{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:45:59Z","timestamp":1791953159416,"version":"4.3.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.neuroscience.2026.09.044","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:24:19Z","timestamp":1790954659000},"page":"70-79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Identification of a shared blood\u2013brain transcriptomic signature in Parkinson\u2019s disease using bioinformatic and network pharmacology approaches"],"prefix":"10.1016","volume":"618","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8242-1877","authenticated-orcid":false,"given":"Hafsa","family":"Mohammad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akanksha","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipika","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7526","key":"10.1016\/j.neuroscience.2026.09.044_b0005","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nj7526-299a","article-title":"Neurodegenerative disease: brain windfall","volume":"515","author":"Gammon","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2026.09.044_b0010","doi-asserted-by":"crossref","unstructured":"Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the global burden of disease study 2015. Lancet Neurol, 2017. 16(11): p. 877-897.","DOI":"10.1016\/S1474-4422(17)30299-5"},{"key":"10.1016\/j.neuroscience.2026.09.044_b0015","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fnagi.2015.00018","article-title":"Intrinsically disordered proteins and their (disordered) proteomes in neurodegenerative disorders","volume":"7","author":"Uversky","year":"2015","journal-title":"Front. Aging Neurosci."},{"issue":"4","key":"10.1016\/j.neuroscience.2026.09.044_b0020","first-page":"879","article-title":"Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies","volume":"152","author":"Baba","year":"1998","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.neuroscience.2026.09.044_b0025","doi-asserted-by":"crossref","first-page":"127","DOI":"10.14802\/jmd.24075","article-title":"\u03b1-synuclein: a promising biomarker for Parkinson\u2019s disease and related disorders","volume":"17","author":"Hatano","year":"2024","journal-title":"J. Mov. Disord."},{"issue":"5","key":"10.1016\/j.neuroscience.2026.09.044_b0030","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a009423","article-title":"Disruption of protein quality control in Parkinson's disease","volume":"2","author":"Cook","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"8","key":"10.1016\/j.neuroscience.2026.09.044_b0035","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/acn3.51141","article-title":"UCHL1 from serum and CSF is a candidate biomarker for amyotrophic lateral sclerosis","volume":"7","author":"Li","year":"2020","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"6","key":"10.1016\/j.neuroscience.2026.09.044_b0040","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/mds.26237","article-title":"Impact of Parkinson's disease risk loci on age at onset","volume":"30","author":"Lill","year":"2015","journal-title":"Mov. Disord."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.09.044_b0045","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41531-021-00189-4","article-title":"Reference SVA insertion polymorphisms are associated with Parkinson's disease progression and differential gene expression","volume":"7","author":"Pfaff","year":"2021","journal-title":"NPJ Parkinsons Dis"},{"issue":"1","key":"10.1016\/j.neuroscience.2026.09.044_b0050","doi-asserted-by":"crossref","first-page":"10932","DOI":"10.1038\/s41598-024-61753-5","article-title":"Deciphering the role of a SINE-VNTR-Alu retrotransposon polymorphism as a biomarker of Parkinson's disease progression","volume":"14","author":"Fr\u00f6hlich","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.09.044_b0055","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1038\/s41467-023-39652-6","article-title":"Blood transcriptomic signatures associated with molecular changes in the brain and clinical outcomes in Parkinson\u2019s disease","volume":"14","author":"Irmady","year":"2023","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.neuroscience.2026.09.044_b0060","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1177\/15353702221081027","article-title":"Longitudinal intronic RNA-Seq analysis of Parkinson's disease patients reveals disease-specific nascent transcription","volume":"247","author":"Koks","year":"2022","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"3","key":"10.1016\/j.neuroscience.2026.09.044_b0065","doi-asserted-by":"crossref","DOI":"10.3390\/biom15030440","article-title":"The exon-based transcriptomic analysis of Parkinson\u2019s disease","volume":"15","author":"K\u00f5ks","year":"2025","journal-title":"Biomolecules"},{"issue":"5","key":"10.1016\/j.neuroscience.2026.09.044_b0070","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1177\/1535370220967325","article-title":"Transcriptomic profiles in Parkinson's disease","volume":"246","author":"Kurvits","year":"2021","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.neuroscience.2026.09.044_b0075","doi-asserted-by":"crossref","first-page":"11099","DOI":"10.3389\/ebm.2026.11099","article-title":"A whole-transcriptome analysis of differentially expressed genes, transcripts, and transcript usage in blood samples from Parkinson's disease patients","volume":"251","author":"Koks","year":"2026","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"1","key":"10.1016\/j.neuroscience.2026.09.044_b0080","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12883-016-0784-z","article-title":"Looking beyond the brain to improve the pathogenic understanding of Parkinson's disease: implications of whole transcriptome profiling of patients' skin","volume":"17","author":"Planken","year":"2017","journal-title":"BMC Neurol."