{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:09:02Z","timestamp":1789132142639,"version":"build-2803163510"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["075\\u201315-2024\\u2013548"],"award-info":[{"award-number":["075\\u201315-2024\\u2013548"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.neuroscience.2026.08.018","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:55:39Z","timestamp":1786722939000},"page":"318-332","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Effects of carbamazepine and phenytoin in Krushinsky-Molodkina rats: further validation of the audiogenic kindling model of epilepsy"],"prefix":"10.1016","volume":"614","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0397-054X","authenticated-orcid":false,"given":"Alexandra A.","family":"Naumova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1385-6903","authenticated-orcid":false,"given":"Alexey A.","family":"Kulikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1019-7188","authenticated-orcid":false,"given":"Svetlana D.","family":"Nikolaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7182-2066","authenticated-orcid":false,"given":"Andrey P.","family":"Ivlev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1041-5619","authenticated-orcid":false,"given":"Elena V.","family":"Chernigovskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6617-3404","authenticated-orcid":false,"given":"Margarita V.","family":"Glazova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2026.08.018_b0005","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1358\/mf.2009.31.7.1393610","article-title":"Effect of various antiepileptic drugs in a pentylenetetrazol-induced seizure model in mice","volume":"31","author":"Akula","year":"2009","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118826","article-title":"Revisiting the role of neurotransmitters in epilepsy: an updated review","volume":"265","author":"Akyuz","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0015","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1007\/s11064-016-2105-8","article-title":"Mechanisms of excessive extracellular glutamate accumulation in temporal lobe epilepsy","volume":"42","author":"Albrecht","year":"2017","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0025","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1134\/S0022093023050083","article-title":"Chronic dysregulation of glutamatergic transmission in the hippocampus of Krushinsky\u2013Molodkina rats induced by repeated epileptiform seizures","volume":"59","author":"Aleksandrova","year":"2023","journal-title":"J. Evol. Biochem. Physiol."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2024.148792","article-title":"Audiogenic kindling activates glutamatergic system in the hippocampus of rats with genetic predisposition to audiogenic seizures","volume":"1829","author":"Aleksandrova","year":"2024","journal-title":"Brain Res."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0030","doi-asserted-by":"crossref","unstructured":"Aleksandrova, E.P., Ivlev, A.P., Kulikov, A.A., Nikitina, L.S., Glazova, M.V., Naumova, A.A., Chernigovskaya, E.V., 2026. Accelerated establishment of limbic seizures in aging krushinsky\u2013molodkina audiogenic rats is associated with neurodegeneration and downregulation of the glutamatergic transmission in the hippocampus. Dev. Neurobiol. 86.","DOI":"10.1002\/dneu.70015"},{"key":"10.1016\/j.neuroscience.2026.08.018_b0035","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/S0028-3908(99)00058-1","article-title":"Carbamazepine inhibits L-type Ca2+ channels in cultured rat hippocampal neurons stimulated with glutamate receptor agonists","volume":"38","author":"Ambr\u00f3sio","year":"1999","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2026.08.018_b0040","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.yebeh.2013.05.028","article-title":"Pharmacological and neuroethological studies of three antiepileptic drugs in the genetic audiogenic seizure hamster (GASH:Sal)","volume":"28","author":"Barrera-Bail\u00f3n","year":"2013","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0045","doi-asserted-by":"crossref","first-page":"192","DOI":"10.5698\/1535-7511-15.4.192","article-title":"Genetics of epilepsy in clinical practice","volume":"15","author":"Berkovic","year":"2015","journal-title":"Epilepsy Curr"},{"key":"10.1016\/j.neuroscience.2026.08.018_b0050","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1111\/epi.16995","article-title":"Chronic limbic epilepsy models for therapy discovery: protocols to improve efficiency","volume":"62","author":"Bertram","year":"2021","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2026.08.018_b0055","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1007\/s00018-013-1550-7","article-title":"Neuronal calcium signaling: function and dysfunction","volume":"71","author":"Brini","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0060","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.pneurobio.2010.04.006","article-title":"The synapsins: key actors of synapse function and plasticity","volume":"91","author":"Cesca","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0065","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1046\/j.1471-4159.1996.67052079.x","article-title":"Attenuation of cyclic AMP production by carbamazepine","volume":"67","author":"Chen","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0070","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0006-8993(00)02623-8","article-title":"Chronic