{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:08:21Z","timestamp":1789132101944,"version":"build-2803163510"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K09994"],"award-info":[{"award-number":["JP24K09994"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K06805"],"award-info":[{"award-number":["JP22K06805"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007106","name":"Gunma University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007106","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.neuroscience.2026.08.014","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T23:19:53Z","timestamp":1786576793000},"page":"200-215","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Standardized depth-resolved mapping of anterior cingulate cortex synaptic markers reveals inhibitory marker alterations following prenatal valproic acid exposure"],"prefix":"10.1016","volume":"614","author":[{"given":"Mirei","family":"Matsumuro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1470-2957","authenticated-orcid":false,"given":"Sotaro","family":"Ichinose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7432-5938","authenticated-orcid":false,"given":"Hirohide","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"38","key":"10.1016\/j.neuroscience.2026.08.014_b0010","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adh3920","article-title":"Local and long-range input balance: a framework for investigating frontal cognitive circuit maturation in health and disease","volume":"10","author":"Allen","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.neuroscience.2026.08.014_b0005","unstructured":"Allen Institute for Brain, S. (2011). Allen Reference Atlas \u2013 Mouse Brain."},{"issue":"7","key":"10.1016\/j.neuroscience.2026.08.014_b0015","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.tins.2021.03.006","article-title":"Circuit organization of the rodent medial prefrontal cortex","volume":"44","author":"Anastasiades","year":"2021","journal-title":"Trends Neurosci."},{"issue":"4","key":"10.1016\/j.neuroscience.2026.08.014_b0020","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.neuron.2018.12.026","article-title":"Increased excitation-inhibition ratio stabilizes synapse and circuit excitability in four autism mouse models","volume":"101","author":"Antoine","year":"2019","journal-title":"Neuron"},{"issue":"11","key":"10.1016\/j.neuroscience.2026.08.014_b0025","doi-asserted-by":"crossref","first-page":"6196","DOI":"10.1073\/pnas.1919303117","article-title":"Anterior cingulate cortex is necessary for adaptation of action plans","volume":"117","author":"Brockett","year":"2020","journal-title":"PNAS"},{"issue":"6","key":"10.1016\/j.neuroscience.2026.08.014_b0030","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1364-6613(00)01483-2","article-title":"Cognitive and emotional influences in anterior cingulate cortex","volume":"4","author":"Bush","year":"2000","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.neuroscience.2026.08.014_b0035","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13229-018-0221-9","article-title":"Sociability deficits after prenatal exposure to valproic acid are rescued by early social enrichment","volume":"9","author":"Campolongo","year":"2018","journal-title":"Mol. Autism"},{"issue":"1","key":"10.1016\/j.neuroscience.2026.08.014_b0040","doi-asserted-by":"crossref","first-page":"5884","DOI":"10.1038\/s41467-023-41645-4","article-title":"DeepSlice: rapid fully automatic registration of mouse brain imaging to a volumetric atlas","volume":"14","author":"Carey","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuroscience.2026.08.014_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.conb.2022.102553","article-title":"Homeostatic plasticity and excitation-inhibition balance: the good, the bad, and the ugly","volume":"75","author":"Chen","year":"2022","journal-title":"Curr. Opin. Neurobiol."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.08.014_b0050","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12929-022-00835-w","article-title":"Generational synaptic functions of GABA","volume":"29","author":"Chu","year":"2022","journal-title":"J. Biomed. Sci."},{"issue":"14","key":"10.1016\/j.neuroscience.2026.08.014_b0055","doi-asserted-by":"crossref","first-page":"5743","DOI":"10.1523\/JNEUROSCI.4565-14.2015","article-title":"The mediodorsal thalamus drives feedforward inhibition in the anterior cingulate cortex via parvalbumin interneurons","volume":"35","author":"Delevich","year":"2015","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.neuroscience.2026.08.014_b0060","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1007\/s00429-016-1290-1","article-title":"Afferents to anterior cingulate areas 24a and 24b and midcingulate areas 24a' and 24b' in the mouse","volume":"222","author":"Fillinger","year":"2017","journal-title":"Brain Struct. Funct."},{"issue":"3","key":"10.1016\/j.neuroscience.2026.08.014_b0065","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/ejn.15893","article-title":"GABAergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder","volume":"57","author":"Fontes-Dutra","year":"2023","journal-title":"Eur. J. Neurosci."},{"issue":"2","key":"10.1016\/j.neuroscience.2026.08.014_b0070","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s11689-009-9023-x","article-title":"Common circuit defect of excitatory-inhibitory balance in mouse models of autism","volume":"1","author":"Gogolla","year":"2009","journal-title":"J. Neurodev. Disord."},{"issue":"2","key":"10.1016\/j.neuroscience.2026.08.014_b0075","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.bbr.2010.11.005","article-title":"Long-term voluntary wheel running is rewarding and produces plasticity in the mesolimbic reward pathway","volume":"217","author":"Greenwood","year":"2011","journal-title":"Behav. Brain Res."