u03b1\/\u03b2","volume":"14","author":"Park","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0625","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.bbr.2008.10.029","article-title":"Evaluation of spatial memory of C57BL\/6J and CD1 mice in the barnes maze, the multiple T-maze and in the Morris water maze","volume":"198","author":"Patil","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0630","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.708190","article-title":"Auditory threshold variability in the SAMP8 mouse model of age-related hearing loss: functional loss and phenotypic change precede outer hair cell loss","volume":"13","author":"Peixoto Pinheiro","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0635","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.686506","article-title":"Amelioration of hippocampal insulin resistance reduces tau hyperphosphorylation and cognitive decline induced by isoflurane in mice","volume":"13","author":"Peng","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0640","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.neubiorev.2021.05.005","article-title":"Anxiety and Alzheimer's disease: behavioral analysis and neural basis in rodent models of Alzheimer's-related neuropathology","volume":"127","author":"Pentkowski","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0645","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1177\/0271678X17709185","article-title":"The improve guidelines (ischaemia models: procedural refinements of in vivo experiments)","volume":"37","author":"Percie du Sert","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0650","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1001\/archneur.56.3.303","article-title":"Mild cognitive impairment: clinical characterization and outcome","volume":"56","author":"Petersen","year":"1999","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0655","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2741\/E605","article-title":"Genetics of familial and sporadic Alzheimer's disease","volume":"5","author":"Piaceri","year":"2013","journal-title":"Front. Biosci. (Elite Ed.)"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0660","doi-asserted-by":"crossref","DOI":"10.3390\/ijms27031222","article-title":"Insulin signaling in Alzheimer's disease: association with brain insulin resistance","volume":"27","author":"Pliszka","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0665","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.neuroscience.2022.05.030","article-title":"Metabolomic, lipidomic and proteomic characterisation of lipopolysaccharide-induced inflammation mouse model","volume":"496","author":"Puris","year":"2022","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0670","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1517\/17460441.2015.1041913","article-title":"Rodent models for Alzheimer's disease drug discovery","volume":"10","author":"Puzzo","year":"2015","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0675","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1103940","article-title":"Isoimperatorin therapeutic effect against aluminum induced neurotoxicity in albino mice","volume":"14","author":"Rajendran","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0680","doi-asserted-by":"crossref","DOI":"10.1016\/j.mex.2022.101933","article-title":"Experimentally induced animal models for cognitive dysfunction and Alzheimer's disease","volume":"9","author":"Rapaka","year":"2022","journal-title":"MethodsX"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0685","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1093\/brain\/awx232","article-title":"Chemogenetic locus coeruleus activation restores reversal learning in a rat model of Alzheimer's disease","volume":"140","author":"Rorabaugh","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0690","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.lfs.2017.08.025","article-title":"Streptozotocin-induced hippocampal astrogliosis and insulin signaling malfunction as experimental scales for subclinical sporadic Alzheimer model","volume":"188","author":"Rostami","year":"2017","journal-title":"Life Sci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0695","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/nature17172","article-title":"Memory retrieval by activating engram cells in mouse models of early Alzheimer's disease","volume":"531","author":"Roy","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0700","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-1326-10-1","article-title":"A\u03b2 reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level","volume":"10","author":"Sadleir","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0705","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/9523758","article-title":"Quinovic acid impedes cholesterol dyshomeostasis, oxidative stress, and neurodegeneration in an amyloid-\u03b2-induced mouse model","volume":"2020","author":"Saeed","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0710","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2018.10.014","article-title":"Biochemical and molecular evidence on the role of vaspin in early detection of the insulin resistance in a rat model of high-fat diet and use of diazinon","volume":"411","author":"Salek-Maghsoudi","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0715","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21197300","article-title":"Adenosine metabolism in the cerebral cortex from several mice models during aging","volume":"21","author":"S\u00e1nchez-Melgar","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0720","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/jnc.14946","article-title":"Hippocampal long-term synaptic depression and memory deficits induced in early amyloidopathy are prevented by enhancing G-protein-gated inwardly rectifying potassium channel activity","volume":"153","author":"S\u00e1nchez-Rodr\u00edguez","year":"2020","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0725","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1021\/acschemneuro.3c00320","article-title":"Neuroprotective effect of saroglitazar on scopolamine-induced Alzheimer's in rats: insights into the underlying mechanisms","volume":"14","author":"Sandeep Ganesh","year":"2023","journal-title":"ACS Chem. Nerosci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0730","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1038\/npp.2012.52","article-title":"Muscarinic receptors modulate the intrinsic excitability of infralimbic neurons and consolidation of fear extinction","volume":"37","author":"Santini","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0735","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsps.2023.101702","article-title":"Ranuncoside's attenuation of scopolamine-induced memory impairment in mice via Nrf2 and NF-\u0138B signaling","volume":"31","author":"Sara Salahuddin","year":"2023","journal-title":"Saudi Pharm J."