inhibition of Ca2+\/calmodulin kinase II activity in the pilocarpine model of epilepsy","volume":"875","author":"Churn","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0075","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.eplepsyres.2018.07.018","article-title":"Perampanel chronic treatment does not induce tolerance and decreases tolerance to clobazam in genetically epilepsy prone rats","volume":"146","author":"Citraro","year":"2018","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0080","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/0014-4886(80)90188-0","article-title":"Acute and chronic antiepileptic drug effects in audiogenic seizure-susceptible rats","volume":"70","author":"Consroe","year":"1980","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0085","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0024-3205(95)02286-4","article-title":"Neurochemical correlates of antiepileptic drugs in the genetically epilepsy-prone rat (GEPR)","volume":"58","author":"Dailey","year":"1995","journal-title":"Life Sci."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0090","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.yebeh.2015.06.030","article-title":"Genetically epilepsy-prone rats (GEPRs) and DBA\/2 mice: two animal models of audiogenic reflex epilepsy for the evaluation of new generation AEDs","volume":"71","author":"De Sarro","year":"2017","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0095","doi-asserted-by":"crossref","first-page":"9327","DOI":"10.3390\/ijms21239327","article-title":"Carbamazepine restores neuronal signaling, protein synthesis, and cognitive function in a mouse model of fragile X syndrome","volume":"21","author":"Ding","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0100","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.775040","article-title":"Screening for activity against AMPA receptors among anticonvulsants\u2014focus on phenytoin","volume":"12","author":"Dron","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0105","first-page":"6","article-title":"The effect of lamotrigine and carbamazepine on the development of the audiogenic seizure reaction in rats of the Krushinski\u012d-Molodkina strain","volume":"59","author":"Fedotova","year":"1996","journal-title":"Eksp. Klin. Farmakol."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0110","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1528-1157.1977.tb04975.x","article-title":"Phenytoin: effects on calcium flux and cyclic nucleotides","volume":"18","author":"Ferrendelli","year":"1977","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2026.08.018_b0115","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0028-3908(85)90124-8","article-title":"Anticonvulsant effects of chronic treatment with phenytoin against pentylenetetrazole-induced seizures in the mouse","volume":"24","author":"File","year":"1985","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2026.08.018_b0120","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.3390\/biomedicines10112934","article-title":"Rodent models of audiogenic epilepsy: genetic aspects, advantages, current problems and perspectives","volume":"10","author":"Garbuz","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.neuroscience.2026.08.018_b0125","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/hipo.20590","article-title":"Increased expression of GluR2\u2010flip in the hippocampus of the Wistar audiogenic rat strain after acute and kindled seizures","volume":"20","author":"Gita\u00ed","year":"2010","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuroscience.2026.08.018_b0130","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/epi.14680","article-title":"Effect of carbamazepine on spontaneous recurrent seizures recorded from the dentate gyrus in rats with kainate\u2010induced epilepsy","volume":"60","author":"Grabenstatter","year":"2019","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2026.08.018_b0135","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1134\/S0022093024060085","article-title":"Dynamic changes of astrocytes in the hippocampus of Krushinsky\u2013Molodkina rats during audiogenic kindling","volume":"60","author":"Grigorieva","year":"2024","journal-title":"J. Evol. Biochem. Physiol."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2020.107683","article-title":"Gamma-aminobutyric acid (GABA) changes in the hippocampus and anterior cingulate cortex in patients with temporal lobe epilepsy","volume":"115","author":"He","year":"2021","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0145","doi-asserted-by":"crossref","unstructured":"Houser, C.R., Huang, C.S., Peng, Z., 2008. Dynamic seizure-related changes in extracellular signal-regulated kinase activation in a mouse model of temporal lobe epilepsy. Neuroscience 156:222\u2013237 Available at: http:\/\/www.ibroneuroscience.org\/article\/S0306452208009949\/fulltext [Accessed April 24, 2024].","DOI":"10.1016\/j.neuroscience.2008.07.010"},{"key":"10.1016\/j.neuroscience.2026.08.018_b0150","first-page":"1119","article-title":"Pathogenesis of epilepsy: challenges in animal models","volume":"16","author":"Hui Yin","year":"2013","journal-title":"Iran. J. Basic Med. Sci."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0155","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1440-1819.1989.tb02946.x","article-title":"Inositol trisphosphate (IP,) receptors and epileptic seizure","volume":"43","author":"Imazawa","year":"1989","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0160","article-title":"Pharmacological modulation of brain levels of glutamate and GABA in rats exposed to total sleep deprivation","author":"Kamal","year":"2010","journal-title":"J. Exp. Pharmacol:65."