},{"issue":"8","key":"10.1016\/j.neuroscience.2026.08.014_b0080","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/s41593-019-0445-9","article-title":"Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice","volume":"22","author":"Guo","year":"2019","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.neuroscience.2026.08.014_b0085","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nn.3917","article-title":"The neocortical circuit: themes and variations","volume":"18","author":"Harris","year":"2015","journal-title":"Nat. Neurosci."},{"issue":"5","key":"10.1016\/j.neuroscience.2026.08.014_b0090","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.neuron.2015.08.008","article-title":"Mechanism of activity-dependent cargo loading via the phosphorylation of KIF3A by PKA and CaMKIIa","volume":"87","author":"Ichinose","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2026.08.014_b0095","doi-asserted-by":"crossref","first-page":"27400","DOI":"10.1038\/srep27400","article-title":"Distinct defects in synaptic differentiation of neocortical neurons in response to prenatal valproate exposure","volume":"6","author":"Iijima","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.neuroscience.2026.08.014_b0100","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.neuron.2011.09.027","article-title":"How inhibition shapes cortical activity","volume":"72","author":"Isaacson","year":"2011","journal-title":"Neuron"},{"issue":"28","key":"10.1016\/j.neuroscience.2026.08.014_b0105","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adf7084","article-title":"Glyoxal fixation: an approach to solve immunohistochemical problem in neuroscience research","volume":"9","author":"Konno","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.neuroscience.2026.08.014_b0110","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neulet.2014.03.066","article-title":"Valproic acid selectively suppresses the formation of inhibitory synapses in cultured cortical neurons","volume":"569","author":"Kumamaru","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuroscience.2026.08.014_b0115","article-title":"Analysis of proportions using arcsine transform with any experimental design","volume":"13","author":"Laurencelle","year":"2022","journal-title":"Front. Psychol."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.08.014_b0120","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/appe.1999.0274","article-title":"Pairings of a distinctive chamber with the aftereffect of wheel running produce conditioned place preference","volume":"34","author":"Lett","year":"2000","journal-title":"Appetite"},{"issue":"6056","key":"10.1016\/j.neuroscience.2026.08.014_b0125","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1126\/science.1209168","article-title":"The big and the small: challenges of imaging the brain\u2019s circuits","volume":"334","author":"Lichtman","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2026.08.014_b0130","article-title":"A selective review of the excitatory-inhibitory imbalance in schizophrenia: underlying biology, genetics, microcircuits, and symptoms","volume":"9","author":"Liu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.neuroscience.2026.08.014_b0135","doi-asserted-by":"crossref","first-page":"285","DOI":"10.5607\/en.2015.24.4.285","article-title":"Exploring the validity of valproic acid animal model of autism","volume":"24","author":"Mabunga","year":"2015","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.neuroscience.2026.08.014_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2024.102695","article-title":"Prefrontal excitation\/inhibition balance supports adolescent enhancements in circuit signal to noise ratio","volume":"243","author":"McKeon","year":"2024","journal-title":"Prog. Neurobiol."},{"issue":"10","key":"10.1016\/j.neuroscience.2026.08.014_b0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026077","article-title":"mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism","volume":"6","author":"Mehta","year":"2011","journal-title":"PLoS One"},{"issue":"23","key":"10.1016\/j.neuroscience.2026.08.014_b0150","doi-asserted-by":"crossref","first-page":"R1442","DOI":"10.1016\/j.cub.2020.10.009","article-title":"Anterior cingulate cortex and the control of dynamic behavior in primates","volume":"30","author":"Monosov","year":"2020","journal-title":"Curr. Biol."},{"issue":"4","key":"10.1016\/j.neuroscience.2026.08.014_b0155","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.neuron.2015.07.033","article-title":"Excitatory\/inhibitory balance and circuit homeostasis in autism spectrum disorders","volume":"87","author":"Nelson","year":"2015","journal-title":"Neuron"},{"issue":"Pt A","key":"10.1016\/j.neuroscience.2026.08.014_b0160","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.expneurol.2017.04.017","article-title":"The valproic acid-induced rodent model of autism","volume":"299","author":"Nicolini","year":"2018","journal-title":"Exp. Neurol."},{"issue":"5","key":"10.1016\/j.neuroscience.2026.08.014_b0165","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.neuron.2009.08.023","article-title":"Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin","volume":"63","author":"Poulopoulos","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2026.08.014_b0170","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.860275","article-title":"Excitatory and inhibitory synaptic imbalance caused by brain-derived neurotrophic factor deficits during development in a valproic acid mouse model of autism","volume":"15","author":"Qi","year":"2022","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.08.014_b0175","doi-asserted-by":"crossref","first-page":"139","DOI":"10.15252\/embj.201695709","article-title":"Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy","volume":"37","author":"Richter","year":"2018","journal-title":"EMBO J."