},{"issue":"Database issue","key":"10.1016\/j.neuroscience.2026.09.044_b0085","first-page":"D991","article-title":"NCBI GEO: archive for functional genomics data sets\u2013update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.neuroscience.2026.09.044_b0090","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1046\/j.1601-183x.2003.00047.x","article-title":"A screen for genes induced in the amygdaloid area during cat odor exposure","volume":"3","author":"K\u00f5ks","year":"2004","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.neuroscience.2026.09.044_b0095","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"Smyth","year":"2004","journal-title":"Stat. Appl. Genet. Mol. Biol."},{"key":"10.1016\/j.neuroscience.2026.09.044_b0100","doi-asserted-by":"crossref","unstructured":"Smyth, G.K., Limma: Linear Models for Microarray Data, in Bioinformatics and Computational Biology Solutions Using R and Bioconductor, R. Gentleman, et al., Editors. 2005, Springer New York: New York, NY. p. 397-420.","DOI":"10.1007\/0-387-29362-0_23"},{"issue":"W1","key":"10.1016\/j.neuroscience.2026.09.044_b0105","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.09.044_b0110","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neuroscience.2026.09.044_b0115","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.2147\/JPR.S532016","article-title":"Identification of common genes for neuropathic pain and Parkinson\u2019s disease based on bioinformatics analysis and their potential value in the diagnosis of neuropathic pain","volume":"18","author":"Xue","year":"2025","journal-title":"J. Pain Res."},{"issue":"10","key":"10.1016\/j.neuroscience.2026.09.044_b0120","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/j.neurobiolaging.2009.10.016","article-title":"Transcriptional profile of Parkinson blood mononuclear cells with LRRK2 mutation","volume":"32","author":"Mutez","year":"2011","journal-title":"Neurobiol. Aging"},{"issue":"2","key":"10.1016\/j.neuroscience.2026.09.044_b0125","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10048-006-0077-6","article-title":"The medial and lateral substantia nigra in Parkinson's disease: mRNA profiles associated with higher brain tissue vulnerability","volume":"8","author":"Duke","year":"2007","journal-title":"Neurogenetics"},{"issue":"1","key":"10.1016\/j.neuroscience.2026.09.044_b0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10048-005-0020-2","article-title":"Whole genome expression profiling of the medial and lateral substantia nigra in Parkinson's disease","volume":"7","author":"Moran","year":"2006","journal-title":"Neurogenetics"},{"issue":"1","key":"10.1016\/j.neuroscience.2026.09.044_b0135","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/ajmg.b.30195","article-title":"Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms","volume":"137b","author":"Zhang","year":"2005","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"issue":"52","key":"10.1016\/j.neuroscience.2026.09.044_b0140","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3001059","article-title":"PGC-1\u03b1, a potential therapeutic target for early intervention in Parkinson's disease","volume":"2","author":"Zheng","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neuroscience.2026.09.044_b0145","article-title":"Methyl-arginine profile of brain from aged PINK1-KO+A53T-SNCA mice suggests altered mitochondrial biogenesis","volume":"2016","author":"Auburger","year":"2016","journal-title":"Parkinsons. Dis."},{"issue":"9","key":"10.1016\/j.neuroscience.2026.09.044_b0150","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1601576","article-title":"Interplay between protein glycosylation pathways in Alzheimer's disease","volume":"3","author":"Frenkel-Pinter","year":"2017","journal-title":"Sci. Adv."},{"issue":"4","key":"10.1016\/j.neuroscience.2026.09.044_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2026.111288","article-title":"Sialylation in the nervous system: functions and mechanisms","volume":"302","author":"Koles","year":"2026","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.09.044_b0160","doi-asserted-by":"crossref","DOI":"10.3390\/genes14010226","article-title":"The potential of ANK1 to predict Parkinson's disease","volume":"14","author":"Xue","year":"2023","journal-title":"Genes (Basel)"},{"issue":"7","key":"10.1016\/j.neuroscience.2026.09.044_b0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0177814","article-title":"ANK1 is up-regulated in laser captured microglia in Alzheimer's brain; the importance of addressing cellular heterogeneity","volume":"12","author":"Mastroeni","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2026.09.044_b0170","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neurobiolaging.2018.09.024","article-title":"A cross-brain regions study of ANK1 DNA methylation in different neurodegenerative