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0165","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00210-011-0636-8","article-title":"Effects of antiepileptic drugs on GABA release from rat and human neocortical synaptosomes","volume":"384","author":"Kammerer","year":"2011","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0170","doi-asserted-by":"crossref","DOI":"10.2147\/NDT.S50371","article-title":"Animal models of epilepsy: use and limitations","author":"Kandratavicius","year":"2014","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0175","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s11064-014-1472-2","article-title":"Alteration in 5-HT2C, NMDA receptor and IP3 in cerebral cortex of epileptic rats: restorative role of Bacopa monnieri","volume":"40","author":"Krishnakumar","year":"2015","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2021.108445","article-title":"Audiogenic kindling stimulates aberrant neurogenesis, synaptopodin expression, and mossy fiber sprouting in the hippocampus of rats genetically prone to audiogenic seizures","volume":"125","author":"Kulikov","year":"2021","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2022.108846","article-title":"Dynamics of neurodegeneration in the hippocampus of Krushinsky-Molodkina rats correlates with the progression of limbic seizures","volume":"134","author":"Kulikov","year":"2022","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0190","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neuroscience.2025.04.013","article-title":"p53 inhibition during audiogenic kindling in Krushinsky-Molodkina rats attenuates seizure severity and prevents neurodegeneration in the hippocampus","volume":"574","author":"Kulikov","year":"2025","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2026.08.018_b0195","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2021.611902","article-title":"Cannabinoids in audiogenic seizures: from neuronal networks to future perspectives for epilepsy treatment","volume":"15","author":"Lazarini-Lopes","year":"2021","journal-title":"Front Behav. Neurosci."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0200","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1134\/S0012496624600489","article-title":"Ontogeny of the epileptic system in the Krushinsky\u2013molodkina rat strain with genetically determined audiogenic epilepsy","volume":"521","author":"Litvinova","year":"2025","journal-title":"Dokl. Biol. Sci."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0205","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neubiorev.2021.08.011","article-title":"An updated reappraisal of synapsins: structure, function and role in neurological and psychiatric disorders","volume":"130","author":"Longhena","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0210","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.seizure.2011.01.003","article-title":"Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs","volume":"20","author":"L\u00f6scher","year":"2011","journal-title":"Seizure"},{"key":"10.1016\/j.neuroscience.2026.08.018_b0215","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1258\/ebm.2009.009225","article-title":"Effect of prolonged phenytoin administration on rat brain gene expression assessed by DNA microarrays","volume":"235","author":"Mariotti","year":"2010","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0220","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s11064-019-02853-x","article-title":"Aspects of cAMP signaling in epileptogenesis and seizures and its potential as drug target","volume":"45","author":"Mertz","year":"2020","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0225","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/BF00969688","article-title":"Effect of chronic administration of phenytoin on regional monoamine levels in rat brain","volume":"20","author":"Meshkibaf","year":"1995","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0230","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.eplepsyres.2007.10.007","article-title":"Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin","volume":"78","author":"Meurs","year":"2008","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0235","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0014-4886(92)90197-X","article-title":"Repetition of audiogenic seizures in genetically epilepsy-prone rats induces cortical epileptiform activity and additional seizure behaviors","volume":"115","author":"Naritoku","year":"1992","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0240","article-title":"Carbamazepine versus phenytoin monotherapy for epilepsy: an individual participant data review","author":"Nevitt","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0245","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0006-8993(00)01996-X","article-title":"Phenytoin administration reveals a differential role of pontine reticular formation and periaqueductal gray neurons in generation of the convulsive behaviors of audiogenic seizures","volume":"859","author":"N\u2019Gouemo","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0250","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0920-1211(98)00025-4","article-title":"Effects of carbamazepine on hippocampal serotonergic system","volume":"31","author":"Okada","year":"1998","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0255","first-page":"742","article-title":"The effects of toluene vapor inhalation on the intensity of audiogenic seizure fits in rats of Krushinsky-Molodkina strain","volume":"105","author":"Poletaeva","year":"2019","journal-title":"Russ. J. Physiol."