{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:08:32Z","timestamp":1789132112711,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["202205AC160019"],"award-info":[{"award-number":["202205AC160019"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160260"],"award-info":[{"award-number":["82160260"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007846","name":"Yunnan Provincial Department of Education","doi-asserted-by":"publisher","award":["2025J0785"],"award-info":[{"award-number":["2025J0785"]}],"id":[{"id":"10.13039\/501100007846","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005147","name":"Yunnan Applied Basic Research Project","doi-asserted-by":"publisher","award":["202201AY070001-083"],"award-info":[{"award-number":["202201AY070001-083"]}],"id":[{"id":"10.13039\/501100005147","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003996","name":"Kunming Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.neuroscience.2026.08.009","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T16:21:48Z","timestamp":1786638108000},"page":"150-162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Nuclear distribution element-like 1 is associated with dentate gyrus remodeling after status epilepticus in a pilocarpine-induced mouse model"],"prefix":"10.1016","volume":"614","author":[{"given":"Jing","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6956-8170","authenticated-orcid":false,"given":"Xiaoyu","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6259-7434","authenticated-orcid":false,"given":"Qian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2026.08.009_b0005","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1152\/jn.00835.2014","article-title":"Intrinsic neurophysiological properties of hilar ectopic and normotopic dentate granule cells in human temporal lobe epilepsy and a rat model","volume":"113","author":"Althaus","year":"2015","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0010","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1177\/1073858406295832","article-title":"Gene expression profile in temporal lobe epilepsy","volume":"13","author":"Aronica","year":"2007","journal-title":"Neuroscientist"},{"key":"10.1016\/j.neuroscience.2026.08.009_b0015","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1750-3639.2012.00583.x","article-title":"Defining clinico-neuropathological subtypes of mesial temporal lobe epilepsy with hippocampal sclerosis","volume":"22","author":"Blumcke","year":"2012","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0030","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neuroscience.2022.05.009","article-title":"Disrupted in schizophrenia 1 regulates ectopic neurogenesis in the mouse hilus after pilocarpine-induced status epilepticus","volume":"494","author":"Chen","year":"2022","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2026.08.009_b0020","doi-asserted-by":"crossref","first-page":"6689","DOI":"10.1007\/s12035-023-03507-4","article-title":"Disrupted in schizophrenia 1 reverse ectopic migration of neural precursors in mouse hilus after pilocarpine-induced status epilepticus","volume":"60","author":"Chen","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0025","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41392-023-01433-4","article-title":"Adult-born neurons in critical period maintain hippocampal seizures via local aberrant excitatory circuits","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0035","series-title":"Mesial Temporal Lobe Epilepsy, StatPearls [internet]","author":"Chetan","year":"2026"},{"key":"10.1016\/j.neuroscience.2026.08.009_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchemneu.2023.102329","article-title":"Dendritic reorganization in the hippocampus, anterior temporal lobe, and frontal neocortex of lithium-pilocarpine induced Status Epilepticus (SE)","volume":"133","author":"Dubey","year":"2023","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0050","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neulet.2009.03.051","article-title":"Decreased levels of disrupted-in-schizophrenia 1 (DISC1) are associated with expansion of the dentate granule cell layer in normal and kindled rats","volume":"455","author":"Fournier","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0045","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/hipo.20653","article-title":"The effect of amygdala kindling on hippocampal neurogenesis coincides with decreased reelin and DISC1 expression in the adult dentate gyrus","volume":"20","author":"Fournier","year":"2010","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuroscience.2026.08.009_b0055","doi-asserted-by":"crossref","first-page":"9357","DOI":"10.1523\/JNEUROSCI.23-28-09357.2003","article-title":"Two distinct subpopulations of nestin-positive cells in adult mouse dentate gyrus","volume":"23","author":"Fukuda","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0060","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3389\/fneur.2018.00298","article-title":"Signaling pathways and cellular mechanisms regulating mossy fiber sprouting in the development of epilepsy","volume":"9","author":"Godale","year":"2018","journal-title":"Front. Neurol."},{"issue":"Suppl 6","key":"10.1016\/j.neuroscience.2026.08.009_b0065","first-page":"S14","article-title":"Remodeling dendritic spines of dentate granule cells in temporal lobe epilepsy patients and the rat pilocarpine model","volume":"41","author":"Isokawa","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2026.08.009_b0070","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1150283","article-title":"Seizure-induced hilar ectopic granule cells in the adult dentate gyrus","volume":"17","author":"Kasahara","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0075","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1523\/JNEUROSCI.5655-09.2010","article-title":"The developmental stage of dentate granule cells dictates their contribution to seizure-induced plasticity","volume":"30","author":"Kron","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0080","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/15357597231218603","article-title":"Exploring dendritic and spine structural profiles in epilepsy: insights from human studies and experimental animal models","volume":"24","author":"Kumari","year":"2024","journal-title":"Epilepsy Curr."