diseases","volume":"74","author":"Smith","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuroscience.2026.09.044_b0175","article-title":"A convergent metabolic-kinase signaling axis links Parkinson's disease and multiple system atrophy","author":"Erika Velasquez","year":"2026","journal-title":"bioRxiv"},{"issue":"1","key":"10.1016\/j.neuroscience.2026.09.044_b0180","doi-asserted-by":"crossref","DOI":"10.1007\/s10753-026-02478-7","article-title":"RELA as a diagnostic biomarker for Parkinson\u2019s disease by integrating ferroptosis, lipid metabolism, and neuroinflammation","volume":"49","author":"Chen","year":"2026","journal-title":"Inflammation"},{"issue":"7","key":"10.1016\/j.neuroscience.2026.09.044_b0185","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1096\/fj.09-140368","article-title":"High regulatability favors genetic selection in SLC18A2, a vesicular monoamine transporter essential for life","volume":"24","author":"Lin","year":"2010","journal-title":"FASEB J."},{"issue":"23","key":"10.1016\/j.neuroscience.2026.09.044_b0190","doi-asserted-by":"crossref","first-page":"8005","DOI":"10.1074\/jbc.RA120.013337","article-title":"The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of \u03b1-synuclein","volume":"295","author":"Underwood","year":"2020","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.neuroscience.2026.09.044_b0195","article-title":"A review on the role of SNCA gene in neurodegenerative diseases","volume":"16","author":"Jahabardeen","year":"2024","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/j.neuroscience.2026.09.044_b0200","doi-asserted-by":"crossref","DOI":"10.1038\/s41531-026-01292-0","article-title":"SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids","volume":"12","author":"Statoulla","year":"2026","journal-title":"NPJ Parkinsons. Dis."},{"issue":"1","key":"10.1016\/j.neuroscience.2026.09.044_b0205","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12862-020-01684-7","article-title":"Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson's disease and other neurological disorders","volume":"20","author":"Nawaz","year":"2020","journal-title":"BMC Evol. Biol."},{"issue":"10","key":"10.1016\/j.neuroscience.2026.09.044_b0210","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1016\/j.gim.2022.07.006","article-title":"Heterozygous UCHL1 loss-of-function variants cause a neurodegenerative disorder with spasticity, ataxia, neuropathy, and optic atrophy","volume":"24","author":"Park","year":"2022","journal-title":"Genet. Med."},{"issue":"18","key":"10.1016\/j.neuroscience.2026.09.044_b0215","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26189012","article-title":"UCH-L1 in Alzheimer's disease: a crucial player in dementia-associated mechanisms","volume":"26","author":"Porchietto","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.neuroscience.2026.09.044_b0220","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1111\/j.1460-9568.2007.05569.x","article-title":"Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII","volume":"25","author":"Liu","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuroscience.2026.09.044_b0225","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.596105","article-title":"Meta-analysis of differentially expressed genes in the substantia Nigra in Parkinson's disease supports phenotype-specific transcriptome changes","volume":"14","author":"Phung","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuroscience.2026.09.044_b0230","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-026-05745-8","article-title":"Regulon reconstruction uncovers novel deregulated factors in Alzheimer\u2019s disease","volume":"63","author":"Bel\u00e9m-Souza","year":"2026","journal-title":"Mol. Neurobiol."},{"issue":"17","key":"10.1016\/j.neuroscience.2026.09.044_b0235","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21176371","article-title":"Proteomic characterization of the olfactory molecular imbalance in dementia with lewy bodies","volume":"21","author":"Lach\u00e9n-Montes","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuroscience.2026.09.044_b0240","article-title":"Molecular disease stages of oligodendrocytic and neuronal tau burden in progressive supranuclear palsy","author":"Briel","year":"2026","journal-title":"bioRxiv"},{"key":"10.1016\/j.neuroscience.2026.09.044_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.parkreldis.2026.108425","article-title":"Serum lipidomics reveals class-specific lipid remodelling and altered acyl chain composition in Parkinson's disease","volume":"150","author":"Price","year":"2026","journal-title":"Parkinsonism Relat. Disord."}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452226006627?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452226006627?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:03:24Z","timestamp":1791950604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452226006627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":49,"alternative-id":["S0306452226006627"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2026.09.044","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of a shared blood\u2013brain transcriptomic signature in Parkinson\u2019s disease using bioinformatic and network pharmacology approaches","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2026.09.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}