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0260","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s40199-018-0224-2","article-title":"New mechanisms of phenytoin in calcium homeostasis: competitive inhibition of CD38 in hippocampal cells","volume":"26","author":"Sadeghi","year":"2018","journal-title":"DARU J. Pharmaceut. Sci."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/863702","article-title":"Genetics of temporal lobe epilepsy: a review","volume":"2012","author":"Salzmann","year":"2012","journal-title":"Epilepsy Res Treat"},{"key":"10.1016\/j.neuroscience.2026.08.018_b0270","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.seizure.2021.06.028","article-title":"Brain concentrations of glutamate and GABA in human epilepsy: a review","volume":"91","author":"Sarlo","year":"2021","journal-title":"Seizure"},{"key":"10.1016\/j.neuroscience.2026.08.018_b0275","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.neuropharm.2006.09.002","article-title":"Effects of carbamazepine, phenytoin, lamotrigine, oxcarbazepine, topiramate and vinpocetine on Na+ channel-mediated release of [3H]glutamate in hippocampal nerve endings","volume":"52","author":"Sitges","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2026.08.018_b0280","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00441-014-1849-1","article-title":"Calcium signaling and epilepsy","volume":"357","author":"Steinlein","year":"2014","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0285","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.3892\/ijmm.2017.2962","article-title":"The extracellular signal-regulated kinase 1\/2 pathway in neurological diseases: a potential therapeutic target (review)","volume":"39","author":"Sun","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0290","doi-asserted-by":"crossref","first-page":"6081","DOI":"10.3390\/ijms26136081","article-title":"Adenylyl cyclases as therapeutic targets in neuroregeneration","volume":"26","author":"Tomczak","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0295","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0006-291X(88)81198-7","article-title":"Carbamazepine inhibits electroconvulsive shock-induced inositol trisphosphate (IP3) accumulation in rat cerebral cortex and hippocampus","volume":"153","author":"Vadnal","year":"1988","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0300","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3109\/00207458709058791","article-title":"Kindling of audiogenic seizures in the rat","volume":"36","author":"Vergnes","year":"1987","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0305","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.yebeh.2015.06.014","article-title":"Audiogenic kindling and secondary subcortico-cortical epileptogenesis: behavioral correlates and electrographic features","volume":"71","author":"Vinogradova","year":"2017","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.neuroscience.2026.08.018_b0315","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1111\/j.1528-1167.2008.01594.x","article-title":"Anticonvulsive and antiepileptogenic effects of levetiracetam in the audiogenic kindling model","volume":"49","author":"Vinogradova","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2026.08.018_b0310","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/j.1528-1167.2005.52604.x","article-title":"Vigabatrin in low doses selectively suppresses the clonic component of audiogenically kindled seizures in rats","volume":"46","author":"Vinogradova","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2026.08.018_b0320","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.neuron.2008.08.021","article-title":"Calmodulin-kinases: modulators of neuronal development and plasticity","volume":"59","author":"Wayman","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2026.08.018_b0325","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3390\/cells15050409","article-title":"Beyond epilepsy control: repurposing antiepileptic drugs in central nervous system tumor therapy","volume":"15","author":"Zhao","year":"2026","journal-title":"Cells"},{"key":"10.1016\/j.neuroscience.2026.08.018_b0330","doi-asserted-by":"crossref","unstructured":"Zhou, J., Du, T., Li, B., Rong, Y., Verkhratsky, A., Peng, L., 2015. Crosstalk between MAPK\/ERK and PI3K\/AKT signal pathways during brain ischemia\/reperfusion. ASN Neuro 7.","DOI":"10.1177\/1759091415602463"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452226005476?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452226005476?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:27:07Z","timestamp":1789129627000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452226005476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":66,"alternative-id":["S0306452226005476"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2026.08.018","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of carbamazepine and phenytoin in Krushinsky-Molodkina rats: further validation of the audiogenic kindling model of epilepsy","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2026.08.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}