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000460","article-title":"Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis","volume":"8","author":"Lavado","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0090","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/glia.23211","article-title":"Nestin-expressing cell types in the temporal lobe and hippocampus: morphology, differentiation, and proliferative capacity","volume":"66","author":"Liu","year":"2018","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2026.08.009_b0095","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s40478-018-0566-5","article-title":"Doublecortin-expressing cell types in temporal lobe epilepsy","volume":"6","author":"Liu","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0100","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: significant answers and significant questions","volume":"70","author":"Ming","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2026.08.009_b0105","first-page":"195","article-title":"NeuN expression in health and disease: a histological perspective on neuronal heterogeneity","volume":"41","author":"Moon","year":"2026","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0110","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3389\/fcell.2019.00158","article-title":"Reactive disruption of the hippocampal neurogenic niche after induction of seizures by injection of kainic acid in the amygdala","volume":"7","author":"Muro-Garcia","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0115","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1523\/JNEUROSCI.5029-13.2015","article-title":"DBZ regulates cortical cell positioning and neurite development by sustaining the anterograde transport of Lis1 and DISC1 through control of Ndel1 dual-phosphorylation","volume":"35","author":"Okamoto","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0120","doi-asserted-by":"crossref","DOI":"10.3390\/metabo13010083","article-title":"Biomarkers of drug resistance in temporal lobe epilepsy in adults","volume":"13","author":"Panina","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.neuroscience.2026.08.009_b0125","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ana.20699","article-title":"Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy","volume":"59","author":"Parent","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0130","article-title":"Reporting animal research: explanation and elaboration for the ARRIVE guidelines 2.0","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neubiorev.2014.01.001","article-title":"Female mice liberated for inclusion in neuroscience and biomedical research","volume":"40","author":"Prendergast","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0140","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/hipo.23447","article-title":"Granule cell dispersion in two mouse models of temporal lobe epilepsy and reeler mice is associated with changes in dendritic orientation and spine distribution","volume":"32","author":"Puhahn-Schmeiser","year":"2022","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuroscience.2026.08.009_b0145","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation. II. Motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0150","doi-asserted-by":"crossref","unstructured":"Ribak CE, Shapiro LA, Yan XX, Dashtipour K, Nadler JV, Obenaus A, Spigelman I, Buckmaster PS (2012) Seizure-induced formation of basal dendrites on granule cells of the rodent dentate gyrus. In: Jasper's Basic Mechanisms of the Epilepsies, vol. (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds). Bethesda (MD).","DOI":"10.1093\/med\/9780199746545.003.0036"},{"key":"10.1016\/j.neuroscience.2026.08.009_b0155","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/1535759719855952","article-title":"The dentate gyrus and temporal lobe epilepsy: an \u201cexciting\u201d era","volume":"19","author":"Scharfman","year":"2019","journal-title":"Epilepsy Curr."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003601","article-title":"Combined role of seizure-induced dendritic morphology alterations and spine loss in newborn granule cells with mossy fiber sprouting on the hyperexcitability of a computer model of the dentate gyrus","volume":"10","author":"Tejada","year":"2014","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0165","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.2174\/1381612828666220616162739","article-title":"Aberrant connection formation and glia involvement in the progression of pharmacoresistant mesial temporal lobe epilepsy","volume":"28","author":"Vega-Garcia","year":"2022","journal-title":"Curr. Pharm. Des."},{"issue":"Suppl 3","key":"10.1016\/j.neuroscience.2026.08.009_b0170","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1528-1167.2010.02629.x","article-title":"Females, their estrogens, and seizures","volume":"51","author":"Veliskova","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2026.08.009_b0175","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2020.591690","article-title":"Astrocytes as guardians of neuronal excitability: mechanisms underlying epileptogenesis","volume":"11","author":"Verhoog","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0180","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/3651735","article-title":"Reproduction-associated hormones and adult hippocampal neurogenesis","volume":"2021","author":"Wan","year":"2021","journal-title":"Neural Plast."},{"key":"10.1016\/j.neuroscience.2026.08.009_b0185","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.neuroscience.2014.03.030","article-title":"NDEL1 was decreased in the CA3 region but increased in the hippocampal blood vessel network during the spontaneous seizure period after pilocarpine-induced status epilepticus","volume":"268","author":"Wu","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2026.08.009_b0190","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/hipo.20409","article-title":"Different effects of mild and severe seizures on hippocampal neurogenesis in adult rats","volume":"18","author":"Yang","year":"2008","journal-title":"Hippocampus"},{"issue":"1041\u20131054","key":"10.1016\/j.neuroscience.2026.08.009_b0195","first-page":"e1045","article-title":"DISC1 regulates neurogenesis via modulating kinetochore attachment of Ndel1\/Nde1 during mitosis","volume":"96","author":"Ye","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2026.08.009_b0200","doi-asserted-by":"crossref","first-page":"15520","DOI":"10.1523\/JNEUROSCI.4630-09.2009","article-title":"Distinct dose-dependent cortical neuronal migration and neurite extension defects in Lis1 and Ndel1 mutant mice","volume":"29","author":"Youn","year":"2009","journal-title":"J. Neurosci."},{"issue":"Suppl 5","key":"10.1016\/j.neuroscience.2026.08.009_b0205","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1528-1167.2008.01632.x","article-title":"Integration of adult generated neurons during epileptogenesis","volume":"49","author":"Zhao","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2026.08.009_b0210","doi-asserted-by":"crossref","DOI":"10.1177\/1759091420926836","article-title":"Role of NDEL1 and VEGF\/VEGFR-2 in mouse hippocampus after status epilepticus","volume":"12","author":"Zhu","year":"2020","journal-title":"ASN Neuro"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452226005385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452226005385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:29:59Z","timestamp":1789129799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452226005385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":42,"alternative-id":["S0306452226005385"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2026.08.009","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nuclear distribution element-like 1 is associated with dentate gyrus remodeling after status epilepticus in a pilocarpine-induced mouse model","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2026.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}