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0740","article-title":"Microalgae Aurantiochytrium Sp. increases neurogenesis and improves spatial learning and memory in senescence-accelerated mouse-prone 8 mice","volume":"8","author":"Sasaki","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0745","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3389\/fncel.2015.00318","article-title":"Gene expression parallels synaptic excitability and plasticity changes in Alzheimer's disease","volume":"9","author":"Saura","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0750","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neurobiolaging.2021.08.004","article-title":"Progressive impairments in executive function in the APP\/PS1 model of Alzheimer's disease as measured by translatable touchscreen testing","volume":"108","author":"Shepherd","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0755","doi-asserted-by":"crossref","first-page":"12766","DOI":"10.1038\/s41598-022-16817-9","article-title":"Pharmacological sequestration of mitochondrial calcium uptake protects against dementia and \u03b2-amyloid neurotoxicity","volume":"12","author":"Shevtsova","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0760","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.expneurol.2003.08.015","article-title":"Intracerebroventricular injection of streptozotocin causes neurotoxicity to myelin that contributes to spatial memory deficits in rats","volume":"184","author":"Shoham","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0765","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.113961","article-title":"D-cycloserine rescues scopolamine-induced deficits in cognitive flexibility in rats measured by the attentional set-shifting task","volume":"431","author":"Siddik","year":"2022","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0770","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2025.115271","article-title":"Neuroprotective roles of SGLT2 and DPP4 inhibitors: modulating ketone metabolism and suppressing NLRP3 inflammasome in T2D induced Alzheimer's disease","volume":"390","author":"Sim","year":"2025","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0775","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s43440-024-00692-4","article-title":"Intranasal amyloid model of Alzheimer's disease - potential opportunities and challenges","volume":"77","author":"Singh","year":"2025","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0780","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10571-009-9463-6","article-title":"Intranasal delivery of human beta-amyloid peptide in rats: effective brain targeting","volume":"30","author":"Sipos","year":"2010","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0785","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0047-6374(99)00022-6","article-title":"Advanced glycation in D-galactose induced mouse aging model","volume":"108","author":"Song","year":"1999","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0790","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120352","article-title":"Baicalin alleviates pathological changes in Alzheimer's disease comorbid with type 2 diabetes: targeting metabolic dysregulation and neuroinflammation","volume":"353","author":"Song","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0795","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2026.158276","article-title":"Gentisic acid confers multimodal neuroprotection in experimental Alzheimer's disease by targeting oxidative stress, neuroinflammation, and protein aggregation","volume":"156","author":"Soni","year":"2026","journal-title":"Phytomedicine"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0800","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0310-24.2024","article-title":"AD-like neuropsychiatric dysfunction in a mice model induced by a combination of high-fat diet and intraperitoneal injection of streptozotocin","volume":"11","author":"Sun","year":"2024","journal-title":"eNeuro"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0805","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104703","article-title":"Anxiety adds the risk of cognitive progression and is associated with axon\/synapse degeneration among cognitively unimpaired older adults","volume":"94","author":"Sun","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0810","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2024.1453038","article-title":"Multifaceted neuroprotective approach of Trolox in Alzheimer's disease mouse model: targeting A\u03b2 pathology, neuroinflammation, oxidative stress, and synaptic dysfunction","volume":"18","author":"Tahir","year":"2024","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0815","doi-asserted-by":"crossref","DOI":"10.3390\/nu12123877","article-title":"Evaluating the effects of grain of isogenic wheat lines differing in the content of anthocyanins in mouse models of neurodegenerative disorders","volume":"12","author":"Tikhonova","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0820","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.114217","article-title":"Long-term treatment with roflumilast improves learning of fear extinction memory and anxiety-like response in a type-1 diabetes mellitus animal model","volume":"439","author":"Waltrick","year":"2023","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0825","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.24272\/j.issn.2095-8137.2024.274","article-title":"Animal models of Alzheimer's disease: current strategies and new directions","volume":"45","author":"Wang","year":"2024","journal-title":"Zool. Res."