},{"issue":"Pt B","key":"10.1016\/j.neuroscience.2026.08.014_b0180","article-title":"GABAergic interneurons in epilepsy: more than a simple change in inhibition","volume":"121","author":"Righes Marafiga","year":"2021","journal-title":"Epilepsy Behav."},{"issue":"33","key":"10.1016\/j.neuroscience.2026.08.014_b0185","doi-asserted-by":"crossref","first-page":"13501","DOI":"10.1073\/pnas.0704391104","article-title":"Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid","volume":"104","author":"Rinaldi","year":"2007","journal-title":"PNAS"},{"issue":"4","key":"10.1016\/j.neuroscience.2026.08.014_b0190","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/cercor\/bhm117","article-title":"Hyperconnectivity of local neocortical microcircuitry induced by prenatal exposure to valproic acid","volume":"18","author":"Rinaldi","year":"2008","journal-title":"Cereb. Cortex"},{"issue":"3","key":"10.1016\/j.neuroscience.2026.08.014_b0195","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s12021-023-09632-8","article-title":"Localization and registration of 2D histological mouse brain images in 3D atlas space","volume":"21","author":"Sadeghi","year":"2023","journal-title":"Neuroinformatics"},{"key":"10.1016\/j.neuroscience.2026.08.014_b0200","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.691931","article-title":"Electroacupuncture ameliorates chronic inflammatory pain-related anxiety by activating PV interneurons in the anterior cingulate cortex","volume":"15","author":"Shao","year":"2021","journal-title":"Front. Neurosci."},{"issue":"9","key":"10.1016\/j.neuroscience.2026.08.014_b0205","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/s41380-019-0426-0","article-title":"Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders","volume":"24","author":"Sohal","year":"2019","journal-title":"Mol. Psychiatry"},{"issue":"3","key":"10.1016\/j.neuroscience.2026.08.014_b0210","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nrn2286","article-title":"Pyramidal neurons: dendritic structure and synaptic integration","volume":"9","author":"Spruston","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.08.014_b0215","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41598-020-79520-7","article-title":"Valproic acid-exposed astrocytes impair inhibitory synapse formation and function","volume":"11","author":"Takeda","year":"2021","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.neuroscience.2026.08.014_b0220","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.neuron.2016.06.033","article-title":"GABAergic interneurons in the neocortex: from cellular properties to circuits","volume":"91","author":"Tremblay","year":"2016","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.neuroscience.2026.08.014_b0225","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a005736","article-title":"Homeostatic synaptic plasticity: local and global mechanisms for stabilizing neuronal function","volume":"4","author":"Turrigiano","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.08.014_b0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2006.06.027","article-title":"Interactions among the medial prefrontal cortex, hippocampus and midline thalamus in emotional and cognitive processing in the rat","volume":"142","author":"Vertes","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2026.08.014_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.conb.2024.102952","article-title":"Release your inhibitions: the cell biology of GABAergic postsynaptic plasticity","volume":"90","author":"Welle","year":"2025","journal-title":"Curr. Opin. Neurobiol."},{"issue":"5","key":"10.1016\/j.neuroscience.2026.08.014_b0240","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cmet.2013.09.008","article-title":"Exercise induces hippocampal BDNF through a PGC-1\u03b1\/FNDC5 pathway","volume":"18","author":"Wrann","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.neuroscience.2026.08.014_b0250","doi-asserted-by":"crossref","DOI":"10.1177\/17448069221087034","article-title":"Mapping thalamic-anterior cingulate monosynaptic inputs in adult mice","volume":"18","author":"Xue","year":"2022","journal-title":"Mol. Pain"},{"key":"10.1016\/j.neuroscience.2026.08.014_b0245","doi-asserted-by":"crossref","DOI":"10.1177\/17448069241300990","article-title":"Whole-brain mapping of afferents to the anterior cingulate cortex in adult mice","volume":"20","author":"Xue","year":"2024","journal-title":"Mol. Pain"},{"key":"10.1016\/j.neuroscience.2026.08.014_b0255","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbr.2017.06.035","article-title":"Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice","volume":"333","author":"Yamaguchi","year":"2017","journal-title":"Behav. Brain Res."},{"issue":"7363","key":"10.1016\/j.neuroscience.2026.08.014_b0260","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nature10360","article-title":"Neocortical excitation\/inhibition balance in information processing and social dysfunction","volume":"477","author":"Yizhar","year":"2011","journal-title":"Nature"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452226005427?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452226005427?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:27:49Z","timestamp":1789129669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452226005427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":52,"alternative-id":["S0306452226005427"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2026.08.014","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Standardized depth-resolved mapping of anterior cingulate cortex synaptic markers reveals inhibitory marker alterations following prenatal valproic acid exposure","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2026.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of International Brain Research Organization (IBRO).","name":"copyright","label":"Copyright"}]}}