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0830","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115411","article-title":"Integrated metabolomics and transcriptomics reveal the neuroprotective effect of nervonic acid on LPS-induced AD model mice","volume":"209","author":"Wang","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0835","doi-asserted-by":"crossref","unstructured":"Wang, Y., et al., 2024. Fermented gastrodia elata Bl. alleviates cognitive deficits by regulating neurotransmitters and gut microbiota in D-Gal\/AlCl(3)-induced Alzheimer's disease-like mice. Foods. 13.","DOI":"10.3390\/foods13132154"},{"key":"10.1016\/j.neuroscience.2026.07.063_b0840","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/jnr.23840","article-title":"Cholinergic regulation of fear learning and extinction","volume":"95","author":"Wilson","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0845","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.4103\/1673-5374.358607","article-title":"The relationship among amyloid-\u03b2 deposition, sphingomyelin level, and the expression and function of P-glycoprotein in Alzheimer's disease pathological process","volume":"18","author":"Xing","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0850","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/tox.23415","article-title":"Alpinae Oxyphyllae Fructus alleviated LPS-induced cognitive impairments via PI3K\/AKT\/NF-\u03baB signaling pathway","volume":"37","author":"Yan","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0855","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.141715","article-title":"Radix Hedysari Polysaccharides modulate the gut-brain axis and improve cognitive impairment in SAMP8 mice","volume":"306","author":"Yang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0860","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2025.149734","article-title":"Crocin drives intestinal microbiota variation in a rat model of Alzheimer's disease by reducing DKK3 expression","volume":"1862","author":"Yang","year":"2025","journal-title":"Brain Res."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0865","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3233\/JAD-2006-102-309","article-title":"Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration","volume":"10","author":"Yokel","year":"2006","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0870","doi-asserted-by":"crossref","first-page":"916","DOI":"10.4103\/1673-5374.297090","article-title":"Preventive electroacupuncture reduces cognitive deficits in a rat model of D-galactose-induced aging","volume":"16","author":"Yu","year":"2021","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0875","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119464","article-title":"Longan aril polysaccharides ameliorate cognitive impairment in AD mice via restoration of the immune phagocytosis of microglia","volume":"343","author":"Zhang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0880","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114739","article-title":"Continuous high-frequency repetitive transcranial magnetic stimulation at extremely low intensity affects exploratory behavior and spatial cognition in mice","volume":"458","author":"Zhang","year":"2024","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0885","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13293-025-00778-5","article-title":"Sex differences in the effects of 10 Hz and 40 Hz transcranial alternating current stimulation on spatial cognition in mice","volume":"16","author":"Zhang","year":"2025","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0890","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2025.115685","article-title":"Blocking the NR2B in the hippocampal dentate gyrus reduced the spatial memory deficits and apoptosis through the PERK-CHOP pathway in a rat model of sporadic Alzheimer's disease","volume":"493","author":"Zhang","year":"2025","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0895","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.1038\/s41598-019-42286-8","article-title":"Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice","volume":"9","author":"Zhao","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0900","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1021\/acschemneuro.0c00621","article-title":"TDMQ20, a specific copper chelator, reduces memory impairments in Alzheimer's disease mouse models","volume":"12","author":"Zhao","year":"2021","journal-title":"ACS Chem. Nerosci."},{"key":"10.1016\/j.neuroscience.2026.07.063_b0905","doi-asserted-by":"crossref","DOI":"10.1007\/s00210-026-05225-9","article-title":"Combined with network pharmacology, the therapeutic effect and mechanism of coumarins from chimonanthus praecox extract in the treatment of Alzheimer's disease were investigated","author":"Zhu","year":"2026","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452226005075?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452226005075?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:45:28Z","timestamp":1793051128000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452226005075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":181,"alternative-id":["S0306452226005075"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2026.07.063","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Non-transgenic rodent models associated with Alzheimer\u2019s disease: applications, evaluations, and perspectives","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2026.07.063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}